KEGG   ENZYME: 3.2.1.49Help
Entry
EC 3.2.1.49                 Enzyme                                 

Name
alpha-N-acetylgalactosaminidase;
alpha-acetylgalactosaminidase;
N-acetyl-alpha-D-galactosaminidase;
N-acetyl-alpha-galactosaminidase;
alpha-NAGAL;
alpha-NAGA;
alpha-GalNAcase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase
Reaction(IUBMB)
Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids
Reaction(KEGG)
(other) R04183 R05966(G)
Show
Comment
The human lysosomal enzyme is involved in the degradation of blood type A epitope.
History
EC 3.2.1.49 created 1972, modified 2011
Pathway
Glycosphingolipid biosynthesis - globo series
Orthology
K01204  
alpha-N-acetylgalactosaminidase
Genes
HSA: 
4668(NAGA)
PTR: 
470279(NAGA)
PPS: 
100991597(NAGA)
GGO: 
101132690(NAGA)
PON: 
100450338(NAGA)
NLE: 
100605546(NAGA)
MCC: 
713068(NAGA)
MCF: 
102145379(NAGA)
CJC: 
100397642(NAGA)
MMU: 
17939(Naga)
RNO: 
315165(Naga)
CGE: 
100751670(Naga)
NGI: 
103743459(Naga)
HGL: 
101726122(Naga)
OCU: 
100350048(NAGA)
TUP: 
102490461(NAGA)
CFA: 
481226(NAGA)
AML: 
UMR: 
103674070(NAGA)
FCA: 
101083277(NAGA)
PTG: 
102963636(NAGA)
BTA: 
533357(NAGA)
BOM: 
102280167(NAGA)
PHD: 
102320395(NAGA)
CHX: 
102170679(NAGA)
OAS: 
100145858(NAGA)
SSC: 
CFR: 
102511662(NAGA)
BACU: 
103005673(NAGA)
LVE: 
103072389(NAGA)
ECB: 
100070793(NAGA)
MYB: 
102258282(NAGA)
MYD: 
102754122(NAGA)
PALE: 
102887437(NAGA)
MDO: 
100018362(NAGA)
SHR: 
100925898(NAGA)
OAA: 
100086854(NAGA)
GGA: 
396547(NAGA)
MGP: 
APLA: 
101792497(NAGA)
TGU: 
100229129(NAGA)
FAB: 
101821644(NAGA)
PHI: 
102103812(NAGA)
FPG: 
101922362(NAGA)
FCH: 
102047533(NAGA)
CLV: 
ASN: 
102387946(NAGA)
AMJ: 
102561061(NAGA)
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
443592(naga-b) 443753(naga-a)
XTR: 
779501(naga)
DRE: 
560778(naga)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
725899(GB10294)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CBR: 
CBG23373(Cbr-gana-1)
TSP: 
HRO: 
LGI: 
NVE: 
HMG: 
TAD: 
AQU: 
DDI: 
DPP: 
DFA: 
ACAN: 
TGO: 
TET: 
EHX: 
 » show all
Taxonomy
Reference
1  [PMID:9741689]
  Authors
Asfaw B, Schindler D, Ledvinova J, Cerny B, Smid F, Conzelmann E
  Title
Degradation of blood group A glycolipid A-6-2 by normal and mutant human skin fibroblasts.
  Journal
J. Lipid. Res. 39 (1998) 1768-80.
  Sequence
[hsa:4668]
Reference
2  [PMID:8954893]
  Authors
Zhu A, Monahan C, Wang ZK, Goldstein J
  Title
Expression, purification, and characterization of recombinant alpha-N-acetylgalactosaminidase produced in the yeast Pichia pastoris.
  Journal
Protein. Expr. Purif. 8 (1996) 456-62.
Reference
3  [PMID:19683538]
  Authors
Clark NE, Garman SC
  Title
The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases.
  Journal
J. Mol. Biol. 393 (2009) 435-47.
  Sequence
[hsa:4668]
Reference
4  [PMID:9065462]
  Authors
Hoskins LC, Boulding ET, Larson G
  Title
Purification and characterization of blood group A-degrading isoforms of alpha-N-acetylgalactosaminidase from Ruminococcus torques strain IX-70.
  Journal
J. Biol. Chem. 272 (1997) 7932-9.
Reference
5  [PMID:20139603]
  Authors
Harun-Or-Rashid M, Matsuzawa T, Satoh Y, Shiraishi T, Ando M, Sadik G, Uda Y
  Title
Purification and characterization of alpha-N-acetylgalactosaminidases I and II from the starfish Asterina amurensis.
  Journal
Biosci. Biotechnol. Biochem. 74 (2010) 256-61.
Reference
6  [PMID:18443780]
  Authors
Weignerova L, Filipi T, Manglova D, Kren V
  Title
Induction, purification and characterization of alpha-N-acetylgalactosaminidase from Aspergillus Niger.
  Journal
Appl. Microbiol. Biotechnol. 79 (2008) 769-74.
Reference
7  [PMID:11368317]
  Authors
Ashida H, Tamaki H, Fujimoto T, Yamamoto K, Kumagai H
  Title
Molecular cloning of cDNA encoding alpha-N-acetylgalactosaminidase from Acremonium sp. and its expression in yeast.
  Journal
Arch. Biochem. Biophys. 384 (2000) 305-10.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9075-63-2

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