KEGG   ORTHOLOGY: K00667Help
Entry
K00667                      KO                                     

Name
FAS2
Definition
fatty acid synthase subunit alpha, fungi type [EC:2.3.1.86]
Pathway
Fatty acid biosynthesis
Fatty acid metabolism
Module
M00082  
Fatty acid biosynthesis, initiation
M00083  
Fatty acid biosynthesis, elongation
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01212 Fatty acid metabolism
    K00667  FAS2; fatty acid synthase subunit alpha, fungi type
  Lipid metabolism
   00061 Fatty acid biosynthesis
    K00667  FAS2; fatty acid synthase subunit alpha, fungi type
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Fatty acid metabolism
    M00082  Fatty acid biosynthesis, initiation
     K00667  FAS2; fatty acid synthase subunit alpha, fungi type
    M00083  Fatty acid biosynthesis, elongation
     K00667  FAS2; fatty acid synthase subunit alpha, fungi type
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.86  fatty-acyl-CoA synthase
     K00667  FAS2; fatty acid synthase subunit alpha, fungi type
Lipid biosynthesis proteins [BR:ko01004]
 Fatty acid synthase
  Yeast type
   K00667  FAS2; fatty acid synthase subunit alpha, fungi type
BRITE hierarchy
Other DBs
Genes
PXB: 
SCE: 
YPL231W(FAS2)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0G01260(NCAS0G01260)
NDI: 
NDAI_0F01390(NDAI0F01390)
TPF: 
TPHA_0H01860(TPHA0H01860)
TBL: 
TBLA_0C02010(TBLA0C02010)
TDL: 
TDEL_0A06700(TDEL0A06700) TDEL_0C04130(TDEL0C04130)
KAF: 
KAFR_0F01200(KAFR0F01200)
PPA: 
PAS_chr1-4_0295
DHA: 
DEHA2B10032g
PIC: 
PICST_80966(FAS2)
PGU: 
PGUG_02105
SPAA: 
SPAPADRAFT_140888(FAS2)
LEL: 
LELG_02891 LELG_02892
CAL: 
CAALFM_C304830CA(FAS2)
CTP: 
CTRG_02501
COT: 
CORT_0C01740
CDU: 
CD36_84800
CTEN: 
CANTEDRAFT_110568
YLI: 
YALI0B19382g
CLU: 
CLUG_04160
CAUR: 
QG37_06024
NCR: 
NCU07308(cel-1)
NTE: 
NEUTE1DRAFT61252(NEUTE1DRAFT_61252)
SMP: 
SMAC_00841
PAN: 
PODANSg3686 PODANSg8560
TTT: 
THITE_2122453
MTM: 
MYCTH_2310232
CTHR: 
CTHT_0037740
MGR: 
MGG_12154
TMN: 
UCRPA7_6808
FGR: 
FGSG_00036 FGSG_05321
FPU: 
FPSE_07169 FPSE_07819
FVR: 
FVEG_04241
FOX: 
FOXG_06391
NHE: 
NECHADRAFT_72277
TRE: 
TRIREDRAFT_48788
MAW: 
MAC_02884 MAC_06764 MAC_07602
MAJ: 
MAA_01139 MAA_01642 MAA_10451
CMT: 
CCM_02998
VAL: 
VDBG_01020
VDA: 
VDAG_00632
CFJ: 
CFIO01_03119
ELA: 
UCREL1_2866 UCREL1_3665
PFY: 
PFICI_02560 PFICI_04684 PFICI_09706
SSL: 
SS1G_13074
BFU: 
BC1G_14055
MBE: 
MBM_00558
PSCO: 
LY89DRAFT_624910 LY89DRAFT_650084
GLZ: 
GLAREA_01153 GLAREA_08471
ANI: 
AN3380.2 AN7815.2 AN7880.2 AN9407.2
AFM: 
AFUA_3G04210
AOR: 
AOR_1_156104(AO090124000083) AOR_1_184024(AO090010000107) AOR_1_26014(AO090026000012) AOR_1_300024(AO090010000171) AOR_1_74054(AO090011000046)
ANG: 
ANI_1_1156084(An09g02010) ANI_1_1466104(An12g01980) ANI_1_202174(An10g00630) ANI_1_2494074(An08g10930) ANI_1_6014(An01g00060)
AFV: 
AFLA_038640 AFLA_089170 AFLA_116820 AFLA_117420 AFLA_139380
ACT: 
ACLA_060590 ACLA_093750
NFI: 
NFIA_006480
PCS: 
Pc14g00750 Pc21g10840
PDP: 
PDIP_67940 PDIP_87700
