KEGG   ENZYME: 3.6.1.17Help
Entry
EC 3.6.1.17                 Enzyme                                 
Name
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical);
bis(5'-guanosyl)-tetraphosphatase;
bis(5'-adenosyl)-tetraphosphatase;
diguanosinetetraphosphatase (asymmetrical);
dinucleosidetetraphosphatase (asymmetrical);
diadenosine P1,P4-tetraphosphatase;
dinucleoside tetraphosphatase;
1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase
Reaction(IUBMB)
P1,P4-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP [RN:R01232]
Reaction(KEGG)
Substrate
P1,P4-bis(5'-guanosyl) tetraphosphate [CPD:C01261];
H2O [CPD:C00001]
Product
GTP [CPD:C00044];
GMP [CPD:C00144]
Comment
Also acts on bis(5'-xanthosyl)-tetraphosphate and, more slowly, on bis(5'-adenosyl)-tetraphosphate and bis(5'-uridyl)-tetraphosphate [cf. EC 3.6.1.41 bis(5'-nucleosyl)-tetraphosphatase (symmetrical)]
Pathway
Purine metabolism
Pyrimidine metabolism
Orthology
K01518  
bis(5'-nucleosidyl)-tetraphosphatase
Genes
HSA: 
318(NUDT2)
PTR: 
465056(NUDT2)
PPS: 
100971204(NUDT2)
GGO: 
101152305(NUDT2)
PON: 
100457720(NUDT2)
MCC: 
700386(NUDT2) 701795(NUDT2)
MMU: 
66401(Nudt2)
RNO: 
CFA: 
474746(NUDT2)
AML: 
FCA: 
101082099(NUDT2)
BTA: 
768044(NUDT2)
SSC: 
397577(NUDT2)
ECB: 
100054044
MDO: 
100021241
SHR: 
100923669(NUDT2)
OAA: 
100088234
GGA: 
427399(NUDT2)
MGP: 
100549295
TGU: 
100225183(NUDT2)
ACS: 
100565132
XLA: 
100049779(nudt2)
XTR: 
448765(nudt2)
DRE: 
436595(nudt2)
TRU: 
101079847
OLA: 
101167782
BFO: 
BRAFLDRAFT_277165
SPU: 
756973
DME: 
Dmel_CG31713(Apf)
DPO: 
Dpse_GA16415
DAN: 
Dana_GF14148
DER: 
Dere_GG23993
DPE: 
Dper_GL19196
DSE: 
Dsec_GM12103
DSI: 
Dsim_GD11976
DWI: 
Dwil_GK14539
DYA: 
Dyak_GE10149
DGR: 
Dgri_GH10668
DMO: 
Dmoj_GI11018
DVI: 
Dvir_GJ18307
AGA: 
AgaP_AGAP008495
AAG: 
AaeL_AAEL002207
CQU: 
CpipJ_CPIJ003519
AME: 
724681(Apf)
NVI: 
100117701(NV11988)
TCA: 
658593
API: 
100164487
PHU: 
Phum_PHUM202300
CEL: 
CELE_Y37H9A.6(ndx-4)
CBR: 
CBG13634(Cbr-ndx-4)
BMY: 
Bm1_25505
TSP: 
Tsp_08826
NVE: 
NEMVE_v1g248108
HMG: 
100200531
PIC: 
PICST_42119(HNT1)
SPO: 
SPCC4G3.02(aph1)
PFA: 
PFE1035c
PFH: 
PFHG_03946
PYO: 
PY04487
PCB: 
PC000336.02.0
PKN: 
PKH_101160
PVX: 
PVX_080215
TAN: 
TA05075 TA07740
TPV: 
TP03_0531 TP04_0303
BBO: 
BBOV_II002610(18.m06210)
TGO: 
TGME49_014780
NOC: 
Noc_1415
HPA: 
HPAG1_0725
BME: 
BMEI0941
SPZ: 
M5005_Spy_0080
SPH: 
MGAS10270_Spy0082
SPI: 
MGAS10750_Spy0087
SPJ: 
MGAS2096_Spy0083
SPA: 
M6_Spy0128
SPB: 
M28_Spy0078
FNU: 
FN1873
TTH: 
TTC1519 TTC1859
HWA: 
HQ3207A(hit)
PTO: 
PTO0464
 » show all
Taxonomy
Reference
1  [PMID:6309793]
  Authors
Jakubowski H, Guranowski A.
  Title
Enzymes hydrolyzing ApppA and/or AppppA in higher plants. Purification and some properties of diadenosine triphosphatase, diadenosine tetraphosphatase, and phosphodiesterase from yellow lupin (Lupinus luteus) seeds.
  Journal
J. Biol. Chem. 258 (1983) 9982-9.
  Organism
Lupinus luteus
Reference
2  [PMID:181087]
  Authors
Vallejo CG, Lobaton CD, Quintanilla M, Sillero A, Sillero MA.
  Title
Dinucleosidasetetraphosphatase in rat liver and Artemia salina.
  Journal
Biochim. Biophys. Acta. 438 (1976) 304-9.
  Organism
Rattus norvegicus [GN:rno], Artemia salina
Reference
3  [PMID:4955726]
  Authors
Warner AH, Finamore FJ.
  Title
Isolation, purification, and characterization of P1,P4-diguanosine 5'-tetraphosphate asymmetrical-pyrophosphohydrolase from brine shrimp eggs.
  Journal
Biochemistry. 4 (1965) 1568-75.
  Organism
Artemia salina
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37289-29-5
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