KEGG   ORTHOLOGY: K00918Help
Entry
K00918                      KO                                     

Name
pfkC
Definition
ADP-dependent phosphofructokinase/glucokinase [EC:2.7.1.146 2.7.1.147]
Pathway
Glycolysis / Gluconeogenesis
Pentose phosphate pathway
Methane metabolism
Carbon metabolism
Module
M00001  
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01200 Carbon metabolism
    K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
  Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
   00030 Pentose phosphate pathway
    K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
  Energy metabolism
   00680 Methane metabolism
    K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Central carbohydrate metabolism
    M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
     K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.146  ADP-specific phosphofructokinase
     K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
    2.7.1.147  ADP-specific glucokinase
     K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
BRITE hierarchy
Other DBs
Genes
SAME: 
RLT: 
TCO: 
CSH: 
LPIL: 
MIM: 
MIH: 
MICR: 
ARE: 
ARW: 
SKE: 
Sked_02970
NOA: 
BKM31_48400
TPY: 
CQ11_09190
TPYO: 
X956_09010
ABAO: 
BEQ56_10310
SSM: 
Spirs_3399
MJA: 
MJ_1604
MFE: 
Mefer_1517
MVU: 
Metvu_0786
MFS: 
MFS40622_0160
MIF: 
Metin_0227
MJH: 
JH146_0031
MIG: 
Metig_1734
MMP: 
MMP1296(pfkC)
MMQ: 
MmarC5_0297
MMX: 
MmarC6_1378
MMZ: 
MmarC7_0541
MMD: 
GYY_07315
MMAK: 
MMKA1_15210(pfkC)
MMAO: 
MMOS7_14030(pfkC)
MAE: 
Maeo_0005
MVN: 
Mevan_0606
MVO: 
Mvol_0050 Mvol_0110
MOK: 
Metok_1190
MAC: 
MA_3562(glkA) MA_3563(pfk)
MBA: 
Mbar_A2004 Mbar_A2005
MBY: 
MSBRM_2497 MSBRM_2498
MBW: 
MSBRW_2730 MSBRW_2731
MBAR: 
MSBR2_2474 MSBR2_2475
MBAK: 
MSBR3_2515 MSBR3_2516
MMA: 
MM_0472 MM_0473
MMJ: 
MSMAS_0831 MSMAS_0832
MMAC: 
MSMAC_0811 MSMAC_0812
MVC: 
MSVAZ_2547 MSVAZ_2548
MEK: 
MSKOL_2555 MSKOL_2556
MLS: 
MSLAZ_2352 MSLAZ_2353
METM: 
MSMTP_2385 MSMTP_2386
MEF: 
MSWH1_2360 MSWH1_2361
MEQ: 
MSWHS_2732 MSWHS_2733
MSJ: 
MSSAC_3156 MSSAC_3157
MSZ: 
MSSIH_0989 MSSIH_0990
MSW: 
MSSIT_1026 MSSIT_1027
MTHE: 
MSTHC_2246 MSTHC_2247
MTHR: 
MSTHT_1057 MSTHT_1058
MHOR: 
MSHOH_0977 MSHOH_0978
MBU: 
Mbur_1338 Mbur_1339
MMET: 
MCMEM_1827 MCMEM_1828
MMH: 
Mmah_1645 Mmah_1646
MHAZ: 
BHR79_05490 BHR79_05495
MEV: 
Metev_0816 Metev_0817
MZH: 
Mzhil_0819 Mzhil_0820
MPY: 
Mpsy_1159 Mpsy_1160
MHZ: 
Metho_2034 Metho_2035
MTP: 
Mthe_1214
MCJ: 
MCON_0234(pfkC)
MBN: 
Mboo_1525
NMG: 
Nmag_3826
NGE: 
Natgr_2898
HRU: 
Halru_0715 Halru_2961
HLC: 
CHINAEXTREME19235
PHO: 
PH0589(PH0589) PH1645(PH1645)
PAB: 
PAB0967 PAB2013
PFU: 
PF0312 PF1784
PFI: 
PFC_00640 PFC_09670
PYN: 
PNA2_0229 PNA2_1204
PYA: 
PYCH_02450 PYCH_10910
PYS: 
Py04_0618 Py04_1537
PYC: 
TQ32_02010 TQ32_08590
TKO: 
TK0376 TK1110
TON: 
TON_0246 TON_1012
TGA: 
TGAM_0818(glkA) TGAM_1465(pfkC)
TSI: 
TSIB_0252 TSIB_1220
TBA: 
TERMP_00004 TERMP_01160
THE: 
GQS_04080 GQS_10400
THA: 
TAM4_1728 TAM4_738
THM: 
CL1_0470 CL1_1657
TLT: 
OCC_01044 OCC_09701
THS: 
TES1_0130 TES1_1218
TNU: 
BD01_0151 BD01_1045
TEU: 
TEU_06460 TEU_11110
TGY: 
X802_00245 X802_07910
THV: 
ADU37_CDS01920 ADU37_CDS09450
TCH: 
CHITON_1323 CHITON_1878
TPEP: 
A0127_02440 A0127_09685
PPAC: 
PAP_01430 PAP_04875
NAC: 
AQV86_01495
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Verhees CH, Kengen SW, Tuininga JE, Schut GJ, Adams MW, De Vos WM, Van Der Oost J
  Title
The unique features of glycolytic pathways in Archaea.
