KEGG   ENZYME: 3.4.21.1Help
Entry
EC 3.4.21.1                 Enzyme                                 

Name
chymotrypsin;
chymotrypsins A and B;
alpha-chymar ophth;
avazyme;
chymar;
chymotest;
enzeon;
quimar;
quimotrase;
alpha-chymar;
alpha-chymotrypsin A;
alpha-chymotrypsin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Tyr!, Trp!, Phe!, Leu!
Comment
Chymotrypsin A is formed from cattle and pig chymotrypsinogen A, several iso-forms being produced according to the number of bonds hydrolysed in the precursor. Chymotrypsin B (formerly listed as EC 3.4.4.6), formed from chymotrypsinogen B, is homologous with chymotrypsin A. Enzymes with specificity similar to that of chymotrypsins A and B have been isolated from many species. In peptidase family S1 (trypsin family)
History
EC 3.4.21.1 created 1961 as EC 3.4.4.5 and EC 3.4.4.6, transferred 1972 to EC 3.4.21.1
Orthology
K01310  
chymotrypsin
Genes
HSA: 
1504(CTRB1) 440387(CTRB2)
PTR: 
736467(CTRB1)
PPS: 
100979112(CTRB2) 100979449(CTRB1)
GGO: 
101134917(CTRB2)
PON: 
MCC: 
711100(CTRB1) 713851(CTRB2)
MCF: 
102146658(CTRB2) 102147021(CTRB1)
MMU: 
66473(Ctrb1)
RNO: 
24291(Ctrb1)
CGE: 
HGL: 
TUP: 
CFA: 
AML: 
FCA: 
BTA: 
BOM: 
PHD: 
CHX: 
SSC: 
ECB: 
MYB: 
MDO: 
SHR: 
OAA: 
GGA: 
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
CLV: 
ASN: 
ACS: 
XLA: 
379495(ctrl) 379607(ctrb1) 444360(ctrb2)
XTR: 
101733231 496968(ctrb2) 548358(ctrl)
DRE: 
322451(ctrb1) 562139
TRU: 
OLA: 
XMA: 
DME: 
DPO: 
NVE: 
 » show all
Taxonomy
Reference
1
  Authors
Wilcox, P.E.
  Title
Chymotrypsinogens - chymotrypsins.
  Journal
Methods Enzymol. 19 (1970) 64-108.
Reference
2
  Authors
Blow, D.M.
  Title
Structure and mechanism of chymotrypsin.
  Journal
Acc. Chem. Res. 9 (1976) 145-152.
Reference
3  [PMID:6768556]
  Authors
Bauer CA.
  Title
Active centers of alpha-chymotrypsin and of Streptomyces griseus proteases 1 and 3. S2-P2 enzyme-substrate interactions.
  Journal
Eur. J. Biochem. 105 (1980) 565-70.
  Organism
Streptomyces griseus [GN:sgr]
Reference
4
  Authors
Polgar, L.
  Title
Structure and function of serine proteases.
  Journal
In: Neuberger, A. and Brocklehurst, K. (Eds.), New Comprehensive Biochemistry: Hydrolytic Enzymes, vol. 16, Elsevier, Amsterdam, 1987, p. 159-200.
Reference
5  [PMID:2917002]
  Authors
Tomita N, Izumoto Y, Horii A, Doi S, Yokouchi H, Ogawa M, Mori T, Matsubara K.
  Title
Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA.
  Journal
Biochem. Biophys. Res. Commun. 158 (1989) 569-75.
  Organism
Homo sapiens [GN:hsa]
  Sequence
[hsa:440387 1504]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9004-07-3

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