KEGG ORTHOLOGY: K00514

ORTHOLOGY: K00514

Entry

K00514 KO

Name

ZDS, crtQ

Definition

zeta-carotene desaturase [EC:1.3.5.6]

Pathway

ko00906

Carotenoid biosynthesis

Module

M00097

beta-Carotene biosynthesis, GGAP => beta-carotene

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Metabolism of terpenoids and polyketides
   00906 Carotenoid biosynthesis
    K00514  ZDS, crtQ; zeta-carotene desaturase
KEGG modules [BR:ko00002]
Pathway module
  Carbohydrate and lipid metabolism
   Other terpenoid biosynthesis
    M00097  beta-Carotene biosynthesis, GGAP => beta-carotene
     K00514  ZDS, crtQ; zeta-carotene desaturase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.5  With a quinone or related compound as acceptor
    1.3.5.6  9,9'-dicis-zeta-carotene desaturase
     K00514  ZDS, crtQ; zeta-carotene desaturase

Other DBs

RN:

R04798 R04800 R07511 R09656 R09658

COG:

COG3349

GO:

0016719

Genes

ATH:	AT3G04870(ZDS)
ALY:	ARALYDRAFT_477758
CRB:	CARUB_v10013363mg
EUS:	EUTSA_v10020402mg
BRP:	103849152
BNA:	106427407 106453079(ZDS)
THJ:	104821685
CIT:	102577969(CitZDS) 102613849 102613928 102614231 102615387 102618311 102628710 107174268
TCC:	18600240
GRA:	105782169 105804712
GHI:	107888796 107893220 107920020 107945977
EGR:	104415463 104430315
GMX:	100776502 100816122
PVU:	PHAVU_007G186000g
VRA:	106772487
VAR:	108345914
CCAJ:	109789910
MTR:	MTR_1g081290
CAM:	101493508
ADU:	107465815
AIP:	107617599
LJA:	Lj0g3v0055279.1(Lj0g3v0055279.1) Lj5g3v1415350.1(Lj5g3v1415350.1)
LANG:	109336428 109345421 109354942
FVE:	101296114
PPER:	18772557
PMUM:	103318575
MDM:	103434148(ZDS1-1) 103451012
PXB:	103954429
ZJU:	107412215 107412247
CSV:	101210522
CMO:	103501020(ZDS)
RCU:	8289444
JCU:	105647663
POP:	POPTR_0005s05230g POPTR_0013s03470g(POPTRDRAFT_806861)
VVI:	100245154(ZDS1)
SLY:	543629(zds)
SPEN:	107003189
SOT:	102598493
INI:	109182207
SIND:	105162430 105172259
BVG:	104890922
NNU:	104596524
OSA:	4342680(zds)
DOSA:	Os07t0204900-01(Os07g0204900)
OBR:	102721567
BDI:	100836583
ATS:	F775_05493
SBI:	8078415
ZMA:	542604(zds1)
SITA:	101786776
PDA:	103723760
EGU:	105054948
MUS:	103981813
ATR:	18448792
SMO:	SELMODRAFT_108745 SELMODRAFT_146971
PPP:	PHYPADRAFT_194107 PHYPADRAFT_232136 PHYPADRAFT_60733
CRE:	CHLREDRAFT_182457(ZDS1)
VCN:	VOLCADRAFT_95071
CSL:	COCSUDRAFT_35471
CVR:	CHLNCDRAFT_141585(ZDS)
APRO:	F751_3908
CME:	CYME_CMT061C
GSL:	Gasu_31940
AAF:	AURANDRAFT_6909 AURANDRAFT_71930
EHX:	EMIHUDRAFT_258445
SYN:	slr0940(crtQ)
SYZ:	MYO_118430(crtQ)
SYY:	SYNGTS_1826(crtQ)
SYT:	SYNGTI_1826(crtQ)
