KEGG   ENZYME: 3.4.21.105Help
Entry
EC 3.4.21.105               Enzyme                                 

Name
rhomboid protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains
Comment
These endopeptidases are multi-spanning membrane proteins. Their catalytic site is embedded within the membrane and they cleave type-1 transmembrane domains. A catalytic dyad is involved in proteolysis rather than a catalytic triad, as was thought previously [14]. They are important for embryo development in Drosophila melanogaster. Rhomboid is a key regulator of EGF receptor signalling and is responsible for cleaving Spitz, the main ligand of the Drosophila EGF receptor pathway. Belongs in peptidase family S54. Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite. Rhomboids are widely conserved from bacteria to archaea to humans [9,13].
History
EC 3.4.21.105 created 2005
Orthology
K02857  rhomboid-related protein 1/2/3
K09650  rhomboid-like protein
K19225  rhomboid protease GluP
Genes
HSA: 162494(RHBDL3) 54933(RHBDL2) 55486(PARL) 9028(RHBDL1)
PTR: 453801(RHBDL1) 456773(RHBDL2) 460877(PARL) 747914(RHBDL3)
PPS: 100972422(RHBDL1) 100981191(PARL) 100991726(RHBDL2) 100995298(RHBDL3)
GGO: 101129399(RHBDL1) 101136818(PARL) 101140065(RHBDL2) 101145550(RHBDL3)
PON: 100173771(PARL) 100442110(RHBDL1) 100450187(RHBDL3) 100452148(RHBDL2)
NLE: 100591442(RHBDL1) 100595259(RHBDL3) 100601797(PARL) 100602665(RHBDL2)
MCC: 704652(PARL) 713926(RHBDL3) 715695(RHBDL2) 722357(RHBDL1)
MCF: 101926657(PARL) 102115426(RHBDL2) 102122957(RHBDL3) 102125336(RHBDL1)
CSAB: 103221155(PARL) 103225071(RHBDL2) 103225592(RHBDL1) 103242692(RHBDL3)
RRO: 104653641(RHBDL2) 104664642(PARL) 104669334(RHBDL3) 104681174(RHBDL1)
RBB: 108518006(RHBDL2) 108519442(RHBDL1) 108521059(PARL) 108541374(RHBDL3)
CJC: 100387112(RHBDL3) 100396196(RHBDL2) 100396223(RHBDL1) 100412777(MAP6D1)
SBQ: 101037572(PARL) 101038537(RHBDL1) 101045295(RHBDL2) 101048766(RHBDL3)
MMU: 214951(Rhbdl1) 230726(Rhbdl2) 246104(Rhbdl3) 381038(Parl)
RNO: 117025(Rhbdl1) 287556(Rhbdl3) 287979(Parl) 298512(Rhbdl2)
CGE: 100751882(Parl) 100770158(Rhbdl2) 100771192(Rhbdl1) 100772788(Rhbdl3)
NGI: 103732644(Parl) 103746081(Rhbdl3) 103747709(Rhbdl2) 103752390(Rhbdl1)
HGL: 101700571(Rhbdl1) 101707842(Rhbdl2) 101719514(Parl) 101721490(Rhbdl3)