CIM: 
CIMG_08477 CIMG_08564
CPW: 
CPC735_061450 CPC735_062220
PBL: 
PAAG_01525
PBN: 
PADG_00254
URE: 
UREG_02553 UREG_04459
ABE: 
ARB_02757 ARB_06048
TVE: 
TRV_06193 TRV_06923
AJE: 
HCAG_07636
PNO: 
SNOG_01107 SNOG_02166 SNOG_09089
PTE: 
PTT_02059 PTT_10814 PTT_18039
BZE: 
COCCADRAFT_102373 COCCADRAFT_31318
BSC: 
COCSADRAFT_97659
BOR: 
COCMIDRAFT_82264
ZTR: 
MYCGRDRAFT_108403(FAS1)
PFJ: 
MYCFIDRAFT_212667
BCOM: 
BAUCODRAFT_144102 BAUCODRAFT_77435
NPA: 
UCRNP2_2699 UCRNP2_3239 UCRNP2_4858 UCRNP2_7999
TML: 
GSTUM_00002095001
SPO: 
SPAC4A8.11c(fas2)
CNE: 
CNE04360
CNB: 
CNBE4360
CGI: 
CGB_E5650C
TMS: 
TREMEDRAFT_45355
LBC: 
LACBIDRAFT_296983(FAS-2)
MPR: 
MPER_12305
CCI: 
CC1G_07064
SCM: 
SCHCODRAFT_82184
PGR: 
PGTG_21688
MLR: 
MELLADRAFT_45383
ACAN: 
ACA1_069690
PIF: 
PITG_10922 PITG_10926 PITG_18025
PSOJ: 
PHYSODRAFT_359145
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2900835
  Authors
Mohamed AH, Chirala SS, Mody NH, Huang WY, Wakil SJ
  Title
Primary structure of the multifunctional alpha subunit protein of yeast fatty acid synthase derived from FAS2 gene sequence.
  Journal
J Biol Chem 263:12315-25 (1988)
  Sequence
[sce:YPL231W]
KEGG   ENZYME: 2.3.1.86Help
Entry
EC 2.3.1.86                 Enzyme                                 

Name
fatty-acyl-CoA synthase;
yeast fatty acid synthase;
FAS1 (gene name);
FAS2 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)
Reaction(IUBMB)
acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H+ = long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP+ [RN:R05190]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
malonyl-CoA [CPD:C00083];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
long-chain-acyl-CoA;
CoA [CPD:C00010];
CO2 [CPD:C00011];
NADP+ [CPD:C00006]
Comment
The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi-functional protein complex composed of two subunits. One subunit catalyses the reactions EC 1.1.1.100, 3-oxoacyl-[acyl-carrier-protein] reductase and EC 2.3.1.41, 3-oxoacyl-[acyl-carrier-protein] synthase, while the other subunit catalyses the reactions of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39, [acyl-carrier-protein] S-malonyltransferase, EC 4.2.1.59, 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.1.1.279, (R)-3-hydroxyacid ester dehydrogenase. The enzyme differs from the animal enzyme (EC 2.3.1.85) in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid.
History
EC 2.3.1.86 created 1984, modified 2003, modified 2013
Pathway
Fatty acid biosynthesis
Metabolic pathways
Orthology
K00667  
fatty acid synthase subunit alpha, fungi type
K00668  
fatty acid synthase subunit beta, fungi type
Genes
PXB: 
SCE: 
YKL182W(FAS1) YPL231W(FAS2)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0G01260(NCAS0G01260) NCAS_0J01680(NCAS0J01680)
NDI: 
NDAI_0F01390(NDAI0F01390) NDAI_0J02670(NDAI0J02670)
TPF: 
TPHA_0B02040(TPHA0B02040) TPHA_0H01860(TPHA0H01860)
TBL: 
TBLA_0C02010(TBLA0C02010) TBLA_0I03120(TBLA0I03120)
TDL: 
