KEGG   ENZYME: 3.1.8.1Help
Entry
EC 3.1.8.1                  Enzyme                                 

Name
aryldialkylphosphatase;
organophosphate hydrolase;
paraoxonase;
A-esterase;
aryltriphosphatase;
organophosphate esterase;
esterase B1;
esterase E4;
paraoxon esterase;
pirimiphos-methyloxon esterase;
OPA anhydrase;
organophosphorus hydrolase;
phosphotriesterase;
paraoxon hydrolase;
OPH;
organophosphorus acid anhydrase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-triester hydrolases
BRITE hierarchy
Sysname
aryltriphosphate dialkylphosphohydrolase
Reaction(IUBMB)
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol [RN:R03979]
Reaction(KEGG)
R03979 > R05548;
(other) R05421
Show
Substrate
aryl dialkyl phosphate [CPD:C03254];
H2O [CPD:C00001]
Product
dialkyl phosphate [CPD:C02534];
phenol [CPD:C15584]
Comment
Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. Inhibited by chelating agents; requires divalent cations for activity. Previously regarded as identical with EC 3.1.1.2 arylesterase.
History
EC 3.1.8.1 created 1989
Pathway
Aminobenzoate degradation
Microbial metabolism in diverse environments
Orthology
K01045  
arylesterase / paraoxonase
Genes
HSA: 
5444(PON1) 5445(PON2) 5446(PON3)
PTR: 
463547(PON1) 463548(PON3) 463549(PON2)
PPS: 
100971627(PON1) 100971959(PON3) 100972315(PON2)
GGO: 
PON: 
100436262(PON3) 100436640(PON1) 100437018(PON2)
NLE: 
100602768(PON1) 100603110(PON3) 100603799(PON2)
MCC: 
699107(PON2) 699236(PON3) 699355(PON1)
MCF: 
102119827(PON2) 102120476(PON3) 102121098(PON1)
CSAB: 
103226525(PON3) 103226526(PON2) 103226528(PON1)
RRO: 
104656585(PON1) 104656587(PON3) 104656588(PON2)
RBB: 
108513529(PON2) 108513530(PON3) 108513531(PON1)
CJC: 
100407939(PON2) 100408549(PON3) 100408915(PON1)
SBQ: 
101047829(PON3) 101048148(PON2) 101048681(PON1)
MMU: 
18979(Pon1) 269823(Pon3) 330260(Pon2)
RNO: 
296851(Pon2) 312086(Pon3) 84024(Pon1)
CGE: 
100762244(Pon1) 100762539(Pon2) 100762826(Pon3)
NGI: 
103725227(Pon3) 103725228(Pon2) 103725260(Pon1)
HGL: 
101696947(Pon1) 101697319(Pon3) 101697694(Pon2)
CCAN: 
109693468 109693469
OCU: 
100008754(PON3) 100009133(PON1) 100340152(PON2)
TUP: 
102467949(PON3) 102482718(PON2) 102503295(PON1)
CFA: 
403855(PON2) 475234(PON1) 475235(PON3)
AML: 
100466658(PON2) 100467410(PON1) 100467660(PON3)
UMR: 
103658742(PON1) 103658743(PON3) 103658801(PON2)
FCA: 
101091522(PON1) 101091774(PON3) 101094492(PON2)
PTG: 
102965359(PON2) 102969631(PON3) 102969909(PON1)
AJU: 
106969955 106969956 106970003
BTA: 
281417(PON2) 510953(PON3) 523798(PON1)
BOM: 
102268223(PON1) 102268513(PON3) 102269334(PON2)
BIU: 
109558220(PON1) 109558221(PON3) 109558222(PON2)
PHD: 
102326568(PON1) 102326932(PON3) 102331586(PON2)
CHX: 
102183658(PON2) 102189091(PON1) 102189455(PON3)
OAS: 
100145861(PON2) 100337686(PON3) 101116983(PON1)
SSC: 
100048952(PON1) 100142663(PON2) 733674(PON3)
CFR: 
102519221(PON3) 102519463(PON1) 102521631(PON2)
CDK: 
105088724(PON2) 105088725(PON3) 105088728(PON1)
BACU: 
103002002(PON2) 103002453(PON3) 103004502(PON1)
LVE: 
103072098(PON3) 103072365(PON2) 103075141(PON1) 103079171
ECB: 
100051896(PON1) 100051959(PON3) 100062686(PON2)
EPZ: 
103541442(PON1) 103542649(PON3) 103542650(PON2) 103566405
EAI: 
106838926(PON2) 106838927(PON3) 106838928(PON1)
MYB: 
102249558(PON3) 102250151(PON1) 102251833(PON2)
MYD: 
102757128(PON2) 102772860(PON1) 102775231(PON3)