CCAN: 109679607(Rhbdl2) 109683330(Rhbdl3) 109694101(Parl) 109694512(Rhbdl1) 109701956 109701958
OCU: 100342968(RHBDL2) 100351338(PARL) 100353868(RHBDL3)
TUP: 102469095(RHBDL1) 102479636(RHBDL2) 102499708(PARL) 102499910(RHBDL3)
CFA: 482466(RHBDL2) 488100(PARL) 490092(RHBDL1) 491155(RHBDL3)
AML: 100474967(RHBDL1) 100475380(PARL) 100478612(RHBDL2) 100484664(RHBDL3)
UMR: 103666358(RHBDL2) 103667429(RHBDL3) 103668457(RHBDL1) 103676189(PARL)
ORO: 101369430(RHBDL2) 101374105(RHBDL3) 101379039(RHBDL1) 101382637(PARL)
FCA: 101091042(PARL) 101093071(RHBDL1) 101094436(RHBDL2) 101094637(RHBDL3)
PTG: 102953926(RHBDL1) 102966303(RHBDL2) 102969628(RHBDL3) 102969917(PARL)
AJU: 106967349(PARL) 106973271(RHBDL2) 106977336(RHBDL1) 106985245(RHBDL3)
BTA: 100336895(RHBDL1) 514191(PARL) 514943(RHBDL2) 535623(RHBDL3)
BOM: 102267300(RHBDL3) 102279965(RHBDL1) 102282409(RHBDL2) 102282701(PARL)
BIU: 109556912(RHBDL2) 109557532(PARL) 109573185(RHBDL3) 109578340(RHBDL1)
PHD: 102324723(PARL) 102330979(RHBDL2) 102339958(RHBDL3) 102341809(RHBDL1)
CHX: 102170845(RHBDL2) 102173434(RHBDL1) 102186804(PARL) 102187708(RHBDL3)
OAS: 101102026(PARL) 101110639(RHBDL1) 101115635(RHBDL3) 101117975(RHBDL2) 105605793
SSC: 100514296(RHBDL2) 100522032(RHBDL3) 100739380(PARL) 102164926(RHBDL1)
CFR: 102508789(RHBDL1) 102513177(RHBDL3) 102515444(PARL) 102522404(RHBDL2)
CDK: 105085895(PARL) 105088219(RHBDL3) 105090970(RHBDL2) 105098438(RHBDL1)
BACU: 102997324(RHBDL1) 103010626(RHBDL3) 103012865(PARL) 103013581 103015879(RHBDL2)
LVE: 103080294(RHBDL1) 103080823(PARL) 103090747(RHBDL2) 103091370(RHBDL3)
OOR: 101286435(RHBDL3) 101289466(RHBDL2) 101290127(RHBDL1) 101290324(PARL)
ECB: 100058851(PARL) 100066958(RHBDL1) 100068889(RHBDL2) 100071775(RHBDL3)
EPZ: 103542974(RHBDL1) 103551231(RHBDL2) 103551829(RHBDL3) 103554759(PARL)
EAI: 106830573(RHBDL2) 106834531(PARL) 106836175(RHBDL1) 106844618(RHBDL3)
MYB: 102241382(RHBDL3) 102246769(PARL) 102248737(RHBDL2) 102254499(RHBDL1)
MYD: 102757308(RHBDL2) 102765700(RHBDL1) 102774042(PARL) 102774862(RHBDL3)
HAI: 109371269(PARL) 109385165(RHBDL3) 109385880(RHBDL1) 109390954(RHBDL2)
RSS: 109444869(RHBDL2) 109449523(PARL) 109457658(RHBDL3) 109460622(RHBDL1)
PALE: 102885710(RHBDL3) 102894455(PARL) 102895339(RHBDL1) 102897150(RHBDL2)
LAV: 100653587(RHBDL1) 100657744(RHBDL2) 100660204(PARL) 100665813(RHBDL3)
