KEGG   ENZYME: 3.1.4.11Help
Entry
EC 3.1.4.11                 Enzyme                                 
Name
phosphoinositide phospholipase C;
triphosphoinositide phosphodiesterase;
phosphoinositidase C;
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase;
monophosphatidylinositol phosphodiesterase;
phosphatidylinositol phospholipase C;
PI-PLC;
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Reaction(KEGG)
(other) R03435
Show
Substrate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637];
H2O [CPD:C00001]
Product
1D-myo-inositol 1,4,5-trisphosphate [CPD:C01245];
diacylglycerol [CPD:C00165]
Comment
These enzymes form some of the cyclic phosphate Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four beta-isoforms regulated by G-proteins, two gamma-forms regulated by tyrosine kinases, four delta-forms regulated at least in part by calcium and an epsilon-form, probably regulated by the oncogene ras, have been found.
Pathway
Inositol phosphate metabolism
Metabolic pathways
Orthology
K01116  
phosphatidylinositol phospholipase C, gamma-1
K05857  
phosphatidylinositol phospholipase C, delta
K05858  
phosphatidylinositol phospholipase C, beta
K05859  
phosphatidylinositol phospholipase C, gamma-2
K05860  
phosphatidylinositol phospholipase C, epsilon
K05861  
phosphatidylinositol phospholipase C, zeta
Genes
HSA: 
113026(PLCD3) 23236(PLCB1) 51196(PLCE1) 5330(PLCB2) 5331(PLCB3) 5332(PLCB4) 5333(PLCD1) 5335(PLCG1) 5336(PLCG2) 84812(PLCD4) 89869(PLCZ1)
PTR: 
450620(PLCE1) 451290(PLCB3) 453330(PLCB2) 454268(PLCG2) 458093(PLCB4) 458253(PLCG1) 460267(PLCD1) 468279(PLCD3) 469875(PLCB1) 470647(PLCD4) 743002(PLCZ1)
PPS: 
100969236(PLCD1) 100969344(PLCB2) 100969660(PLCB1) 100978643(PLCB4) 100980795(PLCD3) 100984694(PLCG2) 100987524(PLCB3) 100988020(PLCZ1) 100988032(PLCD4) 100992707(PLCE1) 100995010(PLCG1)
GGO: 
101125007(PLCE1) 101129357(PLCB3) 101133643(PLCG2) 101135199(PLCG1) 101136081(PLCD4) 101139984(PLCD1) 101140350(PLCB2) 101142984(PLCD3) 101151875(PLCZ1) 101153613 101154323(PLCB4)
PON: 
100171640(PLCD4) 100434502(PLCB1) 100442086(PLCZ1) 100443819(PLCD3) 100444145(PLCE1) 100450941(PLCG1) 100457650 100458716(PLCB2) 100460060(PLCB3) 100461961(PLCB4) 100462440(PLCD1)
MCC: 
696860(PLCD1) 697069(PLCG1) 699569(PLCD4) 701758(PLCE1) 701951(PLCB2) 703293(PLCZ1) 714173(PLCG2) 715924(PLCD3) 717764(PLCB3) 718387(PLCB1) 718418(PLCB4)
MMU: 
114875(Plcz1) 18795(Plcb1) 18796(Plcb2) 18797(Plcb3) 18798(Plcb4) 18799(Plcd1) 18802(Plcd4) 18803(Plcg1) 234779(Plcg2) 72469(Plcd3) 74055(Plce1)
RNO: 
114633(Plce1) 140693(Plcd4) 24654(Plcb1) 24655(Plcd1) 25031(Plcb4) 25738(Plcg1) 287745(Plcd3) 29322(Plcb3) 29337(Plcg2) 497197(Plcz1) 85240(Plcb2)
CFA: 
100856190 476034(PLCB3) 477160(PLCB4) 478910(PLCD4) 485586(PLCD1) 485773(PLCB1) 485874(PLCG1) 486657(PLCZ1) 486808(PLCE1) 489692(PLCG2) 490929(PLCD3)
