KEGG ORTHOLOGY: K00435

ORTHOLOGY: K00435

Entry

K00435 KO

Name

hemQ

Definition

Fe-coproporphyrin III decarboxylase [EC:1.11.1.-]

Pathway

ko00860

Porphyrin and chlorophyll metabolism

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Metabolism of cofactors and vitamins
   00860 Porphyrin and chlorophyll metabolism
    K00435  hemQ; Fe-coproporphyrin III decarboxylase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.-
     K00435  hemQ; Fe-coproporphyrin III decarboxylase

Other DBs

RN:

R11522

COG:

COG3253

Genes

MRM:	A7982_09314
BSU:	BSU37670(ywfI)
BSR:	I33_3915
BSL:	A7A1_0186
BSH:	BSU6051_37670(ywfI)
BSY:	I653_18480
BSUT:	BSUB_04003(hemQ)
BSUL:	BSUA_04003(hemQ)
BSUS:	Q433_20750
BSS:	BSUW23_18605(ywfI)
BST:	GYO_4153
BSO:	BSNT_10425(ywfI)
BSN:	BSn5_09825
BSQ:	B657_37670(hemQ)
BSX:	C663_3672(ywfI)
BSP:	U712_18985
BLI:	BL03956(ywfI)
BLD:	BLi03998(ywfI)
BLH:	BaLi_c40120(ywfI)
BAY:	RBAM_034860(ywfI)
BAQ:	BACAU_3515(ywfI)
BYA:	BANAU_3668(ywfI)
BAMP:	B938_17890
BAML:	BAM5036_3416(hemQ)
BAMA:	RBAU_3624(hemQ)
BAMN:	BASU_3400(hemQ)
BAMB:	BAPNAU_3682(ywfI)
BAMT:	AJ82_19675
BAMY:	V529_37580(ywfI)
BMP:	NG74_03661
BAO:	BAMF_3599(ywfI)
BAZ:	BAMTA208_19065(ywfI)
BQL:	LL3_03911(ywfI)
BXH:	BAXH7_03903(ywfI)
BQY:	MUS_4145(ywfI)
BAMI:	KSO_001630
BAMC:	U471_36310
BAMF:	U722_18625
BAE:	BATR1942_16800
BATR:	TD68_15755
BHA:	BH3825
BAN:	BA_5637
BAR:	GBAA_5637
BAT:	BAS5239
BAH:	BAMEG_5682
BAI:	BAA_5664
BAX:	H9401_5379
BANT:	A16_56490
BANR:	A16R_57170
BANS:	BAPAT_5404
BANH:	HYU01_27515
BANV:	DJ46_4284
BCE:	BC5388
BCA:	BCE_5517
BCZ:	BCE33L5086
BCR:	BCAH187_A5567
BCB:	BCB4264_A5511
BCU:	BCAH820_5483
BCG:	BCG9842_B5440
BCQ:	BCQ_5229
BCX:	BCA_5540
BAL:	BACI_c53830
BNC:	BCN_5316
BCF:	bcf_27060
BCER:	BCK_08415
BCY:	Bcer98_3909
BTK:	BT9727_5069
BTL:	BALH_4887
BTB:	BMB171_C4983
BTT:	HD73_5801
BTHR:	YBT1520_28740
BTHI:	BTK_28590
BTC:	CT43_CH5428
BTF:	YBT020_26870
BTM:	MC28_4621
BTG:	BTB_c55880
BTI:	BTG_21445
BTN:	BTF1_25425
BTHT:	H175_ch5519
BTHU:	YBT1518_30300
BTW:	BF38_1111
BTHY:	AQ980_02350
BWE:	BcerKBAB4_5181
BWW:	bwei_4395
BTY:	Btoyo_2584
BMYC:	DJ92_2476
BMYO:	BG05_621
BCL:	ABC3912
BPU:	BPUM_3416
BPUM:	BW16_18140
BPUS:	UP12_17585
BPF:	BpOF4_07220(ywfI)
BMQ:	BMQ_5203
BMD:	BMD_5189
BMH:	BMWSH_0076
BMEG:	BG04_2197
BCO:	Bcell_4134
BCK:	BCO26_2853
BAG:	Bcoa_1405
BCOA:	BF29_2111
