KEGG   ENZYME: 3.6.4.8Help
Entry
EC 3.6.4.8                  Enzyme                                 
Name
proteasome ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement
BRITE hierarchy
Sysname
ATP phosphohydrolase (polypeptide-degrading)
Reaction(IUBMB)
ATP + H2O = ADP + phosphate [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009]
Comment
Belongs to the AAA-type superfamily and, like EC 3.6.4.5 (minus-end-directed kinesin ATPase), is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome.
Reference
1  [PMID:9228289]
  Authors
Rivett AJ, Mason GG, Murray RZ, Reidlinger J.
  Title
Regulation of proteasome structure and function.
  Journal
Mol. Biol. Rep. 24 (1997) 99-102.
  Organism
Thermoplasma sp.
Reference
2  [PMID:9688553]
  Authors
Mason GG, Murray RZ, Pappin D, Rivett AJ.
  Title
Phosphorylation of ATPase subunits of the 26S proteasome.
  Journal
FEBS. Lett. 430 (1998) 269-74.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system