KEGG   ORTHOLOGY: K00665Help
Entry
K00665                      KO                                     

Name
FASN
Definition
fatty acid synthase, animal type [EC:2.3.1.85]
Pathway
Fatty acid biosynthesis
Fatty acid metabolism
AMPK signaling pathway
Insulin signaling pathway
Module
M00082  
Fatty acid biosynthesis, initiation
M00083  
Fatty acid biosynthesis, elongation
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01212 Fatty acid metabolism
    K00665  FASN; fatty acid synthase, animal type
  Lipid metabolism
   00061 Fatty acid biosynthesis
    K00665  FASN; fatty acid synthase, animal type
 Environmental Information Processing
  Signal transduction
   04152 AMPK signaling pathway
    K00665  FASN; fatty acid synthase, animal type
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K00665  FASN; fatty acid synthase, animal type
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Fatty acid metabolism
    M00082  Fatty acid biosynthesis, initiation
     K00665  FASN; fatty acid synthase, animal type
    M00083  Fatty acid biosynthesis, elongation
     K00665  FASN; fatty acid synthase, animal type
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.85  fatty-acid synthase
     K00665  FASN; fatty acid synthase, animal type
Lipid biosynthesis proteins [BR:ko01004]
 Fatty acid synthase
  Animal type
   K00665  FASN; fatty acid synthase, animal type
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K00665  FASN; fatty acid synthase, animal type
  Exosomal proteins of breast milk
   K00665  FASN; fatty acid synthase, animal type
  Exosomal proteins of colorectal cancer cells
   K00665  FASN; fatty acid synthase, animal type
  Exosomal proteins of bladder cancer cells
   K00665  FASN; fatty acid synthase, animal type
BRITE hierarchy
Other DBs
Genes
HSA: 
2194(FASN)
PTR: 
454986(FASN)
PPS: 
100985873(FASN)
GGO: 
101151060(FASN)
PON: 
100456558(FASN)
NLE: 
MCC: 
715708(FASN)
MCF: 
102119674(FASN)
CSAB: 
103243754(FASN)
RRO: 
104654984(FASN)
CJC: 
100402953(FASN)
SBQ: 
101045175(FASN)
MMU: 
14104(Fasn)
RNO: 
50671(Fasn)
CGE: 
100689207(Fasn)
NGI: 
103730050(Fasn)
HGL: 
101698314(Fasn)
CCAN: 
109702407(Fasn)
TUP: 
102481635(FASN)
CFA: 
483378(FASN)
AML: 
100468470(FASN)
UMR: 
103666012(FASN)
FCA: 
100270775(FASN)
PTG: 
102956933(FASN)
AJU: 
106986313(FASN)
BTA: 
281152(FASN)
BOM: 
102278267(FASN)
BIU: 
109573330(FASN)
PHD: 
102336161(FASN)
CHX: 
100861286(FASN)
OAS: 
100170327(FASN)
SSC: 
397561(FASN)
CFR: 
102509439(FASN)
BACU: 
103017465
LVE: 
103077747(FASN)
ECB: 
100057311(FASN)
MYB: 
102251003(FASN)
MYD: 
102761714(FASN)
HAI: 
109393056(FASN)
RSS: 
109449422(FASN)
PALE: 
102887167(FASN)
LAV: 
100674176(FASN)
MDO: 
100025176(FASN)
SHR: 
100924144(FASN)
OAA: 
100091954
GGA: 
396061(FASN)
MGP: 
100542651(FASN)
CJO: 
107322058(FASN)
APLA: 
101796973(FASN)
ACYG: 
106046771(FASN)
TGU: 
100226957(FASN)
GFR: 
102043163(FASN)
FAB: 
101820764(FASN)
PHI: 
102102393(FASN)
CCW: 
104698180(FASN)
FPG: 
101924649(FASN)
FCH: 
102046127(FASN)
CLV: 
102086015(FASN)
AAM: 
106487141(FASN)
ASN: 
102384493(FASN)
AMJ: 
102571811(FASN)
PSS: 
102458578(FASN)
CMY: 
102933656(FASN)
CPIC: 
101942965(FASN)
ACS: 
100563002(fasn)
PBI: 
103062560(FASN)
GJA: 
107118129(FASN)
XLA: 
108701000
XTR: 
100487052(fasn)
NPR: 