AML: 
FCA: 
101080675(PLCG2) 101085554(PLCZ1) 101086518(PLCD3) 101087777(PLCD1) 101088695(PLCE1) 101090005(PLCB4) 101090455(PLCD4) 101090942(PLCB2) 101092262(PLCB1) 101092925(PLCG1) 101092961(PLCB3)
BTA: 
281985(PLCB4) 281986(PLCD1) 281987(PLCG1) 287026(PLCB1) 497026(PLCZ1) 508888(PLCB2) 513057(PLCD3) 515669(PLCB3) 519037(PLCE1) 540771(PLCD4) 790012(PLCD1)
SSC: 
100152497 100152679(PLCB1) 100157641(PLCB2) 100516581 100518663(PLCG2) 100521111(PLCD3) 100525148(PLCB3) 100627099(PLCD1) 397119(PLCD4) 397632(PLCZ)
ECB: 
100051485(PLCB4) 100051558 100054233(PLCD1) 100055407(PLCB3) 100055670(PLCG2) 100057315(PLCB2) 100058665 100061676(PLCE1) 100064142 100067798 100070545
MDO: 
100011291 100012056 100023487(PLCE1) 100024144 100027579(PLCG2) 100031263(PLCB3) 100031660(PLCB1) 100031869(PLCB2) 100032696(PLCG1) 100033281(PLCB4)
SHR: 
100916816(PLCD3) 100917022(PLCE1) 100919206(PLCG2) 100919591(PLCD4) 100923119(PLCG1) 100929015(PLCB2) 100933386(PLCD1) 100934049(PLCB4) 100934311(PLCB1)
OAA: 
100076776 100078508 100078757 100083809
GGA: 
415805(PLCG2) 416730(PLCB4) 418182(PLCZ1) 419175(PLCG1) 420416(PLCD1) 423014(PLCB2) 424214 427687(PLCB1) 428279(PLCD3) 776273
MGP: 
100540174(PLCE1) 100540750 100542227 100542272 100547667(PLCB4) 100548128 100549684(PLCG2) 100551436 664713(PLCB2)
TGU: 
100219122(PLCB1) 100219388(PLCG2) 100220070(PLCG1) 100221959(PLCB4) 100222362 100222852(PLCE1) 100224924 100227504(PLCD4) 100229323(PLCD1) 100229635(PLCB2) 100229724(PLCZ1)
ACS: 
100551754(plcb2) 100552081(plce1) 100552636 100555994 100559347 100559401(plcd3) 100560758(plcb4) 100566814(plcg2) 100566853 100566976 100567266 100567752(plcb3)
XLA: 
397692(plcb3) 398359(plcg1) 398360(XPLCG1a) 735225(plcd4)
XTR: 
100125098(plcb4) 100379715(plcd4) 100487267 100488677(plcd1) 100495530(plce1) 100496658 100496674 100496686 100497993(plcd3) 780394(plcb1)
DRE: 
100001532(plcb3) 100537538 337489(plcd1b) 373867(plcg1) 555443(plcd1a) 561747(plcg2) 562569(plcd3b) 565669(plcd4a) 568288(plce1) 569040(plcd3a)
TRU: 
101062624 101065367 101065955 101066005 101069039 101072923 101073102 101076025 101076189 101077179 101078575 101078708
OLA: 
100049465(mfplc-beta2) 100049529(mfplc-beta3) 100049535(mfplc-beta4) 101156540 101157053 101163005 101163204 101164102 101166226 101167285 101167907 101167946 101172698 101173208 101175056
BFO: 
BRAFLDRAFT_202613 BRAFLDRAFT_202677 BRAFLDRAFT_205043 BRAFLDRAFT_223817 BRAFLDRAFT_285727
CIN: 
100178711 100182086 100185660 100186259(plcb4)
SPU: 
100888919 494023(plcd) 579102 587412(plcb4)
DME: 
Dmel_CG3620(norpA) Dmel_CG4200(sl) Dmel_CG4574(Plc21C)
DPO: 
Dpse_GA17564 Dpse_GA18024(Dpse_small-wing) Dpse_GA18269
DAN: 
Dana_GF19146 Dana_GF19456 Dana_GF20639
DER: 
Dere_GG17956 Dere_GG18703 Dere_GG24713
DPE: 
Dper_GL14297 Dper_GL15831 Dper_GL18869