BJS:	MY9_3858
BACI:	B1NLA3E_21765
BIF:	N288_24050
BLE:	BleG1_3772
BMET:	BMMGA3_16270
GST:	HW35_09400
BACW:	QR42_17140
BACP:	SB24_11265
BACB:	OY17_01095
BBY:	CY96_26065
BACO:	OXB_1378
BACY:	QF06_17275
BACL:	BS34A_40850(ywfI)
BALM:	BsLM_3797
BEO:	BEH_23695
BSM:	BSM4216_3736
BSJ:	UP17_24425
BON:	A361_26270
BGY:	BGLY_4402
BFX:	BC359_01695 BC359_07410
BGI:	BGM20_13095
BWH:	A9C19_00345
BXI:	BK049_09805
OIH:	OB3023
GKA:	GK3416
GTE:	GTCCBUS3UF5_38380
GTK:	GT3570_16780
GTN:	GTNG_3362
GWC:	GWCH70_3365
GYC:	GYMC61_3473
GYA:	GYMC52_3505
GCT:	GC56T3_3401
GMC:	GY4MC1_3758
GGH:	GHH_c35120(ywfI)
GJF:	M493_17870
GEA:	GARCT_03400
GEL:	IB49_09650
GSE:	GT50_08830
GSR:	GS3922_16185
GEJ:	A0V43_14760
GTH:	Geoth_3863
PTL:	AOT13_03485
AFL:	Aflv_2762
AGN:	AFK25_14125
ANM:	GFC28_2763
AAMY:	GFC30_304
ANL:	GFC29_2671
LSP:	Bsph_0946
LGY:	T479_02470
LFU:	HR49_21280
HHD:	HBHAL_4659
HMN:	HM131_03875
TAP:	GZ22_15085
VIR:	X953_17545
VHL:	BME96_17035
VIG:	BKP57_08490
LAO:	AOX59_15485
FPN:	ABE65_020435
FAR:	ABE41_019595
SJE:	AAV35_002085
BSE:	Bsel_3224
SAU:	SA0544
SAV:	SAV0587
SAW:	SAHV_0585
SAH:	SaurJH1_0625
SAJ:	SaurJH9_0610
SAM:	MW0542
SAS:	SAS0546
SAR:	SAR0593
SAC:	SACOL0633
SAX:	USA300HOU_0580
SAA:	SAUSA300_0569
SAO:	SAOUHSC_00573
SAE:	NWMN_0550
SAD:	SAAV_0549
SUU:	M013TW_0575
SUV:	SAVC_02520
SUE:	SAOV_0621c
SUJ:	SAA6159_00540
SUK:	SAA6008_00594
SUC:	ECTR2_540
SUT:	SAT0131_00649
SUQ:	HMPREF0772_12601
SUZ:	MS7_0576
SUD:	ST398NM01_0661
SUX:	SAEMRSA15_05150
SUW:	SATW20_06560
SUG:	SAPIG0661
SUF:	SARLGA251_05220
SAUA:	SAAG_01009
SAUE:	RSAU_000539
SAUN:	SAKOR_00577
SAUS:	SA40_0528
SAUU:	SA957_0543
SAUG:	SA268_0541
SAUZ:	SAZ172_0589
SAUT:	SAI1T1_2004510
SAUJ:	SAI2T2_1004530
SAUK:	SAI3T3_1004520
SAUQ:	SAI4T8_1004510
SAUV:	SAI7S6_1004520
SAUW:	SAI5S5_1004480
SAUX:	SAI6T6_1004490
SAUY:	SAI8T7_1004520
SAB:	SAB0537c
SUY:	SA2981_0564
SAUB:	C248_0662
SAUM:	BN843_5800
SAUC:	CA347_602
SAUR:	SABB_00636
SAUI:	AZ30_02965
SAUD:	CH52_02825
SAUF:	X998_0628
SAMS:	NI36_02925
SUH:	SAMSHR1132_05310
SEP:	SE0358
SER:	SERP0235
SEPP:	SEB_00280
SEPS:	DP17_1665
SHA:	SH2405
SHH:	ShL2_02200
SSP:	SSP2125
SCA:	SCA_0241
SLG:	SLGD_02298
SLN:	SLUG_22140
SSD:	SPSINT_0283
SDT:	SPSE_2174
SWA:	A284_10370
SPAS:	STP1_1673
SXY:	BE24_00725
SXL:	SXYLSMQ121_2109
SXO:	SXYL_02261
SHU:	SHYC_10700
SCAP:	AYP1020_2337
SSCH:	LH95_10290
SSCZ:	RN70_11025
