KEGG   ORTHOLOGY: K00922Help
Entry
K00922                      KO                                     

Name
PIK3CA_B_D
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Pathway
Inositol phosphate metabolism
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Platinum drug resistance
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Longevity regulating pathway
Longevity regulating pathway - worm
Longevity regulating pathway - multiple species
Cellular senescence
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
AGE-RAGE signaling pathway in diabetic complications
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
Human papillomavirus infection
HTLV-I infection
Kaposi's sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Fluid shear stress and atherosclerosis
Module
M00676  
PI3K-Akt signaling
Disease
H00027  
Ovarian cancer
H01387  
Activated PI3K-delta syndrome (APDS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04015 Rap1 signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04012 ErbB signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04370 VEGF signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04630 Jak-STAT signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04668 TNF signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04066 HIF-1 signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04068 FoxO signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04070 Phosphatidylinositol signaling system
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04072 Phospholipase D signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04071 Sphingolipid signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04024 cAMP signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04151 PI3K-Akt signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04152 AMPK signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04150 mTOR signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  Cell growth and death
   04210 Apoptosis
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04218 Cellular senescence
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  Cellular community - eukaryotes
   04510 Focal adhesion
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04550 Signaling pathways regulating pluripotency of stem cells
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  Cell motility
   04810 Regulation of actin cytoskeleton
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
 Organismal Systems
  Immune system
   04611 Platelet activation
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04620 Toll-like receptor signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04650 Natural killer cell mediated cytotoxicity
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04660 T cell receptor signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04662 B cell receptor signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04664 Fc epsilon RI signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04666 Fc gamma R-mediated phagocytosis
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04670 Leukocyte transendothelial migration
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04062 Chemokine signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  Endocrine system
