KEGG   ENZYME: 4.1.1.21Help
Entry
EC 4.1.1.21                 Enzyme                                 

Name
phosphoribosylaminoimidazole carboxylase;
5-phosphoribosyl-5-aminoimidazole carboxylase;
5-amino-1-ribosylimidazole 5-phosphate carboxylase;
AIR carboxylase;
1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase;
ADE2;
class II PurE;
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]
Reaction(IUBMB)
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2 [RN:R04209]
Reaction(KEGG)
Substrate
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate [CPD:C04751]
Product
5-amino-1-(5-phospho-D-ribosyl)imidazole [CPD:C03373];
CO2 [CPD:C00011]
Comment
While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18, 5-(carboxyamino)imidazole ribonucleotide synthase and EC 5.4.99.18, 5-(carboxyamino)imidazole ribonucleotide mutase [3]. 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
History
EC 4.1.1.21 created 1961, modified 2000, modified 2006
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01587  phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase
K11808  phosphoribosylaminoimidazole carboxylase
Genes
HSA: 10606(PAICS)
PTR: 471236(PAICS)
PPS: 100993147(PAICS)
GGO: 101132763(PAICS)
PON: 100190835(PAICS)
NLE: 100580950(PAICS)
MCC: 694743(PAICS)
MCF: 101864855(PAICS)
CSAB: 103235650 103237366
RRO: 104655715(PAICS)
RBB: 108513484(PAICS)
CJC: 100390231(PAICS)
SBQ: 101031274(PAICS) 104651700
MMU: 67054(Paics)
RNO: 140946(Paics)
CGE: 100753190 100758991(Paics)
NGI: 103734378(Paics)
HGL: 101721606(Paics)
CCAN: 109697886(Paics)
OCU: 100343740(PAICS)
TUP: 102484181(PAICS)
CFA: 100855769(PAICS)
AML: 100482672(PAICS)
UMR: 103672750(PAICS)
ORO: 101383279(PAICS)
FCA: 101084705
PTG: 102951236(PAICS)
AJU: 106971666(PAICS)
BTA: 404170(PAICS)
BOM: 102281546(PAICS)
BIU: 109560492
PHD: 102334474(PAICS) 102339573
CHX: 102182773(PAICS)
OAS: 101115345 101117419(PAICS)
SSC: 100521281(PAICS)
CFR: 102522524(PAICS)
CDK: 105091550(PAICS)
BACU: 103009147(PAICS)
LVE: 103076533(PAICS)
OOR: 101287712(PAICS)
ECB: 100058501(PAICS)
EPZ: 103556488(PAICS)
EAI: 106841680(PAICS)
MYB: 102239537(PAICS)
MYD: 102757395(PAICS)
HAI: 109373280 109394361(PAICS)
RSS: 109451691(PAICS)
PALE: 102899036(PAICS)
LAV: 100658417
TMU: 101346245
MDO: 100012535(PAICS)
SHR: 100923019(PAICS)
OAA: 100086365(PAICS)
GGA: 396534(PAICS)
MGP: 100539860(PAICS)
CJO: 107313717
APLA: 101797218(PAICS)
ACYG: 106048610(PAICS)
TGU: 100225152(PAICS)
GFR: 102043552(PAICS)
FAB: 101808142(PAICS)
PHI: 102111686(PAICS)
PMAJ: 107203210(PAICS)
CCW: 104690617(PAICS)
FPG: 101919014(PAICS)
FCH: 102046009(PAICS)
CLV: 102094220(PAICS)
EGZ: 104129452
AAM: 106490207(PAICS)
ASN: 102380243(PAICS)
AMJ: 102565809(PAICS)
PSS: 102446966(PAICS)
CMY: 102937919(PAICS)
CPIC: 101942651(PAICS)
ACS: 100566555(paics)
PVT: 110077010(PAICS)
PBI: 103060841(PAICS)
GJA: 107123142(PAICS)
XLA: 379855(paics) 431975(paics.2.L) 444677(paics.1.S)
XTR: 100036662(paics.2) 100488155(paics.1)
NPR: 108794756(PAICS)
DRE: 321193(paics)
IPU: 108257759
AMEX: 103037884
TRU: 101073764
LCO: 104919099(paics)
NCC: 104947087(paics)
OLA: 101171736(paics)
XMA: 102236450
PRET: 103463823
NFU: 107393397
CSEM: 103376690(paics)
LCF: 108879073(paics)
HCQ: 109532211(paics)
BPEC: 110154796(paics)
ELS: 105011850(paics)
SFM: 108922797
LCM: 102354332(PAICS)
CMK: 103178180(paics)
CIN: 100177417
SPU: 575874
APLC: 110988626
DME: Dmel_CG3989(ade5)
DSI: Dsimw501_GD15919(Dsim_GD15919) Dsimw501_GD23841(Dsim_GD23841)