SAGQ:	EP23_11460
SEQO:	SE1039_04160
SSIF:	AL483_08620
SCV:	A4G25_06475
MCL:	MCCL_1834
MCAK:	MCCS_23810
SHV:	AAT16_13205
SBAC:	BVH56_01105
LMO:	lmo2113
LMF:	LMOf2365_2146
LMH:	LMHCC_0433
LMC:	Lm4b_02135
LMN:	LM5578_2316
LMY:	LM5923_2267
LMT:	LMRG_01267
LMG:	LMKG_00204
LMS:	LMLG_0313
LMJ:	LMOG_01106
LMQ:	LMM7_2215
LML:	lmo4a_2174
LMP:	MUO_10840
LMW:	LMOSLCC2755_2177
LMX:	LMOSLCC2372_2181
LMZ:	LMOSLCC2482_2175
LMON:	LMOSLCC2376_2070
LMOC:	LMOSLCC5850_2178
LMOS:	LMOSLCC7179_2089
LMOO:	LMOSLCC2378_2141
LMOY:	LMOSLCC2479_2178
LMOT:	LMOSLCC2540_2210
LMOA:	LMOATCC19117_2135
LMOL:	LMOL312_2129
LMOG:	BN389_21440
LMOE:	BN418_2544
LMOB:	BN419_2550
LMOJ:	LM220_14566
LMOZ:	LM1816_07648
LMOD:	LMON_2187
LMOW:	AX10_04825
LMOX:	AX24_08430
LMOQ:	LM6179_2888(hemQ)
LMR:	LMR479A_2224(hemQ)
LMOK:	CQ02_10950
LMV:	Y193_04955
LMOM:	IJ09_14370
LIN:	lin2218
LWE:	lwe2132
LSG:	lse_2102
LIV:	LIV_2104
LII:	JL52_11045
LIW:	AX25_11225
LIA:	JL58_11220
LIO:	JL53_11720
ESI:	Exig_0217
EAT:	EAT1b_1445
EAN:	Eab7_0205
EXM:	U719_01100
EXU:	ESP131_03530
BBE:	BBR47_45550
BLR:	BRLA_c040460
PJD:	Pjdr2_4832
GYM:	GYMC10_5450
PPY:	PPE_03879
PPM:	PPSC2_20370(ywfI)
PPO:	PPM_4082(ywfI)
PPOL:	X809_36505
PPQ:	PPSQR21_041190(ywfI)
PPOY:	RE92_16820
PMS:	KNP414_03744
PMQ:	PM3016_1139
PMW:	B2K_05800
PTA:	HPL003_01340 HPL003_02245
PLV:	ERIC2_c29580
PSAB:	PSAB_19360
PDU:	PDUR_21990
PBD:	PBOR_30050
PGM:	PGRAT_26950
POD:	PODO_25700
PAEN:	P40081_31545
PAEF:	R50345_25635
PAEQ:	R50912_28380
PSTE:	PSTEL_22005
PAEA:	R70723_27190
PAEE:	R70331_26270
PAEH:	H70357_29035
PAEJ:	H70737_25440
PBJ:	VN24_16000
PIH:	UB51_01730
PRI:	PRIO_5637
PPEO:	ABE82_20420
PNP:	IJ22_30930
POW:	IJ21_13710
PBV:	AR543_20595
PXL:	BS614_28260
PYG:	AWM70_14315
PSWU:	SY83_00030
TCO:	Theco_2742
ANX:	ACH33_04545
AAC:	Aaci_1765
AAD:	TC41_1664
BTS:	Btus_1292
TUM:	CBW65_11530
SIV:	SSIL_3430
SSIL:	SOLI23_01285
PLN:	Plano_2453
PKU:	AUO94_03355
PRT:	AUC31_13850
PLL:	I858_010520
PANA:	BBH88_06660
PDG:	BCM40_02930
PHC:	BBI08_09510
PMAR:	B0X71_15305
PPLA:	BBI15_08460
JEO:	JMA_31060
KUR:	ASO14_2586
SPSY:	AZE41_19750
SPOR:	SporoP33_11210
SPOP:	SporoP37_11625
SURE:	SporoP32a_11905
RST:	ATY39_16575
NTR:	B0W44_13830
LCT:	BI355_0138
TMR:	Tmar_0490
SAY:	TPY_1863
SAP:	Sulac_2065
VPR:	Vpar_0219
VAT:	B7L28_08440
LPIL:	LIP_0706
BAST:	BAST_0811
TBC:	A0O31_01283
FMR:	Fuma_03866
PBOR:	BSF38_04551