108791330(FASN)
DRE: 
559001(fasn)
SRX: 
107722180 107755500(fasn)
SANH: 
107682911 107684061(fasn) 107702482
SGH: 
107565779 107565793 107579490 107581585(fasn)
IPU: 
108273998(fasn)
TRU: 
101069108(fasn) 105418859
TNG: 
GSTEN00010858G001 GSTEN00034953G001
LCO: 
104927028(fasn)
NCC: 
104963493(fasn) 104963494 104963495
MZE: 
101485706
OLA: 
101171365(fasn)
XMA: 
102232393
CSEM: 
103381833(fasn)
LCF: 
108879490 108882087
SASA: 
106589612 106610271
ELS: 
105021150(fasn)
SFM: 
108939982(fasn)
LCM: 
102352909(FASN)
CMK: 
103175468(fasn)
CIN: 
100181277
SPU: 
105440011
SKO: 
100369299 100369443 100370573 100374692 100376755 102807132
DME: 
Dmel_CG17374(FASN3) Dmel_CG3523(FASN1) Dmel_CG3524(FASN2)
DPO: 
Dpse_GA17497 Dpse_GA17498 Dpse_GA26263
DAN: 
Dana_GF14400 Dana_GF14401 Dana_GF27091
DER: 
Dere_GG24919 Dere_GG24920
DPE: 
Dper_GL12292 Dper_GL18554
DSE: 
Dsec_GM18393
DSI: 
Dsimw501_GD17693(Dsim_GD17693) Dsimw501_GD23206(Dsim_GD23206) Dsimw501_GD23207(Dsim_GD23207)
DWI: 
Dwil_GK12914 Dwil_GK18431
DYA: 
Dyak_GE18209 Dyak_GE18210 Dyak_GE28239
DGR: 
Dgri_GH10962 Dgri_GH10963 Dgri_GH20680
DMO: 
Dmoj_GI10509 Dmoj_GI10520 Dmoj_GI23207
DVI: 
Dvir_GJ21725 Dvir_GJ21736 Dvir_GJ22868
MDE: 
101888614 101893120
AGA: 
AgaP_AGAP001899 AgaP_AGAP008468 AgaP_AGAP009176
AAG: 
AaeL_AAEL001194 AaeL_AAEL002204 AaeL_AAEL002227 AaeL_AAEL002228 AaeL_AAEL002237 AaeL_AAEL008160
CQU: 
CpipJ_CPIJ003494 CpipJ_CPIJ003495 CpipJ_CPIJ005595 CpipJ_CPIJ008367
AME: 
411959(GB16883) 412815
BIM: 
100742442 100742781
BTER: 
100644763 100652317
SOC: 
105192918 105194712 105196297 105196390 105196493 105197914 105198161 105198162 105198169 105198903 105199667 105199688 105200156 105201607 105201744 105202131 105202179 105202181 105202182 105202184 105202319 105202483 105202557 105202560 105202953 105202955 105202956 105203128 105203232 105203305 105203328 105203981 105204773 105205009 105205072 105205155 105205242 105205264 105206493 105206618 105206869 105206887 105206954 105207003 105207141 105208152 105208165
AEC: 
105145358 105145368 105145528 105151862 105153176 105153178 105153179 105153180 105153181
ACEP: 
105617602 105621803 105621938 105621939 105621941 105621942 105621943 105621944 105626385 105626590
PBAR: 
105422552 105423443 105423444 105426819 105426820 105426871 105427550 105427700 105430349 105430536 105430537
HST: 
105180672 105182081 105182083 105182544 105182988 105184571 105185168 105185682 105185685 105185686 105185960 105186768 105187141 105188623 105188624 105191040 109503983
CFO: 
105248514 105249037 105250609 105250610 105251211 105254245 105254251 105254262 105256048 105256223 105256457 105256463 105256536 105257505 105258487 105258520 105259522 105259556 105259561 109610341
LHU: 
105667548 105667560 105667688 105667834 105668496 105668646 105668856 105669150 105669820 105670248 105670251 105670847 105672402 105673445 105673457 105674779 105675105 105676017 105676185 105676405 105676832 105676834 105677037 105678596 105679005 105679169 105679281 105679506 105679677 105679887 105679904 105679910 105680084 105680116 105680141
NVI: 
100121447 100122083 100122099
TCA: 
103314884 658024 658944 658978 659179 660113 660178 662899
DPA: 
109533543 109533737 109541738 109542929 109542979 109542980 109543417 109544836
NVL: 