TDEL_0A06700(TDEL0A06700) TDEL_0C04130(TDEL0C04130) TDEL_0E00900(TDEL0E00900)
KAF: 
KAFR_0A05730(KAFR0A05730) KAFR_0F01200(KAFR0F01200)
PPA: 
PAS_chr1-1_0008 PAS_chr1-4_0295
DHA: 
DEHA2B08140g DEHA2B10032g
PIC: 
PICST_80966(FAS2) PICST_85125(FAS1)
PGU: 
PGUG_02105 PGUG_02173
SPAA: 
SPAPADRAFT_138494 SPAPADRAFT_140888(FAS2)
LEL: 
LELG_02891 LELG_02892 LELG_03854
CAL: 
CAALFM_C304830CA(FAS2) CAALFM_C500190CA(FAS1)
CTP: 
CTRG_02501 CTRG_05241
COT: 
CORT_0C01740 CORT_0E04830
CDU: 
CD36_50220(FAS1) CD36_84800
CTEN: 
CANTEDRAFT_107026 CANTEDRAFT_110568
YLI: 
YALI0B15059g YALI0B19382g
CLU: 
CLUG_03422 CLUG_04160
CAUR: 
QG37_06024 QG37_06992
NCR: 
NCU07307(cel-2) NCU07308(cel-1)
NTE: 
NEUTE1DRAFT61252(NEUTE1DRAFT_61252) NEUTE1DRAFT61255(NEUTE1DRAFT_61255)
SMP: 
SMAC_00840 SMAC_00841
PAN: 
PODANSg3685 PODANSg3686 PODANSg8559 PODANSg8560
TTT: 
THITE_2122453 THITE_2122457
MTM: 
MYCTH_2310228 MYCTH_2310232
CTHR: 
CTHT_0037740 CTHT_0037750
MGR: 
MGG_04118 MGG_12154
TMN: 
UCRPA7_6807 UCRPA7_6808
FGR: 
FGSG_00036 FGSG_05321 FGSG_05322 FGSG_11656
FPU: 
FPSE_07168 FPSE_07169 FPSE_07818 FPSE_07819
FVR: 
FVEG_04241 FVEG_04242
FOX: 
FOXG_06391 FOXG_06392 FOXG_14342 FOXG_15138
NHE: 
NECHADRAFT_64009 NECHADRAFT_72277
TRE: 
TRIREDRAFT_48788 TRIREDRAFT_78591
MAW: 
MAC_02878 MAC_02884 MAC_06764 MAC_06765 MAC_07602
MAJ: 
MAA_01138 MAA_01139 MAA_01642 MAA_10451
CMT: 
CCM_02997 CCM_02998
VAL: 
VDBG_01018 VDBG_01020 VDBG_08384
VDA: 
VDAG_00631 VDAG_00632
CFJ: 
CFIO01_03118 CFIO01_03119
ELA: 
UCREL1_11324 UCREL1_2864 UCREL1_2866 UCREL1_3665 UCREL1_3666
PFY: 
PFICI_02555 PFICI_02560 PFICI_04683 PFICI_04684 PFICI_09703 PFICI_09706
SSL: 
SS1G_13073 SS1G_13074
BFU: 
BC1G_14051 BC1G_14055
MBE: 
MBM_00558 MBM_00559
PSCO: 
LY89DRAFT_624908 LY89DRAFT_624910 LY89DRAFT_650084 LY89DRAFT_784300
GLZ: 
GLAREA_01152 GLAREA_01153 GLAREA_08470 GLAREA_08471
ANI: 
AN3380.2 AN3381.2 AN7814.2 AN7815.2 AN7873.2 AN7880.2 AN9407.2 AN9408.2
AFM: 
AFUA_3G04210 AFUA_3G04220
AOR: 
AOR_1_156104(AO090124000083) AOR_1_158104(AO090124000084) AOR_1_184024(AO090010000107) AOR_1_186024(AO090010000108) AOR_1_26014(AO090026000012) AOR_1_276024(AO090010000156) AOR_1_28014(AO090026000013) AOR_1_300024(AO090010000171) AOR_1_62054(AO090011000040) AOR_1_74054(AO090011000046)
ANG: 
ANI_1_1114084(An09g01740) ANI_1_1156084(An09g02010) ANI_1_1466104(An12g01980) ANI_1_1468104(An12g01990) ANI_1_202174(An10g00630) ANI_1_204174(An10g00650) ANI_1_2056014(An01g00050) ANI_1_2488074(An08g10860) ANI_1_2494074(An08g10930) ANI_1_6014(An01g00060)
AFV: 
AFLA_038570 AFLA_038640 AFLA_089160 AFLA_089170 AFLA_116820 AFLA_116830 AFLA_117290 AFLA_117420 AFLA_139370 AFLA_139380
ACT: 
ACLA_060580 ACLA_060590 ACLA_093750 ACLA_093760
NFI: 
NFIA_006480 NFIA_006490
PCS: 
Pc14g00740 Pc14g00750 Pc21g10840 Pc21g10870
PDP: 
PDIP_67930 PDIP_67940 PDIP_87680 PDIP_87700
CIM: 
CIMG_08477 CIMG_08479 CIMG_08564 CIMG_08565
CPW: 
CPC735_061450 CPC735_061460 CPC735_062220 CPC735_062230
PBL: 
PAAG_01524 PAAG_01525
PBN: 
PADG_00254 PADG_00255
URE: 
