| Entry |
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| Name |
orotidine-5'-phosphate decarboxylase;
orotidine-5'-monophosphate decarboxylase;
orotodylate decarboxylase;
orotidine phosphate decarboxylase;
OMP decarboxylase;
orotate monophosphate decarboxylase;
orotidine monophosphate decarboxylase;
orotidine phosphate decarboxylase;
OMP-DC;
orotate decarboxylase;
orotidine 5'-phosphate decarboxylase;
orotidylic decarboxylase;
orotidylic acid decarboxylase;
orotodylate decarboxylase;
ODCase;
orotic decarboxylase;
orotidine-5'-phosphate carboxy-lyase
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| Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
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| Sysname |
orotidine-5'-phosphate carboxy-lyase (UMP-forming)
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| Reaction(IUBMB) |
orotidine 5'-phosphate = UMP + CO2 [RN: R00965]
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| Reaction(KEGG) |
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| Substrate |
orotidine 5'-phosphate [CPD: C01103]
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| Product |
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| Comment |
The enzyme from higher eukaryotes is identical with EC 2.4.2.10 orotate phosphoribosyltransferase .
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| History |
EC 4.1.1.23 created 1961, modified 1986
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| Pathway |
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| Orthology |
| K01591 | orotidine-5'-phosphate decarboxylase |
| K13421 | uridine monophosphate synthetase |
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| Genes |
» show all
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| Reference |
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| Authors |
Jones ME, Kavipurapu PR, Traut TW. |
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| Title |
Orotate phosphoribosyltransferase: orotidylate decarboxylase (Ehrlich ascites cell). |
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| Journal |
Methods. Enzymol. 51 (1978) 155-67. |
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| Reference |
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| Authors |
LIEBERMAN I, KORNBERG A, SIMMS ES. |
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| Title |
Enzymatic synthesis of pyrimidine nucleotides; orotidine-5'-phosphate and uridine-5'-phosphate. |
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| Journal |
J. Biol. Chem. 215 (1955) 403-51. |
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| Reference |
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| Authors |
McClard RW, Black MJ, Livingstone LR, Jones ME. |
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| Title |
Isolation and initial characterization of the single polypeptide that synthesizes uridine 5'-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5'-monophosphate synthase. |
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| Journal |
Biochemistry. 19 (1980) 4699-706. |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.1.1.23 |
| ExPASy - ENZYME nomenclature database: | 4.1.1.23 |
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