KEGG   ENZYME: 3.4.23.46Help
Entry
EC 3.4.23.46                Enzyme                                 
Name
memapsin 2;
beta-secretase;
beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu!Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein
Comment
Suggested to be the major "beta-secretase" responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. In peptidase family A1 but is atypical in containing a C-terminal membrane-spanning domain.
Orthology
K04521  
beta-site APP-cleaving enzyme 1 (memapsin 2)
Genes
HSA: 
23621(BACE1)
PTR: 
451573(BACE1)
PPS: 
100986447(BACE1)
GGO: 
101153063(BACE1)
PON: 
100459804(BACE1)
MCC: 
697694(BACE1)
MMU: 
23821(Bace1)
RNO: 
29392(Bace1)
CFA: 
489390(BACE1)
AML: 
FCA: 
101086840(BACE1)
BTA: 
614333(BACE1)
SSC: 
100511707(BACE1)
ECB: 
100071137(BACE1)
MDO: 
100025518(BACE1)
SHR: 
100927154(BACE1)
OAA: 
100079669(BACE1)
GGA: 
419768(BACE1)
TGU: 
101233428(BACE1)
ACS: 
100560416
XTR: 
779940(bace1)
DRE: 
403005(bace1)
TRU: 
101062918
OLA: 
101160575
BFO: 
BRAFLDRAFT_83387
SPU: 
585631
NVE: 
NEMVE_v1g110829
HMG: 
100215715
TAD: 
TRIADDRAFT_23825 TRIADDRAFT_55204
 » show all
Taxonomy
Reference
1  [PMID:11513577]
  Authors
Turner RT 3rd, Koelsch G, Hong L, Castanheira P, Ermolieff J, Ghosh AK, Tang J.
  Title
Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design.
  Journal
Biochemistry. 40 (2001) 10001-6.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:12206667]
  Authors
Hong L, Turner RT 3rd, Koelsch G, Shin D, Ghosh AK, Tang J.
  Title
Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3.
  Journal
Biochemistry. 41 (2002) 10963-7.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
158736-49-3
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