KEGG   ENZYME: 3.4.22.39Help
Entry
EC 3.4.22.39                Enzyme                                 

Name
adenain
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleaves proteins of the adenovirus and its host cell at two consensus sites: -Yaa-Xaa-Gly-Gly!Xaa- and -Yaa-Xaa-Gly-Xaa!Gly- (in which Yaa is Met, Ile or Leu, and Xaa is any amino acid)
Comment
A cysteine endopeptidase from adenoviruses, the type example of peptidase family C5, with a protein fold unlike that known for any other peptidase [2]. Activity is greatly stimulated by the binding to the enzyme of an 11-residue peptide from the adenovirus capsid protein pre-VI at a site separate from the active site [1]
History
EC 3.4.22.39 created 2000
Reference
1  [PMID:8422686]
  Authors
Webster A, Hay RT, Kemp G.
  Title
The adenovirus protease is activated by a virus-coded disulphide-linked peptide.
  Journal
Cell. 72 (1993) 97-104.
  Sequence
[up:P03274]
Reference
2  [PMID:8617222]
  Authors
Ding J, McGrath WJ, Sweet RM, Mangel WF.
  Title
Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor.
  Journal
EMBO. J. 15 (1996) 1778-83.
  Sequence
[up:P03252]
Reference
3
  Authors
Weber, J.M.
  Title
Adenovirus protease.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 741-743.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
369652-03-9

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