KEGG ORTHOLOGY: K00237

ORTHOLOGY: K00237

Entry

K00237 KO

Name

SDHD, SDH4

Definition

succinate dehydrogenase (ubiquinone) membrane anchor subunit

Pathway

ko00020	Citrate cycle (TCA cycle)
ko00190	Oxidative phosphorylation
ko01200	Carbon metabolism
ko04932	Non-alcoholic fatty liver disease (NAFLD)
ko05010	Alzheimer's disease
ko05012	Parkinson's disease
ko05016	Huntington's disease

Module

M00009	Citrate cycle (TCA cycle, Krebs cycle)
M00011	Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00148	Succinate dehydrogenase (ubiquinone)

Disease

H00034	Carcinoid
H01222	Cowden-like syndrome
H01510	Malignant paraganglioma

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Overview
   01200 Carbon metabolism
    K00237  SDHD, SDH4; succinate dehydrogenase (ubiquinone) membrane anchor subunit
  Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K00237  SDHD, SDH4; succinate dehydrogenase (ubiquinone) membrane anchor subunit
  Energy metabolism
   00190 Oxidative phosphorylation
    K00237  SDHD, SDH4; succinate dehydrogenase (ubiquinone) membrane anchor subunit
Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K00237  SDHD, SDH4; succinate dehydrogenase (ubiquinone) membrane anchor subunit
   05012 Parkinson's disease
    K00237  SDHD, SDH4; succinate dehydrogenase (ubiquinone) membrane anchor subunit
   05016 Huntington's disease
    K00237  SDHD, SDH4; succinate dehydrogenase (ubiquinone) membrane anchor subunit
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K00237  SDHD, SDH4; succinate dehydrogenase (ubiquinone) membrane anchor subunit
KEGG modules [BR:ko00002]
Pathway module
  Carbohydrate and lipid metabolism
   Central carbohydrate metabolism
    M00009  Citrate cycle (TCA cycle, Krebs cycle)
     K00237  SDHD, SDH4; succinate dehydrogenase (ubiquinone) membrane anchor subunit
    M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
     K00237  SDHD, SDH4; succinate dehydrogenase (ubiquinone) membrane anchor subunit
Structural complex
  Energy metabolism
   ATP synthesis
    M00148  Succinate dehydrogenase (ubiquinone)
     K00237  SDHD, SDH4; succinate dehydrogenase (ubiquinone) membrane anchor subunit

Other DBs

RN:

R02164

COG:

