KEGG   ENZYME: 5.3.3.1Help
Entry
EC 5.3.3.1                  Enzyme                                 

Name
steroid Delta-isomerase;
hydroxysteroid isomerase;
steroid isomerase;
Delta5-ketosteroid isomerase;
Delta5(or Delta4)-3-keto steroid isomerase;
Delta5-steroid isomerase;
3-oxosteroid isomerase;
Delta5-3-keto steroid isomerase;
Delta5-3-oxosteroid isomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
BRITE hierarchy
Sysname
3-oxosteroid Delta5-Delta4-isomerase
Reaction(IUBMB)
a 3-oxo-Delta5-steroid = a 3-oxo-Delta4-steroid [RN:R02644]
Reaction(KEGG)
Substrate
3-oxo-Delta5-steroid [CPD:C01034]
Product
3-oxo-Delta4-steroid [CPD:C00619]
Comment
This activity is catalysed by several distinct enzymes (cf. EC 1.1.3.6, cholesterol oxidase and EC 1.1.1.145, 3-hydroxy-5-steroid dehydrogenase).
History
EC 5.3.3.1 created 1961
Pathway
Steroid hormone biosynthesis
Steroid degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K00070  
3beta-hydroxy-delta5-steroid dehydrogenase / steroid delta-isomerase
K01822  
steroid delta-isomerase
K16045  
3beta-hydroxy-delta5-steroid dehydrogenase / steroid delta-isomerase
Genes
HSA: 
3283(HSD3B1) 3284(HSD3B2)
PTR: 
457165(HSD3B2) 469446(HSD3B1)
PPS: 
GGO: 
PON: 
100451655(HSD3B1) 100452394(HSD3B2)
NLE: 
MCC: 
MCF: 
CJC: 
MMU: 
15492(Hsd3b1) 15493(Hsd3b2) 15495(Hsd3b4) 15496(Hsd3b5) 15497(Hsd3b6)
RNO: 
100911116 100911154 24470(Hsd3b5) 29632(Hsd3b6) 360348(Hsd3b1) 682974(Hsd3b)
CGE: 
HGL: 
TUP: 
CFA: 
483146(HSD3B2)
AML: 
100464280(HSD3B1)
UMR: 
FCA: 
100616070(HSD3B1)
PTG: 
BTA: 
281824(HSD3B1)
BOM: 
PHD: 
CHX: 
100860869(3BHSD)
OAS: 
100190978(HSD3B1)
SSC: 
445539(HSD3B1)
CFR: 
BACU: 
LVE: 
ECB: 
100034078(HSD3B1)
MYB: 
102250585(HAO2)
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
396015(HSD3B2)
APLA: 
TGU: 
751770(HSD3B1)
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
102570362(3B-HSD)
PSS: 
CMY: 
ACS: 
100561899(hsd3b1)
PBI: 
XLA: 
734818(hsd3b1)
XTR: 
DRE: 
373131(hsd3b1) 553532
TRU: 
MZE: 
OLA: 
100144358(3bhsd)
XMA: 
LCM: 
CMK: 
BFO: 
DME: 
DPO: 
DAN: 
DER: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
NVI: 
ISC: 
TSP: 
HRO: 
LGI: 
SPL: 
SHL: 
GPB: 
REU: 
REH: 
CNC: 
CTI: 
AJS: 
DIA: 
CTT: 
AZO: 
XAU: 
HNE: 
NAR: 
NPP: 
SWI: 
OIH: 
MTU: 
MTV: 
MTC: 
MRA: 
MTF: 
MTB: 
MTK: 
MTZ: 
MTG: 
MTI: 
MTE: 
MTUR: 
MTL: 
MTO: 
MTD: 
MTN: 
MTJ: 
MTUB: 
MTUC: 
MTUE: 
MTX: 
MTUH: 
MTUL: 
MTUT: 
MTUU: 
MTQ: 
MBO: 
MBB: 
MBT: 
MBM: 
MBK: 
MAF: 
MCE: 
MCQ: 
MCV: 
MCX: 
MCZ: 
MLE: 
MLB: 
MPA: 
MAO: 
MAV: 
MIT: 
MIR: 
MIA: 
MID: 
MYO: 
MSM: 
MSG: 
MSA: 
MUL: 
MVA: 
MGI: 
MSP: 
MAB: 
MMC: 
MKM: 
MJL: 
MJD: 
MMI: 
MRH: 
MMM: 
MCB: 
MLI: 
MKN: 
MNE: 
ASD: 
NFA: 
NCY: 
RHA: 
RER: 
ROP: 
REQ: 
GBR: 
GPO: 
SGR: 
NCA: 
FAL: 
SEN: 
SAQ: 
CYC: 
CYN: 
 » show all
Taxonomy
Reference
1  [PMID:5867327]
  Authors
Ewald W, Werbin H, Chaikoff IL.
  Title
Evidence for the presence of 17-hydroxypregnenedione isomerase in beef adrenal cortex.
  Journal
Biochim. Biophys. Acta. 111 (1965) 306-12.
Reference
2  [PMID:14404954]
  Authors
KAWAHARA FS, TALALAY P.
  Title
Crystalline Delta 5-3-ketosteroid isomerase.
  Journal
J. Biol. Chem. 235 (1960) PC1-2.
Reference
3  [PMID:13276386]
  Authors
TALALAY P, WANG VS.
  Title
Enzymic isomerization of delta5-3-ketosteroids.
  Journal
Biochim. Biophys. Acta. 18 (1955) 300-1.
Reference
4  [PMID:10822008]
  Authors
MacLachlan J, Wotherspoon AT, Ansell RO, Brooks CJ
  Title
Cholesterol oxidase: sources, physical properties and analytical applications.
  Journal
J. Steroid. Biochem. Mol. Biol. 72 (2000) 169-95.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9031-36-1

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