KEGG   ENZYME: 3.4.23.1Help
Entry
EC 3.4.23.1                 Enzyme                                 
Name
pepsin A;
pepsin;
lactated pepsin;
pepsin fortior;
fundus-pepsin;
elixir lactate of pepsin;
P I;
lactated pepsin elixir;
P II;
pepsin R;
pepsin D
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1!Val, Gln4!His, Glu13!Ala, Ala14!Leu, Leu15!Tyr, Tyr16!Leu, Gly23!Phe, Phe24!Phe and Phe25!Tyr bonds in the B chain of insulin
Comment
The predominant endopeptidase in the gastric juice of vertebrates, formed from pepsinogen A by limited proteolysis. Human pepsin A occurs in five molecular forms. Pig pepsin D [1,2] is unphosphorylated pepsin A. Type example of peptidase family A1.
Orthology
K06002  
pepsin A
Genes
HSA: 
5222(PGA5) 643834(PGA3) 643847(PGA4)
PTR: 
738012(PGA4)
PPS: 
100973723(PGA5)
GGO: 
PON: 
MCC: 
694562(PGA4) 694706(PGA4)
MMU: 
58803(Pga5)
RNO: 
CFA: 
AML: 
FCA: 
101080826 493954
BTA: 
337904(PAG10) 337906(PAG12) 414350(PGA5) 784113
SSC: 
100523770 100737419 396749(PAG6) 396892(PGA)
ECB: 
100034171(PAG) 100059232 100062179
GGA: 
395691(PGA)
MGP: 
100539041
TGU: 
100231572
ACS: 
100567277
XLA: 
373564(pga4)
XTR: 
496914(pga4)
TRU: 
777954(pga)
PFA: 
PF08_0108
PFH: 
PFHG_02623
PYO: 
PY06692
PCB: 
PC000654.04.0
PBE: 
PB001294.02.0
PKN: 
PKH_011000
PVX: 
PVX_088125
TAN: 
TA02750
TPV: 
TP01_0692 TP03_0306
TGO: 
TGME49_046550
TET: 
TTHERM_00046380 TTHERM_00433600 TTHERM_00971740 TTHERM_01128620
 » show all
Taxonomy
Reference
1  [PMID:4167464]
  Authors
Lee D, Ryle AP.
  Title
Pepsinogen D. A fourth proteolytic zymogen from pig gastric mucosa.
  Journal
Biochem. J. 104 (1967) 735-41.
  Organism
Sus scofa [GN:ssc]
Reference
2  [PMID:4860638]
  Authors
Lee D, Ryle AP.
  Title
Pepsin D. A minor component of commercial pepsin preparations.
  Journal
Biochem. J. 104 (1967) 742-8.
  Organism
Sus scofa [GN:ssc]
Reference
3  [PMID:6795036]
  Authors
Foltmann B.
  Title
Gastric proteinases--structure, function, evolution and mechanism of action.
  Journal
Essays. Biochem. 17 (1981) 52-84.
Reference
4  [PMID:3941737]
  Authors
James MN, Sielecki AR.
  Title
Molecular structure of an aspartic proteinase zymogen, porcine pepsinogen, at 1.8 A resolution.
  Journal
Nature. 319 (1986) 33-8.
  Organism
Sus scofa [GN:ssc]
Reference
5
  Authors
Fruton, J.S.
  Title
Aspartyl proteinases.
  Journal
In: Neuberger, A. and Brocklehurst, K. (Eds.), New Comprehensive Biochemistry: Hydrolytic Enzymes, vol. 16, Elsevier, Amsterdam, 1987, p. 1-38.
Reference
6  [PMID:3546346]
  Authors
Tang J, Wong RN.
  Title
Evolution in the structure and function of aspartic proteases.
  Journal
J. Cell. Biochem. 33 (1987) 53-63.
  Organism
Homo sapiens [GN:hsa], Bos taurus [GN:bta], Sus scofa [GN:ssc]
Reference
7  [PMID:3139029]
  Authors
Pohl J, Dunn BM.
  Title
Secondary enzyme-substrate interactions: kinetic evidence for ionic interactions between substrate side chains and the pepsin active site.
  Journal
Biochemistry. 27 (1988) 4827-34.
  Organism
Sus scofa [GN:ssc]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9001-75-6
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