Entry |
|
Name |
aryldialkylphosphatase;
organophosphate hydrolase;
paraoxonase;
A-esterase;
aryltriphosphatase;
organophosphate esterase;
esterase B1;
esterase E4;
paraoxon esterase;
pirimiphos-methyloxon esterase;
OPA anhydrase;
organophosphorus hydrolase;
phosphotriesterase;
paraoxon hydrolase;
OPH;
organophosphorus acid anhydrase
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Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-triester hydrolases
 |
Sysname |
aryltriphosphate dialkylphosphohydrolase
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Reaction(IUBMB) |
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol [RN: R03979]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. Inhibited by chelating agents; requires divalent cations for activity. Previously regarded as identical with EC 3.1.1.2 arylesterase.
|
History |
EC 3.1.8.1 created 1989
|
Pathway |
ec01120 | Microbial metabolism in diverse environments |
|
Orthology |
K01045 | arylesterase / paraoxonase |
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Genes |
» show all
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Reference |
|
Authors |
ALDRIDGE WN. |
Title |
Serum esterases. I. Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determination. |
Journal |
Biochem. J. 53 (1953) 110-7. |
Reference |
|
Authors |
Bosmann HB. |
Title |
Membrane marker enzymes. Characterization of an arylesterase of guinea pig cerebral cortex utilizing p-nitrophenyl acetate as substrate. |
Journal |
Biochim. Biophys. Acta. 276 (1972) 180-91. |
Reference |
|
Authors |
Mackness MI, Thompson HM, Hardy AR, Walker CH. |
Title |
Distinction between 'A'-esterases and arylesterases. Implications for esterase classification. |
Journal |
Biochem. J. 245 (1987) 293-6. |
Reference |
|
Authors |
MAIN AR. |
Title |
The differentiation of the A-type esterases in sheep serum. |
Journal |
Biochem. J. 75 (1960) 188-95. |
Reference |
5 |
Authors |
In: Reiner, E., Aldridge, W.N. and Hoskin, C.G. (Eds.), Enzymes Hydrolysing Organophosphorus Compounds, Ellis Horwood, Chichester, UK, 1989. |
Other DBs |
ExplorEnz - The Enzyme Database: | 3.1.8.1 |
ExPASy - ENZYME nomenclature database: | 3.1.8.1 |
UM-BBD (Biocatalysis/Biodegradation Database): | 3.1.8.1 |
BRENDA, the Enzyme Database: | 3.1.8.1 |
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