HAI: 
109393132 109393133(PON1)
RSS: 
109446396 109446397
PALE: 
102878821(PON1) 102879084(PON3) 102879651(PON2)
LAV: 
100667197(PON2) 100675274(PON3) 100675554(PON1)
MDO: 
100017970(PON2) 100018559(PON3) 100028798
SHR: 
100922843(PON2) 100929514(PON3) 105750837
OAA: 
103168141
GGA: 
395830(PON2)
MGP: 
100303695(PON2)
CJO: 
107309112(PON2)
APLA: 
101800414(PON2)
ACYG: 
106037501(PON2)
TGU: 
100218152(PON2)
GFR: 
102033037(PON2)
FAB: 
101812552(PON2)
PHI: 
102101075(PON2)
PMAJ: 
107200070
CCW: 
104689162
FPG: 
101913744(PON2)
FCH: 
102055053(PON2)
CLV: 
102089494(PON2)
AAM: 
106483521(PON2)
ASN: 
102370400(PON2)
AMJ: 
102569523(PON2)
PSS: 
102457846(PON2)
CMY: 
102930790(PON2)
CPIC: 
101938475(PON2)
ACS: 
100551677(pon2)
PVT: 
110074724
PBI: 
103052672(PON2)
GJA: 
107118000(PON2)
XLA: 
108718843 380341(pon2.L) 432039(pon2.S)
XTR: 
448598(pon2)
NPR: 
108790495 108790498 108790499
DRE: 
335176(pon2) 554122(pon3.1) 568655(pon3.2)
SRX: 
107714733 107714734 107723437
SANH: 
107657594 107657661 107699523 107699524
SGH: 
107570834 107595282 107595292
IPU: 
108271509
TRU: 
101062836
TNG: 
GSTEN00034170G001 GSTEN00034171G001
LCO: 
104925500 104925501
NCC: 
104965579 104965581
MZE: 
101475101 101475704 106676101
OLA: 
101174858 101175104
XMA: 
102228189 102233391
CSEM: 
103388494
LCF: 
108891018 108891027
HCQ: 
109517591 109517598
BPEC: 
110166446 110171411
SASA: 
100196477(pon2) 106573659 106598067 106598982 106605980
ELS: 
105018843 105018844
SFM: 
108940718
LCM: 
102361851
CMK: 
103176917
BFO: 
BRAFLDRAFT_100225 BRAFLDRAFT_118130 BRAFLDRAFT_208249 BRAFLDRAFT_221411 BRAFLDRAFT_225661 BRAFLDRAFT_237432 BRAFLDRAFT_260864
SPU: 
100889706 582780 752021
SKO: 
100378655 102801568 102806936 102809273
NAI: 
NECAME_03451
LOA: 
LOAG_02638
HRO: 
HELRODRAFT_97933
LGI: 
LOTGIDRAFT_174719
CRG: 
105322421 105340244 105346951
OBI: 
106873488
LAK: 
106158780 106181365
NVE: 
NEMVE_v1g112795
ADF: 
107327691 107348033
HMG: 
100211341
AQU: 
105316431
YLI: 
YALI0C21516g
PBL: 
PAAG_03299
PBN: 
PADG_03170
GTR: 
GLOTRDRAFT_93268
SCM: 
SCHCODRAFT_28591
WSE: 
WALSEDRAFT_62365 WALSEDRAFT_70483
PGR: 
PGTG_01500
MLR: 
MELLADRAFT_91179
SRE: 
PTSG_06241
TET: 
TTHERM_000470733
OSG: 
BST96_17895
PSPI: 
PS2015_622
MSD: 
MYSTI_07768
 » show all
Taxonomy
Reference
1  [PMID:13032041]
  Authors
ALDRIDGE WN.
  Title
Serum esterases.  I.  Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determination.
  Journal
Biochem. J. 53 (1953) 110-7.
Reference
2  [PMID:5047702]
  Authors
Bosmann HB.
  Title
Membrane marker enzymes. Characterization of an arylesterase of guinea pig cerebral cortex utilizing p-nitrophenyl acetate as substrate.
  Journal
Biochim. Biophys. Acta. 276 (1972) 180-91.
Reference
3  [PMID:2822017]
  Authors
Mackness MI, Thompson HM, Hardy AR, Walker CH.
  Title
Distinction between 'A'-esterases and arylesterases. Implications for esterase classification.
  Journal
Biochem. J. 245 (1987) 293-6.
Reference
4  [PMID:14420012]
  Authors
MAIN AR.
  Title
The differentiation of the A-type esterases in sheep serum.
  Journal
Biochem. J. 75 (1960) 188-95.
Reference
5
  Authors
In: Reiner, E., Aldridge, W.N. and Hoskin, C.G. (Eds.), Enzymes Hydrolysing Organophosphorus Compounds, Ellis Horwood, Chichester, UK, 1989.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
117698-12-1
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