COG2142

Genes

HSA:	6392(SDHD)
PTR:	451547(SDHD)
PPS:	100975025(SDHD) 100992849
GGO:	101141433 101141792 101151822 109028866(SDHD)
PON:	100172275(SDHD)
NLE:	100584747(SDHD) 100590500 101178881
MCC:	106992278(SDHD) 711326(SDHD)
MCF:	102132064(SDHD)
CSAB:	103240581 103248461(SDHD)
RRO:	104677354(SDHD)
CJC:	100413949(SDHD)
SBQ:	101028994(SDHD)
MMU:	66925(Sdhd)
RNO:	363061(Sdhd)
CGE:	100774657(Sdhd)
NGI:	103733879(Sdhd)
HGL:	101702014(Sdhd)
CCAN:	109699440(Sdhd)
OCU:	100341256 100346169 108175360(SDHD)
TUP:	102480188 102489690 102501460
CFA:	479438(SDHD)
FCA:	101095280(SDHD)
PTG:	102952867(SDHD)
AJU:	106975241 106984276(SDHD)
BTA:	281481(SDHD)
BOM:	102281830(SDHD)
BIU:	109556917(SDHD)
PHD:	102320363 102321274 102337506 102339747 102340808
CHX:	100860881(SDHD)
OAS:	101111485(SDHD) 780442 780772
SSC:	100048954(SDHD)
CFR:	102521513(SDHD)
BACU:	103014249(SDHD)
LVE:	103087853(SDHD)
ECB:	100629334(SDHD)
MYB:	102259933(SDHD)
MYD:	102763784(SDHD)
HAI:	109388702(SDHD)
RSS:	109436603(SDHD)
PALE:	102885251(SDHD)
LAV:	100655924 100668090(SDHD)
MDO:	100032261(SDHD)
SHR:	100916627(SDHD)
GGA:	419793(SDHD)
MGP:	104909347(SDHD)
CJO:	107324125(SDHD)
APLA:	101804599(SDHD)
ACYG:	106039722(SDHD)
TGU:	100190674 101232963
GFR:	102032079(SDHD)
FAB:	107604174(SDHD)
PHI:	102105389(SDHD)
CCW:	104692077(SDHD)
FPG:	101915216(SDHD)
FCH:	102046315(SDHD)
CLV:	102089042(SDHD)
ASN:	102375141(SDHD)
AMJ:	102571129(SDHD)
PSS:	102453028(SDHD)
CMY:	102934024(SDHD)
CPIC:	101931568(SDHD)
PBI:	103052888(SDHD)
GJA:	107116139(SDHD)
XLA:	494586(sdhd.S) 496372(sdhd.L)
XTR:	394986(sdhd)
NPR:	108801745(SDHD)
DRE:	436762(sdhda) 445500(sdhdb)
SRX:	107709126 107717284 107717883 107722759
SANH:	107657257 107670952 107681256
SGH:	107577886 107586238 107598448 107601715
IPU:	108277787(sdhd)
TRU:	101073558(sdhd)
LCO:	104940581(sdhd)
NCC:	104945632(sdhd)
MZE:	101471207(sdhd)
OLA:	101167814(sdhd)
XMA:	102225550(sdhd)
CSEM:	103377767(sdhd)
LCF:	108900022(sdhd)
SASA:	106580927 106612556
ELS:	105024040(sdhd)
SFM:	108928640(sdhd)
LCM:	102347390(SDHD)
CMK:	103191157(sdhd)
BFO:	BRAFLDRAFT_274889
CIN:	100180725
SPU:	588082
SKO:	100371519
DME:	Dmel_CG10219(SdhD)
DPO:	Dpse_GA10165
DAN:	Dana_GF18741
DER:	Dere_GG12408
DPE:	Dper_GL24273
DSE:	Dsec_GM23542
DSI:	Dsimw501_GD18356(Dsim_GD18356)
DWI:	Dwil_GK22767
DYA:	Dyak_GE23927
DGR:	Dgri_GH11519
DMO:	Dmoj_GI22398
DVI:	Dvir_GJ24648
MDE:	101892117 105262046
AGA:	AgaP_AGAP000618
AAG:	AaeL_AAEL010519 AaeL_AAEL014505
CQU:	CpipJ_CPIJ003756
AME:	725566
BIM:	100742104
BTER:	100650698
SOC:	105203611
AEC:	105150009
ACEP:	105625215
PBAR:	105432798
HST:	105183236
CFO:	105250939
LHU:	105677497
NVI:	100114881(SdhD)
TCA:	660493
DPA:	109540617
NVL:	108556564 108556565
BMOR:	101737567 105842987
PXY:	105395521
API:	100165798 100166213
DNX:	107166097
PHU:	Phum_PHUM459220
DPX:	DAPPUDRAFT_306337
ISC:	IscW_ISCW012012
TUT:	107366938
CEL:	CELE_F33A8.5(sdhd-1)
CBR:	CBG02978(Cbr-sdhd-1)
NAI:	NECAME_19506 NECAME_19556
BMY:	Bm1_35660
LOA:	LOAG_00689
TSP:	Tsp_00425
HRO:	HELRODRAFT_66046
LGI:	LOTGIDRAFT_115222
CRG:	105338659
OBI:	106871739
SMM:	Smp_037910
OVI:	T265_09911
NVE:	NEMVE_v1g90548
ADF:	107335288
HMG:	100205518
TAD:	TRIADDRAFT_55207
AQU:	100633514
CRE:	CHLREDRAFT_146346(SDH4)
OLU:	OSTLU_33089
OTA:	Ot08g02220
