| Entry |
|
| Name |
glucose 1-dehydrogenase (PQQ, quinone);
quinoprotein glucose dehydrogenase;
membrane-bound glucose dehydrogenase;
mGDH;
glucose dehydrogenase (PQQ-dependent);
glucose dehydrogenase (pyrroloquinoline-quinone);
quinoprotein D-glucose dehydrogenase
|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With a quinone or similar compound as acceptor
 |
| Sysname |
D-glucose:ubiquinone oxidoreductase
|
| Reaction(IUBMB) |
D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol [RN: R06620]
|
| Reaction(KEGG) |
|
| Substrate |
|
| Product |
|
| Comment |
Integral membrane protein containing PQQ as prosthetic group. It also contains bound ubiquinone and Mg2+ or Ca2+. Electron acceptor is membrane ubiquinone but usually assayed with phenazine methosulfate. Like in all other quinoprotein alcohol dehydrogenases the catalytic domain has an 8-bladed propeller structure. It occurs in a wide range of bacteria. Catalyses a direct oxidation of the pyranose form of D-glucose to the lactone and thence to D-gluconate in the periplasm. Oxidizes other monosaccharides including the pyranose forms of pentoses.
|
| History |
EC 1.1.5.2 created 1982 as 1.1.99.17, transferred 2003 to EC 1.1.5.2, modified 2010
|
| Pathway |
| Pentose phosphate pathway |
|
| Orthology |
| quinoprotein glucose dehydrogenase |
|
| Genes |
ECO: | | ECJ: | | ECD: | | EBW: | | ECOK: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOJ: | | EOI: | | EOH: | | ECG: | | EOK: | | ELR: | | ECC: | | ECP: | | ECI: | | ECV: | | ECX: | | ECW: | | ECM: | | ECY: | | ECR: | | ECQ: | | ECK: | | ECT: | | EOC: | | EUM: | | ECZ: | | ELO: | | ELN: | | ELH: | | ESE: | | ESO: | | ESM: | | ESL: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | EAB: | | EDH: | | EDJ: | | EIH: | | ENA: | | ELU: | | EUN: | | ELW: | | ELL: | | ELC: | | ELD: | | EBL: | | EBE: | | ELF: | | ECOA: | | ECOL: | | ECOI: | | ECOJ: | | ECOO: | | ECOH: | | ECOS: | | EFE: | | EAL: | | STY: | | STT: | | SEX: | | SENT: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SETC: | | SENR: | | SEND: | | SENI: | | SEEN: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEC: | | SEH: | | SHB: | | SENH: | | SEEH: | | SEE: | | SENN: | | SEW: | | SEA: | | SENS: | | SED: | | SEL: | | SEGA: | | SET: | | SENA: | | SENO: | | SENV: | | SENQ: | | SENL: | | SENJ: | | SEEC: | | SEEB: | | SEEP: | | SENB: | | SENE: | | SENC: | | SES: | | SBG: | | SBZ: | | SBV: | | SFX: | | SFV: | | SFE: | | SFN: | | SFS: | | SFT: | | SSN: | | SBO: | | SDZ: | | SHQ: | | ENT: | | ENC: | | ENO: | | ECLO: | | EEC: | | ENL: | | ECLG: | | ECLE: | | ECLN: | | ECLI: | | ECLX: | | ECLY: | | ECLZ: | | ECLA: | | ECLC: | | ESC: | | KLE: | | EAS: | | EAU: | | EHM: | | EKB: | | ELG: | | EXF: | | ECLS: | | ENR: | | ENX: | | ENF: | | ESA: | | CSK: | | CSZ: | | CSI: | | CSJ: | | CCON: | | CDM: | | CMJ: | | CUI: | | CMW: | | CTU: | | KPN: | | KPU: | | KPM: | | KPP: | | KPK: | | KPH: | | KPZ: | | KPV: | | KPW: | | KPY: | | KPG: | | KPC: | | KPQ: | | KPT: | | KPE: | | KPO: | | KPR: | | KPJ: | | KPI: | | KPA: | | KPS: | | KPX: | | KPB: | | KPNE: | | KPNU: | | KVA: | | KVD: | | KVQ: | | KOX: | | KOE: | | KOY: | | KMI: | | KOK: | | KOC: | | KOM: | | KQU: | | EAE: | | EAR: | | CKO: | | CRO: | | CFD: | | CBRA: | | CAMA: | | CAF: | | ROR: | | RON: | | CNT: | | CEM: | | CEN: | | PGE: | | KSA: | | KOR: | | KRD: | | KCO: | | KIN: | | KGO: | | LAX: | | LAZ: | | EBF: | | SPE: | | SRR: | | SRL: | | SRY: | | SPLY: | | SRS: | | SRA: | | SMAF: | | SMW: | | SMAR: | | SMAC: | | SLQ: | | SERF: | | SERS: | | SRZ: | | RAH: | | RAQ: | | RAA: | | SOD: | | ETA: | | EPY: | | EPR: | | EAM: | | EAY: | | EBI: | | ERJ: | | EGE: | | PAM: | | PLF: | | PAJ: | | PAQ: | | PVA: | | PAO: | | KLN: | | PANT: | | PANP: | | PAGG: | | PAGC: | | TCI: | | PMR: | | PMIB: | | PVL: | | XCC: | | XCB: | | XCA: | | XCP: | | XCV: | | XAC: | | XCI: | | XCT: | | XCU: | | XCN: | | XCW: | | XCR: | | XCM: | | XCF: | | XCJ: | | XFU: | | XAX: | | XAO: | | XOR: | | XOZ: | | XSA: | | XTN: | | XGA: | | XVE: | | XPE: | | SML: | | SMT: | | BUJ: | | SMZ: | | STEK: | | SRH: | | SLM: | | LGU: | | FAU: | | DTX: | | DKO: | | LRZ: | | PAE: | | PAEV: | | PAEI: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PAEB: | | PDK: | | PSG: | | PRP: | | PAEP: | | PAER: | | PAEM: | | PAEL: | | PAES: | | PAEU: | | PAEG: | | PAEC: | | PAEO: | | PMY: | | PMK: | | PCQ: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUT: | | PPUN: | | PPUD: | | PFV: | | PMON: | | PMOT: | | PMOS: | | PPJ: | | POR: | | PST: | | PSB: | | PSYR: | | PSP: | | PCI: | | PFL: | | PPRC: | | PPRO: | | PFO: | | PFS: | | PFE: | | PFC: | | PFN: | | PFW: | | PFB: | | PFF: | | PFX: | | PPZ: | | PMAN: | | PTV: | | PCG: | | PVR: | | PEN: | | PSA: | | PSZ: | | PSR: | | PSC: | | PSJ: | | PSH: | | PSTU: | | PSTT: | | PBM: | | PBA: | | PBC: | | PPUU: | | PSV: | | PSK: | | PCH: | | PCZ: | | PCP: | | PFZ: | | PALK: | | PRH: | | PSW: | | PPV: | | PSES: | | PSEM: | | PSEC: | | PPSY: | | PSOS: | | PKR: | | PFK: | | PANR: | | AVN: | | AVL: | | AVD: | | ACX: | | PBB: | | PAR: | | PRW: | | PSO: | | PALI: | | ACB: | | ABM: | | ABY: | | ABC: | | ABN: | | ABB: | | ABX: | | ABZ: | | ABR: | | ABD: | | ABH: | | ABAD: | | ABJ: | | ABAB: | | ABAJ: | | ABAZ: | | ABK: | | ABAU: | | ABAA: | | ABW: | | ABAL: | | ACC: | | ANO: | | ACD: | | ACI: | | ATT: | | AJO: | | ACW: | | ACV: | | AHL: | | AJN: | | ASOL: | | ALA: | | ASJ: | | ILO: | | ILI: | | PAT: | | GAG: | | PIN: | | ZAL: | | OSG: | | NWA: | | WOC: | | CSA: | | HEL: | | HCS: | | HAK: | | HAM: | | HHU: | | HALO: | | HAA: | | KUS: | | KMA: | | ADI: | | APAC: | | AXE: | | MMW: | | FPP: | | PSPI: | | SALV: | | BCT: | | BUB: | | BGL: | | BGP: | | BGU: | | BUG: | | BGE: | | BGF: | | BGD: | | BGO: | | BYI: | | BUO: | | BUE: | | BUQ: | | BPLA: | | BXE: | | BXB: | | BPH: | | BPX: | | BPY: | | BCAI: | | PSPW: | | BPT: | | BHO: | | BHM: | | BHZ: | | AKA: | | AMIM: | | CDN: | | RHY: | | AAV: | | AAA: | | DAC: | | DEL: | | DTS: | | DHK: | | VAP: | | VPE: | | VPD: | | VAA: | | CKE: | | HYB: | | MPT: | | JAZ: | | JAL: | | RGE: | | RDP: | | RGU: | | MLO: | | MLN: | | MCI: | | MOP: | | MAM: | | MAMO: | | MESO: | | MESW: | | MES: | | HOE: | | PLA: | | SME: | | SMK: | | SMQ: | | SMX: | | SMI: | | SMEG: | | SMEL: | | SMER: | | SMD: | | RHI: | | SFH: | | SFD: | | SIX: | | SAME: | | EAD: | | EAH: | | ATU: | | ARA: | | ATF: | | ATA: | | AVI: | | AGR: | | AGC: | | ARO: | | RET: | | REC: | | REL: | | REI: | | REP: | | RLE: | | RLT: | | RLG: | | RLB: | | RLU: | | RTR: | | RIR: | | RHL: | | RGA: | | RHN: | | RPHA: | | RHT: | | RHX: | | NGL: | | NGG: | | SHZ: | | OAN: | | OAH: | | OPS: | | BJU: | | BJP: | | BRA: | | BBT: | | BRS: | | AOL: | | BRC: | | BRAD: | | BIC: | | RPB: | | RPT: | | RPX: | | MRD: | | MOR: | | CHEL: | | HNI: | | PHL: | | MEY: | | MAAD: | | MMED: | | AUA: | | PZU: | | BRD: | | BNE: | | BRG: | | RSP: | | RSH: | | RSQ: | | RSK: | | PYE: | | KVU: | | KVL: | | CID: | | PPHR: | | YAN: | | SUAM: | | TPRO: | | NPP: | | NRE: | | SPHK: | | SPHP: | | STER: | | SGI: | | SWI: | | SPHM: | | STAX: | | SPHI: | | SPAN: | | SKR: | | SPLM: | | SJP: | | SCH: | | SSY: | | SYB: | | SBD: | | SPMI: | | SPHB: | | SPHR: | | SINB: | | SPHG: | | BLAS: | | AAY: | | AMX: | | CNA: | | CMAN: | | GOX: | | GOH: | | GOY: | | GAL: | | GDI: | | GDJ: | | GXY: | | GXL: | | KNA: | | KEU: | | APT: | | APW: | | APF: | | APU: | | APG: | | APQ: | | APX: | | APZ: | | APK: | | ASZ: | | ASV: | | AACE: | | APER: | | ABG: | | KBA: | | RGI: | | NCH: | | RCE: | | AZL: | | ALI: | | ATI: | | TMO: | | TXI: | | PUB: | | APM: | | TTH: | | OTE: | | OBG: | | RBA: | | PLH: | | FMR: | | SACI: | | PBOR: | | GMA: | | TSA: | | TRS: | | SUS: | | ABAC: | | GAU: | | GPH: | | GBA: | | RBAR: | | CPI: | | NSO: | | NIA: | | HHY: | | SHG: | | MUP: | | CMR: | | CAMU: | | ALM: | | DFE: | | SLI: | | SRD: | | SMON: | | LBY: | | RSI: | | EOL: | | FAE: | | FIB: | | FBT: | | RBI: | | FBC: | | MART: | | ZGA: | | MRS: | | MLT: | | HMA: | | » show all
 |
| Reference |
|
| Authors |
Yamada M, Sumi K, Matsushita K, Adachi O, Yamada Y. |
| Title |
Topological analysis of quinoprotein glucose dehydrogenase in Escherichia coli and its ubiquinone-binding site. |
