KEGG   ENZYME: 3.1.1.7Help
Entry
EC 3.1.1.7                  Enzyme                                 

Name
acetylcholinesterase;
true cholinesterase;
choline esterase I;
cholinesterase;
acetylthiocholinesterase;
acetylcholine hydrolase;
acetyl.beta-methylcholinesterase;
AcCholE
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
acetylcholine acetylhydrolase
Reaction(IUBMB)
acetylcholine + H2O = choline + acetate [RN:R01026]
Reaction(KEGG)
Substrate
acetylcholine [CPD:C01996];
H2O [CPD:C00001]
Product
choline [CPD:C00114];
acetate [CPD:C00033]
Comment
Acts on a variety of acetic esters; also catalyses transacetylations.
History
EC 3.1.1.7 created 1961
Pathway
Glycerophospholipid metabolism
Orthology
K01049  
acetylcholinesterase
Genes
HSA: 
43(ACHE)
PTR: 
100609296(ACHE)
PPS: 
100980268(ACHE)
GGO: 
101143749(ACHE)
PON: 
100432513(ACHE)
NLE: 
100579679(ACHE)
MCC: 
713370(ACHE)
MCF: 
102143626(ACHE)
CJC: 
100392257(ACHE)
MMU: 
11423(Ache)
RNO: 
83817(Ache)
CGE: 
100770679(Ache)
NGI: 
103733499(Ache)
HGL: 
101705724(Ache)
TUP: 
102479743(ACHE)
CFA: 
489828(ACHE)
AML: 
UMR: 
103670049(ACHE)
FCA: 
493674(ACHE)
PTG: 
102948945(ACHE)
BTA: 
540446(ACHE)
BOM: 
102281882(ACHE)
PHD: 
102322343(ACHE)
CHX: 
102186824(ACHE)
OAS: 
101123006(ACHE)
SSC: 
100621099(ACHE)
CFR: 
102504654(ACHE)
BACU: 
103020153(ACHE)
LVE: 
103068775(ACHE)
ECB: 
100069149(ACHE)
MYB: 
102261529(ACHE)
MYD: 
102759473(ACHE)
PALE: 
102880690(ACHE)
MDO: 
100017989(ACHE)
SHR: 
100923959(ACHE)
OAA: 
100087817(ACHE)
GGA: 
396388(ACHE)
PHI: 
FPG: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
PBI: 
XLA: 
100158421(ache)
XTR: 
DRE: 
114549(ache)
TRU: 
MZE: 
OLA: 
XMA: 
CMK: 
103173352(ache)
BFO: 
CIN: 
100169895(ache)
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsim_GD20515(Dsim_Ace)
DWI: 
Dwil_GK22772(Dwil_Ace)
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
406104(AChE-2) 410270(AChE-1)
NVI: 
100115855(AChE-1) 100121967(AChE-2)
TCA: 
659368(AChE) 662258(AChE-1)
BMOR: 
101740604 692776(ace2) 692783(ace1)
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG02827(Cbr-ace-4) CBG14965(Cbr-ace-2) CBG16374(Cbr-ace-1)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
NVE: 
TAD: 
CRE: 
VCN: 
NHE: 
AFM: 
ZTR: 
PFJ: 
ADL: 
DPP: 
DFA: 
ACAN: 
TGO: 
NGD: 
EHX: 
 » show all
Taxonomy
Reference
1
  Authors
Augustinsson, K.-B.
  Title
Cholinesterases. A study in comparative enzymology.
  Journal
Acta Physiol. Scand. 15, Suppl. 2 (1948)
Reference
2  [PMID:13522650]
  Authors
BERGMANN F, RIMON S, SEGAL R.
  Title
Effect of pH on the activity of eel esterase towards different substrates.
  Journal
Biochem. J. 68 (1958) 493-9.
Reference
3  [PMID:5073758]
  Authors
Ciliv G, Ozand PT.
  Title
Human erythrocyte acetylcholinesterase purification, properties and kinetic behavior.
  Journal
Biochim. Biophys. Acta. 284 (1972) 136-56.
Reference
4  [PMID:5238989]
  Authors
Leuzinger W, Baker AL, Cauvin E.
  Title
Acetylcholinesterase. II. Crystallization, absorption spectra, isoionic point.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 59 (1968) 620-3.
Reference
5  [PMID:14885021]
  Authors
NACHMANSOHN D, WILSON IB.
  Title
The enzymic hydrolysis and synthesis of acetylcholine.
  Journal
Adv. Enzymol. Relat. Subj. Biochem. 12 (1951) 259-339.
Reference
6  [PMID:14377597]
  Authors
ZITTLE CA, DELLAMONICA ES, CUSTER JH, KRIKORIAN R.
  Title
Purification of human red cell acetylcholinesterase by electrophoresis, ultracentrifugation and gradient extraction.
  Journal
Arch. Biochem. 56 (1955) 469-75.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9000-81-1

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