» show all

Reference

PMID:20543190

Authors

Dailey TA, Boynton TO, Albetel AN, Gerdes S, Johnson MK, Dailey HA

Title

Discovery and Characterization of HemQ: an essential heme biosynthetic pathway component.

Journal

J Biol Chem 285:25978-86 (2010)
DOI:10.1074/jbc.M110.142604

Reference

PMID:25711532

Authors

Dailey HA, Gerdes S

Title

HemQ: An iron-coproporphyrin oxidative decarboxylase for protoheme synthesis in Firmicutes and Actinobacteria.

Journal

Arch Biochem Biophys 574:27-35 (2015)
DOI:10.1016/j.abb.2015.02.017

Reference

PMID:27936663

Authors

Celis AI, Gauss GH, Streit BR, Shisler K, Moraski GC, Rodgers KR, Lukat-Rodgers GS, Peters JW, DuBois JL

Title

Structure-Based Mechanism for Oxidative Decarboxylation Reactions Mediated by Amino Acids and Heme Propionates in Coproheme Decarboxylase (HemQ).

Journal

J Am Chem Soc (2017)
DOI:10.1021/jacs.6b11324

All links

Ontology (3)   
   KEGG BRITE (2)   
   COG (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (391)   
   KEGG GENES (370)   
   EGENES (15)   
   OC (6)   
Protein sequence (248)   
   UniProt (199)   
   SWISS-PROT (49)   
Literature (3)   
   PubMed (3)   
All databases (653)   

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REACTION: R11522

Entry

R11522 Reaction

Definition

Fe-coproporphyrin III + 2 Hydrogen peroxide <=> Heme + 2 CO2 + 4 H2O

Equation

C21284 + 2 C00027 <=> C00032 + 2 C00011 + 4 C00001

Comment

coproheme decarboxylase

Reaction class

RC00884

C00032_C21284

Enzyme

1.11.1.-

Pathway

rn00860	Porphyrin and chlorophyll metabolism
rn01100	Metabolic pathways
rn01110	Biosynthesis of secondary metabolites

Orthology

K00435

Fe-coproporphyrin III decarboxylase [EC:1.11.1.-]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (1)   
   KEGG RCLASS (1)   
Gene (371)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (370)   
All databases (384)   

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