SYS:	SYNPCCN_1825(crtQ)
SYQ:	SYNPCCP_1825(crtQ)
SYJ:	D082_20520(crtQ-2)
SYW:	SYNW2213(crtQ)
SYC:	syc2497_c(zds)
SYF:	Synpcc7942_1512
SYD:	Syncc9605_2356
SYE:	Syncc9902_0335
SYG:	sync_2568
SYR:	SynRCC307_0275(crtQ)
SYX:	SynWH7803_2224(crtQ)
SYP:	SYNPCC7002_A0529(crtQ)
CYA:	CYA_0668(zds)
CYB:	CYB_1060(zds)
SYNE:	Syn6312_1408
SYNP:	Syn7502_03575
SYNK:	KR100_14605
SYNR:	KR49_07360
SYND:	KR52_04330
SYU:	M744_08565
SYH:	Syncc8109_2460(crtQ)
SYNW:	SynWH8103_02544(zds)
TEL:	tll0337(crtQ)
THN:	NK55_00380(crtQ)
CGC:	Cyagr_2942
CYI:	CBM981_3121(zds)
DSL:	Dacsa_1294
CMP:	Cha6605_0709
LEP:	Lepto7376_0182
LEN:	LEP3755_42080
LET:	O77CONTIG1_02617(pds_2)
LBO:	LBWT_35440
PSEU:	Pse7367_2939
PMA:	Pro_0136(crtQ)
PMM:	PMM0115(crtQ)
PMT:	PMT_1968
PMN:	PMN2A_1484
PMI:	PMT9312_0118
PMB:	A9601_01331(crtQ)
PMC:	P9515_01291(crtQ)
PMF:	P9303_26211(crtQ)
PMG:	P9301_01321(crtQ)
PMH:	P9215_01331(crtQ)
PMJ:	P9211_01311(crtQ)
PME:	NATL1_01891(crtQ)
PRC:	EW14_0141
PRM:	EW15_0204
AMR:	AM1_3692
MAR:	MAE_53100(crtQ)
MPK:	VL20_1522
CAN:	Cyan10605_2265
CSN:	Cyast_1610
HAO:	PCC7418_2975
GEN:	GM3709_2071
GEE:	GM3708_3458
CYT:	cce_2779(crtQ)
CYP:	PCC8801_3430
CYC:	PCC7424_0679
CYN:	Cyan7425_3176
CYH:	Cyan8802_2686
TER:	Tery_3954
MIC:	Mic7113_1472
ARP:	NIES39_B00980(crtQb)
GEI:	GEI7407_2276
OAC:	Oscil6304_0259
ONI:	Osc7112_1468
MPRO:	BJP34_05885
CEP:	Cri9333_4053
ANA:	all2382(crtQ)
NPU:	Npun_R0498
NOS:	Nos7107_5121
NOP:	Nos7524_4587
NON:	NOS3756_07760(crtQ)
AVA:	Ava_0200
ANB:	ANA_C11939
ACY:	Anacy_2337
AWA:	AA650_01540
NAZ:	Aazo_4788
CSG:	Cylst_6049
CALO:	Cal7507_4291
CALT:	Cal6303_5059
CALH:	IJ00_20820
RIV:	Riv7116_6892
FIS:	FIS3754_41450
NCN:	BZZ01_28110
CTHE:	Chro_1619
PLP:	Ple7327_2403
SCS:	Sta7437_0865
CEO:	ETSB_0758(crtQ)
ABA:	Acid345_1747
CTE:	CT1414
CPC:	Cpar_0751
CLZ:	BIU88_03670
CCH:	Cag_1590
CPH:	Cpha266_0830
CPB:	Cphamn1_0949
CLI:	Clim_0916
PVI:	Cvib_1233
PLT:	Plut_1415
PPH:	Ppha_1769
PAA:	Paes_1524
PROC:	Ptc2401_00675(pds_1)
PRS:	B9H02_04065
CTS:	Ctha_1697
AG:	CAA61985(ZDS)

» show all

Reference

PMID:9526505 (Synechocystis)

Authors

Breitenbach J, Fernandez-Gonzalez B, Vioque A, Sandmann G

Title

A higher-plant type zeta-carotene desaturase in the cyanobacterium Synechocystis PCC6803.

Journal

Plant Mol Biol 36:725-32 (1998)
DOI:10.1023/A:1005997405431

Reference

PMID:9914519

Authors

Bartley GE, Scolnik PA, Beyer P.

Title

Two Arabidopsis thaliana carotene desaturases, phytoene desaturase and zeta-carotene desaturase, expressed in Escherichia coli, catalyze a poly-cis pathway to yield pro-lycopene.

