KEGG   ENZYME: 3.4.23.4Help
Entry
EC 3.4.23.4                 Enzyme                                 

Name
chymosin;
rennin (but this should be avoided since it leads to confusion with renin)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe105!Met-Ala bond in kappa-chain of casein
Comment
Neonatal gastric enzyme with high milk clotting and weak general proteolytic activity, formed from prochymosin. Found among mammals with postnatal uptake of immunoglobulins. In peptidase family A1(pepsin A family)
History
EC 3.4.23.4 created 1961 as EC 3.4.4.3, transferred 1972 to EC 3.4.23.4, modified 1986
Orthology
K01378  
chymosin
Genes
PTR: 
PPS: 
GGO: 
PON: 
MCF: 
MMU: 
229697(Cym)
RNO: 
56825(Cym)
CGE: 
TUP: 
CFA: 
AML: 
FCA: 
PTG: 
BTA: 
529879(CYM)
BOM: 
PHD: 
CHX: 
SSC: 
CFR: 
BACU: 
LVE: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
ASN: 
AMJ: 
ACS: 
PBI: 
 » show all
Taxonomy
Reference
1  [PMID:5330666]
  Authors
Foltmann B.
  Title
A review on prorennin and rennin.
  Journal
C. R. Trav. Lab. Carlsberg. 35 (1966) 143-231.
Reference
2  [PMID:6283469]
  Authors
Harris TJ, Lowe PA, Lyons A, Thomas PG, Eaton MA, Millican TA, Patel TP, Bose CC, Carey NH, Doel MT.
  Title
Molecular cloning and nucleotide sequence of cDNA coding for calf preprochymosin.
  Journal
Nucleic. Acids. Res. 10 (1982) 2177-87.
  Organism
Bos taurus
  Sequence
[bta:529879]
Reference
3  [PMID:3128264]
  Authors
Visser S, Slangen CJ, van Rooijen PJ.
  Title
Peptide substrates for chymosin (rennin). Interaction sites in kappa-casein-related sequences located outside the (103-108)-hexapeptide region that fits into the enzyme's active-site cleft.
  Journal
Biochem. J. 244 (1987) 553-8.
  Organism
Bos taurus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9001-98-3

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