KEGG   ENZYME: 3.1.8.1Help
Entry
EC 3.1.8.1                  Enzyme                                 

Name
aryldialkylphosphatase;
organophosphate hydrolase;
paraoxonase;
A-esterase;
aryltriphosphatase;
organophosphate esterase;
esterase B1;
esterase E4;
paraoxon esterase;
pirimiphos-methyloxon esterase;
OPA anhydrase;
organophosphorus hydrolase;
phosphotriesterase;
paraoxon hydrolase;
OPH;
organophosphorus acid anhydrase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-triester hydrolases
BRITE hierarchy
Sysname
aryltriphosphate dialkylphosphohydrolase
Reaction(IUBMB)
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol [RN:R03979]
Reaction(KEGG)
R03979 > R05548;
(other) R05421
Show
Substrate
aryl dialkyl phosphate [CPD:C03254];
H2O [CPD:C00001]
Product
dialkyl phosphate [CPD:C02534];
phenol [CPD:C15584]
Comment
Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. Inhibited by chelating agents; requires divalent cations for activity. Previously regarded as identical with EC 3.1.1.2 arylesterase.
History
EC 3.1.8.1 created 1989
Pathway
ec00627  Aminobenzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K01045  arylesterase / paraoxonase
Genes
HSA: 5444(PON1) 5445(PON2) 5446(PON3)
PTR: 463547(PON1) 463548(PON3) 463549(PON2)
PPS: 100971627(PON1) 100971959(PON3) 100972315(PON2)
GGO: 101146649(PON1) 101147009(PON3) 101147360(PON2) 109027758
PON: 100436262(PON3) 100436640(PON1) 100437018(PON2)
NLE: 100602768(PON1) 100603110(PON3) 100603799(PON2)
MCC: 699107(PON2) 699236(PON3) 699355(PON1)
MCF: 102119827(PON2) 102120476(PON3) 102121098(PON1)
CSAB: 103226525(PON3) 103226526(PON2) 103226528(PON1)
RRO: 104656585(PON1) 104656587(PON3) 104656588(PON2)
RBB: 108513529(PON2) 108513530(PON3) 108513531(PON1)
CJC: 100407939(PON2) 100408549(PON3) 100408915(PON1)
SBQ: 101047829(PON3) 101048148(PON2) 101048681(PON1)
MMU: 18979(Pon1) 269823(Pon3) 330260(Pon2)
RNO: 296851(Pon2) 312086(Pon3) 84024(Pon1)
CGE: 100762244(Pon1) 100762539(Pon2) 100762826(Pon3)
NGI: 103725227(Pon3) 103725228(Pon2) 103725260(Pon1)
HGL: 101696947(Pon1) 101697319(Pon3) 101697694(Pon2)
CCAN: 109693468 109693469
OCU: 100008754(PON3) 100009133(PON1) 100340152(PON2)
TUP: 102467949(PON3) 102482718(PON2) 102503295(PON1)
CFA: 403855(PON2) 475234(PON1) 475235(PON3)
AML: 100466658(PON2) 100467410(PON1) 100467660(PON3)
UMR: 103658742(PON1) 103658743(PON3) 103658801(PON2)
ORO: 101371249(PON2) 101371749(PON3) 101372042(PON1)
FCA: 101091522(PON1) 101091774(PON3) 101094492(PON2)
PTG: 102965359(PON2) 102969631(PON3) 102969909(PON1)
AJU: 106969955 106969956 106970003
BTA: 281417(PON2) 510953(PON3) 523798(PON1)
BOM: 102268223(PON1) 102268513(PON3) 102269334(PON2)
BIU: 109558220(PON1) 109558221(PON3) 109558222(PON2)
PHD: 102326568(PON1) 102326932(PON3) 102331586(PON2)
CHX: 102183658(PON2) 102189091(PON1) 102189455(PON3)
OAS: 100145861(PON2) 100337686(PON3) 101116983(PON1)
SSC: 100048952(PON1) 100142663(PON2) 733674(PON3)
CFR: 102519221(PON3) 102519463(PON1) 102521631(PON2)
CDK: 105088724(PON2) 105088725(PON3) 105088728(PON1)
BACU: 103002002(PON2) 103002453(PON3) 103004502(PON1)
LVE: 103072098(PON3) 103072365(PON2) 103075141(PON1) 103079171
OOR: 101286851(PON2) 101287293(PON3)
ECB: 100051896(PON1) 100051959(PON3) 100062686(PON2)
EPZ: 103541442(PON1) 103542649(PON3) 103542650(PON2) 103566405
EAI: 106838926(PON2) 106838927(PON3) 106838928(PON1)
MYB: 102249558(PON3) 102250151(PON1) 102251833(PON2)
MYD: 102757128(PON2) 102772860(PON1) 102775231(PON3)
HAI: 109393132 109393133(PON1)
RSS: 109446396 109446397
PALE: 102878821(PON1) 102879084(PON3) 102879651(PON2)
