adenain

Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases

Cleaves proteins of the adenovirus and its host cell at two consensus sites: -Yaa-Xaa-Gly-Gly!Xaa- and -Yaa-Xaa-Gly-Xaa!Gly- (in which Yaa is Met, Ile or Leu, and Xaa is any amino acid)

A cysteine endopeptidase from adenoviruses, the type example of peptidase family C5, with a protein fold unlike that known for any other peptidase [2]. Activity is greatly stimulated by the binding to the enzyme of an 11-residue peptide from the adenovirus capsid protein pre-VI at a site separate from the active site [1]

1  [PMID:8422686]

Webster A, Hay RT, Kemp G.

The adenovirus protease is activated by a virus-coded disulphide-linked peptide.

Cell. 72 (1993) 97-104.

adenovirus

2  [PMID:8617222]

Ding J, McGrath WJ, Sweet RM, Mangel WF.

Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor.

EMBO. J. 15 (1996) 1778-83.

adenovirus

3

Weber, J.M.

Adenovirus protease.

In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 741-743.