MDO: 100016926(RHBDL1) 100018675(RHBDL3) 100027636(PARL) 100031939(RHBDL2)
SHR: 100921266(RHBDL3) 100926501(PARL) 100930684(RHBDL1) 100932354(RHBDL2)
OAA: 100078408(PARL) 100082184(RHBDL2) 100087354(RHBDL1) 100089671(RHBDL3)
GGA: 417411(RHBDL3) 424767(PARL) 429205(RHBDL1)
MGP: 100544045(RHBDL3) 100544454(PARL) 100546725(RHBDL1)
CJO: 107317817(PARL) 107320910(RHBDL1) 107322155(RHBDL3)
APLA: 101792169(RHBDL3) 101803884(PARL) 106020203(RHBDL1)
ACYG: 106034754(RHBDL3) 106039200(PARL)
TGU: 100190158(PARL) 100219547 100221056(RHBDL3)
GFR: 102042149(RHBDL3) 102042645(PARL)
FAB: 101812184(RHBDL1) 101814172(PARL) 101816853(RHBDL3)
PHI: 102100139(RHBDL3) 102100599(RHBDL1) 102108104(PARL)
PMAJ: 107208963(PARL) 107210962(RHBDL1) 107212561(RHBDL3)
CCW: 104693060(PARL) 104694250(RHBDL3)
FPG: 101910681(PARL) 101916424(RHBDL3) 106112721(RHBDL1)
FCH: 102050957(RHBDL1) 102055499(RHBDL3) 102059074(PARL)
CLV: 102085794(RHBDL3) 102087133(PARL) 102094909(RHBDL1)
EGZ: 104123756(RHBDL3) 104135493(PARL)
AAM: 106484745(PARL) 106493114(RHBDL3)
ASN: 102368004(RHBDL3) 102375886(RHBDL2) 102376993(PARL) 102377147(RHBDL1)
AMJ: 102569235(PARL) 102572703(RHBDL1) 102572803(RHBDL3) 102573319(RHBDL2)
PSS: 102448376(RHBDL2) 102448490(PARL) 102454812(RHBDL1) 102462839(RHBDL3)
CMY: 102932324(RHBDL2) 102942181(PARL) 102943255(RHBDL1) 102945614(RHBDL3)
CPIC: 101932732(PARL) 101932755(RHBDL2) 101949096(RHBDL1) 101951639(RHBDL3)
ACS: 100552010(rhbdl3) 100553171(parl) 100556273(rhbdl2) 100556287 103281783(rhbdl1)
PVT: 110073840(RHBDL3) 110082751(RHBDL2) 110084041(PARL) 110089424(RHBDL1)
PBI: 103050233(RHBDL1) 103052191(PARL) 103053550(RHBDL3) 103063065(RHBDL2)
GJA: 107108690(RHBDL2) 107117310(RHBDL1) 107121725(RHBDL3) 107124094(PARL)
XLA: 108701217 108701693 108704657(rhbdl2.S) 108708122 444640(rhbdl1.S) 495156(rhbdl2.L)
XTR: 100036610(parl) 101732375 549275(rhbdl2)
NPR: 108790110(RHBDL2) 108799529(RHBDL1) 108801895 108804886(PARL)
DRE: 100887821(rhbdl1) 541485(parla) 550128(rhbdl3) 792002(rhbdl2) 792889(parl)
IPU: 108262806(rhbdl1) 108272931(rhbdl3) 108277433(parl) 108280367
AMEX: 103025472(parl) 103026852(rhbdl1) 103027172 103036677(rhbdl2) 103039963(rhbdl3)
TRU: 101066388 101069435(rhbdl2) 101070725(rhbdl1) 101076161 101079532(rhbdl3)
LCO: 104919692(rhbdl1) 104924720(rhbdl2) 104929841(rhbdl3) 104933382 104936814
NCC: 104941896(rhbdl2) 104946346(rhbdl1) 104947982(rhbdl3) 104951470(parl)
