KEGG   ENZYME: 2.7.7.86Help
Entry
EC 2.7.7.86                 Enzyme                                 

Name
cyclic GMP-AMP synthase;
cGAMP synthase;
cGAS
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
ATP:GTP adenylyltransferase (cyclizing)
Reaction(IUBMB)
ATP + GTP = 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') (overall reaction) [RN:R10462];
(1a) ATP + GTP = pppGp(2'-5')A + diphosphate;
(1b) pppGp(2'-5')A = cyclic Gp(2'-5')Ap(3'-5') + diphosphate
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
GTP [CPD:C00044];
pppGp(2'-5')A
Product
diphosphate [CPD:C00013];
cyclic Gp(2'-5')Ap(3'-5') [CPD:C20640];
pppGp(2'-5')A
Comment
Cyclic Gp(2'-5')Ap(3'-5') is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.
History
EC 2.7.7.86 created 2013, modified 2014
Orthology
K17834  
cyclic GMP-AMP synthase
Genes
HSA: 
115004(MB21D1)
PTR: 
462822(MB21D1)
PPS: 
GGO: 
101146170(MB21D1)
PON: 
100456001(MB21D1)
NLE: 
100583298(MB21D1)
MCC: 
MCF: 
102133276(MB21D1)
CJC: 
100387233(MB21D1)
MMU: 
214763(Mb21d1)
RNO: 
682147(Mb21d1)
CGE: 
NGI: 
103744364(Mb21d1)
HGL: 
101717623(Mb21d1)
OCU: 
100349407(MB21D1)
TUP: 
102474401(MB21D1)
CFA: 
611033(MB21D1)
AML: 
UMR: 
103657480(MB21D1)
FCA: 
101098056(MB21D1)
PTG: 
102952381(MB21D1)
BTA: 
782472(MB21D1)
BOM: 
102285090(MB21D1)
PHD: 
102315593(MB21D1)
CHX: 
102187049(MB21D1)
OAS: 
101117253(MB21D1)
SSC: 
100516408(MB21D1)
CFR: 
102523852(MB21D1)
BACU: 
LVE: 
103082954(MB21D1)
ECB: 
100067982(MB21D1)
MYB: 
MYD: 
102775467(MB21D1)
PALE: 
102883365(MB21D1)
MDO: 
100021282(MB21D1)
SHR: 
100920386(MB21D1)
OAA: 
100087769(MB21D1)
GGA: 
421864(MB21D1)
MGP: 
APLA: 
101797757(MB21D1)
TGU: 
100224044(MB21D1)
FAB: 
101809319(MB21D1)
PHI: 
102108130(MB21D1)
FPG: 
101922902(MB21D1)
FCH: 
102047663(MB21D1)
CLV: 
102091030(MB21D1)
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
100567354(mb21d1)
XTR: 
DRE: 
557043(mb21d1)
MZE: 
OLA: 
XMA: 
LCM: 
102346272(MB21D1)
CMK: 
BFO: 
TCA: 
NVE: 
 » show all
Taxonomy
Reference
1  [PMID:23258413]
  Authors
Sun L, Wu J, Du F, Chen X, Chen ZJ
  Title
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
  Journal
Science. 339 (2013) 786-91.
  Sequence
[hsa:115004] [mmu:214763]
Reference
2  [PMID:23722158]
  Authors
Ablasser A, Goldeck M, Cavlar T, Deimling T, Witte G, Rohl I, Hopfner KP, Ludwig J, Hornung V.
  Title
cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates  STING.
  Journal
Nature. 498 (2013) 380-4.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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