KEGG   ENZYME: 3.1.4.35Help
Entry
EC 3.1.4.35                 Enzyme                                 
Name
3',5'-cyclic-GMP phosphodiesterase;
guanosine cyclic 3',5'-phosphate phosphodiesterase;
cyclic GMP phosphodiesterase;
cyclic 3',5'-GMP phosphodiesterase;
cyclic guanosine 3',5'-monophosphate phosphodiesterase;
cyclic guanosine 3',5'-phosphate phosphodiesterase;
cGMP phosphodiesterase;
cGMP-PDE
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
3',5'-cyclic-GMP 5'-nucleotidohydrolase
Reaction(IUBMB)
guanosine 3',5'-cyclic phosphate + H2O = GMP [RN:R01234]
Reaction(KEGG)
Substrate
guanosine 3',5'-cyclic phosphate [CPD:C00942];
H2O [CPD:C00001]
Product
GMP [CPD:C00144]
Pathway
Purine metabolism
Orthology
K08718  
rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
K13298  
dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11
K13756  
rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
K13757  
cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
K13761  
high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9
K13762  
cGMP-specific 3',5'-cyclic phosphodiesterase
K13763  
cGMP-specific 3',5'-cyclic phosphodiesterase, invertebrate
Genes
HSA: 
50940(PDE11A) 5145(PDE6A) 5146(PDE6C) 5152(PDE9A) 5158(PDE6B) 8654(PDE5A)
PTR: 
461041(PDE6B) 461461(PDE5A) 462184(PDE6A) 474020(PDE9A) 740456(PDE6C) 740616(PDE11A)
PPS: 
100976834(PDE9A) 100977317(PDE6A) 100982736(PDE11A) 100988192(PDE6B) 100991111(PDE6C) 100991956(PDE5A)
GGO: 
101124811(PDE6B) 101125879(PDE11A) 101144851(PDE9A) 101147391(PDE6C) 101150214(PDE6A) 101150404 101152369(PDE5A)
PON: 
MCC: 
100301991(PDE9A2) 677688(PDE6A) 700261(PDE6C) 702458(PDE11A) 704196(PDE6B) 705592(PDE5A)
MMU: 
110855(Pde6c) 18585(Pde9a) 18587(Pde6b) 225600(Pde6a) 241489(Pde11a) 242202(Pde5a)
RNO: 
140928(Pde11a) 171115(Pde5a) 191569(Pde9a) 289878(Pde6b) 307401(Pde6a) 361752(Pde6c)
CFA: 
399653(PDE6B) 403620(PDE6A) 403825(PDE5A) 486805(PDE6C) 488422(PDE11A) 611022(PDE9A)
AML: 
FCA: 
100533976(PDE5A) 101085100(PDE6A) 101093538(PDE9A) 101094627(PDE6C) 101095012(PDE6B) 101100071(PDE11A)
BTA: 
281972(PDE5A) 281973(PDE6A) 281974(PDE6B) 281975(PDE6C) 511665(PDE9A) 524446(PDE11A)
SSC: 
100037971 100127144 100512867 100515715 100625130 100625223 100738835 397616(PDE5)
ECB: 
100050793 100053692(PDE11A) 100057783(PDE9A) 100060489 100061774 100072395(PDE5A)
MDO: 
100018314 100018608 100023714 100024005 100026785(PDE11A) 100028818(PDE6A)
SHR: 
100916160(PDE6A) 100916226(PDE5A) 100917797(PDE6C) 100919404(PDE11A) 100928402(PDE6B) 100932946(PDE9A)
OAA: 
100075073 100080806(PDE9A) 100081836(PDE5A) 100083769 100084944(PDE11A) 100088736
GGA: 
395092(PDE6B) 395834(PDE6C) 418538(PDE9A) 422677(PDE5A) 424133(PDE11A)
MGP: 
100539087(PDE5A) 100542971 100548192 100549810(PDE9A)
TGU: 
100221188(PDE9A) 100224716(PDE6B) 100225567(PDE11A) 100225742(PDE5A) 100231485(PDE6C)
ACS: 
100560285 100560459(pde5a) 100560718 100566240 100567129
XLA: 
495103(pde5a) 734701(pde9a)
XTR: 
100379882(pde11a) 100485634 100487945 100488870 100493061 780273(pde5a)
DRE: 
368410(pde6a) 393845(pde6c) 553270(pde5ab) 559332(pde6b) 561338(pde11a) 562357 564389 799942(pde9a)
TRU: 
101061997 101062462 101062977 101066408 101074688 101077492
OLA: 
101158412 101163363 101163533 101166781 101169304 101169549
BFO: 
BRAFLDRAFT_163784 BRAFLDRAFT_256436 BRAFLDRAFT_67316
CIN: 
100184226
SPU: 
582146(pde5) 589578 755676
DME: 
Dmel_CG34341(Pde11) Dmel_CG42276(Pde9) Dmel_CG8279(Pde6)
DPO: 
Dpse_GA17041 Dpse_GA20950 Dpse_GA25777
DAN: 
Dana_GF14841 Dana_GF17478 Dana_GF20888
DER: 
Dere_GG19538 Dere_GG21262
DPE: 
Dper_GL18744 Dper_GL22965 Dper_GL24177
DSE: 
Dsec_GM11531 Dsec_GM17084 Dsec_GM25848
DSI: 
Dsim_GD15869 Dsim_GD20415 Dsim_GD21829
DWI: 
Dwil_GK10275 Dwil_GK11355 Dwil_GK24656
DYA: 
Dyak_GE16198 Dyak_GE26445
DGR: 
Dgri_GH10531 Dgri_GH14135 Dgri_GH24569
DMO: 
Dmoj_GI10668 Dmoj_GI11066 Dmoj_GI17200
DVI: 
Dvir_GJ16925 Dvir_GJ19829 Dvir_GJ23019
AGA: 
AgaP_AGAP002927 AgaP_AGAP004119
AAG: 
AaeL_AAEL009630
CQU: 
CpipJ_CPIJ014126
AME: 
410379(Pde9) 410630
NVI: 
100116395(NV18596) 100122718(NV50011)
TCA: 
656211 658906
API: 
100162827(PDE11A) 100165174
PHU: 
Phum_PHUM066610 Phum_PHUM155210 Phum_PHUM361080
SMM: 
Smp_163100
NVE: 
NEMVE_v1g183341 NEMVE_v1g218243
HMG: 
100205805
TAD: 
TRIADDRAFT_10459 TRIADDRAFT_55920
AQU: 
100635061 100640664
MBR: 
MONBRDRAFT_35957
 » show all
Taxonomy
Reference
1
  Authors
Marks, F. and Raab, I.
  Title
The second messenger system of mouse epidermis. IV. Cyclic AMP and cyclic GMP phosphodiesterase.
  Journal
Biochim. Biophys. Acta 334 (1974) 368-377.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9068-52-4
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