KEGG   ENZYME: 3.4.21.90Help
Entry
EC 3.4.21.90                Enzyme                                 

Name
togavirin;
Sindbis virus protease;
Sindbis virus core protein;
NsP2 proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp!Ser- bond
Comment
Known from the Sindbis and Semliki forest togaviruses. Once released, the core protein does not retain catalytic activity. Togavirin is the type example of peptidase family S3 and has a similar tertiary structure to chymotrypsin [3]
History
EC 3.4.21.90 created 1995
Reference
1  [PMID:3052288]
  Authors
Krausslich HG, Wimmer E.
  Title
Viral proteinases.
  Journal
Annu. Rev. Biochem. 57 (1988) 701-54.
Reference
2  [PMID:1448929]
  Authors
Strauss EG, De Groot RJ, Levinson R, Strauss JH.
  Title
Identification of the active site residues in the nsP2 proteinase of Sindbis virus.
  Journal
Virology. 191 (1992) 932-40.
Reference
3  [PMID:8450538]
  Authors
Tong L, Wengler G, Rossmann MG.
  Title
Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures.
  Journal
J. Mol. Biol. 230 (1993) 228-47.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
342882-56-8

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