KEGG   ENZYME: 3.6.1.17Help
Entry
EC 3.6.1.17                 Enzyme                                 

Name
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical);
bis(5'-guanosyl)-tetraphosphatase;
bis(5'-adenosyl)-tetraphosphatase;
diguanosinetetraphosphatase (asymmetrical);
dinucleosidetetraphosphatase (asymmetrical);
diadenosine P1,P4-tetraphosphatase;
dinucleoside tetraphosphatase;
1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase
Reaction(IUBMB)
P1,P4-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP [RN:R01232]
Reaction(KEGG)
Substrate
P1,P4-bis(5'-guanosyl) tetraphosphate [CPD:C01261];
H2O [CPD:C00001]
Product
GTP [CPD:C00044];
GMP [CPD:C00144]
Comment
Also acts on bis(5'-xanthosyl)-tetraphosphate and, more slowly, on bis(5'-adenosyl)-tetraphosphate and bis(5'-uridyl)-tetraphosphate [cf. EC 3.6.1.41 bis(5'-nucleosyl)-tetraphosphatase (symmetrical)]
History
EC 3.6.1.17 created 1972, modified 1976, modified 1986
Pathway
Purine metabolism
Pyrimidine metabolism
Orthology
K01518  
bis(5'-nucleosidyl)-tetraphosphatase
Genes
HSA: 
318(NUDT2)
PTR: 
465056(NUDT2)
PPS: 
100971204(NUDT2)
GGO: 
101152305(NUDT2)
PON: 
100457720(NUDT2)
MCC: 
700386(NUDT2) 701795(NUDT2)
MCF: 
MMU: 
66401(Nudt2)
RNO: 
CGE: 
100769146(Nudt2)
HGL: 
101699878(Nudt2)
TUP: 
102486667(NUDT2)
CFA: 
474746(NUDT2)
AML: 
FCA: 
101082099(NUDT2)
PTG: 
102968333(NUDT2)
BTA: 
768044(NUDT2)
BOM: 
102273937(NUDT2)
PHD: 
102336471(NUDT2)
CHX: 
102169758(NUDT2)
SSC: 
397577(NUDT2)
CFR: 
102521003(NUDT2)
BACU: 
103006665(NUDT2)
ECB: 
100054044(NUDT2)
MYB: 
102259354(NUDT2)
MYD: 
102754972(NUDT2)
PALE: 
102896710(NUDT2)
MDO: 
100021241(NUDT2)
SHR: 
100923669(NUDT2)
OAA: 
100088234(NUDT2)
GGA: 
427399(NUDT2)
MGP: 
TGU: 
100225183(NUDT2)
FAB: 
101813659(NUDT2)
PHI: 
102108717(NUDT2)
APLA: 
101790344(NUDT2)
FPG: 
101924519(NUDT2)
FCH: 
102057462(NUDT2)
CLV: 
102090406(NUDT2)
ASN: 
102378006(NUDT2)
PSS: 
102448176(NUDT2)
ACS: 
XLA: 
100049779(nudt2)
XTR: 
448765(nudt2)
DRE: 
436595(nudt2)
TRU: 
MZE: 
OLA: 
XMA: 
BFO: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
724681(Apf)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
CEL: 
CBR: 
CBG13634(Cbr-ndx-4)
BMY: 
LOA: 
TSP: 
NVE: 
HMG: 
PIC: 
SPO: 
PFA: 
PFH: 
PYO: 
PCB: 
PKN: 
PVX: 
TAN: 
TPV: 
BBO: 
BBOV_II002610(18.m06210)
TGO: 
NOC: 
HPA: 
BME: 
SPZ: 
SPH: 
SPI: 
SPJ: 
SPA: 
SPB: 
TTH: 
HWA: 
HQ3207A(hit)
PTO: 
 » show all
Taxonomy
Reference
1  [PMID:6309793]
  Authors
Jakubowski H, Guranowski A.
  Title
Enzymes hydrolyzing ApppA and/or AppppA in higher plants. Purification and some properties of diadenosine triphosphatase, diadenosine tetraphosphatase, and phosphodiesterase from yellow lupin (Lupinus luteus) seeds.
  Journal
J. Biol. Chem. 258 (1983) 9982-9.
  Organism
Lupinus luteus
Reference
2  [PMID:181087]
  Authors
Vallejo CG, Lobaton CD, Quintanilla M, Sillero A, Sillero MA.
  Title
Dinucleosidasetetraphosphatase in rat liver and Artemia salina.
  Journal
Biochim. Biophys. Acta. 438 (1976) 304-9.
  Organism
Rattus norvegicus, Artemia salina
Reference
3  [PMID:4955726]
  Authors
Warner AH, Finamore FJ.
  Title
Isolation, purification, and characterization of P1,P4-diguanosine 5'-tetraphosphate asymmetrical-pyrophosphohydrolase from brine shrimp eggs.
  Journal
Biochemistry. 4 (1965) 1568-75.
  Organism
Artemia salina
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37289-29-5

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