   04910 Insulin signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04923 Regulation of lipolysis in adipocyte
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04915 Estrogen signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04914 Progesterone-mediated oocyte maturation
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04917 Prolactin signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04919 Thyroid hormone signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  Digestive system
   04973 Carbohydrate digestion and absorption
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  Nervous system
   04725 Cholinergic synapse
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04722 Neurotrophin signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  Development
   04360 Axon guidance
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04380 Osteoclast differentiation
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  Aging
   04211 Longevity regulating pathway - mammal
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04212 Longevity regulating pathway - worm
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04213 Longevity regulating pathway - multiple species
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05230 Central carbon metabolism in cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05231 Choline metabolism in cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05205 Proteoglycans in cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05203 Viral carcinogenesis
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05210 Colorectal cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05212 Pancreatic cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05214 Glioma
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05221 Acute myeloid leukemia
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05220 Chronic myeloid leukemia
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05218 Melanoma
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05211 Renal cell carcinoma
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05215 Prostate cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05213 Endometrial cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05224 Breast cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05222 Small cell lung cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05223 Non-small cell lung cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04931 Insulin resistance
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04933 AGE-RAGE signaling pathway in diabetic complications
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05166 HTLV-I infection
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05162 Measles
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05164 Influenza A
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05161 Hepatitis B
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05160 Hepatitis C
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05169 Epstein-Barr virus infection
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05165 Human papillomavirus infection
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05146 Amoebiasis
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05142 Chagas disease (American trypanosomiasis)