Journal

Eur J Biochem 259:396-403 (1999)
DOI:10.1046/j.1432-1327.1999.00051.x

Reference

PMID:10491195

Authors

Breitenbach J, Kuntz M, Takaichi S, Sandmann G

Title

Catalytic properties of an expressed and purified higher plant type zeta-carotene desaturase from Capsicum annuum.

Journal

Eur J Biochem 265:376-83 (1999)
DOI:10.1046/j.1432-1327.1999.00746.x

Sequence

[ag:CAA61985]

All links

Ontology (5)   
   KEGG BRITE (3)   
   GO (1)   
   COG (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical reaction (8)   
   KEGG ENZYME (1)   
   KEGG REACTION (5)   
   KEGG RCLASS (2)   
Gene (2941)   
   KEGG GENES (199)   
   KEGG MGENES (2017)   
   RefGene (547)   
   EGENES (166)   
   OC (12)   
Protein sequence (151)   
   UniProt (145)   
   SWISS-PROT (6)   
Literature (3)   
   PubMed (3)   
All databases (3115)   

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ENZYME: 1.3.5.6

Entry

EC 1.3.5.6 Enzyme

Name

9,9'-dicis-zeta-carotene desaturase;
zeta-carotene desaturase;
ZDS

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With a quinone or related compound as acceptor

Sysname

9,9'-dicis-zeta-corotene:quinone oxidoreductase

Reaction(IUBMB)

9,9'-dicis-zeta-carotene + 2 quinone = 7,9,7',9'-tetracis-lycopene + 2 quinol (overall reaction) [RN:R07511];
(1a) 9,9'-dicis-zeta-carotene + a quinone = 7,9,9'-tricis-neurosporene + a quinol [RN:R09656];
(1b) 7,9,9'-tricis-neurosporene + a quinone = 7,9,7',9'-tetracis-lycopene + a quinol [RN:R09658]

Reaction(KEGG)

R07511 R09656 R09658;
(other) R04798 R04800

Substrate

9,9'-dicis-zeta-carotene [CPD:C15857];
quinone [CPD:C15602];
7,9,9'-tricis-neurosporene [CPD:C19759]

Product

7,9,7',9'-tetracis-lycopene [CPD:C15858];
quinol [CPD:C15603];
7,9,9'-tricis-neurosporene [CPD:C19759]

Comment

This enzyme is involved in carotenoid biosynthesis in plants and cyanobacteria.

History

EC 1.3.5.6 created 1999 as EC 1.14.99.30, transferred 2011 to EC 1.3.5.6

Pathway

ec00906	Carotenoid biosynthesis
ec01100	Metabolic pathways
ec01110	Biosynthesis of secondary metabolites