MZE: 101467219(rhbdl1) 101469142 101471225 101484197(rhbdl3) 101485896(rhbdl2)
OLA: 101155323(parl) 101157837(rhbdl3) 101162960(rhbdl1) 101173974 101175267(rhbdl2)
XMA: 102220748(rhbdl1) 102221859 102232512(rhbdl2) 102234504(rhbdl3) 102237666
PRET: 103468056(rhbdl3) 103475301(parl) 103477786(rhbdl2) 103479407 103481079(rhbdl1)
NFU: 107379334(rhbdl2) 107379887(parl) 107382321(rhbdl3) 107384009 107388048(rhbdl1)
CSEM: 103378338(parl) 103381702(rhbdl1) 103383613(rhbdl3) 103387918(rhbdl2)
HCQ: 109510735(parl) 109511186(rhbdl3) 109515419(rhbdl2) 109516844 109530205(rhbdl1)
BPEC: 110158798 110158822 110159797(rhbdl1) 110172660(rhbdl3) 110174331(rhbdl2) 110174766
ELS: 105006886 105007687 105019293(rhbdl2) 105021283(rhbdl1) 105029033(rhbdl3)
SFM: 108919105(rhbdl2) 108923855(rhbdl1) 108926825(parl) 108940046(rhbdl3)
LCM: 102345090(PARL) 102357284(RHBDL1) 102357617(RHBDL3) 102365369(RHBDL2)
CMK: 103186052(rhbdl1) 103186427(parl) 103191477
DME: Dmel_CG1004(rho) Dmel_CG1214(ru) Dmel_CG1697(rho-4) Dmel_CG33166(stet) Dmel_CG8972(rho-7)
DSI: Dsimw501_GD13615(Dsim_GD13615) Dsimw501_GD13619(Dsim_GD13619) Dsimw501_GD17034(Dsim_GD17034) Dsimw501_GD25869(Dsim_GD25869) Dsimw501_GD26881(Dsim_GD26881)
AME: 412194(rho-7) 412319 726936
TCA: 657740(stet) 661151 661276 663099(rho-4)
CEL: CELE_C48B4.2(rom-2) CELE_F26F4.3(rom-1) CELE_Y54E10A.14(rom-5)
CBR: CBG10042(Cbr-rom-2) CBG14977(Cbr-rom-5) CBG18183(Cbr-rom-1)
EPA: 110246136
HMG: 100197728
AQU: 105315300
HBR: 110653878
BVG: 104902064
SCE: YGR101W(PCP1)
ERC: Ecym_4420
KMX: KLMA_50443(PCP1)
NCS: NCAS_0E01050(NCAS0E01050)
NDI: NDAI_0G01180(NDAI0G01180)
TPF: TPHA_0D03000(TPHA0D03000)
TBL: TBLA_0E00580(TBLA0E00580)
TDL: TDEL_0F03280(TDEL0F03280)
KAF: KAFR_0K01640(KAFR0K01640)
CAL: CAALFM_C302030WA(CaO19.1643)
CAUR: QG37_02591
SLB: AWJ20_4032(PCP1)
NCR: NCU03080
NTE: NEUTE1DRAFT91388(NEUTE1DRAFT_91388)
MGR: MGG_04531
MAW: MAC_03768
MAJ: MAA_04245
CMT: CCM_05958
ANI: AN1372.2
ANG: ANI_1_82074(An08g00670)
ABE: ARB_08031
TVE: TRV_04346
CNE: CNG04190
CNB: CNBG0510
ABP: AGABI1DRAFT70511(AGABI1DRAFT_70511)
ABV: AGABI2DRAFT193382(AGABI2DRAFT_193382)
MGL: MGL_1969
DFA: DFA_08225
SMIN: v1.2.028034.t1(symbB.v1.2.028034.t1) v1.2.037180.t1(symbB.v1.2.037180.t1)
SPAR: SPRG_20100
MMK: MU9_1476
HCH: HCH_03410
RSO: RSp1525
RSE: F504_4997