108557772 108557776 108557782 108557787 108558974 108560588 108561518 108561519 108565026 108567254 108568351
BMOR: 
101742625 101745748 105842784 693037 693038
PXY: 
105384625 105386886 105386888 105386889 105386890 105386891 105393722 105393935
API: 
100158855 100158857 100159146 100160920 100162692 100163154 100164777 100166426 100166618 100167255 100570193 103308252 103311453 107882750 107882754 107882755
DNX: 
107162347 107162355 107162370 107162813 107164658 107166448 107166454 107167281 107171142 107172899 107172901 107172913
PHU: 
Phum_PHUM080440 Phum_PHUM448390 Phum_PHUM565830
ISC: 
IscW_ISCW001566 IscW_ISCW009053 IscW_ISCW014149
TUT: 
107359791 107360391 107361055 107361744 107361815 107366193 107368728 107369476 107370796 107371424
CEL: 
CELE_F32H2.5(fasn-1)
CBR: 
CBG12408(Cbr-fasn-1)
NAI: 
NECAME_11215
BMY: 
Bm1_35180
LOA: 
LOAG_17873 LOAG_17874
TSP: 
Tsp_06638
HRO: 
HELRODRAFT_99033
LGI: 
LOTGIDRAFT_101255 LOTGIDRAFT_235996
CRG: 
105318687 105334039 105338805
OBI: 
106872926 106874238
ADF: 
107350794
TAD: 
TRIADDRAFT_31339 TRIADDRAFT_34034 TRIADDRAFT_34041
CSL: 
COCSUDRAFT_42572 COCSUDRAFT_44339 COCSUDRAFT_47508 COCSUDRAFT_49000 COCSUDRAFT_58178 COCSUDRAFT_58179 COCSUDRAFT_58181
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2717611
  Authors
Amy CM, Witkowski A, Naggert J, Williams B, Randhawa Z, Smith S
  Title
Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase.
  Journal
Proc Natl Acad Sci U S A 86:3114-8 (1989)
DOI:10.1073/pnas.86.9.3114
  Sequence
[rno:50671]
KEGG   ENZYME: 2.3.1.85Help
Entry
EC 2.3.1.85                 Enzyme                                 

Name
fatty-acid synthase;
FASN (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
Reaction(IUBMB)
acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+ [RN:R05188]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
malonyl-CoA [CPD:C00083];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
long-chain fatty acid [CPD:C00638];
CoA [CPD:C00010];
CO2 [CPD:C00011];
NADP+ [CPD:C00006]
Comment
The animal enzyme is a multi-functional protein catalysing the reactions of EC 2.3.1.38 [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39 [acyl-carrier-protein] S-malonyltransferase, EC 2.3.1.41 3-oxoacyl-[acyl-carrier-protein] synthase, EC 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase, EC 4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) and EC 3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase. cf. EC 2.3.1.86, fatty-acyl-CoA synthase.
History
EC 2.3.1.85 created 1984
Pathway
Fatty acid biosynthesis
Metabolic pathways
Orthology
K00665  
fatty acid synthase, animal type
Genes
HSA: 
2194(FASN)
PTR: 
454986(FASN)
PPS: 
100985873(FASN)
GGO: 
101151060(FASN)
PON: 
100456558(FASN)
NLE: 
MCC: 
715708(FASN)
MCF: 
102119674(FASN)
CSAB: 
103243754(FASN)
RRO: 
104654984(FASN)
CJC: 
100402953(FASN)
SBQ: 
101045175(FASN)
MMU: 
14104(Fasn)
RNO: 
50671(Fasn)
CGE: 
100689207(Fasn)
NGI: 
103730050(Fasn)
HGL: 
101698314(Fasn)
CCAN: 
109702407(Fasn)
TUP: 
102481635(FASN)
CFA: 
483378(FASN)
AML: 
100468470(FASN)
UMR: 
103666012(FASN)
FCA: 
100270775(FASN)
PTG: 
102956933(FASN)
AJU: 
106986313(FASN)
BTA: 
281152(FASN)
BOM: 
102278267(FASN)
BIU: 
109573330(FASN)
PHD: 
102336161(FASN)
CHX: 
100861286(FASN)
OAS: 
100170327(FASN)