  Journal
Biochem J 375:231-46 (2003)
DOI:10.1042/BJ20021472
Reference
  Authors
Sakuraba H, Yoshioka I, Koga S, Takahashi M, Kitahama Y, Satomura T, Kawakami R, Ohshima T
  Title
ADP-dependent glucokinase/phosphofructokinase, a novel bifunctional enzyme from the hyperthermophilic archaeon Methanococcus jannaschii.
  Journal
J Biol Chem 277:12495-8 (2002)
DOI:10.1074/jbc.C200059200
KEGG   ENZYME: 2.7.1.146Help
Entry
EC 2.7.1.146                Enzyme                                 

Name
ADP-specific phosphofructokinase;
ADP-6-phosphofructokinase, ADP-dependent phosphofructokinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ADP:D-fructose-6-phosphate 1-phosphotransferase
Reaction(IUBMB)
ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate [RN:R05805]
Reaction(KEGG)
Substrate
ADP [CPD:C00008];
D-fructose 6-phosphate [CPD:C00085]
Product
AMP [CPD:C00020];
D-fructose 1,6-bisphosphate [CPD:C00354]
Comment
ADP can be replaced by GDP, ATP and GTP, to a limited extent. Divalent cations are necessary for activity, with Mg2+ followed by Co2+ being the most effective.
History
EC 2.7.1.146 created 2001
Pathway
Glycolysis / Gluconeogenesis
Pentose phosphate pathway
Methane metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Biosynthesis of antibiotics
Orthology
K00918  
ADP-dependent phosphofructokinase/glucokinase
Genes
SAME: 
RLT: 
TCO: 
CSH: 
LPIL: 
MIM: 
MIH: 
MICR: 
ARE: 
ARW: 
SKE: 
Sked_02970
NOA: 
BKM31_48400
TPY: 
CQ11_09190
TPYO: 
X956_09010
ABAO: 
BEQ56_10310
SSM: 
Spirs_3399
MJA: 
MJ_1604
MFE: 
Mefer_1517
MVU: 
Metvu_0786
MFS: 
MFS40622_0160
MIF: 
Metin_0227
MJH: 
JH146_0031
MIG: 
Metig_1734
MMP: 
MMP1296(pfkC)
MMQ: 
MmarC5_0297
MMX: 
MmarC6_1378
MMZ: 
MmarC7_0541
MMD: 
GYY_07315
MMAK: 
MMKA1_15210(pfkC)
MMAO: 
MMOS7_14030(pfkC)
MAE: 
Maeo_0005
MVN: 
Mevan_0606
MVO: 
Mvol_0050 Mvol_0110
MOK: 
Metok_1190
MAC: 
MA_3562(glkA) MA_3563(pfk)
MBA: 
Mbar_A2004 Mbar_A2005
MBY: 
MSBRM_2497 MSBRM_2498
MBW: 
MSBRW_2730 MSBRW_2731
MBAR: 
MSBR2_2474 MSBR2_2475
MBAK: 
MSBR3_2515 MSBR3_2516
MMA: 
MM_0472 MM_0473
MMJ: 
MSMAS_0831 MSMAS_0832
MMAC: 
MSMAC_0811 MSMAC_0812
MVC: 
MSVAZ_2547 MSVAZ_2548
MEK: 
MSKOL_2555 MSKOL_2556
MLS: 
MSLAZ_2352 MSLAZ_2353
METM: 
MSMTP_2385 MSMTP_2386
MEF: 
MSWH1_2360 MSWH1_2361
MEQ: 
MSWHS_2732 MSWHS_2733
MSJ: 
MSSAC_3156 MSSAC_3157