Orthology

K00514

zeta-carotene desaturase

Genes

ATH:	AT3G04870(ZDS)
ALY:	ARALYDRAFT_477758
CRB:	CARUB_v10013363mg
EUS:	EUTSA_v10020402mg
BRP:	103849152
BNA:	106427407 106453079(ZDS)
THJ:	104821685
CIT:	102577969(CitZDS) 102613849 102613928 102614231 102615387 102618311 102628710 107174268
TCC:	18600240
GRA:	105782169 105804712
GHI:	107888796 107893220 107920020 107945977
EGR:	104415463 104430315
GMX:	100776502 100816122
PVU:	PHAVU_007G186000g
VRA:	106772487
VAR:	108345914
CCAJ:	109789910
MTR:	MTR_1g081290
CAM:	101493508
ADU:	107465815
AIP:	107617599
LJA:	Lj0g3v0055279.1(Lj0g3v0055279.1) Lj5g3v1415350.1(Lj5g3v1415350.1)
LANG:	109336428 109345421 109354942
FVE:	101296114
PPER:	18772557
PMUM:	103318575
MDM:	103434148(ZDS1-1) 103451012
PXB:	103954429
ZJU:	107412215 107412247
CSV:	101210522
CMO:	103501020(ZDS)
RCU:	8289444
JCU:	105647663
POP:	POPTR_0005s05230g POPTR_0013s03470g(POPTRDRAFT_806861)
VVI:	100245154(ZDS1)
SLY:	543629(zds)
SPEN:	107003189
SOT:	102598493
INI:	109182207
SIND:	105162430 105172259
BVG:	104890922
NNU:	104596524
OSA:	4342680(zds)
DOSA:	Os07t0204900-01(Os07g0204900)
OBR:	102721567
BDI:	100836583
ATS:	F775_05493
SBI:	8078415
ZMA:	542604(zds1)
SITA:	101786776
PDA:	103723760
EGU:	105054948
MUS:	103981813
ATR:	18448792
SMO:	SELMODRAFT_108745 SELMODRAFT_146971
PPP:	PHYPADRAFT_194107 PHYPADRAFT_232136 PHYPADRAFT_60733
CRE:	CHLREDRAFT_182457(ZDS1)
VCN:	VOLCADRAFT_95071
CSL:	COCSUDRAFT_35471
CVR:	CHLNCDRAFT_141585(ZDS)
APRO:	F751_3908
CME:	CYME_CMT061C
GSL:	Gasu_31940
AAF:	AURANDRAFT_6909 AURANDRAFT_71930
EHX:	EMIHUDRAFT_258445
SYN:	slr0940(crtQ)
SYZ:	MYO_118430(crtQ)
SYY:	SYNGTS_1826(crtQ)
SYT:	SYNGTI_1826(crtQ)
SYS:	SYNPCCN_1825(crtQ)
SYQ:	SYNPCCP_1825(crtQ)
SYJ:	D082_20520(crtQ-2)
SYW:	SYNW2213(crtQ)
SYC:	syc2497_c(zds)
SYF:	Synpcc7942_1512
SYD:	Syncc9605_2356
SYE:	Syncc9902_0335
SYG:	sync_2568
SYR:	SynRCC307_0275(crtQ)
SYX:	SynWH7803_2224(crtQ)
SYP:	SYNPCC7002_A0529(crtQ)
CYA:	CYA_0668(zds)
CYB:	CYB_1060(zds)
SYNE:	Syn6312_1408
SYNP:	Syn7502_03575
SYNK:	KR100_14605
SYNR:	KR49_07360
SYND:	KR52_04330
SYU:	M744_08565
SYH:	Syncc8109_2460(crtQ)
SYNW:	SynWH8103_02544(zds)
TEL:	tll0337(crtQ)
THN:	NK55_00380(crtQ)
CGC:	Cyagr_2942
CYI:	CBM981_3121(zds)
DSL:	Dacsa_1294
CMP:	Cha6605_0709
LEP:	Lepto7376_0182
LEN:	LEP3755_42080
LET:	O77CONTIG1_02617(pds_2)
LBO:	LBWT_35440
PSEU:	Pse7367_2939
PMA:	Pro_0136(crtQ)
PMM:	PMM0115(crtQ)
PMT:	PMT_1968
PMN:	PMN2A_1484
PMI:	PMT9312_0118
PMB:	A9601_01331(crtQ)
PMC:	P9515_01291(crtQ)
PMF:	P9303_26211(crtQ)
PMG:	P9301_01321(crtQ)
PMH:	P9215_01331(crtQ)
PMJ:	P9211_01311(crtQ)
PME:	NATL1_01891(crtQ)
PRC:	EW14_0141
PRM:	EW15_0204
AMR:	AM1_3692
MAR:	MAE_53100(crtQ)
MPK:	VL20_1522
CAN:	Cyan10605_2265
CSN:	Cyast_1610
HAO:	PCC7418_2975
GEN:	GM3709_2071
GEE:	GM3708_3458
CYT:	cce_2779(crtQ)
CYP:	PCC8801_3430
CYC:	PCC7424_0679
CYN:	Cyan7425_3176
CYH:	Cyan8802_2686
TER:	Tery_3954
MIC:	Mic7113_1472
ARP:	NIES39_B00980(crtQb)
GEI:	GEI7407_2276
OAC:	Oscil6304_0259
ONI:	Osc7112_1468
MPRO:	BJP34_05885
CEP:	Cri9333_4053
ANA:	all2382(crtQ)
NPU:	Npun_R0498
NOS:	Nos7107_5121
NOP:	Nos7524_4587
NON:	NOS3756_07760(crtQ)
AVA:	Ava_0200
ANB:	ANA_C11939
ACY:	Anacy_2337
AWA:	AA650_01540
NAZ:	Aazo_4788
CSG:	Cylst_6049
CALO:	Cal7507_4291
CALT:	Cal6303_5059
CALH:	IJ00_20820
RIV:	Riv7116_6892
FIS:	FIS3754_41450
NCN:	BZZ01_28110
CTHE:	Chro_1619
PLP:	Ple7327_2403
SCS:	Sta7437_0865
CEO:	ETSB_0758(crtQ)
ABA:	Acid345_1747
CTE:	CT1414
CPC:	Cpar_0751
CLZ:	BIU88_03670
CCH:	Cag_1590
CPH:	Cpha266_0830
CPB:	Cphamn1_0949
CLI:	Clim_0916
PVI:	Cvib_1233
PLT:	Plut_1415
PPH:	Ppha_1769
PAA:	Paes_1524
PROC:	Ptc2401_00675(pds_1)
PRS:	B9H02_04065
CTS:	Ctha_1697

