KEGG   ORTHOLOGY: K00070Help
Entry
K00070                      KO                                     
Name
HSD3B
Definition
3beta-hydroxy-delta5-steroid dehydrogenase / steroid delta-isomerase [EC:1.1.1.145 5.3.3.1]
Pathway
Steroid hormone biosynthesis
Ovarian steroidogenesis
Module
M00107  
Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone
M00110  
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
Disease
H00216  
Congenital adrenal hyperplasia (CAH)
H00599  
46,XX disorders of sex development (Disorders related to androgen excess)
H00608  
46,XY disorders of sex development (Disorders in androgen synthesis or action)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00070  HSD3B; 3beta-hydroxy-delta5-steroid dehydrogenase / steroid delta-isomerase
 Organismal Systems
  Endocrine system
   04913 Ovarian Steroidogenesis
    K00070  HSD3B; 3beta-hydroxy-delta5-steroid dehydrogenase / steroid delta-isomerase
KEGG pathway modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Sterol biosynthesis
    M00107  Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone
     K00070  HSD3B; 3beta-hydroxy-delta5-steroid dehydrogenase / steroid delta-isomerase
    M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
     K00070  HSD3B; 3beta-hydroxy-delta5-steroid dehydrogenase / steroid delta-isomerase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     K00070  HSD3B; 3beta-hydroxy-delta5-steroid dehydrogenase / steroid delta-isomerase
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     K00070  HSD3B; 3beta-hydroxy-delta5-steroid dehydrogenase / steroid delta-isomerase
BRITE hierarchy
Other DBs
Genes
HSA: 
3283(HSD3B1) 3284(HSD3B2)
PTR: 
457165(HSD3B2) 469446(HSD3B1)
PPS: 
GGO: 
PON: 
100451655(HSD3B1) 100452394(HSD3B2)
MCC: 
MMU: 
15492(Hsd3b1) 15493(Hsd3b2) 15495(Hsd3b4) 15496(Hsd3b5) 15497(Hsd3b6)
RNO: 
100911116 100911154 24470(Hsd3b5) 29632(Hsd3b6) 360348(Hsd3b1) 682974(Hsd3b)
CFA: 
483146(HSD3B2)
AML: 
100464280(HSD3B1)
FCA: 
100616070(HSD3B1)
BTA: 
281824(HSD3B1)
SSC: 
445539(HSD3B1)
ECB: 
100034078(HSD3B1)
MDO: 
100012668
SHR: 
100913530
OAA: 
100080135
GGA: 
396015(HSD3B2)
TGU: 
751770(HSD3B1)
ACS: 
100561899
XLA: 
734818(hsd3b1)
XTR: 
100490622
DRE: 
373131(hsd3b1) 553532
TRU: 
101069884
OLA: 
100144358(3bhsd)
BFO: 
BRAFLDRAFT_221648
DME: 
Dmel_CG7724
DPO: 
Dpse_GA20545
DAN: 
Dana_GF10105
DER: 
Dere_GG13606
DSE: 
Dsec_GM25688
DSI: 
Dsim_GD14693
DWI: 
Dwil_GK12665
DYA: 
Dyak_GE19901
DGR: 
Dgri_GH16404
DMO: 
Dmoj_GI12485
DVI: 
Dvir_GJ12388
AGA: 
AgaP_AGAP006654
AAG: 
AaeL_AAEL000733
CQU: 
CpipJ_CPIJ003056
NVI: 
100120136(NV12423)
ISC: 
IscW_ISCW018715
TSP: 
Tsp_09898
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2243100
  Authors
Lachance Y, Luu-The V, Labrie C, Simard J, Dumont M, de Launoit Y, Guerin S, Leblanc G, Labrie F
  Title
Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells.
  Journal
J Biol Chem 265:20469-75 (1990)
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