KEGG   ENZYME: 3.4.21.4Help
Entry
EC 3.4.21.4                 Enzyme                                 
Name
trypsin;
alpha-trypsin;
beta-trypsin;
cocoonase;
parenzyme;
parenzymol;
tryptar;
trypure;
pseudotrypsin;
tryptase;
tripcellim;
sperm receptor hydrolase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Arg!, Lys!
Comment
The single polypeptide chain cattle beta-trypsin is formed from trypsinogen by cleavage of one peptide bond. Further peptide bond cleavages produce alpha and other iso-forms. Isolated as multiple cationic and anionic trypsins [5] from the pancreas of many vertebrates and from lower species including crayfish, insects (cocoonase) and microorganisms (Streptomyces griseus) [3]. Type example of peptidase family S1.
Orthology
K01312  
trypsin
Genes
HSA: 
5644(PRSS1) 5645(PRSS2) 5646(PRSS3)
PTR: 
PPS: 
GGO: 
PON: 
MCC: 
698352(PRSS2) 698729(PRSS1) 698983(PRSS1) 699238(PRSS2) 716882
MMU: 
100040233(Gm10334) 103964(Try5) 22072(Prss2) 22074(Try4) 436522(Try10) 67373(2210010C04Rik) 73626(1810009J06Rik)
RNO: 
100912089 24691(Prss1) 25052(Prss2) 286911(Prss3) 286960(Try4) 362347(Try4) 683849
CFA: 
AML: 
FCA: 
101085453 101085707
BTA: 
282603(PRSS2) 615026 780933
SSC: 
100302368 100525899(try)
ECB: 
100049983 100050047 100055297
MDO: 
100010059 100010109 100010619 100010951
SHR: 
100913350 100929943
OAA: 
100086459 100088455 100092420
GGA: 
396344(PRSS2) 396345(PRSS3)
MGP: 
100544478
TGU: 
100221157 100224083
ACS: 
100565603 100565795
XLA: 
379460(MGC64344)
XTR: 
496623 496627(prss2) 496640(try10) 548509(prss1)
DRE: 
571079 65223(try)
TRU: 
101071041
OLA: 
101154931
BFO: 
BRAFLDRAFT_88359
CIN: 
100177164 100179089 100179934 100187393
SPU: 
578844
DME: 
Dmel_CG12350(lambdaTry) Dmel_CG12351(deltaTry) Dmel_CG12385(thetaTry) Dmel_CG12386(etaTry) Dmel_CG12387(zetaTry) Dmel_CG18211(betaTry) Dmel_CG18444(alphaTry) Dmel_CG18681(epsilonTry) Dmel_CG30028(gammaTry) Dmel_CG30031 Dmel_CG7754(iotaTry) Dmel_CG9564(Try29F)
DPO: 
Dpse_GA11574 Dpse_GA11597 Dpse_GA11598 Dpse_GA11599 Dpse_GA14937 Dpse_GA15051 Dpse_GA15202 Dpse_GA18102 Dpse_GA19543 Dpse_GA20562 Dpse_GA21879
DAN: 
Dana_GF12402 Dana_GF12403 Dana_GF12404 Dana_GF12405 Dana_GF12406 Dana_GF12548 Dana_GF22696
DER: 
Dere_GG20196 Dere_GG22660(Dere_epsilonTry) Dere_GG22661(Dere_alphaTry) Dere_GG22662(Dere_thetaTry) Dere_GG22663(Dere_etaTry) Dere_GG22664(Dere_zetaTry) Dere_GG25325
DPE: 
Dper_GL17144 Dper_GL17338 Dper_GL17339 Dper_GL17340 Dper_GL17341 Dper_GL17342 Dper_GL26238
DSE: 
Dsec_GM17347 Dsec_GM20441 Dsec_GM20442 Dsec_GM20443 Dsec_GM21283
DSI: 
Dsim_GD10793 Dsim_GD15392 Dsim_GD25907 Dsim_GD25908 Dsim_GD25909 Dsim_GD25910
DWI: 
