| Entry |
|
|---|
| Name |
alpha-N-acetylgalactosaminidase;
alpha-acetylgalactosaminidase;
N-acetyl-alpha-D-galactosaminidase;
N-acetyl-alpha-galactosaminidase;
alpha-NAGAL;
alpha-NAGA;
alpha-GalNAcase
|
|---|
| Class |
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
 |
|---|
| Sysname |
alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase
|
|---|
| Reaction(IUBMB) |
Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids
|
|---|
| Reaction(KEGG) |
|
|---|
| Comment |
The human lysosomal enzyme is involved in the degradation of blood type A epitope.
|
|---|
| Pathway |
| Glycosphingolipid biosynthesis - globo series |
|
|---|
| Orthology |
| alpha-N-acetylgalactosaminidase |
|
|---|
| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | NVI: | | TCA: | | API: | | PHU: | | ISC: | | CBR: | | NVE: | | HMG: | | TAD: | | AQU: | | DPP: | | TGO: | | TET: | |
» show all
 |
|---|
| Reference |
|
|---|
| Authors |
Asfaw B, Schindler D, Ledvinova J, Cerny B, Smid F, Conzelmann E |
|---|
| Title |
Degradation of blood group A glycolipid A-6-2 by normal and mutant human skin fibroblasts. |
|---|
| Journal |
J. Lipid. Res. 39 (1998) 1768-80. |
|---|
| Reference |
|
|---|
| Authors |
Zhu A, Monahan C, Wang ZK, Goldstein J |
|---|
| Title |
Expression, purification, and characterization of recombinant alpha-N-acetylgalactosaminidase produced in the yeast Pichia pastoris. |
|---|
| Journal |
Protein. Expr. Purif. 8 (1996) 456-62. |
|---|
| Reference |
|
|---|
| Authors |
Clark NE, Garman SC |
|---|
| Title |
The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases. |
|---|
| Journal |
J. Mol. Biol. 393 (2009) 435-47. |
|---|
| Reference |
|
|---|
| Authors |
Hoskins LC, Boulding ET, Larson G |
|---|
| Title |
Purification and characterization of blood group A-degrading isoforms of alpha-N-acetylgalactosaminidase from Ruminococcus torques strain IX-70. |
|---|
| Journal |
J. Biol. Chem. 272 (1997) 7932-9. |
|---|
| Reference |
|
|---|
| Authors |
Harun-Or-Rashid M, Matsuzawa T, Satoh Y, Shiraishi T, Ando M, Sadik G, Uda Y |
|---|
| Title |
Purification and characterization of alpha-N-acetylgalactosaminidases I and II from the starfish Asterina amurensis. |
|---|
| Journal |
Biosci. Biotechnol. Biochem. 74 (2010) 256-61. |
|---|
| Reference |
|
|---|
| Authors |
Weignerova L, Filipi T, Manglova D, Kren V |
|---|
| Title |
Induction, purification and characterization of alpha-N-acetylgalactosaminidase from Aspergillus Niger. |
|---|
| Journal |
Appl. Microbiol. Biotechnol. 79 (2008) 769-74. |
|---|
| Reference |
|
|---|
| Authors |
Ashida H, Tamaki H, Fujimoto T, Yamamoto K, Kumagai H |
|---|
| Title |
Molecular cloning of cDNA encoding alpha-N-acetylgalactosaminidase from Acremonium sp. and its expression in yeast. |
|---|
| Journal |
Arch. Biochem. Biophys. 384 (2000) 305-10. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9075-63-2 |
|---|