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   01524 Platinum drug resistance
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   01522 Endocrine resistance
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00676  PI3K-Akt signaling
     K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
HSA: 
5290(PIK3CA) 5291(PIK3CB) 5293(PIK3CD)
PTR: 
457922(PIK3CD) 460858(PIK3CA) 471079(PIK3CB)
PPS: 
100989732(PIK3CD) 100990108(PIK3CB) 100990828(PIK3CA)
GGO: 
101143811(PIK3CA) 101146434(PIK3CD) 101152123(PIK3CB)
PON: 
100432846(PIK3CB) 100453779(PIK3CA) 103889133(PIK3CD)
NLE: 
100580872(PIK3CD) 100584384(PIK3CB) 100588218(PIK3CA)
MCC: 
709959(PIK3CA) 710552(PIK3CD) 716098(PIK3CB)
MCF: 
102122725(PIK3CA) 102142026(PIK3CB) 102143464(PIK3CD)
CSAB: 
103221212(PIK3CA) 103225637(PIK3CD) 103241599(PIK3CB)
RRO: 
104663050(PIK3CD) 104665061(PIK3CB) 104670605(PIK3CA)
CJC: 
100391655(PIK3CB) 100398849(PIK3CD) 100403494(PIK3CA)
SBQ: 
101027982(PIK3CB) 101029768(PIK3CA) 101052779(PIK3CD)
MMU: 
18706(Pik3ca) 18707(Pik3cd) 74769(Pik3cb)
RNO: 
170911(Pik3ca) 366508(Pik3cd) 85243(Pik3cb)
CGE: 
100689251(Pik3ca) 100689252(Pik3cb) 100769225(Pik3cd)
NGI: 
103733121(Pik3cd) 103738596(Pik3ca) 103742946(Pik3cb)
HGL: 
101711934(Pik3ca) 101712941(Pik3cd) 101715249(Pik3cb)
CCAN: 
109681900(Pik3cd) 109689664(Pik3ca)
OCU: 
100337822(PIK3CA) 100345181(PIK3CB) 100348663(PIK3CD)
TUP: 
102483329(PIK3CA) 102500530(PIK3CD) 102502163(PIK3CB) 106736453
CFA: 
477085(PIK3CB) 488084(PIK3CA) 489644(PIK3CD)
AML: 
100463775(PIK3CB) 100479294(PIK3CA) 100479580(PIK3CD)
UMR: 
103666874(PIK3CD) 103676125(PIK3CA) 103678592(PIK3CB)
FCA: 
101091892(PIK3CB) 101094274(PIK3CD) 101097413(PIK3CA)
PTG: 
102953082(PIK3CD) 102965070(PIK3CA) 102972487(PIK3CB)
AJU: 
106973880(PIK3CA) 106984265(PIK3CB) 106984896(PIK3CD)
BTA: 
282306(PIK3CA) 504531(PIK3CD) 517948(PIK3CB)
BOM: 
102274461(PIK3CD) 102274553(PIK3CA) 102277548(PIK3CB)
BIU: 
109557823(PIK3CA) 109559805(PIK3CB) 109570415(PIK3CD)
PHD: 
102320516(PIK3CB) 102321231(PIK3CA) 102333324(PIK3CD)
CHX: 
102168391(PIK3CA) 102177551(PIK3CD) 102185042(PIK3CB)
OAS: 
101109759(PIK3CB) 101110015(PIK3CA) 101117348(PIK3CD)
SSC: 
100518131(PIK3CD) 100621789(PIK3CA)
CFR: 
102518643(PIK3CD) 102519994(PIK3CB) 102523502(PIK3CA)
BACU: 
103012691(PIK3CA) 103012931(PIK3CB) 103014043(PIK3CD)
LVE: 
103085303(PIK3CA) 103088756(PIK3CB) 103089257(PIK3CD)
ECB: 
100051623(PIK3CD) 100051753(PIK3CB) 100058141(PIK3CA)
MYB: 
102239669(PIK3CA) 102252921(PIK3CD) 102260487(PIK3CB)
MYD: 
102758951(PIK3CA) 102764343(PIK3CB) 102766356(PIK3CD)
HAI: 
109372681(PIK3CA) 109381238(PIK3CD) 109394108(PIK3CB)
RSS: 
109455259(PIK3CD) 109455777(PIK3CB) 109458390(PIK3CA)
PALE: 
102880320(PIK3CB) 102889227(PIK3CA) 102889576(PIK3CD)
LAV: 
100657948(PIK3CA) 100658340(PIK3CB) 100666266(PIK3CD)
MDO: 
100010412(PIK3CA) 100017332(PIK3CB) 100024769(PIK3CD)
SHR: 
100929811(PIK3CB) 100932099(PIK3CA)
OAA: 
100073788(PIK3CA) 100074273(PIK3CD) 100086270(PIK3CB)
GGA: 
419444(PIK3CD) 424826(PIK3CB) 424971(PIK3CA)
MGP: 
100543492(PIK3CD) 100546867(PIK3CA)
CJO: 
107317945(PIK3CB) 107318114(PIK3CA) 107323497(PIK3CD)
APLA: 
101796183(PIK3CA) 101800900(PIK3CB) 101802796(PIK3CD)
ACYG: 
106032026(PIK3CA) 106040311(PIK3CB) 106044285(PIK3CD)
TGU: 
100219602(PIK3CB) 100224188(PIK3CD) 100229768(PIK3CA)