Dwil_GK19331 Dwil_GK19332 Dwil_GK19456 Dwil_GK19675 Dwil_GK19694 Dwil_GK21994 Dwil_GK23995
DYA: 
Dyak_GE12353 Dyak_GE12355 Dyak_GE13534(Dyak_epsilonTry) Dyak_GE13535(Dyak_alphaTry) Dyak_GE13536 Dyak_GE13537 Dyak_GE13538 Dyak_GE18820
DGR: 
Dgri_GH13258 Dgri_GH22866 Dgri_GH22867 Dgri_GH22868 Dgri_GH22926 Dgri_GH22928
DMO: 
Dmoj_GI17455 Dmoj_GI18414 Dmoj_GI18415 Dmoj_GI21243 Dmoj_GI21245 Dmoj_GI21246 Dmoj_GI21247
DVI: 
Dvir_GJ14373 Dvir_GJ20849 Dvir_GJ20850 Dvir_GJ20851 Dvir_GJ20852 Dvir_GJ21501(Dvir_Try2)
AGA: 
AgaP_AGAP008296(TRY1_ANOGA)
AAG: 
AaeL_AAEL006425 AaeL_AAEL008085 AaeL_AAEL008093 AaeL_AAEL010196 AaeL_AAEL010203 AaeL_AAEL013712
CQU: 
CpipJ_CPIJ004660 CpipJ_CPIJ007079
AME: 
413645(SP22)
NVI: 
100114919(SP12)
TCA: 
655678(P76)
PHU: 
Phum_PHUM375640
NVE: 
NEMVE_v1g170524
TAD: 
TRIADDRAFT_20634 TRIADDRAFT_25111 TRIADDRAFT_63128
FGR: 
FG11164.1
SSL: 
SS1G_06534
BFU: 
BC1G_04810
ANI: 
AN2366.2
AFV: 
AFLA_018910
PNO: 
SNOG_05556 SNOG_05978
TPS: 
THAPSDRAFT_263451 THAPSDRAFT_263452 THAPS_42804
BBA: 
Bd0564 Bd2630
MXA: 
MXAN_5435
SMA: 
SAV_2443
 » show all
Taxonomy
Reference
1
  Authors
Huber, R. and Bode, W.
  Title
Structural basis of the activation and action of trypsin.
  Journal
Acc. Chem. Res. 11 (1978) 114-122.
Reference
2
  Authors
Walsh, K.A.
  Title
Trypsinogens and trypsins of various species.
  Journal
Methods Enzymol. 19 (1970) 41-63.
Reference
3  [PMID:6442164]
  Authors
Read RJ, Brayer GD, Jurasek L, James MN.
  Title
Critical evaluation of comparative model building of Streptomyces griseus trypsin.
  Journal
Biochemistry. 23 (1984) 6570-5.
  Organism
Streptomyces griseus
Reference
4  [PMID:3643848]
  Authors
Fiedler F.
  Title
Effects of secondary interactions on the kinetics of peptide and peptide ester hydrolysis by tissue kallikrein and trypsin.
  Journal
Eur. J. Biochem. 163 (1987) 303-12.
  Organism
Bos taurus [GN:bta]
Reference
5  [PMID:3112218]
  Authors
Jelinek DF, Lipsky PE.
  Title
Comparative activation requirements of human peripheral blood, spleen, and lymph node B cells.
  Journal
J. Immunol. 139 (1987) 1005-13.
  Organism
Homo sapiens [GN:hsa]
Reference
6
  Authors
Polgar, L.
  Title
Structure and function of serine proteases.
  Journal
In: Neuberger, A. and Brocklehurst, K. (Eds.), New Comprehensive Biochemistry: Hydrolytic Enzymes, vol. 16, Elsevier, Amsterdam, 1987, p. 159-200.
Reference
7  [PMID:2326201]
  Authors
Tani T, Kawashima I, Mita K, Takiguchi Y.
  Title
Nucleotide sequence of the human pancreatic trypsinogen III cDNA.
  Journal
Nucleic. Acids. Res. 18 (1990) 1631.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9002-07-7
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