| Entry |
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| Name |
thermolysin;
Bacillus thermoproteolyticus neutral proteinase;
thermoase;
thermoase Y10;
TLN
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
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| Reaction(IUBMB) |
Preferential cleavage: !Leu > !Phe
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| Comment |
A thermostable extracellular metalloendopeptidase containing four calcium ions. Enzymes that may be species variants of thermolysin are reported from Micrococcus caseolyticus [4] and Aspergillus oryzae [5]. Type example of peptidase family M4. Closely related but distinct enzymes are aeromonolysin, pseudolysin, bacillolysin, aureolysin and mycolysin
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| Orthology |
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| Genes |
BAN: | | BAR: | | BAT: | | BCY: | | BWE: | | GKA: | | ESI: | | EAT: | | FRA: | | HAU: | |
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| Reference |
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| Authors |
Ohta Y, Ogura Y, Wada A. |
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| Title |
Thermostable protease from thermophilic bacteria. I. Thermostability, physiocochemical properties, and amino acid composition. |
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| Journal |
J. Biol. Chem. 241 (1966) 5919-25. |
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| Organism |
Bacillus thermoproteolyticus |
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| Reference |
|
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| Authors |
Morihara K, Tsuzuki H, Oka T. |
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| Title |
Comparison of the specificities of various neutral proteinases from microorganisms. |
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| Journal |
Arch. Biochem. Biophys. 123 (1968) 572-88. |
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| Reference |
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| Authors |
Latt SA, Holmquist B, Vallee BL. |
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| Title |
Thermolysin: a zinc metalloenzyme. |
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| Journal |
Biochem. Biophys. Res. Commun. 37 (1969) 333-9. |
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| Organism |
Bacillus thermoproteolyticus |
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| Reference |
|
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| Authors |
Desmazeaud MJ, Hermier JH. |
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| Title |
[Specificity of the nuclear protease produced by Micrococcus caseolyticus] |
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| Journal |
Eur. J. Biochem. 19 (1971) 51-5. |
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| Organism |
Micrococcus caseolyticus |
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| Reference |
|
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| Authors |
Morihara K, Tsuzuki H. |
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| Title |
Comparative study of various neutral proteinases from microorganisms: specificity with oligopeptides. |
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| Journal |
Arch. Biochem. Biophys. 146 (1971) 291-6. |
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| Reference |
6 |
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| Authors |
Titani, K., Hermodson, M. |
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| Title |
A., Ericson, L. H., Walsh, K. A. and Neurath, H. Amino-acid sequence of thermolysin. |
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| Journal |
Nature New Biol. 238 (1972) 35-37. |
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| Reference |
7 |
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| Authors |
Matthews, B. |
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| Title |
W. Structural basis of the action of thermolysin and related zinc peptidases. |
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| Journal |
Acc. Chem. Res. 21 (1988) 333-340. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9073-78-3 |
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