GFR: 
102040845(PIK3CB) 102040853(PIK3CD) 102042284(PIK3CA)
FAB: 
101811931(PIK3CD) 101814811(PIK3CA) 101821801(PIK3CB)
PHI: 
102099156(PIK3CA) 102103635(PIK3CD) 102106643(PIK3CB)
CCW: 
104688020(PIK3CA) 104693039(PIK3CB) 104693336(PIK3CD)
FPG: 
101911441(PIK3CA) 101919202(PIK3CD) 101923805(PIK3CB)
FCH: 
102049197(PIK3CA) 102049812(PIK3CD) 102057414(PIK3CB)
CLV: 
102083735(PIK3CB) 102084293(PIK3CA) 102095297(PIK3CD)
AAM: 
106482245(PIK3CA) 106496183(PIK3CB) 106499152(PIK3CD)
ASN: 
102372482(PIK3CB) 102387818(PIK3CA) 102388304(PIK3CD)
AMJ: 
102564312(PIK3CD) 102571877(PIK3CB) 106737094(PIK3CA)
PSS: 
102448624(PIK3CA) 102459577(PIK3CD) 102461096(PIK3CB) 102462482
CMY: 
102929971(PIK3CA) 102932183(PIK3CD) 102936956(PIK3CB)
CPIC: 
101934126(PIK3CD) 101935421(PIK3CA) 101940315(PIK3CB) 101943751 101952320
ACS: 
100562345(pik3ca) 100567254(pik3cb) 100567364 100568252(pik3cd)
PBI: 
103049546(PIK3CB) 103050043(PIK3CA) 103061550(PIK3CD) 103063682
GJA: 
107107376(PIK3CD) 107110507(PIK3CB) 107110982(PIK3CA) 107118085
XLA: 
108717120(pik3cb.L) 108718090 108718190(pik3cb.S) 373752(pik3ca.L)
XTR: 
100144924(pik3ca) 780390(pik3cb)
NPR: 
108785765(PIK3CA) 108796670(PIK3CB) 108798423(PIK3CD)
DRE: 
100002263(pik3cb) 394174(pik3cd) 561737(pik3ca)
SRX: 
107708832 107715769 107718208(pik3ca) 107718809 107719529 107726123 107736520 107747314 107757304
SANH: 
107653898 107655300 107671515 107677508(pik3ca) 107681979 107685965 107695767
SGH: 
107551780 107567258 107571428 107571432 107571564 107574159 107577515 107586517(pik3cd) 107598784
IPU: 
108271155(pik3ca) 108275608 108276156(pik3cd) 108280664(pik3cb)
TRU: 
101066166 101067191 101068840(pik3cb) 101072152 101076867(pik3cd)
TNG: 
GSTEN00004055G001 GSTEN00006075G001 GSTEN00013008G001 GSTEN00014961G001 GSTEN00026768G001 GSTEN00028231G001
LCO: 
104919391(pik3cb) 104921281 104927097(pik3cd) 104933269(pik3ca) 104934900
NCC: 
104956376 104960975(pik3ca) 104967189 104967191
MZE: 
101466374(pik3cb) 101469095(pik3cd) 101473981 101474114 101487871(pik3ca)
OLA: 
101161626(pik3ca) 101161887(pik3cd) 101165660(pik3cb) 101168152
XMA: 
102218230 102225882 102226157 102230257(pik3cb) 102231707(pik3cd)
CSEM: 
103378227(pik3cb) 103385041(pik3cd) 103396148 103396566(pik3ca) 107988201
LCF: 
108876542(pik3cd) 108880106 108882207 108883763 108888220(pik3cb) 108892325
SASA: 
106568747 106572046(pik3cd) 106581359 106598808 106613172 106613931(pik3ca)
ELS: 
105009967 105025897(pik3ca) 105026926(pik3cd) 105028918 105029118(pik3cb) 106024560
SFM: 
108921677 108923074 108932407(pik3cb) 108933929(pik3cd) 108937366
LCM: 
102350948(PIK3CA) 102351332 102351622(PIK3CD) 102359335(PIK3CB)
CMK: 
103175241(pik3cb) 103175843(pik3ca) 103184230(pik3cd)
BFO: 
BRAFLDRAFT_228095 BRAFLDRAFT_94886
CIN: 
100180252 100183611
SPU: 
100887922 588097 754280
SKO: 
100377266 100377675
DME: 
Dmel_CG4141(Pi3K92E)
DPO: 
Dpse_GA17984
DAN: 
Dana_GF18327
DER: 
Dere_GG15290
DPE: 
Dper_GL27142
DSE: 
Dsec_GM23175
DSI: 
Dsimw501_GD20048(Dsim_GD20048)
DWI: 
Dwil_GK22711
DYA: 
Dyak_GE25053
DGR: 
Dgri_GH16124
DMO: 
Dmoj_GI22170
DVI: 
Dvir_GJ24290
MDE: 
101900071
AGA: 
AgaP_AGAP000018
AAG: 
AaeL_AAEL002903
CQU: 
CpipJ_CPIJ005543
AME: 
551500
BIM: 
100748255
BTER: 
100646352
SOC: 
105205485
AEC: 
105149725
ACEP: 
105620083
PBAR: 
105432118
HST: 
105189236
CFO: 
105253109
