KEGG   ENZYME: 3.6.4.1Help
Entry
EC 3.6.4.1                  Enzyme                                 

Name
myosin ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement
BRITE hierarchy
Sysname
ATP phosphohydrolase (actin-translocating)
Reaction(IUBMB)
ATP + H2O = ADP + phosphate [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009]
Comment
Proteins of the contractile apparatus of muscle and nonmuscle cells; myosin molecule consists of two heavy chains (about 200 kDa) and two pairs of light chains (15-27 kDa). The head region of the heavy chain contains actin- and ATP-binding sites. ATP hydrolysis provides energy for actomyosin contraction.
History
EC 3.6.4.1 created 1984 as EC 3.6.1.32, transferred 2000 to EC 3.6.4.1
Pathway
Purine metabolism
Orthology
K01553  
myosin ATPase
Genes
PIC: 
CAL: 
PFA: 
PKN: 
HPA: 
Taxonomy
Reference
1  [PMID:8663496]
  Authors
Rayment I.
  Title
The structural basis of the myosin ATPase activity.
  Journal
J. Biol. Chem. 271 (1996) 15850-3.
  Organism
Dictyostelium discoideum [GN:ddi]
Reference
2  [PMID:8690736]
  Authors
Hasson T, Mooseker MS.
  Title
Vertebrate unconventional myosins.
  Journal
J. Biol. Chem. 271 (1996) 16431-4.
  Organism
Homo sapiens [GN:hsa], Mus musculus [GN:mmu], Rattus norvegicus [GN:rno], Gallus gallus [GN:gga]
Reference
3  [PMID:10090768]
  Authors
Murphy CT, Spudich JA.
  Title
The sequence of the myosin 50-20K loop affects Myosin's affinity for actin throughout the actin-myosin ATPase cycle and its maximum ATPase activity.
  Journal
Biochemistry. 38 (1999) 3785-92.
  Organism
Gallus gallus [GN:gga], Oryctolagus cuniculus, Dictyostelium sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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