SSC: 
397561(FASN)
CFR: 
102509439(FASN)
BACU: 
103017465
LVE: 
103077747(FASN)
ECB: 
100057311(FASN)
MYB: 
102251003(FASN)
MYD: 
102761714(FASN)
HAI: 
109393056(FASN)
RSS: 
109449422(FASN)
PALE: 
102887167(FASN)
LAV: 
100674176(FASN)
MDO: 
100025176(FASN)
SHR: 
100924144(FASN)
OAA: 
100091954
GGA: 
396061(FASN)
MGP: 
100542651(FASN)
CJO: 
107322058(FASN)
APLA: 
101796973(FASN)
ACYG: 
106046771(FASN)
TGU: 
100226957(FASN)
GFR: 
102043163(FASN)
FAB: 
101820764(FASN)
PHI: 
102102393(FASN)
CCW: 
104698180(FASN)
FPG: 
101924649(FASN)
FCH: 
102046127(FASN)
CLV: 
102086015(FASN)
AAM: 
106487141(FASN)
ASN: 
102384493(FASN)
AMJ: 
102571811(FASN)
PSS: 
102458578(FASN)
CMY: 
102933656(FASN)
CPIC: 
101942965(FASN)
ACS: 
100563002(fasn)
PBI: 
103062560(FASN)
GJA: 
107118129(FASN)
XLA: 
108701000
XTR: 
100487052(fasn)
NPR: 
108791330(FASN)
DRE: 
559001(fasn)
SRX: 
107722180 107755500(fasn)
SANH: 
107682911 107684061(fasn) 107702482
SGH: 
107565779 107565793 107579490 107581585(fasn)
IPU: 
108273998(fasn)
TRU: 
101069108(fasn) 105418859
TNG: 
GSTEN00010858G001 GSTEN00034953G001
LCO: 
104927028(fasn)
NCC: 
104963493(fasn) 104963494 104963495
MZE: 
101485706
OLA: 
101171365(fasn)
XMA: 
102232393
CSEM: 
103381833(fasn)
LCF: 
108879490 108882087
SASA: 
106589612 106610271
ELS: 
105021150(fasn)
SFM: 
108939982(fasn)
LCM: 
102352909(FASN)
CMK: 
103175468(fasn)
CIN: 
100181277
SPU: 
105440011
SKO: 
100369299 100369443 100370573 100374692 100376755 102807132
DME: 
Dmel_CG17374(FASN3) Dmel_CG3523(FASN1) Dmel_CG3524(FASN2)
DPO: 
Dpse_GA17497 Dpse_GA17498 Dpse_GA26263
DAN: 
Dana_GF14400 Dana_GF14401 Dana_GF27091
DER: 
Dere_GG24919 Dere_GG24920
DPE: 
Dper_GL12292 Dper_GL18554
DSE: 
Dsec_GM18393
DSI: 
Dsimw501_GD17693(Dsim_GD17693) Dsimw501_GD23206(Dsim_GD23206) Dsimw501_GD23207(Dsim_GD23207)
DWI: 
Dwil_GK12914 Dwil_GK18431
DYA: 
Dyak_GE18209 Dyak_GE18210 Dyak_GE28239
DGR: 
Dgri_GH10962 Dgri_GH10963 Dgri_GH20680
DMO: 
Dmoj_GI10509 Dmoj_GI10520 Dmoj_GI23207
DVI: 
Dvir_GJ21725 Dvir_GJ21736 Dvir_GJ22868
MDE: 
101888614 101893120
AGA: 
AgaP_AGAP001899 AgaP_AGAP008468 AgaP_AGAP009176
AAG: 
AaeL_AAEL001194 AaeL_AAEL002204 AaeL_AAEL002227 AaeL_AAEL002228 AaeL_AAEL002237 AaeL_AAEL008160
CQU: 
CpipJ_CPIJ003494 CpipJ_CPIJ003495 CpipJ_CPIJ005595 CpipJ_CPIJ008367
AME: 
411959(GB16883) 412815
BIM: 
100742442 100742781
BTER: 
100644763 100652317
SOC: 
105192918 105194712 105196297 105196390 105196493 105197914 105198161 105198162 105198169 105198903 105199667 105199688 105200156 105201607 105201744 105202131 105202179 105202181 105202182 105202184 105202319 105202483 105202557 105202560 105202953 105202955 105202956 105203128 105203232 105203305 105203328 105203981 105204773 105205009 105205072 105205155 105205242 105205264 105206493 105206618 105206869 105206887 105206954 105207003 105207141 105208152 105208165
AEC: 
105145358 105145368 105145528 105151862 105153176 105153178 105153179 105153180 105153181
ACEP: 
105617602 105621803 105621938 105621939 105621941 105621942 105621943 105621944 105626385 105626590
PBAR: 
105422552 105423443 105423444 105426819 105426820 105426871 105427550 105427700 105430349 105430536 105430537
HST: 
105180672 105182081 105182083 105182544 105182988 105184571 105185168 105185682 105185685 105185686 105185960 105186768 105187141 105188623 105188624 105191040 109503983