LHU: 
105678402
NVI: 
100115810(Pik3cb)
TCA: 
657286
DPA: 
109538758
NVL: 
108565087
BMOR: 
101741278
PXY: 
105394660
API: 
100160001
DNX: 
107164340
PHU: 
Phum_PHUM169940
DPX: 
DAPPUDRAFT_117886 DAPPUDRAFT_300912 DAPPUDRAFT_333863
ISC: 
IscW_ISCW010469 IscW_ISCW014229
TUT: 
107362674 107364432
CEL: 
CELE_B0334.8(age-1)
CBR: 
CBG02868(Cbr-age-1)
NAI: 
NECAME_14812
BMY: 
Bm1_55680
LOA: 
LOAG_16863
HRO: 
HELRODRAFT_155850 HELRODRAFT_96068
LGI: 
LOTGIDRAFT_179045 LOTGIDRAFT_205708
CRG: 
105320169 105346575
OBI: 
106874488 106883036
SMM: 
Smp_164960
OVI: 
T265_11834
NVE: 
NEMVE_v1g242402
ADF: 
107327044
HMG: 
100210375 101235289
TAD: 
TRIADDRAFT_26293
AQU: 
100637686 100640192
MBR: 
MONBRDRAFT_18656(PI3K-CA_alpha)
SRE: 
PTSG_02075
DDI: 
DDB_G0268548(pikF) DDB_G0275011(pikC) DDB_G0278727(pikA) DDB_G0282625(pikG) DDB_G0283081(pikB)
DPP: 
DICPUDRAFT_149892 DICPUDRAFT_35373 DICPUDRAFT_38568 DICPUDRAFT_52203 DICPUDRAFT_58194
DFA: 
DFA_00682 DFA_02787(pikB) DFA_06196(pikC) DFA_10225(pikF) DFA_11886(pikA)
EHI: 
EHI_006130(83.t00026) EHI_095130(269.t00003) EHI_188970(67.t00015)
EDI: 
EDI_013060 EDI_083720 EDI_198920
EIV: 
EIN_082310 EIN_133870 EIN_151380 EIN_229690 EIN_249470
ACAN: 
ACA1_065770 ACA1_078600 ACA1_155440 ACA1_181940 ACA1_199620 ACA1_208110 ACA1_360410
TET: 
TTHERM_00951960
PTM: 
GSPATT00012877001 GSPATT00018694001 GSPATT00019938001 GSPATT00027505001 GSPATT00039649001
AAF: 
AURANDRAFT_39233
PIF: 
PITG_00569
PSOJ: 
PHYSODRAFT_286362
SPAR: 
SPRG_01338 SPRG_03714 SPRG_03720 SPRG_03722 SPRG_18804
EHX: 
EMIHUDRAFT_632222(PI3K1)
TCR: 
508859.90 510167.10
LIF: 
LINJ_14_0020
LDO: 
LDBPK_140020
LMI: 
LMXM_14_0020
NGR: 
NAEGRDRAFT_48457 NAEGRDRAFT_81057
TVA: 
TVAG_284350
GLA: 
GL50803_14855
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7713498
  Authors
Volinia S, Hiles I, Ormondroyd E, Nizetic D, Antonacci R, Rocchi M, Waterfield MD
  Title
Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene.
  Journal
Genomics 24:472-7 (1994)
DOI:10.1006/geno.1994.1655
  Sequence
[hsa:5290]
Reference
PMID:8246984
  Authors
Hu P, Mondino A, Skolnik EY, Schlessinger J
  Title
Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.
  Journal
Mol Cell Biol 13:7677-88 (1993)
DOI:10.1128/MCB.13.12.7677
  Sequence
[hsa:5291]
Reference
PMID:9113989
  Authors
Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD
  Title
P110delta, a novel phosphoinositide 3-kinase in leukocytes.
  Journal
Proc Natl Acad Sci U S A 94:4330-5 (1997)
DOI:10.1073/pnas.94.9.4330
  Sequence
[hsa:5293]
KEGG   ORTHOLOGY: K21289Help
Entry
K21289                      KO                                     

Name
PIK3CG
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153]
Pathway
Inositol phosphate metabolism
cGMP-PKG signaling pathway
Phospholipase D signaling pathway
PI3K-Akt signaling pathway
Adrenergic signaling in cardiomyocytes
Apelin signaling pathway
Platelet activation
Cholinergic synapse
Oxytocin signaling pathway
Toxoplasmosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
 Environmental Information Processing
  Signal transduction
   04371 Apelin signaling pathway
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
   04072 Phospholipase D signaling pathway
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
   04022 cGMP - PKG signaling pathway