MSZ: 
MSSIH_0989 MSSIH_0990
MSW: 
MSSIT_1026 MSSIT_1027
MTHE: 
MSTHC_2246 MSTHC_2247
MTHR: 
MSTHT_1057 MSTHT_1058
MHOR: 
MSHOH_0977 MSHOH_0978
MBU: 
Mbur_1338 Mbur_1339
MMET: 
MCMEM_1827 MCMEM_1828
MMH: 
Mmah_1645 Mmah_1646
MHAZ: 
BHR79_05490 BHR79_05495
MEV: 
Metev_0816 Metev_0817
MZH: 
Mzhil_0819 Mzhil_0820
MPY: 
Mpsy_1159 Mpsy_1160
MHZ: 
Metho_2034 Metho_2035
MTP: 
Mthe_1214
MCJ: 
MCON_0234(pfkC)
MBN: 
Mboo_1525
NMG: 
Nmag_3826
NGE: 
Natgr_2898
HRU: 
Halru_0715 Halru_2961
HLC: 
CHINAEXTREME19235
PHO: 
PH0589(PH0589) PH1645(PH1645)
PAB: 
PAB0967 PAB2013
PFU: 
PF0312 PF1784
PFI: 
PFC_00640 PFC_09670
PYN: 
PNA2_0229 PNA2_1204
PYA: 
PYCH_02450 PYCH_10910
PYS: 
Py04_0618 Py04_1537
PYC: 
TQ32_02010 TQ32_08590
TKO: 
TK0376 TK1110
TON: 
TON_0246 TON_1012
TGA: 
TGAM_0818(glkA) TGAM_1465(pfkC)
TSI: 
TSIB_0252 TSIB_1220
TBA: 
TERMP_00004 TERMP_01160
THE: 
GQS_04080 GQS_10400
THA: 
TAM4_1728 TAM4_738
THM: 
CL1_0470 CL1_1657
TLT: 
OCC_01044 OCC_09701
THS: 
TES1_0130 TES1_1218
TNU: 
BD01_0151 BD01_1045
TEU: 
TEU_06460 TEU_11110
TGY: 
X802_00245 X802_07910
THV: 
ADU37_CDS01920 ADU37_CDS09450
TCH: 
CHITON_1323 CHITON_1878
TPEP: 
A0127_02440 A0127_09685
PPAC: 
PAP_01430 PAP_04875
NAC: 
AQV86_01495
 » show all
Taxonomy
Reference
1  [PMID:10409652]
  Authors
Tuininga JE, Verhees CH, van der Oost J, Kengen SW, Stams AJ, de Vos WM.
  Title
Molecular and biochemical characterization of the ADP-dependent phosphofructokinase from the hyperthermophilic archaeon Pyrococcus furiosus.
  Journal
J. Biol. Chem. 274 (1999) 21023-8.
  Sequence
[pfu:PF1784]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
237739-62-7
KEGG   REACTION: R09084Help
Entry
R09084                      Reaction                               

Name
ADP:D-fructose-6-phosphate 1-phosphotransferase
Definition
beta-D-Fructose 6-phosphate + ADP <=> beta-D-Fructose 1,6-bisphosphate + AMP
Equation
Reaction class
C00008_C00020
C05345_C05378
Enzyme
Pathway
Glycolysis / Gluconeogenesis
Pentose phosphate pathway
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Biosynthesis of antibiotics
Carbon metabolism
Module
M00001  
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
Orthology
K00918  
ADP-dependent phosphofructokinase/glucokinase [EC:2.7.1.146 2.7.1.147]
DBGET integrated database retrieval system