DYA: Dyak_GE16201(Dyak_ade5)
MDE: 101893760
AAG: 5578622
AME: 551966(ade5)
BIM: 100749872
BTER: 100649872
SOC: 105195586
AEC: 105144565
ACEP: 105618440
PBAR: 105431681
HST: 105184394
CFO: 105253371
LHU: 105673924
PGC: 109857193
NVI: 100122105
TCA: 656066
DPA: 109546155
NVL: 108561415
BMOR: 732910
API: 100169501
DNX: 107169969
ZNE: 110838439
FCD: 110857027
TUT: 107361566
CEL: CELE_B0286.3(pacs-1)
CBR: CBG03675
TSP: Tsp_02239
CRG: 105333392
MYI: 110447155
OBI: 106881666
EPA: 110243452
ADF: 107351950
HMG: 100210246
ATH: AT2G37690
CRB: 17887570
CPAP: 110807756
CIT: 102626933
TCC: 18600133
DZI: 111295264
EGR: 104421141
VRA: 106772452
CCAJ: 109795409
CAM: 101492527
ADU: 107465696
AIP: 107618371
LJA: Lj0g3v0036439.1(Lj0g3v0036439.1) Lj0g3v0036669.1(Lj0g3v0036669.1) Lj0g3v0076349.1(Lj0g3v0076349.1) Lj0g3v0078859.1(Lj0g3v0078859.1) Lj0g3v0078859.2(Lj0g3v0078859.2)
FVE: 101294659
PPER: 18774979
PMUM: 103318670
PAVI: 110754361
ZJU: 107412170
CSV: 101220975
CMO: 103485386
MCHA: 111020171
RCU: 8268191
JCU: 105647717
HBR: 110638277
JRE: 108992651
VVI: 100250122
SPEN: 107004897
SOT: 102597319
CANN: 107851129
NTA: 107826110
NSY: 104210402
OEU: 111390339
SOE: 110803454
OSA: 4327345
DOSA: Os01t0199900-01(Os01g0199900)
OBR: 102703081
BDI: 100840405
ATS: 109769837(LOC109769837)
SBI: 8084329
PDA: 103708454
EGU: 105040545
MUS: 103973031
DCT: 110098127
AOF: 109824587
ATR: 18438490
PPP: 112295424
APRO: F751_2359
SCE: YOR128C(ADE2)
ERC: Ecym_4634
KMX: KLMA_20598(ADE2)
NCS: NCAS_0H02150(NCAS0H02150)
NDI: NDAI_0C01500(NDAI0C01500)
TPF: TPHA_0J02670(TPHA0J02670)
TBL: TBLA_0A02680(TBLA0A02680)
TDL: TDEL_0D02460(TDEL0D02460)
KAF: KAFR_0D05120(KAFR0D05120)
PIC: PICST_81265(ADE2)
CAL: CAALFM_C304520CA(ADE2)
CAUR: QG37_00159
SLB: AWJ20_1637(ADE2)
NCR: NCU03194
NTE: NEUTE1DRAFT72443(NEUTE1DRAFT_72443)
MGR: MGG_01256
MAW: MAC_00025
MAJ: MAA_01998
CMT: CCM_06867
MBE: MBM_05356
ANI: AN3626.2
ANG: ANI_1_1076014(An01g08090)
PBN: PADG_12229(PADG_07036)
ABE: ARB_04901
TVE: TRV_05910
PTE: PTT_18788
SPO: SPCC1322.13(ade6)
CNE: CNE02500
CNB: CNBE2520
ABP: AGABI1DRAFT63686(AGABI1DRAFT_63686)
ABV: AGABI2DRAFT230061(AGABI2DRAFT_230061)
MGL: MGL_2675
DDI: DDB_G0283987(purC/E)
DFA: DFA_08571(purC/E)
SMIN: v1.2.002376.t1(symbB.v1.2.002376.t1) v1.2.002376.t2(symbB.v1.2.002376.t2) v1.2.002376.t3(symbB.v1.2.002376.t3) v1.2.002376.t4(symbB.v1.2.002376.t4)
SPAR: SPRG_11850
MPH: MLP_03890(purC)
 » show all
Taxonomy
Reference
1  [PMID:13672967]
  Authors
LUKENS LN, BUCHANAN JM.
  Title
Biosynthesis of the purines. XXIV. The enzymatic synthesis of 5-amino-1-ribosyl-4-imidazolecarboxylic acid 5'-phosphate from 5-amino-1-ribosylimidazole 5'-phosphate and carbon dioxide.
  Journal
J. Biol. Chem. 234 (1959) 1799-805.
Reference
2  [PMID:7918411]
  Authors
Firestine SM, Poon SW, Mueller EJ, Stubbe J, Davisson VJ.
  Title
Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms.
  Journal
Biochemistry. 33 (1994) 11927-34.
Reference
3  [PMID:9500840]
  Authors
Firestine SM, Misialek S, Toffaletti DL, Klem TJ, Perfect JR, Davisson VJ.
  Title
Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis.
  Journal
Arch. Biochem. Biophys. 351 (1998) 123-34.
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.21
IUBMB Enzyme Nomenclature: 4.1.1.21
ExPASy - ENZYME nomenclature database: 4.1.1.21
BRENDA, the Enzyme Database: 4.1.1.21
CAS: 9032-04-6

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