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
   04151 PI3K-Akt signaling pathway
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
 Organismal Systems
  Immune system
   04611 Platelet activation
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  Endocrine system
   04921 Oxytocin signaling pathway
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  Nervous system
   04725 Cholinergic synapse
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
 Human Diseases
  Infectious diseases
   05145 Toxoplasmosis
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
HSA: 
5294(PIK3CG)
PTR: 
463649(PIK3CG)
PPS: 
100988420(PIK3CG)
GGO: 
101153738(PIK3CG)
PON: 
100453085(PIK3CG)
NLE: 
100586512(PIK3CG)
MCC: 
698857(PIK3CG)
MCF: 
102146644(PIK3CG)
CSAB: 
103226710(PIK3CG)
RRO: 
104677402(PIK3CG)
CJC: 
100394268(PIK3CG)
SBQ: 
101028650(PIK3CG)
MMU: 
30955(Pik3cg)
RNO: 
298947(Pik3cg)
CGE: 
100765862(Pik3cg)
NGI: 
103732179(Pik3cg)
HGL: 
101707055(Pik3cg)
CCAN: 
109687395(Pik3cg)
OCU: 
100344144(PIK3CG)
TUP: 
102472442(PIK3CG)
CFA: 
483266(PIK3CG)
AML: 
100470322(PIK3CG)
UMR: 
103674633(PIK3CG)
FCA: 
101096215(PIK3CG)
PTG: 
102953306(PIK3CG)
AJU: 
106987833(PIK3CG)
BTA: 
530001(PIK3CG)
BOM: 
102277419(PIK3CG)
BIU: 
109557383(PIK3CG)
PHD: 
102342662(PIK3CG)
CHX: 
102173256(PIK3CG)
OAS: 
101102896(PIK3CG)
SSC: 
396979(PIK3CG)
CFR: 
102503674(PIK3CG)
BACU: 
103004888(PIK3CG)
LVE: 
103069455(PIK3CG)
ECB: 
100050532(PIK3CG)
MYB: 
102241723(PIK3CG)
MYD: 
102773870(PIK3CG)
HAI: 
109375969(PIK3CG)
RSS: 
109454601(PIK3CG)
PALE: 
102884972(PIK3CG)
LAV: 
100673566(PIK3CG)
MDO: 
100009879(PIK3CG)
SHR: 
100925455(PIK3CG)
OAA: 
100078046(PIK3CG)
GGA: 
417706(PIK3CG)
MGP: 
104914241
CJO: 
107306688(PIK3CG)
APLA: 
101796856(PIK3CG)
ACYG: 
106042023(PIK3CG)
TGU: 
100229232(PIK3CG)
GFR: 
102044692(PIK3CG)
FAB: 
101811117(PIK3CG)
PHI: 
102102611(PIK3CG)
CCW: 
104686866(PIK3CG)
FPG: 
101910831(PIK3CG)
FCH: 
102051392(PIK3CG)
CLV: 
102090627(PIK3CG)
AAM: 
106487739(PIK3CG)
ASN: 
102381149(PIK3CG)
AMJ: 
102559272(PIK3CG)
PSS: 
102460136(PIK3CG)
CMY: 
102945282(PIK3CG)
CPIC: 
101948128(PIK3CG)
ACS: 
100561444(pik3cg)
PBI: 
103057875(PIK3CG)
GJA: 
107108982(PIK3CG)
XLA: 
108711184 108713077(pik3cg.S)
XTR: 
100158519(pik3cg)
NPR: 
108797066(PIK3CG)
DRE: 
406598(pik3cg) 564261(si:rp71-17i16.5)
SRX: 
107705338 107712701 107718546
SANH: 
107656384 107658948 107699595
SGH: 
107583938 107584052 107590535 107593445
IPU: 
108276435 108279798(pik3cg)
TRU: 
101071229(pik3cg) 101075343
TNG: 
GSTEN00013245G001
LCO: 
104931247 104933235(pik3cg)
NCC: 
104952370 104967044(pik3cg) 104967097
MZE: 
101471620 101474181(pik3cg)
OLA: 
101159013 101173828(pik3cg)
XMA: 
102225994 102229099(pik3cg)
CSEM: 
103383124(pik3cg) 103384699
LCF: 
108884757 108888339(pik3cg)
SASA: 
106572104 106576084 106609208
ELS: 
105025656(pik3cg) 105027772
SFM: 
108918751(pik3cg) 108925594
LCM: 
102353565(PIK3CG) 102362971
CMK: 
103175665 103176691(pik3cg)
CIN: 
100180112(pik3cg)
AQU: 
100638758 100641746
SRE: 
PTSG_12633
AAF: 
AURANDRAFT_61515
PIF: 
PITG_07286 PITG_07289
PSOJ: 
PHYSODRAFT_354120 PHYSODRAFT_354122
SPAR: 
SPRG_03711
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7624799
  Authors
Stoyanov B, Volinia S, Hanck T, Rubio I, Loubtchenkov M, Malek D, Stoyanova S, Vanhaesebroeck B, Dhand R, Nurnberg B, et al.