RME: Rmet_3861
BGU: KS03_807
BGO: BM43_1280
ODI: ODI_R2291
MFA: Mfla_1842
MEH: M301_1965
DAR: Daro_2385
GME: Gmet_2385
GEB: GM18_3916
DEU: DBW_1342
DSF: UWK_00417
SAT: SYN_01026
BBAT: Bdt_2373
MSC: BN69_0387
BSU: BSU24870(glpG)
BSR: I33_2569
BSL: A7A1_3554
BSH: BSU6051_24870(glpG)
BSUT: BSUB_02664(glpG)
BSUL: BSUA_02664(glpG)
BSUS: Q433_13610
BSS: BSUW23_12330(glpG)
BST: GYO_2752
BSO: BSNT_08929(yqgP)
BSQ: B657_24870(glpG)
BSX: C663_2371
BLI: BL03719(gluP)
BLD: BLi02664(yggP)
BLH: BaLi_c27450(gluP)
BATR: TD68_09845
BHA: BH1421
BCL: ABC1726
BPU: BPUM_2217
BPUM: BW16_12010
BPUS: UP12_11260
BMQ: BMQ_4503(glpG)
BMD: BMD_4489(glpG)
BMH: BMWSH_0732(yqgP)
BMEG: BG04_1495
BAG: Bcoa_2807
BCOA: BF29_755
BJS: MY9_2511
BACW: QR42_11205
BACO: OXB_0477
BACY: QF06_10630
BACL: BS34A_27280(glpG)
BALM: BsLM_2445
BEO: BEH_19800
BGY: BGLY_2940
BKW: BkAM31D_05720(gluP_2)
BBEV: BBEV_1267(gluP)
OIH: OB1923
GKA: GK2446
GTN: GTNG_2385
GEA: GARCT_02427(gluP_2)
AFL: Aflv_0891
AAMY: GFC30_2641
AXL: AXY_07440
HHD: HBHAL_3523(yqgP)
VPN: A21D_03231(gluP_2)
BSE: Bsel_2310
SAU: SA1379
SAV: SAV1549
SAW: SAHV_1536
SAM: MW1501
SAS: SAS1487
SAR: SAR1626
SAC: SACOL1606
SAE: NWMN_1452
SAD: SAAV_1541
SUE: SAOV_1549
SUJ: SAA6159_01484(gluP)
SUK: SAA6008_01518(gluP)
SUZ: MS7_1566
SUG: SAPIG1614
SAUA: SAAG_01463
SAUS: SA40_1420
SAUU: SA957_1503
SAUG: SA268_1507
SAUF: X998_1574
SAB: SAB1421c
SAUB: C248_1592
SAUC: CA347_1545
SAUR: SABB_00470
SAUI: AZ30_07895
SAUD: CH52_11325
SAMS: NI36_08355
SEP: SE1235
SER: SERP1114
SEPP: SEB_01255
SEPS: DP17_193
SHA: SH1367
SHH: ShL2_01250(gluP)
SSP: SSP1207
SCA: SCA_1171
SDT: SPSE_1248
SPAS: STP1_0126
SHU: SHYC_06835(gluP)
SCAP: AYP1020_0847(gluP)
SSCH: LH95_06040
SSCZ: RN70_06220
SAGQ: EP23_03580
MCL: MCCL_1192
MCAK: MCCS_14770(gluP)
LMO: lmo1337
LMS: LMLG_1920
LMQ: LMM7_1422
LMP: MUO_06905
LMOE: BN418_1576
LMOB: BN419_1570
LMOD: LMON_1400
LMOW: AX10_00760
LMOX: AX24_04140
LMOK: CQ02_06875
LMOM: IJ09_03325
LIN: lin1374
LWE: lwe1352
LSG: lse_1253
LIV: LIV_1288
PMW: B2K_25730
PSAB: PSAB_09765
PRI: PRIO_2558
ASOC: CB4_01514(gluP)
AAD: TC41_2338
LPL: lp_1571
LPJ: JDM1_1316
LPZ: Lp16_1192
LJO: LJ_1618
LJH: LJP_1358c
LAC: LBA1506
LAD: LA14_1500
LAF: SD55_1480
LSL: LSL_0550
LSI: HN6_00497
LSJ: LSJ_0595
LDB: Ldb1479
LBU: LBUL_1374
LDL: LBU_1267
LBR: LVIS_0998
LCA: LSEI_1661
LPAP: LBPC_1583
