HIV-1 retropepsin;
human immunodeficiency virus type 1 protease;
gag protease;
HIV aspartyl protease;
HIV proteinase;
retroproteinase;
HIV-1 protease;
HIV-2 protease

Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases

Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro

Present in human immunodeficiency virus type 1. Contributes to the maturation of the viral particle, and is a target of antiviral drugs. Active enzyme is a dimer of identical 11-kDa subunits. Similar enzymes occur in other retroviruses [1]. Type example of peptidase family A2

1

Kuo, L.C. and Shafer, J.A.

(eds) Retroviral Proteases.

Methods Enzymol. 241 (1994) 1-431.

2

Dunn, B.M.

Human immunodeficiency virus 1 retropepsin.

In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 919-928.