KEGG   ENZYME: 5.3.99.3Help
Entry
EC 5.3.99.3                 Enzyme                                 
Name
prostaglandin-E synthase;
prostaglandin-H2 E-isomerase;
endoperoxide isomerase;
endoperoxide isomerase;
prostaglandin R-prostaglandin E isomerase;
prostaglandin endoperoxide E isomerase;
PGE isomerase;
PGH-PGE isomerase;
PGE2 isomerase;
prostaglandin endoperoxide E2 isomerase;
prostaglandin H-E isomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
BRITE hierarchy
Sysname
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase
Reaction(IUBMB)
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate [RN:R02265]
Reaction(KEGG)
Substrate
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD:C00427]
Product
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate [CPD:C00584]
Comment
Brings about the opening of the epidioxy bridge. Requires glutathione.
Pathway
Arachidonic acid metabolism
Metabolic pathways
Orthology
K05309  
microsomal prostaglandin-E synthase 2
K15729  
microsomal prostaglandin-E synthase 1
K15730  
cytosolic prostaglandin-E synthase
Genes
HSA: 
10728(PTGES3) 80142(PTGES2) 9536(PTGES)
PTR: 
464763(PTGES2) 473071(PTGES) 746021(PTGES3)
PPS: 
100967487(PTGES3) 100988615(PTGES) 100990863(PTGES2)
GGO: 
101144874(PTGES) 101151389(PTGES3) 101154357(PTGES2)
PON: 
100174118(PTGES3) 100432421(PTGES) 100443538(PTGES2)
MCC: 
697949(PTGES2) 713353(PTGES3) 716657(PTGES)
MMU: 
100043508(Gm9769) 100048119 56351(Ptges3) 64292(Ptges) 96979(Ptges2)
RNO: 
311865(Ptges2) 362809(Ptges3) 367808(Ptges3l1) 59103(Ptges)
CFA: 
480698(PTGES) 609101(PTGES2) 612760(PTGES3)
AML: 
FCA: 
101086187(PTGES) 101087496(PTGES3) 101098264(PTGES2)
BTA: 
282019(PTGES) 493638(PTGES3) 493639(PTGES2)
SSC: 
100155133(PTGES2) 100155956 654407(PTGES)
ECB: 
100034143(PTGES) 100059858 100070332
MDO: 
100012458 100014431 100015030
SHR: 
100922238(PTGES3) 100922522(PTGES2) 100928080(PTGES)
OAA: 
100082173 100089752
GGA: 
417193(PTGES) 417214(PTGES2)
MGP: 
100538709 100545081 100547804
TGU: 
100220496(PTGES2) 100226316(PTGES)
ACS: 
100556359 100559049 100563447
XLA: 
380300(ptges3) 446534(ptges)
XTR: 
100038070(ptges2) 100038203(ptges) 492275(ptges3)
DRE: 
100536108 406449(ptges3a) 415227(ptges3b) 544666(ptges) 799964(ptgesl)
TRU: 
101067534 101075005 101078041
OLA: 
101156737 101162769 101163397
BFO: 
BRAFLDRAFT_122389 BRAFLDRAFT_66624
CIN: 
100175706 100184120
SPU: 
584887
DME: 
Dmel_CG16817 Dmel_CG4086(Su(P))
DPO: 
Dpse_GA14165 Dpse_GA17946
DAN: 
Dana_GF10514 Dana_GF23063
DER: 
Dere_GG15865(Dere_Su(P)) Dere_GG17015
DPE: 
Dper_GL12369 Dper_GL12723
DSE: 
Dsec_GM23826 Dsec_GM24381
DSI: 
Dsim_GD12454(Dsim_Su(P)) Dsim_GD18637
DWI: 
Dwil_GK11119 Dwil_GK20317
DYA: 
Dyak_GE22204 Dyak_GE25973
DGR: 
Dgri_GH16457 Dgri_GH19405
DMO: 
Dmoj_GI16712 Dmoj_GI22609
DVI: 
Dvir_GJ12456 Dvir_GJ23854
AGA: 
AgaP_AGAP004992 AgaP_AGAP011157
AAG: 
AaeL_AAEL008776 AaeL_AAEL008783 AaeL_AAEL014943
CQU: 
CpipJ_CPIJ003988 CpipJ_CPIJ008199 CpipJ_CPIJ018524
AME: 
552470 726977
NVI: 
100114871(NV17381) 100118449(NV17215)
TCA: 
660107 662467
API: 
100159849 100162234 100569237
PHU: 
Phum_PHUM504110 Phum_PHUM580720
ISC: 
IscW_ISCW020922
CEL: 
CELE_R11A8.5(R11A8.5) CELE_ZC395.10(ZC395.10)
CBR: 
CBG21192 CBG23755
BMY: 
Bm1_30230 Bm1_30235 Bm1_53785
SMM: 
Smp_072900.1
NVE: 
NEMVE_v1g29018
HMG: 
100211597
TAD: 
TRIADDRAFT_63654 TRIADDRAFT_63793
AQU: 
100633880 100638237
ATH: 
AT5G42150
ALY: 
ARALYDRAFT_917592
GMX: 
100775694 100804696 100811576
MTR: 
MTR_3g114070 MTR_6g069420
CSV: 
101215364 101221439
RCU: 
RCOM_1598650
POP: 
POPTR_251614 POPTR_569734 POPTR_860476
VVI: 
100248972 100266342
OSA: 
4335293
DOSA: 
Os04t0244400-01(Os04g0244400)
BDI: 
100832419
SBI: 
SORBI_06g003270(SORBIDRAFT_06g003270)
ZMA: 
100191300(umc1949)
SMO: 
SELMODRAFT_103322 SELMODRAFT_46863
PPP: 
PHYPADRAFT_117397 PHYPADRAFT_45591
CRE: 
CHLREDRAFT_142756(TEF18)
VCN: 
VOLCADRAFT_82699
OLU: 
OSTLU_29981
OTA: 
Ot02g05510
CME: 
CMH214C CMM110C
MBR: 
MONBRDRAFT_8222
NGR: 
NAEGRDRAFT_29414
TGO: 
TGME49_104660
TBR: 
Tb927.7.3500(Tb07.28B13.560)
TCR: 
506443.70 508265.10
LMA: 
LMJF_14_1480
LIF: 
LINJ_14_1580
LDO: 
LDBPK_141580
LMI: 
LMXM_14_1480
LBZ: 
LBRM_14_1670
TPS: 
THAPS_6816
PIF: 
PITG_11458
 » show all
Taxonomy
Reference
1  [PMID:838703]
  Authors
Ogino N, Miyamoto T, Yamamoto S, Hayaishi O.
  Title
Prostaglandin endoperoxide E isomerase from bovine vesicular gland microsomes, a glutathione-requiring enzyme.
  Journal
J. Biol. Chem. 252 (1977) 890-5.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:3100531]
  Authors
Tanaka Y, Ward SL, Smith WL.
  Title
Immunochemical and kinetic evidence for two different prostaglandin H-prostaglandin E isomerases in sheep vesicular gland microsomes.
  Journal
J. Biol. Chem. 262 (1987) 1374-81.
  Organism
Ovis aries
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
52227-79-9
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