LCB: LCABL_18770(yqgP)
LCE: LC2W_1835
LGA: LGAS_1384
LRE: Lreu_1208
LRF: LAR_1141
LRT: LRI_0762
LHE: lhv_1567
LHL: LBHH_0606
LHV: lhe_1453
LHH: LBH_1309
LHD: HUO_04240
LFE: LAF_1281
LFF: LBFF_1394
LRH: LGG_01705
LRG: LRHM_1641
LRA: LRHK_1677
LAM: LA2_08440
LBH: Lbuc_1167
LKE: WANG_0278
LRM: LRC_12370
LSN: LSA_06440
LAE: LBAT_0572
PPE: PEPE_0730
PPEN: T256_03870
PCE: PECL_1103
EFA: EF2790
EFL: EF62_2942
EFS: EFS1_2253
EFQ: DR75_1481
ENE: ENT_19560
EFM: M7W_1166
EHR: EHR_10090
ECAS: ECBG_01850
EMU: EMQU_1729
EDU: LIU_09940
MPS: MPTP_0601
THL: TEH_19890
LME: LEUM_0674
LMM: MI1_03060
LMK: LMES_0600
LCI: LCK_01146
LKI: LKI_08900
LGS: LEGAS_0752(glpP)
WCE: WS08_0997
WCT: WS74_1063
CRN: CAR_c13220(glpG)
CML: BN424_2049(gluP)
CARC: NY10_687
JDA: BW727_100604(gluP)
CAC: CA_C0954
CAE: SMB_G0971(gluP)
CAY: CEA_G0966
CPE: CPE1452
CPF: CPF_1705
CPR: CPR_1438
CTC: CTC_00530
CBO: CBO0398
CBY: CLM_0468
CBL: CLK_3588
CBK: CLL_A0777
CBB: CLD_0351
CBI: CLJ_B0456
CBN: CbC4_0744
CBT: CLH_0743
CBF: CLI_0473
CBM: CBF_0444
CBE: Cbei_4326
CBZ: Cbs_4326
CBEI: LF65_04849
CKL: CKL_2722
CKR: CKR_2416
CSR: Cspa_c40870(gluP1) Cspa_c46070(gluP2)
CPAS: Clopa_3971
CSB: CLSA_c39990(gluP)
CBV: U729_109
CSQ: CSCA_3699
CTYK: CTK_C06420
CTH: Cthe_1048
CCE: Ccel_1860
HSC: HVS_13290(gluP)
BFI: CIY_28860
RIX: RO1_32130
RIM: ROI_34840
COO: CCU_19090
CCT: CC1_12330
ROB: CK5_02110
RTO: RTO_02300
BPRL: CL2_01890
HSD: SD1D_0053
CPRO: CPRO_29880(gluP)
DSY: DSY1625
DHD: Dhaf_2772
SGY: Sgly_1786
EHL: EHLA_3226
BPRS: CK3_08240
APR: Apre_0056
LPIL: LIP_1494
ABRA: BN85311620
APAL: BN85411490
SMIR: SMM_0701
SMIA: P344_04210
MBJ: KQ51_00751(gluP)
CUR: cu0051
BTP: D805_1619
GPA: GPA_30260
RCA: Rcas_1097
CAU: Caur_0757
CAG: Cagg_2850
HAU: Haur_3513
OTE: Oter_2194
PLH: VT85_02370(gluP_2) VT85_19075(gluP_5) VT85_19585(gluP_6)
TTF: THTE_2742
GES: VT84_37865(gluP_2)
IPA: Isop_1315
PBOR: BSF38_02455(gluP_3) BSF38_04440(gluP_5)
LIE: LIF_A0775(glpG)
SUS: Acid_0319
ABAC: LuPra_01410(gluP_1)
BTH: BT_1807
BTHO: Btheta7330_01204(aarA_2)
BXY: BXY_14590
BOA: Bovatus_01862(aarA_1)
PHE: Phep_0482
MGOT: MgSA37_01611(gluP)
FAE: FAES_4812(glpG)
HSW: Hsw_1020
MARM: YQ22_04295
TAF: THA_1375
PYS: Py04_1384
THE: GQS_10345
THA: TAM4_1542
THM: CL1_1648
KCR: Kcr_0205
BARB: AOA66_0232
 » show all
Taxonomy
Reference
1  [PMID:15684070]
  Authors
Urban S, Wolfe MS.
