KEGG   ENZYME: 3.1.1.25Help
Entry
EC 3.1.1.25                 Enzyme                                 

Name
1,4-lactonase;
gamma-lactonase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
1,4-lactone hydroxyacylhydrolase
Reaction(IUBMB)
a 1,4-lactone + H2O = a 4-hydroxyacid [RN:R03708]
Reaction(KEGG)
Substrate
1,4-lactone [CPD:C01770];
H2O [CPD:C00001]
Product
4-hydroxyacid [CPD:C01991]
Comment
The enzyme is specific for 1,4-lactones with 4-8 carbon atoms. It does not hydrolyse simple aliphatic esters, acetylcholine, sugar lactones or substituted aliphatic lactones, e.g. 3-hydroxy-4-butyrolactone; requires Ca2+.
History
EC 3.1.1.25 created 1972, modified 1981
Pathway
Galactose metabolism
Ascorbate and aldarate metabolism
Metabolic pathways
Reference
1  [PMID:4958984]
  Authors
Fishbein WN, Bessman SP.
  Title
Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of gamma-lactones. I. Tissue localization, stoichiometry, specificity, distinction from esterase.
  Journal
J. Biol. Chem. 241 (1966) 4835-41.
  Organism
Homo sapiens, Rattus norvegicus
Reference
2  [PMID:4958985]
  Authors
Fishbein WN, Bessman SP.
  Title
Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of gamma-lactones. II. Metal ion effects, kinetics, and equilibra.
  Journal
J. Biol. Chem. 241 (1966) 4842-7.
  Organism
Homo sapiens, Rattus norvegicus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37278-38-9

DBGET integrated database retrieval system