| Entry |
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| Name |
phosphatidylinositol diacylglycerol-lyase;
monophosphatidylinositol phosphodiesterase;
phosphatidylinositol phospholipase C;
1-phosphatidylinositol phosphodiesterase;
1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming);
1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)
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| Class |
Lyases;
Phosphorus-oxygen lyases;
Phosphorus-oxygen lyases (only sub-subclass identified to date)
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| Sysname |
1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)
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| Reaction(IUBMB) |
1-phosphatidyl-1D-myo-inositol = 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol [RN: R03364]
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| Reaction(KEGG) |
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| Substrate |
1-phosphatidyl-1D-myo-inositol [CPD: C01194]
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| Product |
1D-myo-inositol 1,2-cyclic phosphate [CPD: C04299];
1,2-diacyl-sn-glycerol [CPD: C00641]
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| Comment |
This enzyme is bacterial. Activity is also found in animals, but this activity is due to the presence of EC 3.1.4.11, phosphoinositide phospholipase C.
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| Pathway |
| Inositol phosphate metabolism |
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| Orthology |
| 1-phosphatidylinositol phosphodiesterase |
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| Genes |
ACS: | | XTR: | | DRE: | | TRU: | | OLA: | | AGO: | | ERC: | | LTH: | | PPA: | | TBL: | | DHA: | | PIC: | | PGU: | | LEL: | | CAL: | | CTP: | | CDU: | | COT: | | YLI: | | CLU: | | NCR: | | SMP: | | PAN: | | TTT: | | MTM: | | MGR: | | FGR: | | NHE: | | VAL: | | SSL: | | BFU: | | ANI: | | NFI: | | AFM: | | AOR: | | AFV: | | ACT: | | PCS: | | CIM: | | CPW: | | PBL: | | URE: | | ABE: | | TVE: | | AJE: | | PNO: | | PTE: | | ZTR: | | TML: | | LBC: | | MPR: | | CCI: | | SCM: | | UMA: | | PGR: | | TET: | | TVA: | | YEP: | | YEY: | | EPY: | | EPR: | | EAM: | | EAY: | | ERJ: | | MMK: | | HSO: | | HSM: | | GAN: | | BVI: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BAM: | | BAC: | | BCT: | | BGE: | | BUK: | | DAS: | | SUR: | | BAN: | | BAR: | | BAT: | | BAH: | | BAI: | | BAX: | | BAL: | | BCE: | | BCA: | | BCZ: | | BCR: | | BCB: | | BCU: | | BCG: | | BCQ: | | BCX: | | BNC: | | BCF: | | BCER: | | BTK: | | BTL: | | BTB: | | BTT: | | BTC: | | BTF: | | BTM: | | BTG: | | BTI: | | BTN: | | BTHT: | | BWE: | | SAU: | | SAV: | | SAW: | | SAH: | | SAJ: | | SAM: | | SAR: | | SAC: | | SAX: | | SAA: | | SAO: | | SAE: | | SAD: | | SUU: | | SUV: | | SUH: | | SUE: | | SUJ: | | SUK: | | SUC: | | SUT: | | SUQ: | | SUZ: | | SUD: | | SUX: | | SUW: | | SUG: | | SUF: | | SAB: | | SUY: | | SAUB: | | SAUM: | | LMO: | | LMF: | | LMH: | | LMC: | | LMN: | | LMY: | | LMT: | | LMG: | | LMS: | | LMJ: | | LMQ: | | LML: | | LMP: | | LMW: | | LMX: | | LMZ: | | LMON: | | LMOC: | | LMOS: | | LMOO: | | LMOY: | | LMOT: | | LMOA: | | LMOL: | | LMOG: | | LMOE: | | LMOB: | | LSG: | | LSP: | | CBN: | | CCB: | | ASF: | | ASM: | | ASB: | | BFI: | | RAL: | | SGR: | | SSX: | | SVL: | | SFA: | | SBH: | | SVE: | | STRP: | | FAL: | | CAI: | | SNA: | | BFR: | | BFG: | | BHL: | | CPI: | | DFE: | | FCO: | |
» show all
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| Reference |
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| Authors |
Allan D, Michell RH. |
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| Title |
Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes. Activity at pH5.5 and pH7.0. |
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| Journal |
Biochem. J. 142 (1974) 591-7. |
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| Organism |
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| Reference |
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| Authors |
Friedel RO, Brown JD, Durell. |
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| Title |
Monophosphatidyl inositol inositolphosphohydrolase in guinea-pig brain. |
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| Journal |
Biochim. Biophys. Acta. 144 (1967) 684-6. |
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| Organism |
Cavia porcellus |
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| Reference |
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| Authors |
Irvine RF. |
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| Title |
The enzymology of stimulated inositol lipid turnover. |
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| Journal |
Cell. Calcium. 3 (1982) 295-309. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Reference |
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| Authors |
Michell RH, Allan D. |
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| Title |
Inositol cyclis phosphate as a product of phosphatidylinositol breakdown by phospholipase C (Bacillus cereus). |
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| Journal |
FEBS. Lett. 53 (1975) 302-4. |
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| Organism |
Bacillus cereus |
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| Reference |
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| Authors |
Low MG, Finean JB. |
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| Title |
Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C. |
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| Journal |
Biochem. J. 167 (1977) 281-4. |
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| Organism |
Staphylococcus aureus |
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| Reference |
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| Authors |
Henner DJ, Yang M, Chen E, Hellmiss R, Rodriguez H, Low MG. |
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| Title |
Sequence of the Bacillus thuringiensis phosphatidylinositol specific phospholipase C. |
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| Journal |
Nucleic. Acids. Res. 16 (1988) 10383. |
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| Organism |
Bacillus thuringiensis |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 37288-19-0 |
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