KEGG   ENZYME: 3.2.1.45Help
Entry
EC 3.2.1.45                 Enzyme                                 
Name
glucosylceramidase;
psychosine hydrolase;
glucosphingosine glucosylhydrolase;
GlcCer-beta-glucosidase;
beta-D-glucocerebrosidase;
glucosylcerebrosidase;
beta-glucosylceramidase;
ceramide glucosidase;
glucocerebrosidase;
glucosylsphingosine beta-glucosidase;
glucosylsphingosine beta-D-glucosidase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
D-glucosyl-N-acylsphingosine glucohydrolase
Reaction(IUBMB)
a D-glucosyl-N-acylsphingosine + H2O = D-glucose + a ceramide [RN:R01498]
Reaction(KEGG)
Substrate
D-glucosyl-N-acylsphingosine [CPD:C01190];
H2O [CPD:C00001]
Product
D-glucose [CPD:C00031];
ceramide [CPD:C00195]
Comment
Also acts on glucosylsphingosine (cf. EC 3.2.1.62 glycosylceramidase).
Pathway
Other glycan degradation
Sphingolipid metabolism
Metabolic pathways
Orthology
K01201  
glucosylceramidase
Genes
HSA: 
2629(GBA)
PTR: 
449571(GBA)
PPS: 
GGO: 
PON: 
MMU: 
14466(Gba)
RNO: 
684536(Gba)
CFA: 
612206(GBA)
AML: 
FCA: 
BTA: 
537087(GBA)
SSC: 
449572(GBA)
ECB: 
100063514
MDO: 
100022104
SHR: 
100919688(GBA)
TGU: 
100226768 100227578(GBA)
ACS: 
100559029
XLA: 
447570
XTR: 
100487077
DRE: 
559072
TRU: 
101064629
OLA: 
101157882
BFO: 
BRAFLDRAFT_85797
CIN: 
100183961 100185182
SPU: 
100892921 582024 589647 592425 594677
DME: 
Dmel_CG31148 Dmel_CG31414
DPO: 
Dpse_GA16046 Dpse_GA26980
DAN: 
Dana_GF16253 Dana_GF16254
DER: 
Dere_GG11218 Dere_GG11220
DPE: 
Dper_GL13654 Dper_GL13655
DSE: 
Dsec_GM26520 Dsec_GM26522
DSI: 
Dsim_GD21027 Dsim_GD21030
DWI: 
Dwil_GK13189 Dwil_GK22396
DYA: 
Dyak_GE10384 Dyak_GE10386
DGR: 
Dgri_GH17457 Dgri_GH17458
DMO: 
Dmoj_GI22782 Dmoj_GI22783
DVI: 
Dvir_GJ22784 Dvir_GJ22785
AGA: 
AgaP_AGAP001649
AAG: 
AaeL_AAEL003742 AaeL_AAEL014321
CQU: 
CpipJ_CPIJ005343
AME: 
409708 409709
NVI: 
100122982(NV13655)
TCA: 
664516 664560 664563 664564
API: 
100167276
PHU: 
Phum_PHUM388700
ISC: 
IscW_ISCW004661 IscW_ISCW006884
CEL: 
CELE_C33C12.3(gba-1) CELE_C33C12.8(gba-2) CELE_Y4C6B.6(gba-4)
CBR: 
CBG00434 CBG17050 CBG17056 CBG19964
BMY: 
Bm1_32350
TSP: 
Tsp_02907
NVE: 
NEMVE_v1g168783
TAD: 
TRIADDRAFT_22822
AQU: 
100638213
NCR: 
NCU04395
SMP: 
SMAC_07359
TTT: 
THITE_2117640
NFI: 