| Journal |
J. Biol. Chem. 268 (1993) 12812-7. |
| Sequence |
|
| Reference |
|
| Authors |
Dewanti AR, Duine JA. |
| Title |
Reconstitution of membrane-integrated quinoprotein glucose dehydrogenase apoenzyme with PQQ and the holoenzyme's mechanism of action. |
| Journal |
Biochemistry. 37 (1998) 6810-8. |
| Reference |
|
| Authors |
Duine JA, Frank J, van Zeeland JK. |
| Title |
Glucose dehydrogenase from Acinetobacter calcoaceticus: a 'quinoprotein'. |
| Journal |
FEBS. Lett. 108 (1979) 443-6. |
| Reference |
|
| Authors |
Ameyama M, Matsushita K, Ohno Y, Shinagawa E, Adachi O |
| Title |
Existence of a novel prosthetic group, PQQ, in membrane-bound, electron transport chain-linked, primary dehydrogenases of oxidative bacteria. |
| Journal |
FEBS. Lett. 130 (1981) 179-83. |
| Reference |
|
| Authors |
Cozier GE, Anthony C |
| Title |
Structure of the quinoprotein glucose dehydrogenase of Escherichia coli modelled on that of methanol dehydrogenase from Methylobacterium extorquens. |
| Journal |
Biochem. J. 312 ( Pt 3) (1995) 679-85. |
| Sequence |
|
| Reference |
|
| Authors |
Cozier GE, Salleh RA, Anthony C |
| Title |
Characterization of the membrane quinoprotein glucose dehydrogenase from Escherichia coli and characterization of a site-directed mutant in which histidine-262 has been changed to tyrosine. |
| Journal |
Biochem. J. 340 ( Pt 3) (1999) 639-47. |
| Sequence |
|
| Reference |
|
| Authors |
Elias M, Tanaka M, Sakai M, Toyama H, Matsushita K, Adachi O, Yamada M. |
| Title |
C-terminal periplasmic domain of Escherichia coli quinoprotein glucose dehydrogenase transfers electrons to ubiquinone. |
| Journal |
J. Biol. Chem. 276 (2001) 48356-61. |
| Sequence |
|
| Reference |
|
| Authors |
James PL, Anthony C |
| Title |
The metal ion in the active site of the membrane glucose dehydrogenase of Escherichia coli. |
| Journal |
Biochim. Biophys. Acta. 1647 (2003) 200-5. |
| Sequence |
|
| Reference |
|
| Authors |
Elias MD, Nakamura S, Migita CT, Miyoshi H, Toyama H, Matsushita K, Adachi O, Yamada M |
| Title |
Occurrence of a bound ubiquinone and its function in Escherichia coli membrane-bound quinoprotein glucose dehydrogenase. |
| Journal |
J. Biol. Chem. 279 (2004) 3078-83. |
| Sequence |
|
| Reference |
|
| Authors |
Mustafa G, Ishikawa Y, Kobayashi K, Migita CT, Elias MD, Nakamura S, Tagawa S, Yamada M |
| Title |
Amino acid residues interacting with both the bound quinone and coenzyme, pyrroloquinoline quinone, in Escherichia coli membrane-bound glucose dehydrogenase. |
| Journal |
J. Biol. Chem. 283 (2008) 22215-21. |
| Sequence |
|
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 81669-60-5 |