KEGG   ENZYME: 3.6.4.8Help
Entry
EC 3.6.4.8                  Enzyme                                 

Name
proteasome ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement
BRITE hierarchy
Sysname
ATP phosphohydrolase (polypeptide-degrading)
Reaction(IUBMB)
ATP + H2O = ADP + phosphate [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009]
Comment
Belongs to the AAA-type superfamily and, like EC 3.6.4.5 (minus-end-directed kinesin ATPase), is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome.
History
EC 3.6.4.8 created 2000
Reference
1  [PMID:9228289]
  Authors
Rivett AJ, Mason GG, Murray RZ, Reidlinger J.
  Title
Regulation of proteasome structure and function.
  Journal
Mol. Biol. Rep. 24 (1997) 99-102.
Reference
2  [PMID:9688553]
  Authors
Mason GG, Murray RZ, Pappin D, Rivett AJ.
  Title
Phosphorylation of ATPase subunits of the 26S proteasome.
  Journal
FEBS. Lett. 430 (1998) 269-74.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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