NFIA_099910
AFM: 
AFUA_8G07120
ACT: 
ACLA_060250
PCS: 
Pc22g13580
ZTR: 
MYCGRDRAFT_92113(MgBGN16.1)
NGR: 
NAEGRDRAFT_73722 NAEGRDRAFT_77531
TVA: 
TVAG_074640
PTI: 
PHATRDRAFT_54536
TPS: 
THAPSDRAFT_264891
PIF: 
PITG_04255 PITG_08001 PITG_17501 PITG_17507 PITG_19939
ECQ: 
ECED1_0305(srfJ)
STM: 
STM4426(srfJ)
SEO: 
STM14_5318(srfJ)
SEV: 
STMMW_43701
SEY: 
SL1344_4358
SEM: 
STMDT12_C45550
SEJ: 
STMUK_4412(srfJ)
SEB: 
STM474_4623(srfJ)
SEF: 
UMN798_4793
SETU: 
STU288_22200
SPQ: 
SPAB_05573
SEA: 
SeAg_B4708
PLU: 
plu2272
SRR: 
SerAS9_2178
SRS: 
SerAS12_2178
SRA: 
SerAS13_2179
XCC: 
XCC1077(srfJ)
XCB: 
XC_3172
XCA: 
xccb100_3269
XCV: 
XCV1202
XCP: 
XCR_1285
XAC: 
XAC1176(srfJ)
XAX: 
XACM_1146
XAO: 
XAC29_05905
XCI: 
XCAW_01277
RHD: 
R2APBS1_0443
CJA: 
CJA_3306(gly30A)
CPS: 
CPS_3714
SDE: 
Sde_2994
RFR: 
Rfer_1106
CCX: 
COCOR_05184(srfJ)
SUR: 
STAUR_1534 STAUR_3860 STAUR_3866
SCL: 
sce1832(srfJ)
HOH: 
Hoch_6250
CCR: 
CC_1757
CCS: 
CCNA_01833
CAK: 
Caul_2067
MAI: 
MICA_2006
MAN: 
A11S_1924
BAO: 
BAMF_2031(RBAM_019350)
BAY: 
RBAM_019350
BAQ: 
BACAU_1936(gba)
BYA: 
BANAU_2059(egbG)
BAMP: 
B938_10025
BAML: 
BAM5036_1867
BAZ: 
BAMTA208_07350
BQL: 
LL3_02134
BXH: 
BAXH7_01494
BQY: 
MUS_2312
BAMI: 
KSO_009675
BCO: 
Bcell_0689 Bcell_0821 Bcell_3505
HHD: 
HBHAL_1426 HBHAL_4388(srfJ)
PJD: 
Pjdr2_0476 Pjdr2_0477
GYM: 
GYMC10_0229
PPY: 
PPE_00621 PPE_00923
PPM: 
PPSC2_c0694 PPSC2_c0977
PPO: 
PPM_0644(srfJ1) PPM_0899(srfJ3)
PTA: 
HPL003_10925 HPL003_12515
TCO: 
Theco_0462 Theco_0926
LBR: 
LVIS_2226
LBK: 
LVISKB_0246 LVISKB_2298
LRL: 
LC705_00049(srfJ)
LRA: 
LRHK_53
LBH: 
Lbuc_0391
LBN: 
LBUCD034_0428
CBO: 
CBO1200
CBA: 
CLB_1230
CBH: 
CLC_1242
CBY: 
CLM_1353
CBL: 
CLK_0638
CBB: 
CLD_3368
CBI: 
CLJ_B1240
CBF: 
CLI_1283
CBM: 
CBF_1256
CBJ: 
H04402_01270
CBE: 
Cbei_4675
CPY: 
Cphy_0858 Cphy_3404
TTE: 
TTE2348 TTE2349
CSC: 
Csac_2513
ATE: 
Athe_0097
COB: 
COB47_0089
CHD: 
Calhy_0094
CKN: 
Calkro_0115
HOR: 
Hore_04190
HHL: 
Halha_0266
ACL: 
ACL_0726
SMA: 
SAV_2709
SGR: 
SGR_6911
SSX: 
SACTE_4730
SVL: 
Strvi_0841
SFA: 
Sfla_1811
SHY: 
SHJG_0181 SHJG_0686 SHJG_6637
SHO: 
SHJGH_0519 SHJGH_6397
SVE: 
SVEN_7349
SDV: 
BN159_2868
STRP: 
F750_5023
KSK: 
KSE_67260
SKE: 
Sked_34530
KFL: 
Kfla_5264 Kfla_7049
GOB: 
Gobs_1516
SEN: 
SACE_4785
