KEGG   ENZYME: 3.4.22.28Help
Entry
EC 3.4.22.28                Enzyme                                 

Name
picornain 3C;
picornavirus endopeptidase 3C;
poliovirus protease 3C;
rhinovirus protease 3C;
foot-and-mouth protease 3C;
poliovirus proteinase 3C;
rhinovirus proteinase 3C;
coxsackievirus 3C proteinase;
foot-and-mouth-disease virus proteinase 3C;
3C protease;
3C proteinase;
cysteine proteinase 3C;
hepatitis A virus 3C proteinase;
protease 3C;
tomato ringspot nepovirus 3C-related protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Gln!Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly
Comment
From entero-, rhino-, aphto- and cardioviruses. Larger than the homologous virus picornain 2A. Type example of peptidase family C3
History
EC 3.4.22.28 created 1992
Reference
1  [PMID:3016701]
  Authors
Ivanoff LA, Towatari T, Ray J, Korant BD, Petteway SR Jr.
  Title
Expression and site-specific mutagenesis of the poliovirus 3C protease in Escherichia coli.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 83 (1986) 5392-6.
  Organism
poliovirus
Reference
2  [PMID:3186696]
  Authors
Bazan JF, Fletterick RJ.
  Title
Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 7872-6.
  Organism
poliovirus
Reference
3  [PMID:3052288]
  Authors
Krausslich HG, Wimmer E.
  Title
Viral proteinases.
  Journal
Annu. Rev. Biochem. 57 (1988) 701-54.
Reference
4  [PMID:2846872]
  Authors
Nicklin MJ, Harris KS, Pallai PV, Wimmer E.
  Title
Poliovirus proteinase 3C: large-scale expression, purification, and specific cleavage activity on natural and synthetic substrates in vitro.
  Journal
J. Virol. 62 (1988) 4586-93.
  Organism
poliovirus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
97162-88-4

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