KEGG   ENZYME: 3.4.23.15Help
Entry
EC 3.4.23.15                Enzyme                                 

Name
renin;
angiotensin-forming enzyme;
angiotensinogenase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of Leu! bond in angiotensinogen to generate angiotensin I
Comment
Formed from prorenin in plasma and kidney. In peptidase family A1 (pepsin A family).
History
EC 3.4.23.15 created 1961 as EC 3.4.4.15, transferred 1972 to EC 3.4.99.19, transferred 1981 to EC 3.4.23.15
Orthology
K01380  
renin
Genes
HSA: 
5972(REN)
PTR: 
469651(REN)
PPS: 
GGO: 
PON: 
MCC: 
574299(REN)
MCF: 
MMU: 
19701(Ren1) 19702(Ren2)
RNO: 
24715(Ren)
CGE: 
HGL: 
TUP: 
CFA: 
403838(REN)
AML: 
FCA: 
BTA: 
280909(REN)
BOM: 
PHD: 
CHX: 
SSC: 
CFR: 
ECB: 
MYB: 
MDO: 
SHR: 
OAA: 
GGA: 
431167(REN)
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
PSS: 
ACS: 
XTR: 
DRE: 
405786(ren)
TRU: 
777957(ren)
MZE: 
OLA: 
XMA: 
LCM: 
 » show all
Taxonomy
Reference
1  [PMID:16012]
  Authors
Inagami T, Murakami K.
  Title
Pure Renin. Isolation from hog kidney and characterization.
  Journal
J. Biol. Chem. 252 (1977) 2978-83.
  Organism
Sus scofa [GN:ssc]
Reference
2  [PMID:7043197]
  Authors
Slater EE.
  Title
Renin.
  Journal
Methods. Enzymol. 80 Pt C (1981) 427-42.
Reference
3  [PMID:2666611]
  Authors
Inagami T
  Title
Structure and function of renin.
  Journal
J. Hypertens. Suppl. 7 (1989) S3-8.
Reference
4  [PMID:2493678]
  Authors
Sielecki AR, Hayakawa K, Fujinaga M, Murphy ME, Fraser M, Muir AK, Carilli CT, Lewicki JA, Baxter JD, James MN.
  Title
Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution.
  Journal
Science. 243 (1989) 1346-51.
  Organism
Homo sapiens [GN:hsa]
  Sequence
[hsa:5972]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9015-94-5

DBGET integrated database retrieval system