AMD: 
AMED_8379(srfJ)
AMN: 
RAM_43025
AMM: 
AMES_8250(srfJ)
AMS: 
AMIS_8420
ASE: 
ACPL_1035 ACPL_2610(gba)
CAI: 
Caci_3714 Caci_3716 Caci_7221
SNA: 
Snas_3362 Snas_5017
BLB: 
BBMN68_1791
BLM: 
BLLJ_1503
BAD: 
BAD_1208
BLA: 
BLA_0043 BLA_0619
BLC: 
Balac_0052 Balac_1418
BLT: 
Balat_0052 Balat_1418
BBB: 
BIF_01487 BIF_01558
BBC: 
BLC1_0046 BLC1_1375
BNM: 
BALAC2494_01068 BALAC2494_01320
BLV: 
BalV_0050 BalV_1375
BLW: 
W7Y_0050 W7Y_1416
BLS: 
W91_0049 W91_1450
BNI: 
BANAN_06905
BDE: 
BDP_1680
BBRU: 
Bbr_0306
BAST: 
BAST_0471 BAST_1396 BAST_1397
CWO: 
Cwoe_4287
EYY: 
EGYY_03550
TBE: 
Trebr_0326 Trebr_2488
STA: 
STHERM_c13900
STQ: 
Spith_1530
SCD: 
Spica_2177
SFC: 
Spiaf_0704
SGP: 
SpiGrapes_0572 SpiGrapes_0573
ABA: 
Acid345_4153
ACA: 
ACP_1970
ACM: 
AciX9_3990
GMA: 
AciX8_4163
TSA: 
AciPR4_1330
TRS: 
Terro_0753
SUS: 
Acid_2638
BTH: 
BT_3312
BVU: 
BVU_0498 BVU_2170
BHL: 
Bache_0611
BXY: 
BXY_25640
PDI: 
BDI_1787 BDI_3785
PPN: 
Palpr_0237 Palpr_0238
TFO: 
BFO_2803 BFO_2966
ASH: 
AL1_02150
CPI: 
Cpin_3590 Cpin_4356 Cpin_6735 Cpin_6736
NKO: 
Niako_0670 Niako_6169 Niako_6170
PSN: 
Pedsa_3076 Pedsa_3077 Pedsa_3078
SHG: 
Sph21_2358
SCN: 
Solca_0315 Solca_1072 Solca_1073
HHY: 
Halhy_1114 Halhy_1362
DFE: 
Dfer_5601
SLI: 
Slin_2261
RSI: 
Runsl_2268
EOL: 
Emtol_1140
FAE: 
FAES_2215
FJO: 
Fjoh_1562 Fjoh_1563
FBR: 
FBFL15_1323 FBFL15_1324
COC: 
Coch_0445
CCM: 
Ccan_14050
ZPR: 
ZPR_3472 ZPR_4392 ZPR_4394
RAG: 
B739_0046
PTQ: 
P700755_003223
NDO: 
DDD_2363
POM: 
MED152_00455 MED152_11364
OTE: 
Oter_1268 Oter_1287
PHM: 
PSMK_29890
DMR: 
Deima_0235
FNO: 
Fnod_0296
FPE: 
Ferpe_0453
 » show all
Taxonomy
Reference
1  [PMID:14253443]
  Authors
BRADY RO, KANFER J, SHAPIRO D.
  Title
THE METABOLISM OF GLUCOCEREBROSIDES. I. PURIFICATION AND PROPERTIES OF A GLUCOCEREBROSIDE-CLEAVING ENZYME FROM SPLEEN TISSUE.
  Journal
J. Biol. Chem. 240 (1965) 39-43.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:3967661]
  Authors
Vaccaro AM, Muscillo M, Suzuki K.
  Title
Characterization of human glucosylsphingosine glucosyl hydrolase and comparison with glucosylceramidase.
  Journal
Eur. J. Biochem. 146 (1985) 315-21.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37228-64-1
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