BPG:	Bathy01g05210
MPP:	MICPUCDRAFT_37472
CSL:	COCSUDRAFT_52340
CVR:	CHLNCDRAFT_141411
APRO:	F751_3513
SCE:	YDR178W(SDH4) YLR164W(SHH4)
AGO:	AGOS_AGL137W
ERC:	Ecym_4190
KLA:	KLLA0D18117g
LTH:	KLTH0F08932g
VPO:	Kpol_1024p21
ZRO:	ZYRO0C03828g
CGR:	CAGL0F05863g
NCS:	NCAS_0B03140(NCAS0B03140)
NDI:	NDAI_0A01150(NDAI0A01150)
TPF:	TPHA_0C02440(TPHA0C02440)
TBL:	TBLA_0H01000(TBLA0H01000)
TDL:	TDEL_0F05010(TDEL0F05010)
KAF:	KAFR_0B06070(KAFR0B06070) KAFR_0H02020(KAFR0H02020)
PPA:	PAS_chr2-2_0283 PAS_chr3_0424
DHA:	DEHA2D13970g DEHA2G15928g
PIC:	PICST_35330(SDH5) PICST_90476(SDH4)
PGU:	PGUG_00504 PGUG_04469
SPAA:	SPAPADRAFT_58095 SPAPADRAFT_63063
LEL:	LELG_01522 LELG_04095
CAL:	CAALFM_C103940WA(CaO19.4468) CAALFM_C505280CA(SDH4)
CTP:	CTRG_04772 CTRG_06134
COT:	CORT_0B09550 CORT_0F00350
CDU:	CD36_03670 CD36_54880
CTEN:	CANTEDRAFT_108004 CANTEDRAFT_112442
YLI:	YALI0A14784g
CLU:	CLUG_00636 CLUG_03577
CAUR:	QG37_00206 QG37_03163
NCR:	NCU03031(tca-13)
NTE:	NEUTE1DRAFT119188(NEUTE1DRAFT_119188)
SMP:	SMAC_00413
PAN:	PODANSg09574
TTT:	THITE_2121235
MTM:	MYCTH_2294375
CTHR:	CTHT_0059080
MGR:	MGG_00666
TMN:	UCRPA7_6158
FGR:	FGSG_00743
FPU:	FPSE_01262
FVR:	FVEG_00440
FOX:	FOXG_01074
NHE:	NECHADRAFT_102395
TRE:	TRIREDRAFT_22707
MAW:	MAC_07488
MAJ:	MAA_07462
CMT:	CCM_00099
VAL:	VDBG_03683
VDA:	VDAG_00917
CFJ:	CFIO01_08358
ELA:	UCREL1_10819
PFY:	PFICI_13717
SSL:	SS1G_06173
BFU:	BC1G_01333
MBE:	MBM_03493
PSCO:	LY89DRAFT_679428
GLZ:	GLAREA_08485
ANI:	AN0896.2
AFM:	AFUA_1G15590
AOR:	AOR_1_1996174
ANG:	ANI_1_1886014(An01g13930)
AFV:	AFLA_083880
ACT:	ACLA_019770
NFI:	NFIA_009730
PCS:	Pc06g01810
PDP:	PDIP_65360
CIM:	CIMG_03134
CPW:	CPC735_010220
PBL:	PAAG_05415
PBN:	PADG_06764
URE:	UREG_02833
ABE:	ARB_01822
TVE:	TRV_06423
AJE:	HCAG_02344
PNO:	SNOG_11620
PTE:	PTT_07579
BZE:	COCCADRAFT_93223
BSC:	COCSADRAFT_203527
BOR:	COCMIDRAFT_89111
ZTR:	MYCGRDRAFT_57478(SDH4)
PFJ:	MYCFIDRAFT_50482
BCOM:	BAUCODRAFT_64927
NPA:	UCRNP2_8753
TML:	GSTUM_00001949001
SPO:	SPBP23A10.16(sdh4)
CNE:	CNB00800
CNB:	CNBB4910
CGI:	CGB_B8170W
TMS:	TREMEDRAFT_43822
TVS:	TRAVEDRAFT_50112
DSQ:	DICSQDRAFT_54865
PCO:	PHACADRAFT_264548
SHS:	STEHIDRAFT_60709
HIR:	HETIRDRAFT_65732
PSQ:	PUNSTDRAFT_76292
ADL:	AURDEDRAFT_114629 AURDEDRAFT_115600
FME:	FOMMEDRAFT_85917
GTR:	GLOTRDRAFT_45569
LBC:	LACBIDRAFT_249103
MRR:	Moror_3016
CCI:	CC1G_02650
SCM:	SCHCODRAFT_73094
ABP:	AGABI1DRAFT87403(SDH4)
ABV:	AGABI2DRAFT195170(SDH4)
SLA:	SERLADRAFT_471409(SDH4)
WSE:	WALSEDRAFT_70583
WIC:	J056_001666
UMA:	UMAG_03845
PFP:	PFL1_06450
MGL:	MGL_2021
PGR:	PGTG_10911
MLR:	MELLADRAFT_35945
MBR:	MONBRDRAFT_32293
SRE:	PTSG_02255
DDI:	DDB_G0278157(sdhD)
DPP:	DICPUDRAFT_150238
DFA:	DFA_05926(sdhD)
PIF:	PITG_11452
PSOJ:	PHYSODRAFT_285034
SPAR:	SPRG_04463
EHX:	EMIHUDRAFT_237621

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Ontology (3)   
   KEGG BRITE (2)   
   COG (1)   
Pathway (25)   
   KEGG PATHWAY (22)   
   KEGG MODULE (3)   
Disease (3)   
   KEGG DISEASE (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (426)   
   KEGG GENES (325)   
   KEGG MGENES (46)   
   RefGene (5)   
   EGENES (43)   
   OC (7)   
Protein sequence (219)   
   UniProt (198)   
   SWISS-PROT (21)   
All databases (678)   

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