  Title
Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 1883-8.
  Sequence
[bsu:BSU24870]
Reference
2  [PMID:15753289]
  Authors
Brossier F, Jewett TJ, Sibley LD, Urban S.
  Title
A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 4146-51.
  Sequence
Reference
3  [PMID:15096522]
  Authors
Herlan M, Bornhovd C, Hell K, Neupert W, Reichert AS.
  Title
Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor.
  Journal
J. Cell. Biol. 165 (2004) 167-73.
Reference
4  [PMID:15047175]
  Authors
Pascall JC, Brown KD.
  Title
Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2.
  Journal
Biochem. Biophys. Res. Commun. 317 (2004) 244-52.
  Sequence
[hsa:54933]
Reference
5  [PMID:14732705]
  Authors
Sik A, Passer BJ, Koonin EV, Pellegrini L.
  Title
Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pbeta, a nuclear-targeted peptide.
  Journal
J. Biol. Chem. 279 (2004) 15323-9.
  Sequence
[hsa:55486]
Reference
6  [PMID:12820957]
  Authors
Urban S, Freeman M.
  Title
Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain.
  Journal
Mol. Cell. 11 (2003) 1425-34.
Reference
7  [PMID:12707284]
  Authors
Herlan M, Vogel F, Bornhovd C, Neupert W, Reichert AS.
  Title
Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA.
  Journal
J. Biol. Chem. 278 (2003) 27781-8.
  Sequence
[sce:YGR101W]
Reference
8  [PMID:12774122]
  Authors
McQuibban GA, Saurya S, Freeman M.
  Title
Mitochondrial membrane remodelling regulated by a conserved rhomboid protease.
  Journal
Nature. 423 (2003) 537-41.
  Sequence
[sce:YGR101W]
Reference
9  [PMID:12620104]
  Authors
Koonin EV, Makarova KS, Rogozin IB, Davidovic L, Letellier MC, Pellegrini L.
  Title
The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers.
  Journal
Genome. Biol. 4 (2003) R19.
Reference
10 [PMID:12200155]
  Authors
Urban S, Freeman M.
  Title
Intramembrane proteolysis controls diverse signalling pathways throughout evolution.
  Journal
Curr. Opin. Genet. Dev. 12 (2002) 512-8.
Reference
11 [PMID:12225666]
  Authors
Urban S, Schlieper D, Freeman M.
  Title
Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic rhomboids.
  Journal
Curr. Biol. 12 (2002) 1507-12.
Reference
12 [PMID:12169630]
  Authors
Urban S, Lee JR, Freeman M.
  Title
A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands.
  Journal
EMBO. J. 21 (2002) 4277-86.
Reference
13 [PMID:11672525]
  Authors
Urban S, Lee JR, Freeman M.
  Title
Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases.
  Journal
Cell. 107 (2001) 173-82.
  Sequence
Reference
14 [PMID:15616571]
  Authors
Lemberg MK, Menendez J, Misik A, Garcia M, Koth CM, Freeman M.
  Title
Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases.
  Journal
EMBO. J. 24 (2005) 464-72.
  Sequence
[bsu:BSU24870]
Reference
15 [PMID:17051161]
  Authors
Wang Y, Zhang Y, Ha Y.
  Title
Crystal structure of a rhomboid family intramembrane protease.
  Journal
Nature. 444 (2006) 179-80.
  Sequence
[eco:b3424]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.105
IUBMB Enzyme Nomenclature: 3.4.21.105
ExPASy - ENZYME nomenclature database: 3.4.21.105
BRENDA, the Enzyme Database: 3.4.21.105
CAS: 713145-02-9

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