KEGG   ENZYME: 3.4.23.46Help
Entry
EC 3.4.23.46                Enzyme                                 

Name
memapsin 2;
beta-secretase;
beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu!Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein
Comment
Suggested to be the major "beta-secretase" responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. In peptidase family A1 but is atypical in containing a C-terminal membrane-spanning domain.
History
EC 3.4.23.46 created 2003
Orthology
K04521  
beta-site APP-cleaving enzyme 1 (memapsin 2)
Genes
HSA: 
23621(BACE1)
PTR: 
451573(BACE1)
PPS: 
100986447(BACE1)
GGO: 
101153063(BACE1)
PON: 
100459804(BACE1)
MCC: 
697694(BACE1)
MCF: 
102116923(BACE1)
MMU: 
23821(Bace1)
RNO: 
29392(Bace1)
CGE: 
100762079(Bace1)
HGL: 
101701890(Bace1)
TUP: 
102484569(BACE1)
CFA: 
489390(BACE1)
AML: 
FCA: 
101086840(BACE1)
BTA: 
614333(BACE1)
BOM: 
102275622(BACE1)
PHD: 
102335723(BACE1)
CHX: 
102180953(BACE1)
SSC: 
100511707(BACE1)
CFR: 
102520718(BACE1)
ECB: 
100071137(BACE1)
MYB: 
102247187(BACE1)
MDO: 
100025518(BACE1)
SHR: 
100927154(BACE1)
OAA: 
100079669(BACE1)
GGA: 
419768(BACE1)
TGU: 
101233428(BACE1)
FAB: 
101816019(BACE1)
PHI: 
102108176(BACE1)
APLA: 
101796410(BACE1)
FPG: 
101915520(BACE1)
FCH: 
102053287(BACE1)
CLV: 
102086831(BACE1)
ASN: 
102373334(BACE1)
PSS: 
102457565(BACE1)
ACS: 
XTR: 
779940(bace1)
DRE: 
403005(bace1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102351539(BACE1)
BFO: 
SPU: 
NVE: 
HMG: 
TAD: 
 » show all
Taxonomy
Reference
1  [PMID:11513577]
  Authors
Turner RT 3rd, Koelsch G, Hong L, Castanheira P, Ermolieff J, Ghosh AK, Tang J.
  Title
Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design.
  Journal
Biochemistry. 40 (2001) 10001-6.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:12206667]
  Authors
Hong L, Turner RT 3rd, Koelsch G, Shin D, Ghosh AK, Tang J.
  Title
Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3.
  Journal
Biochemistry. 41 (2002) 10963-7.
  Organism
Homo sapiens [GN:hsa]
  Sequence
[hsa:23621]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
158736-49-3

DBGET integrated database retrieval system