DSE: 
Dsec_GM12340 Dsec_GM13428 Dsec_GM16735
DSI: 
Dsim_GD23017 Dsim_GD24832
DWI: 
Dwil_GK15712 Dwil_GK23786 Dwil_GK25059
DYA: 
Dyak_GE16341 Dyak_GE16747(Dyak_Plc21C) Dyak_GE17264
DGR: 
Dgri_GH10584 Dgri_GH12692 Dgri_GH24286
DMO: 
Dmoj_GI14457 Dmoj_GI16411 Dmoj_GI23110
DVI: 
Dvir_GJ17032 Dvir_GJ18791(Dvir_small-wing) Dvir_GJ23620
AGA: 
AgaP_AGAP001936 AgaP_AGAP002529 AgaP_AGAP009115 AgaP_AGAP011152
AAG: 
AaeL_AAEL004431 AaeL_AAEL008246 AaeL_AAEL009380 AaeL_AAEL010124
CQU: 
CpipJ_CPIJ000778 CpipJ_CPIJ008193 CpipJ_CPIJ008403 CpipJ_CPIJ018676
AME: 
408791(Plc) 408804(Fucta) 408996(norpA2) 551709(sl)
NVI: 
100115054(NV15983) 100116596(NV15424) 100120894(NV13419) 100123217(NV50307)
TCA: 
659062 661312 662602
API: 
100161327 100162131 100166756 100166969 100168206
PHU: 
Phum_PHUM019460 Phum_PHUM231170 Phum_PHUM602870
ISC: 
IscW_ISCW001177 IscW_ISCW001178 IscW_ISCW009315 IscW_ISCW015942 IscW_ISCW020642
CEL: 
CELE_B0348.4(egl-8) CELE_F31B12.1(plc-1) CELE_R05G6.8(plc-4) CELE_T01E8.3(plc-3)
CBR: 
CBG05896(Cbr-plc-4) CBG06373(Cbr-egl-8) CBG17587(Cbr-plc-1) CBG18715(Cbr-plc-3)
BMY: 
Bm1_31705 Bm1_40160 Bm1_42205 Bm1_51505
TSP: 
Tsp_02482 Tsp_02544 Tsp_05005 Tsp_07594 Tsp_10563
SMM: 
Smp_146330
NVE: 
NEMVE_v1g101739 NEMVE_v1g114299 NEMVE_v1g124290 NEMVE_v1g136833 NEMVE_v1g174
HMG: 
100198602 100200484 100212273
TAD: 
TRIADDRAFT_29799 TRIADDRAFT_61893 TRIADDRAFT_61894
AQU: 
100633163(Plcg1) 100641378
ATH: 
AT2G40116 AT3G08510(PLC2) AT3G55940 AT4G38530(PLC1) AT5G58670(PLC1) AT5G58690(PLC5) AT5G58700(PLC4)
ALY: 
ARALYDRAFT_486035 ARALYDRAFT_490617 ARALYDRAFT_495989 ARALYDRAFT_495993 ARALYDRAFT_671640 ARALYDRAFT_685532 ARALYDRAFT_903282
GMX: 
100037460 100777010 100784534 100786997 100799027 100817915 100820253 547863 547864
MTR: 
MTR_3g069280 MTR_3g070560 MTR_3g070710 MTR_3g070720 MTR_5g071040 MTR_5g082590 MTR_5g082620
CSV: 
101203631 101204232 101204418 101204663 101212421 101225877
RCU: 
RCOM_0339630 RCOM_0339640 RCOM_0612550 RCOM_0612560 RCOM_0612570 RCOM_1398830
POP: 
POPTR_564023 POPTR_567270 POPTR_752026 POPTR_803315 POPTR_805439 POPTR_815304 POPTR_875869
VVI: 
100241574 100243703 100246006 100248420 100255373 100267383 100853282
OSA: 
4332497 4337686 4344391
DOSA: 
Os03t0289300-00(Os03g0289300) Os05t0127200-01(Os05g0127200) Os07t0694000-01(Os07g0694000) Os12t0562400-00(Os12g0562400)
BDI: 
100831986 100835224 100839274 100840369
SBI: 
SORBI_01g038540(SORBIDRAFT_01g038540) SORBI_02g044010(SORBIDRAFT_02g044010) SORBI_05g001610(SORBIDRAFT_05g001610) SORBI_08g000360(SORBIDRAFT_08g000360) SORBI_09g002320(SORBIDRAFT_09g002320)
ZMA: 
100136827 100191466 542162(PLC)
SMO: 
SELMODRAFT_109775 SELMODRAFT_158000 SELMODRAFT_180165 SELMODRAFT_75628
PPP: 
PHYPADRAFT_110278(PLC2) PHYPADRAFT_133245(PLC3) PHYPADRAFT_154928(PLC7) PHYPADRAFT_202996(PLC4) PHYPADRAFT_221032(PLC5) PHYPADRAFT_228841(PLC6)
