togavirin;
Sindbis virus protease;
Sindbis virus core protein;
NsP2 proteinase

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp!Ser- bond

Known from the Sindbis and Semliki forest togaviruses. Once released, the core protein does not retain catalytic activity. Togavirin is the type example of peptidase family S3 and has a similar tertiary structure to chymotrypsin [3]

1  [PMID:3052288]

Krausslich HG, Wimmer E.

Viral proteinases.

Annu. Rev. Biochem. 57 (1988) 701-54.

2  [PMID:1448929]

Strauss EG, De Groot RJ, Levinson R, Strauss JH.

Identification of the active site residues in the nsP2 proteinase of Sindbis virus.

Virology. 191 (1992) 932-40.

Sindbis virus

3  [PMID:8450538]

Tong L, Wengler G, Rossmann MG.

Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures.

J. Mol. Biol. 230 (1993) 228-47.

Sindbis virus