» show all

Reference

1 [PMID:8617254]

Authors

Albrecht M, Linden H, Sandmann G.

Title

Biochemical characterization of purified zeta-carotene desaturase from Anabaena PCC 7120 after expression in Escherichia coli.

Journal

Eur. J. Biochem. 236 (1996) 115-20.

Reference

2 [PMID:10938359]

Authors

Josse EM, Simkin AJ, Gaffe J, Laboure AM, Kuntz M, Carol P

Title

A plastid terminal oxidase associated with carotenoid desaturation during chromoplast differentiation.

Journal

Plant. Physiol. 123 (2000) 1427-36.

Reference

3 [PMID:10491195]

Authors

Breitenbach J, Kuntz M, Takaichi S, Sandmann G

Title

Catalytic properties of an expressed and purified higher plant type zeta-carotene desaturase from Capsicum annuum.

Journal

Eur. J. Biochem. 265 (1999) 376-83.

Sequence

[ag:CAA61985]

Reference

4 [PMID:15503129]

Authors

Breitenbach J, Sandmann G

Title

zeta-Carotene cis isomers as products and substrates in the plant poly-cis carotenoid biosynthetic pathway to lycopene.

Journal

Planta. 220 (2005) 785-93.

Sequence

[ag:CAA61985]

Other DBs

ExplorEnz - The Enzyme Database:

1.3.5.6

IUBMB Enzyme Nomenclature:

1.3.5.6

ExPASy - ENZYME nomenclature database:

1.3.5.6

BRENDA, the Enzyme Database:

1.3.5.6

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Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (12)   
   KEGG COMPOUND (12)   
Chemical reaction (7)   
   KEGG REACTION (5)   
   KEGG RCLASS (2)   
Gene (2930)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (199)   
   KEGG MGENES (2017)   
   RefGene (547)   
   EGENES (166)   
Protein sequence (688)   
   UniProt (634)   
   SWISS-PROT (10)   
   RefSeq(pep) (44)   
DNA sequence (300)   
   RefSeq(nuc) (52)   
   GenBank (181)   
   EMBL (67)   
Protein domain (1)   
   InterPro (1)   
All databases (3945)   

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REACTION: R09656

Entry

R09656 Reaction

Name

9,9'-dicis-zeta-carotene:quinone oxidoreductase

Definition

9,9'-dicis-zeta-Carotene + Quinone <=> 7,9,9'-tricis-Neurosporene + Hydroquinone

Equation

C15857 + C15602 <=> C19759 + C15603

Comment

9,9'-dicis-zeta-carotene desaturase
the first step of two-step reaction (see R07511, R09656+R09658)
subsequently R09658

Reaction class

RC01214

C15857_C19759

Enzyme

1.3.5.6

Pathway

rn00906	Carotenoid biosynthesis
rn01100	Metabolic pathways
rn01110	Biosynthesis of secondary metabolites

Module

M00097

beta-Carotene biosynthesis, GGAP => beta-carotene

Orthology

K00514

zeta-carotene desaturase [EC:1.3.5.6]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG RCLASS (1)   
Gene (200)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (199)   
All databases (214)   

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