KEGG   ENZYME: 3.1.8.1Help
Entry
EC 3.1.8.1                  Enzyme                                 

Name
aryldialkylphosphatase;
organophosphate hydrolase;
paraoxonase;
A-esterase;
aryltriphosphatase;
organophosphate esterase;
esterase B1;
esterase E4;
paraoxon esterase;
pirimiphos-methyloxon esterase;
OPA anhydrase;
organophosphorus hydrolase;
phosphotriesterase;
paraoxon hydrolase;
OPH;
organophosphorus acid anhydrase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-triester hydrolases
BRITE hierarchy
Sysname
aryltriphosphate dialkylphosphohydrolase
Reaction(IUBMB)
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol [RN:R03979]
Reaction(KEGG)
R03979 > R05548;
(other) R05421
Show
Substrate
aryl dialkyl phosphate [CPD:C03254];
H2O [CPD:C00001]
Product
dialkyl phosphate [CPD:C02534];
phenol [CPD:C15584]
Comment
Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. Inhibited by chelating agents; requires divalent cations for activity. Previously regarded as identical with EC 3.1.1.2 arylesterase.
History
EC 3.1.8.1 created 1989
Pathway
Aminobenzoate degradation
Microbial metabolism in diverse environments
Orthology
K01045  
arylesterase / paraoxonase
Genes
HSA: 
5444(PON1) 5445(PON2) 5446(PON3)
PTR: 
463547(PON1) 463548(PON3) 463549(PON2)
PPS: 
100971627(PON1) 100971959(PON3) 100972315(PON2)
GGO: 
PON: 
100436262(PON3) 100436640(PON1) 100437018(PON2)
MCC: 
699107(PON2) 699236(PON3) 699355(PON1)
MCF: 
102119827(PON2) 102120476(PON3) 102121098(PON1)
MMU: 
18979(Pon1) 269823(Pon3) 330260(Pon2)
RNO: 
296851(Pon2) 312086(Pon3) 84024(Pon1)
CGE: 
100762244(Pon1) 100762539(Pon2) 100762826(Pon3)
HGL: 
101696947(Pon1) 101697319(Pon3) 101697694(Pon2)
TUP: 
102467949(PON3) 102482718(PON2) 102503295(PON1)
CFA: 
403855(PON2) 475234(PON1) 475235(PON3)
AML: 
FCA: 
101091522(PON1) 101091774(PON3) 101094492(PON2)
PTG: 
102965359(PON2) 102969631(PON3) 102969909(PON1)
BTA: 
281417(PON2) 510953(PON3) 523798(PON1)
BOM: 
102268223(PON1) 102268513(PON3) 102269334(PON2)
PHD: 
102326568(PON1) 102326932(PON3) 102331586(PON2)
CHX: 
102183658(PON2) 102189091(PON1) 102189455(PON3)
SSC: 
CFR: 
102519221(PON3) 102519463(PON1) 102521631(PON2)
BACU: 
103002002(PON2) 103002453(PON3) 103004502(PON1)
LVE: 
ECB: 
100051896(PON1) 100051959(PON3) 100062686(PON2)
MYB: 
102249558(PON3) 102250151(PON1) 102251833(PON2)
MYD: 
102757128(PON2) 102772860(PON1) 102775231(PON3)
PALE: 
102878821(PON1) 102879084(PON3) 102879651(PON2)
MDO: 
SHR: 
100922843(PON2) 100929514(PON3)
GGA: 
395830(PON2)
MGP: 
100303695(PON2)
TGU: 
100218152(PON2)
FAB: 
101812552(PON2)
PHI: 
102101075(PON2)
APLA: 
101800414(PON2)
FPG: 
101913744(PON2)
FCH: 
102055053(PON2)
CLV: 
102089494(PON2)
ASN: 
102370400(PON2)
AMJ: 
102569523(PON2)
PSS: 
102457846(PON2)
CMY: 
102930790(PON2)
ACS: 
PBI: 
103052672(PON2)
XLA: 
XTR: 
448598(pon2)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
SPU: 
LOA: 
NVE: 
HMG: 
YLI: 
PGR: 
EHX: 
MSD: 
 » show all
Taxonomy
Reference
1  [PMID:13032041]
  Authors
ALDRIDGE WN.
  Title
Serum esterases.  I.  Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determination.
  Journal
Biochem. J. 53 (1953) 110-7.
  Organism
Rattus norvegicus, Equus caballus, Oryctolagus cuniculus
Reference
2  [PMID:5047702]
  Authors
Bosmann HB.
  Title
Membrane marker enzymes. Characterization of an arylesterase of guinea pig cerebral cortex utilizing p-nitrophenyl acetate as substrate.
  Journal
Biochim. Biophys. Acta. 276 (1972) 180-91.
  Organism
Cavia porcellus
Reference
3  [PMID:2822017]
  Authors
Mackness MI, Thompson HM, Hardy AR, Walker CH.
  Title
Distinction between 'A'-esterases and arylesterases. Implications for esterase classification.
  Journal
Biochem. J. 245 (1987) 293-6.
  Organism
Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Ovis aries, Capra hircus, Felis catus, Meles taxus, Oryctolagus cuniculus
Reference
4  [PMID:14420012]
  Authors
MAIN AR.
  Title
The differentiation of the A-type esterases in sheep serum.
  Journal
Biochem. J. 75 (1960) 188-95.
  Organism
Ovis aries
Reference
5
  Authors
In: Reiner, E., Aldridge, W.N. and Hoskin, C.G. (Eds.), Enzymes Hydrolysing Organophosphorus Compounds, Ellis Horwood, Chichester, UK, 1989.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
117698-12-1

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