| Entry |
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| Name |
short-chain acyl-CoA dehydrogenase;
butyryl-CoA dehydrogenase;
butanoyl-CoA dehydrogenase;
butyryl dehydrogenase;
unsaturated acyl-CoA reductase;
ethylene reductase;
enoyl-coenzyme A reductase;
unsaturated acyl coenzyme A reductase;
butyryl coenzyme A dehydrogenase;
short-chain acyl CoA dehydrogenase;
short-chain acyl-coenzyme A dehydrogenase;
3-hydroxyacyl CoA reductase;
butanoyl-CoA:(acceptor) 2,3-oxidoreductase;
ACADS (gene name).
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
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| Sysname |
short-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
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| Reaction(IUBMB) |
a short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein [RN: R01178]
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| Reaction(KEGG) |
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| Substrate |
short-chain acyl-CoA [CPD: C20675];
electron-transfer flavoprotein [CPD: C04253]
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| Product |
short-chain trans-2,3-dehydroacyl-CoA [CPD: C20676];
reduced electron-transfer flavoprotein [CPD: C04570]
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| Comment |
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme catalyses the oxidation of saturated short-chain acyl-CoA thioesters to give a trans 2,3-unsaturated product by removal of the two pro-R-hydrogen atoms. The enzyme from beef liver accepts substrates with acyl chain lengths of 3 to 8 carbon atoms. The highest activity was reported with either butanoyl-CoA [2] or pentanoyl-CoA [4]. The enzyme from rat has only 10% activity with hexanoyl-CoA (compared to butanoyl-CoA) and no activity with octanoyl-CoA [6]. cf. EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.
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| History |
EC 1.3.8.1 created 1961 as EC 1.3.2.1, transferred 1964 to EC 1.3.99.2, transferred 2011 to EC 1.3.8.1, modified 2012
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| Pathway |
| Fatty acid degradation | | Valine, leucine and isoleucine degradation | | Butanoate metabolism | | Metabolic pathways | | Biosynthesis of secondary metabolites | | Microbial metabolism in diverse environments |
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| Orthology |
| butyryl-CoA dehydrogenase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | NLE: | | MCC: | | MCF: | | CSAB: | | RRO: | | CJC: | | SBQ: | | MMU: | | RNO: | | CGE: | | NGI: | | HGL: | | OCU: | | TUP: | | CFA: | | AML: | | UMR: | | FCA: | | PTG: | | AJU: | | BTA: | | BOM: | | PHD: | | CHX: | | OAS: | | SSC: | | CFR: | | BACU: | | LVE: | | ECB: | | MYB: | | MYD: | | HAI: | | PALE: | | LAV: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | CJO: | | APLA: | | TGU: | | GFR: | | FAB: | | PHI: | | CCW: | | FPG: | | FCH: | | CLV: | | AAM: | | ASN: | | AMJ: | | PSS: | | CMY: | | CPIC: | | ACS: | | PBI: | | GJA: | | XLA: | | XTR: | | DRE: | | IPU: | | TRU: | | TNG: | | LCO: | | MZE: | | OLA: | | XMA: | | SASA: | | LCM: | | CMK: | | BFO: | | CIN: | | SPU: | | SKO: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | MDE: | | AGA: | | AAG: | | CQU: | | AME: | | BIM: | | BTER: | | SOC: | | AEC: | | HST: | | CFO: | | NVI: | | TCA: | | BMOR: | | PXY: | | API: | | PHU: | | DPX: | | ISC: | | HRO: | | LGI: | | CRG: | | OBI: | | NVE: | | ADF: | | MBR: | | SRE: | | PTI: | | FCY: | | TPS: | | AAF: | | PIF: | | PSOJ: | | SPAR: | | EHX: | | GTT: | | PAE: | | PAEV: | | PAEI: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PAEB: | | PDK: | | PSG: | | PRP: | | PAEP: | | PAER: | | PAEM: | | PAEL: | | PAES: | | PAEU: | | PAEG: | | PAEC: | | PAEO: | | PMY: | | PMK: | | PRE: | | PPSE: | | PALC: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUT: | | PPUN: | | PPUD: | | PFV: | | PMON: | | PMOT: | | PMOS: | | PPJ: | | PST: | | PSB: | | PSYR: | | PSP: | | PCI: | | PFL: | | PPRC: | | PPRO: | | PFO: | | PFS: | | PFE: | | PFC: | | PFN: | | PFW: | | PFB: | | PFF: | | PPZ: | | PMAN: | | PEN: | | PSA: | | PSZ: | | PSR: | | PSC: | | PSJ: | | PSH: | | PSTU: | | PSTT: | | PBM: | | PBA: | | PBC: | | PPUU: | | PDR: | | PSV: | | PSK: | | PKC: | | PCH: | | PCZ: | | PCP: | | PALK: | | PPV: | | PSEM: | | PSEC: | | PSOS: | | PCR: | | PRW: | | PSO: | | PALI: | | PSPG: | | PSYG: | | SFR: | | SLO: | | PAT: | | MAQ: | | MHC: | | MAD: | | MBS: | | MSX: | | MPQ: | | MARI: | | AMC: | | AMH: | | AMAA: | | AMAL: | | AMAE: | | AMAO: | | AMAD: | | AMAI: | | AMAG: | | AMAC: | | AMB: | | AMG: | | AMK: | | ALT: | | AAL: | | AAUS: | | ASP: | | ASQ: | | AAW: | | GAG: | | GNI: | | GPS: | | SAGA: | | LPF: | | LPP: | | ABO: | | ALN: | | TOL: | | TOR: | | OAI: | | RSO: | | RSC: | | RSL: | | RSN: | | RSM: | | RSE: | | RPI: | | RPF: | | RPJ: | | RMN: | | REU: | | REH: | | CNC: | | RME: | | CTI: | | CBW: | | CGD: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BCEO: | | BAM: | | BAC: | | BCED: | | BPYR: | | BCON: | | BUB: | | BUG: | | BPY: | | BFN: | | RFR: | | POL: | | AAV: | | AJS: | | DIA: | | AAA: | | VEI: | | DAC: | | DEL: | | VAP: | | VPE: | | CTT: | | ADN: | | ADK: | | RTA: | | MPT: | | JAG: | | TIN: | | PBH: | | SHD: | | BEB: | | GME: | | GUR: | | GBM: | | GEO: | | GEM: | | GEB: | | BBA: | | BMX: | | DPR: | | DAL: | | DAT: | | ADE: | | ACP: | | AFW: | | ANK: | | MXA: | | MFU: | | MSD: | | CCX: | | SUR: | | SCL: | | SCU: | | HOH: | | SFU: | | BMB: | | BRA: | | BBT: | | RPE: | | MEX: | | MEA: | | RDE: | | HBA: | | SJP: | | ACR: | | RRU: | | RCE: | | TMO: | | PBR: | | BCZ: | | BTK: | | BTL: | | BCL: | | OIH: | | EAT: | | LBR: | | LBH: | | CRN: | | CAC: | | CAE: | | CAY: | | CPE: | | CPF: | | CPR: | | CTC: | | CTET: | | CNO: | | CBO: | | CBA: | | CBH: | | CBY: | | CBL: | | CBK: | | CBB: | | CBI: | | CBN: | | CBT: | | CBF: | | CBM: | | CBJ: | | CBE: | | CBZ: | | CKL: | | CKR: | | CCB: | | CLS: | | CSR: | | CPAS: | | CPAT: | | CPAE: | | CSB: | | CLT: | | CBV: | | CSQ: | | CLD: | | CCK: | | CBUT: | | CTYK: | | AMT: | | AOE: | | BPB: | | RHO: | | CSH: | | BPRL: | | ERE: | | CDF: | | CDC: | | CDL: | | CST: | | SWO: | | DSY: | | DHD: | | DRM: | | PTH: | | DOR: | | DMI: | | ELM: | | OVA: | | IBU: | | TTE: | | CHY: | | NTH: | | APR: | | MAV: | | MVA: | | MGI: | | MSP: | | MMC: | | MKM: | | MJL: | | ASD: | | NFA: | | RHA: | | GBR: | | TPR: | | NCA: | | TFU: | | NDA: | | TCU: | | FRA: | | FRI: | | FAL: | | ACE: | | GOB: | | PDX: | | MAU: | | MIL: | | RXY: | | DRA: | | DGE: | | DDR: | | TTH: | | TTJ: | | MRB: | | BHY: | | BRM: | | BPO: | | ABA: | | ACA: | | SUS: | | FNU: | | IPO: | | PGI: | | PGN: | | PAH: | | OSP: | | HHY: | | SLI: | | RSI: | | FBC: | | TLE: | | TME: | | TAF: | | FNO: | | CEX: | | DDF: | | CNI: | | FSI: | | PIS: | | PCL: | | PAS: | |
» show all
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| Reference |
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| Authors |
MAHLER HR. |
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| Title |
Studies on the fatty acid oxidizing system of animal tissues. IV. The prosthetic group of butyryl coenzyme A dehydrogenase. |
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| Journal |
J. Biol. Chem. 206 (1954) 13-26. |
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| Reference |
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| Authors |
GREEN DE, MII S, MAHLER HR, BOCK RM |
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| Title |
Studies on the fatty acid oxidizing system of animal tissues. III. Butyryl coenzyme A dehydrogenase. |
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| Journal |
J. Biol. Chem. 206 (1954) 1-12. |
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| Reference |
3 |
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| Authors |
Beinert, H. |
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| Title |
Acyl coenzyme A dehydrogenase. |
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| Journal |
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 447-466. |
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| Reference |
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| Authors |
Shaw L, Engel PC |
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| Title |
The purification and properties of ox liver short-chain acyl-CoA dehydrogenase. |
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| Journal |
Biochem. J. 218 (1984) 511-20. |
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| Reference |
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| Authors |
Thorpe C, Kim JJ |
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| Title |
Structure and mechanism of action of the acyl-CoA dehydrogenases. |
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| Journal |
FASEB. J. 9 (1995) 718-25. |
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| Reference |
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| Authors |
Ikeda Y, Okamura-Ikeda K, Tanaka K. |
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| Title |
Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme. |
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| Journal |
J. Biol. Chem. 260 (1985) 1311-25. |
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| Sequence |
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| Reference |
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| Authors |
McMahon B, Gallagher ME, Mayhew SG |
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| Title |
The protein coded by the PP2216 gene of Pseudomonas putida KT2440 is an acyl-CoA dehydrogenase that oxidises only short-chain aliphatic substrates. |
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| Journal |
FEMS. Microbiol. Lett. 250 (2005) 121-7. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: UM-BBD (Biocatalysis/Biodegradation Database): BRENDA, the Enzyme Database: CAS: 9027-88-7 |
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