LAV: 100667197(PON2) 100675274(PON3) 100675554(PON1)
TMU: 101344330 101360527 101360792
MDO: 100017970(PON2) 100018559(PON3) 100028798
SHR: 100922843 100929514 105750837
OAA: 103168141
GGA: 395830(PON2)
MGP: 100303695(PON2)
CJO: 107309112(PON2)
APLA: 101800414(PON2)
ACYG: 106037501(PON2)
TGU: 100218152(PON2)
GFR: 102033037(PON2)
FAB: 101812552(PON2)
PHI: 102101075(PON2)
PMAJ: 107200070
CCW: 104689162
FPG: 101913744(PON2)
FCH: 102055053(PON2)
CLV: 102089494
EGZ: 104128625
AAM: 106483521(PON2)
ASN: 102370400(PON2)
AMJ: 102569523(PON2)
PSS: 102457846(PON2)
CMY: 102930790(PON2)
CPIC: 101938475(PON2)
ACS: 100551677(pon2)
PVT: 110074724
PBI: 103052672(PON2)
GJA: 107118000(PON2)
XLA: 108718843 380341(pon2.L) 432039(pon2.S)
XTR: 448598(pon2)
NPR: 108790495 108790498 108790499
DRE: 335176(pon2) 554122(pon3.1) 568655(pon3.2)
SRX: 107714733 107714734 107723437
SANH: 107657594 107657661 107699523 107699524
SGH: 107570834 107595282 107595292
CCAR: 109074161 109074777
IPU: 108271509
AMEX: 103046166
TRU: 101062836
TNG: GSTEN00034170G001 GSTEN00034171G001
LCO: 104925500 104925501
NCC: 104965579 104965581
MZE: 101475101 101475704 106676101
OLA: 101174858 101175104
XMA: 102228189 102233391
PRET: 103478535 103478537
NFU: 107378667 107378669
CSEM: 103388494
LCF: 108891018 108891027
HCQ: 109517591 109517598
BPEC: 110166446 110171411
SASA: 100196477(pon2) 106573659 106598067 106598982 106605980
ELS: 105018843 105018844
SFM: 108940718
LCM: 102361851
CMK: 103176917
BFO: BRAFLDRAFT_100225 BRAFLDRAFT_118130 BRAFLDRAFT_208249 BRAFLDRAFT_221411 BRAFLDRAFT_225661 BRAFLDRAFT_237432 BRAFLDRAFT_260864
SPU: 100889706 582780 752021
APLC: 110985577 110985825 110988044
SKO: 100378655 102801568 102809273
NAI: NECAME_03451
LOA: LOAG_02638
HRO: HELRODRAFT_97933
LGI: LOTGIDRAFT_174719
CRG: 105322421 105340244 105346951
MYI: 110446029 110446051 110450177 110450178 110460254
OBI: 106873488
LAK: 106158780 106181365
NVE: NEMVE_v1g112795
EPA: 110240777 110240778 110246487
ADF: 107327691 107348033
HMG: 100211341
AQU: 105316431
YLI: YALI0C21516g
PBL: PAAG_03299
PBN: PADG_03170
GTR: GLOTRDRAFT_93268
SCM: SCHCODRAFT_28591
WSE: WALSEDRAFT_62365 WALSEDRAFT_70483
PGR: PGTG_01500
MLR: MELLADRAFT_91179
SRE: PTSG_06241
TET: TTHERM_000470733
OSG: BST96_17895
PSPI: PS2015_622
MSD: MYSTI_07768
 » show all
Taxonomy
Reference
1  [PMID:13032041]
  Authors
ALDRIDGE WN.
  Title
Serum esterases.  I.  Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determination.
  Journal
Biochem. J. 53 (1953) 110-7.
Reference
2  [PMID:5047702]
  Authors
Bosmann HB.
  Title
Membrane marker enzymes. Characterization of an arylesterase of guinea pig cerebral cortex utilizing p-nitrophenyl acetate as substrate.
  Journal
Biochim. Biophys. Acta. 276 (1972) 180-91.
Reference
3  [PMID:2822017]
  Authors
Mackness MI, Thompson HM, Hardy AR, Walker CH.
  Title
Distinction between 'A'-esterases and arylesterases. Implications for esterase classification.
  Journal
Biochem. J. 245 (1987) 293-6.
Reference
4  [PMID:14420012]
  Authors
MAIN AR.
  Title
The differentiation of the A-type esterases in sheep serum.
  Journal
Biochem. J. 75 (1960) 188-95.
Reference
5
  Authors
In: Reiner, E., Aldridge, W.N. and Hoskin, C.G. (Eds.), Enzymes Hydrolysing Organophosphorus Compounds, Ellis Horwood, Chichester, UK, 1989.
Other DBs
ExplorEnz - The Enzyme Database: 3.1.8.1
IUBMB Enzyme Nomenclature: 3.1.8.1
ExPASy - ENZYME nomenclature database: 3.1.8.1
UM-BBD (Biocatalysis/Biodegradation Database): 3.1.8.1
BRENDA, the Enzyme Database: 3.1.8.1
CAS: 117698-12-1

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