KEGG   ORTHOLOGY: K00498Help
Entry
K00498                      KO                                     

Name
CYP11A
Definition
cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]
Pathway
Steroid hormone biosynthesis
Ovarian steroidogenesis
Aldosterone synthesis and secretion
Module
M00107  
Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone
Disease
H00216  
Congenital adrenal hyperplasia (CAH)
H00608  
46,XY disorders of sex development (Disorders in androgen synthesis or action)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
 Organismal Systems
  Endocrine system
   04913 Ovarian Steroidogenesis
    K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
   04925 Aldosterone synthesis and secretion
    K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Sterol biosynthesis
    M00107  Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone
     K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.6  cholesterol monooxygenase (side-chain-cleaving)
     K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP11 family
   K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
BRITE hierarchy
Other DBs
Genes
HSA: 
1583(CYP11A1)
PTR: 
748998(CYP11A1)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
708065(CYP11A1)
MCF: 
102120640(CYP11A)
CSAB: 
RRO: 
CJC: 
100389930(CYP11A1)
SBQ: 
MMU: 
13070(Cyp11a1)
RNO: 
29680(Cyp11a1)
CGE: 
NGI: 
HGL: 
OCU: 
100345737(CYP11A1)
TUP: 
CFA: 
478365(CYP11A1)
AML: 
UMR: 
FCA: 
PTG: 
BTA: 
338048(CYP11A1)
BOM: 
PHD: 
CHX: 
102173131(CYP11A1)
OAS: 
100048994(CYP11A1)
SSC: 
403329(CYP11A1)
CFR: 
BACU: 
LVE: 
ECB: 
100034229(CYP11A1)
MYB: 
MYD: 
PALE: 
LAV: 
MDO: 
SHR: 
OAA: 
GGA: 
414838(CYP11A1)
MGP: 
CJO: 
107318663(P-450scc)
APLA: 
TGU: 
100151695(CYP11A1)
GFR: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
102569028(CYP11A1)
PSS: 
CMY: 
PBI: 
GJA: 
XTR: 
100495360(cyp11a1)
DRE: 
563363(cyp11a2) 80374(cyp11a1)
TRU: 
TNG: 
MZE: 
OLA: 
100302421(cyp11a)
XMA: 
SASA: 
106561846(P450scc)
LCM: 
CMK: 
LGI: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3024157
  Authors
Chung BC, Matteson KJ, Voutilainen R, Mohandas TK, Miller WL
  Title
Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta.
  Journal
Proc Natl Acad Sci U S A 83:8962-6 (1986)
  Sequence
[hsa:1583]
Reference
  Authors
Seals RC, Urban RJ, Sekar N, Veldhuis JD
  Title
Up-regulation of basal transcriptional activity of the cytochrome P450 cholesterol side-chain cleavage (CYP11A) gene by isoform-specific calcium-calmodulin-dependent protein kinase in primary cultures of ovarian granulosa cells.
  Journal
Endocrinology 145:5616-22 (2004)
Reference
  Authors
Mast N, Annalora AJ, Lodowski DT, Palczewski K, Stout CD, Pikuleva IA
  Title
Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1.
  Journal
J Biol Chem 286:5607-13 (2011)
  Sequence
[bta:338048]

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