CRE: 
CHLREDRAFT_142126
OLU: 
OSTLU_50249
OTA: 
Ot08g01240
SCE: 
YPL268W(PLC1)
AGO: 
AGOS_ACR024W
ERC: 
Ecym_3005
KLA: 
KLLA0D00638g
LTH: 
KLTH0C11660g
PPA: 
PAS_chr4_0700
VPO: 
Kpol_449p13
ZRO: 
ZYRO0F00352g
CGR: 
CAGL0A01177g
NCS: 
NCAS_0D02230(NCAS0D02230)
NDI: 
NDAI_0I02690(NDAI0I02690)
TPF: 
TPHA_0J00210(TPHA0J00210)
TBL: 
TBLA_0A07020(TBLA0A07020)
TDL: 
TDEL_0G04680(TDEL0G04680)
KAF: 
KAFR_0B06460(KAFR0B06460)
DHA: 
DEHA2A04510g
PIC: 
PICST_42966(PLC1)
PGU: 
PGUG_00206
LEL: 
LELG_05130
CAL: 
CaO19.5506(PLC1) CaO19_5506(CaJ7_0425)
CTP: 
CTRG_05145
CDU: 
CD36_73380(PLC1)
COT: 
CORT_0G03510
YLI: 
YALI0C04180g
CLU: 
CLUG_03263
NCR: 
NCU01266
SMP: 
SMAC_03962
PAN: 
PODANSg8027
TTT: 
THITE_2106937
MTM: 
MYCTH_2300779
MGR: 
MGG_02444
FGR: 
FG05898.1
NHE: 
NECHADRAFT_85080
VAL: 
VDBG_03354
SSL: 
SS1G_05754
BFU: 
BC1G_01559
ANI: 
AN0664.2
NFI: 
NFIA_012260
AFM: 
AFUA_1G13250
AOR: 
AOR_1_976194(AO090012000557)
ANG: 
ANI_1_884074(An08g06320)
AFV: 
AFLA_018170
ACT: 
ACLA_022180
PCS: 
Pc13g12130
CIM: 
CIMG_06831
CPW: 
CPC735_032410
PBL: 
PAAG_07722
URE: 
UREG_03646
ABE: 
ARB_06692
TVE: 
TRV_04036
AJE: 
HCAG_00760
PNO: 
SNOG_10714
PTE: 
PTT_08861
ZTR: 
MYCGRDRAFT_66273
TML: 
GSTUM_00002161001
SPO: 
SPAC22F8.11(plc1)
CNE: 
CNC04820
CNB: 
CNBC2360
CGI: 
CGB_C7130W
LBC: 
LACBIDRAFT_315547
MPR: 
MPER_02532 MPER_08907
CCI: 
CC1G_07213 CC1G_09463
SCM: 
SCHCODRAFT_79892 SCHCODRAFT_82573
UMA: 
UM02982.1
MGL: 
MGL_2569
PGR: 
PGTG_13407
MBR: 
MONBRDRAFT_21166 MONBRDRAFT_34469
NGR: 
NAEGRDRAFT_1225 NAEGRDRAFT_80564
DDI: 
DDB_G0292736(plc)
DPP: 
DICPUDRAFT_96532
TAN: 
TA06965
TPV: 
TP01_0775
BBO: 
BBOV_IV011070(23.m06338)
CPV: 
cgd4_2560
CHO: 
Chro.40288
TET: 
TTHERM_00238850
PTM: 
GSPATT00008002001 GSPATT00030070001 GSPATT00031253001 GSPATT00031342001
TBR: 
Tb11.02.3780
TCR: 
504149.160
LMA: 
LMJF_22_1680
LIF: 
LINJ_22_1530 LINJ_30_2970
LDO: 
LDBPK_221530 LDBPK_302970
LMI: 
LMXM_29_2950
LBZ: 
LBRM_22_1590
PTI: 
PHATRDRAFT_42683(PLC-delta) PHATRDRAFT_bd1000 PHATRDRAFT_bd1611
TPS: 
THAPS_263246
 » show all
Taxonomy
Reference
1  [PMID:6275838]
  Authors
Downes CP, Michell RH.
  Title
The polyphosphoinositide phosphodiesterase of erythrocyte membranes.
  Journal
Biochem. J. 198 (1981) 133-40.
  Organism
Homo sapiens [GN:hsa], Rattus norvegicus [GN:rno], Oryctolagus cuniculus
Reference
2
  Authors
Thompson, W. and Dawson, R.M.C.
  Title
The triphosphoinositide phosphodiesterase of brain tissue.
  Journal
Biochem. J. 91 (1964) 237-243.
Reference
3  [PMID:9182519]
  Authors
Rhee SG, Bae YS.
  Title
Regulation of phosphoinositide-specific phospholipase C isozymes.
  Journal
J. Biol. Chem. 272 (1997) 15045-8.
  Organism
mammalian
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
63551-76-8
DBGET integrated database retrieval system