UREG_02553 UREG_02554 UREG_04458 UREG_04459
ABE: 
ARB_02752 ARB_02757 ARB_06046 ARB_06048
TVE: 
TRV_06188 TRV_06193 TRV_06922 TRV_06923
AJE: 
HCAG_07636 HCAG_07637
PNO: 
SNOG_01107 SNOG_01108 SNOG_02166 SNOG_02167 SNOG_09089 SNOG_09091
PTE: 
PTT_02058 PTT_02059 PTT_10814 PTT_10815 PTT_18039
BZE: 
COCCADRAFT_102373 COCCADRAFT_113337 COCCADRAFT_113803 COCCADRAFT_31318 COCCADRAFT_7010
BSC: 
COCSADRAFT_235908 COCSADRAFT_97659
BOR: 
COCMIDRAFT_1000 COCMIDRAFT_82264
ZTR: 
MYCGRDRAFT_108403(FAS1) MYCGRDRAFT_69244
PFJ: 
MYCFIDRAFT_212667 MYCFIDRAFT_53243
BCOM: 
BAUCODRAFT_144102 BAUCODRAFT_151421 BAUCODRAFT_62139 BAUCODRAFT_77435
NPA: 
UCRNP2_2698 UCRNP2_2699 UCRNP2_3235 UCRNP2_3239 UCRNP2_4858 UCRNP2_7996 UCRNP2_7999
TML: 
GSTUM_00002095001
SPO: 
SPAC4A8.11c(fas2) SPAC926.09c(fas1)
CNE: 
CNE04360 CNE04370
CNB: 
CNBE4360 CNBE4370
CGI: 
CGB_E5650C CGB_E5660W
TMS: 
TREMEDRAFT_40511 TREMEDRAFT_45355
TVS: 
TRAVEDRAFT_41081 TRAVEDRAFT_51938
SHS: 
STEHIDRAFT_116267
PSQ: 
PUNSTDRAFT_137436
LBC: 
LACBIDRAFT_296983(FAS-2)
MPR: 
MPER_07767 MPER_12305
CCI: 
CC1G_07064
SCM: 
SCHCODRAFT_235165 SCHCODRAFT_82184
ABP: 
AGABI1DRAFT134019(AGABI1DRAFT_134019)
ABV: 
AGABI2DRAFT146869(AGABI2DRAFT_146869)
PGR: 
PGTG_06184 PGTG_21688
MLR: 
MELLADRAFT_115404 MELLADRAFT_39635 MELLADRAFT_45383 MELLADRAFT_79679
ACAN: 
ACA1_069690
PIF: 
PITG_10922 PITG_10926 PITG_18025
PSOJ: 
PHYSODRAFT_339257 PHYSODRAFT_340175 PHYSODRAFT_340187 PHYSODRAFT_341458 PHYSODRAFT_359145
 » show all
Taxonomy
Reference
1  [PMID:4590449]
  Authors
Schweizer E, Kniep B, Castorph H, Holzner U.
  Title
Pantetheine-free mutants of the yeast fatty-acid-synthetase complex.
  Journal
Eur. J. Biochem. 39 (1973) 353-62.
Reference
2  [PMID:6137188]
  Authors
Wakil SJ, Stoops JK, Joshi VC.
  Title
Fatty acid synthesis and its regulation.
  Journal
Annu. Rev. Biochem. 52 (1983) 537-79.
Reference
3  [PMID:16950653]
  Authors
Tehlivets O, Scheuringer K, Kohlwein SD
  Title
Fatty acid synthesis and elongation in yeast.
  Journal
Biochim. Biophys. Acta. 1771 (2007) 255-70.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
94219-29-1
KEGG   REACTION: R04963Help
Entry
R04963                      Reaction                               

Name
Decanoyl-[acyl-carrier protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating)
Definition
Decanoyl-[acp] + Malonyl-[acyl-carrier protein] <=> 3-Oxododecanoyl-[acp] + CO2 + Acyl-carrier protein
Equation
Reaction class
C00229_C05755
C05755_C05756
C01209_C05756
Enzyme
2.3.1.41        2.3.1.85        2.3.1.86        2.3.1.179       
2.3.1.-
Pathway
Fatty acid biosynthesis
Metabolic pathways
Fatty acid metabolism
Orthology
K00647  
3-oxoacyl-[acyl-carrier-protein] synthase I [EC:2.3.1.41]
K00665  
fatty acid synthase, animal type [EC:2.3.1.85]
K00667  
fatty acid synthase subunit alpha, fungi type [EC:2.3.1.86]
K09458  
3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
K11533  
fatty acid synthase, bacteria type [EC:2.3.1.-]
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