KEGG   ENZYME: 3.4.22.29Help
Entry
EC 3.4.22.29                Enzyme                                 

Name
picornain 2A;
picornavirus endopeptidase 2A;
poliovirus protease 2A;
rhinovirus protease 2A;
2A protease;
2A proteinase;
protease 2A;
proteinase 2Apro;
picornaviral 2A proteinase;
Y-G proteinase 2A;
poliovirus proteinase 2A;
poliovirus protease 2Apro;
picornaviral 2A proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Tyr!Gly bond in picornavirus polyprotein
Comment
From entero-, rhino-, aphto- and cardioviruses. Smaller than the homologous picornain 3C, which is also in peptidase family C3 (picornain 3C family)
History
EC 3.4.22.29 created 1992
Reference
1  [PMID:3186696]
  Authors
Bazan JF, Fletterick RJ.
  Title
Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 7872-6.
Reference
2  [PMID:2831385]
  Authors
Konig H, Rosenwirth B.
  Title
Purification and partial characterization of poliovirus protease 2A by means of a functional assay.
  Journal
J. Virol. 62 (1988) 1243-50.
Reference
3  [PMID:3052288]
  Authors
Krausslich HG, Wimmer E.
  Title
Viral proteinases.
  Journal
Annu. Rev. Biochem. 57 (1988) 701-54.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
103406-62-8

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