CFO: 
105248514 105249037 105250609 105250610 105251211 105254245 105254251 105254262 105256048 105256223 105256457 105256463 105256536 105257505 105258487 105258520 105259522 105259556 105259561 109610341
LHU: 
105667548 105667560 105667688 105667834 105668496 105668646 105668856 105669150 105669820 105670248 105670251 105670847 105672402 105673445 105673457 105674779 105675105 105676017 105676185 105676405 105676832 105676834 105677037 105678596 105679005 105679169 105679281 105679506 105679677 105679887 105679904 105679910 105680084 105680116 105680141
NVI: 
100121447 100122083 100122099
TCA: 
103314884 658024 658944 658978 659179 660113 660178 662899
DPA: 
109533543 109533737 109541738 109542929 109542979 109542980 109543417 109544836
NVL: 
108557772 108557776 108557782 108557787 108558974 108560588 108561518 108561519 108565026 108567254 108568351
BMOR: 
101742625 101745748 105842784 693037 693038
PXY: 
105384625 105386886 105386888 105386889 105386890 105386891 105393722 105393935
API: 
100158855 100158857 100159146 100160920 100162692 100163154 100164777 100166426 100166618 100167255 100570193 103308252 103311453 107882750 107882754 107882755
DNX: 
107162347 107162355 107162370 107162813 107164658 107166448 107166454 107167281 107171142 107172899 107172901 107172913
PHU: 
Phum_PHUM080440 Phum_PHUM448390 Phum_PHUM565830
ISC: 
IscW_ISCW001566 IscW_ISCW009053 IscW_ISCW014149
TUT: 
107359791 107360391 107361055 107361744 107361815 107366193 107368728 107369476 107370796 107371424
CEL: 
CELE_F32H2.5(fasn-1)
CBR: 
CBG12408(Cbr-fasn-1)
NAI: 
NECAME_11215
BMY: 
Bm1_35180
LOA: 
LOAG_17873 LOAG_17874
TSP: 
Tsp_06638
HRO: 
HELRODRAFT_99033
LGI: 
LOTGIDRAFT_101255 LOTGIDRAFT_235996
CRG: 
105318687 105334039 105338805
OBI: 
106872926 106874238
ADF: 
107350794
TAD: 
TRIADDRAFT_31339 TRIADDRAFT_34034 TRIADDRAFT_34041
CSL: 
COCSUDRAFT_42572 COCSUDRAFT_44339 COCSUDRAFT_47508 COCSUDRAFT_49000 COCSUDRAFT_58178 COCSUDRAFT_58179 COCSUDRAFT_58181
 » show all
Taxonomy
Reference
1  [PMID:457689]
  Authors
Stoops JK, Ross P, Arslanian MJ, Aune KC, Wakil SJ, Oliver RM.
  Title
Physicochemical studies of the rat liver and adipose fatty acid synthetases.
  Journal
J. Biol. Chem. 254 (1979) 7418-26.
Reference
2  [PMID:6137188]
  Authors
Wakil SJ, Stoops JK, Joshi VC.
  Title
Fatty acid synthesis and its regulation.
  Journal
Annu. Rev. Biochem. 52 (1983) 537-79.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9045-77-6
KEGG   REACTION: R04959Help
Entry
R04959                      Reaction                               

Name
octanoyl-[acp]:NADP+ trans-2-oxidoreductase
Definition
Octanoyl-[acp] + NADP+ <=> trans-Oct-2-enoyl-[acp] + NADPH + H+
Equation
Reaction class
C00005_C00006
C05751_C05752
Enzyme
1.3.1.10        1.3.1.39        1.3.1.104       2.3.1.85        
2.3.1.86
Pathway
Fatty acid biosynthesis
Metabolic pathways
Fatty acid metabolism
Orthology
K00208  
enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10]
K00665  
fatty acid synthase, animal type [EC:2.3.1.85]
K00668  
fatty acid synthase subunit beta, fungi type [EC:2.3.1.86]
K10780  
enoyl-[acyl-carrier protein] reductase III [EC:1.3.1.104]
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