KEGG   ENZYME: 3.6.4.1Help
Entry
EC 3.6.4.1                  Enzyme                                 

Name
myosin ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement
BRITE hierarchy
Sysname
ATP phosphohydrolase (actin-translocating)
Reaction(IUBMB)
ATP + H2O = ADP + phosphate [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009]
Comment
Proteins of the contractile apparatus of muscle and nonmuscle cells; myosin molecule consists of two heavy chains (about 200 kDa) and two pairs of light chains (15-27 kDa). The head region of the heavy chain contains actin- and ATP-binding sites. ATP hydrolysis provides energy for actomyosin contraction.
History
EC 3.6.4.1 created 1984 as EC 3.6.1.32, transferred 2000 to EC 3.6.4.1
Reference
1  [PMID:8663496]
  Authors
Rayment I.
  Title
The structural basis of the myosin ATPase activity.
  Journal
J. Biol. Chem. 271 (1996) 15850-3.
  Organism
Dictyostelium discoideum
Reference
2  [PMID:8690736]
  Authors
Hasson T, Mooseker MS.
  Title
Vertebrate unconventional myosins.
  Journal
J. Biol. Chem. 271 (1996) 16431-4.
  Organism
Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
Reference
3  [PMID:10090768]
  Authors
Murphy CT, Spudich JA.
  Title
The sequence of the myosin 50-20K loop affects Myosin's affinity for actin throughout the actin-myosin ATPase cycle and its maximum ATPase activity.
  Journal
Biochemistry. 38 (1999) 3785-92.
  Organism
Gallus gallus, Oryctolagus cuniculus, Dictyostelium sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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