KEGG   ENZYME: 3.2.2.29Help
Entry
EC 3.2.2.29                 Enzyme                                 

Name
thymine-DNA glycosylase;
mismatch-specific thymine-DNA glycosylase;
mismatch-specific thymine-DNA N-glycosylase;
hTDG;
hsTDG;
TDG;
thymine DNA glycosylase;
G/T glycosylase;
uracil/thymine DNA glycosylase;
T:G mismatch-specific thymidine-DNA glycosylase;
G:T mismatch-specific thymine DNA-glycosylase
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
BRITE hierarchy
Sysname
thymine-DNA deoxyribohydrolase (thymine-releasing)
Reaction(IUBMB)
Hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free thymine.
Comment
Thymine-DNA glycosylase is part of the DNA-repair machinery. Thymine removal is fastest when it is from a G/T mismatch with a 5'-flanking C/G pair. The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T [3].
History
EC 3.2.2.29 created 2009
Reference
1  [PMID:10767625]
  Authors
Waters TR, Swann PF
  Title
Thymine-DNA glycosylase and G to A transition mutations at CpG sites.
  Journal
Mutat. Res. 462 (2000) 137-47.
Reference
2  [PMID:8407958]
  Authors
Neddermann P, Jiricny J
  Title
The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells.
  Journal
J. Biol. Chem. 268 (1993) 21218-24.
  Organism
Homo sapiens
  Sequence
[hsa:6996]
Reference
3  [PMID:9685338]
  Authors
Waters TR, Swann PF
  Title
Kinetics of the action of thymine DNA glycosylase.
  Journal
J. Biol. Chem. 273 (1998) 20007-14.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system