  Title
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase.
  Journal
Science 269:690-3 (1995)
DOI:10.1126/science.7624799
  Sequence
[hsa:5294]
KEGG   ENZYME: 2.7.1.153Help
Entry
EC 2.7.1.153                Enzyme                                 

Name
phosphatidylinositol-4,5-bisphosphate 3-kinase;
type I phosphoinositide 3-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase
Reaction(IUBMB)
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [RN:R04545]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637]
Product
ADP [CPD:C00008];
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [CPD:C05981]
Comment
This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist.
History
EC 2.7.1.153 created 2002
Pathway
Inositol phosphate metabolism
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
K21289  
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Genes
HSA: 
5290(PIK3CA) 5291(PIK3CB) 5293(PIK3CD) 5294(PIK3CG)
PTR: 
457922(PIK3CD) 460858(PIK3CA) 463649(PIK3CG) 471079(PIK3CB)
PPS: 
100988420(PIK3CG) 100989732(PIK3CD) 100990108(PIK3CB) 100990828(PIK3CA)
GGO: 
101143811(PIK3CA) 101146434(PIK3CD) 101152123(PIK3CB) 101153738(PIK3CG)
PON: 
100432846(PIK3CB) 100453085(PIK3CG) 100453779(PIK3CA) 103889133(PIK3CD)
NLE: 
100580872(PIK3CD) 100584384(PIK3CB) 100586512(PIK3CG) 100588218(PIK3CA)
MCC: 
698857(PIK3CG) 709959(PIK3CA) 710552(PIK3CD) 716098(PIK3CB)
MCF: 
102122725(PIK3CA) 102142026(PIK3CB) 102143464(PIK3CD) 102146644(PIK3CG)
CSAB: 
103221212(PIK3CA) 103225637(PIK3CD) 103226710(PIK3CG) 103241599(PIK3CB)
RRO: 
104663050(PIK3CD) 104665061(PIK3CB) 104670605(PIK3CA) 104677402(PIK3CG)
CJC: 
100391655(PIK3CB) 100394268(PIK3CG) 100398849(PIK3CD) 100403494(PIK3CA)
SBQ: 
101027982(PIK3CB) 101028650(PIK3CG) 101029768(PIK3CA) 101052779(PIK3CD)
MMU: 
18706(Pik3ca) 18707(Pik3cd) 30955(Pik3cg) 74769(Pik3cb)
RNO: 
170911(Pik3ca) 298947(Pik3cg) 366508(Pik3cd) 85243(Pik3cb)
CGE: 
100689251(Pik3ca) 100689252(Pik3cb) 100765862(Pik3cg) 100769225(Pik3cd)
NGI: 
103732179(Pik3cg) 103733121(Pik3cd) 103738596(Pik3ca) 103742946(Pik3cb)
HGL: 
101707055(Pik3cg) 101711934(Pik3ca) 101712941(Pik3cd) 101715249(Pik3cb)
CCAN: 
109681900(Pik3cd) 109687395(Pik3cg) 109689664(Pik3ca)
OCU: 
100337822(PIK3CA) 100344144(PIK3CG) 100345181(PIK3CB) 100348663(PIK3CD)
TUP: 
102472442(PIK3CG) 102483329(PIK3CA) 102500530(PIK3CD) 102502163(PIK3CB) 106736453
CFA: 
477085(PIK3CB) 483266(PIK3CG) 488084(PIK3CA) 489644(PIK3CD)
AML: 
100463775(PIK3CB) 100470322(PIK3CG) 100479294(PIK3CA) 100479580(PIK3CD)
UMR: 
103666874(PIK3CD) 103674633(PIK3CG) 103676125(PIK3CA) 103678592(PIK3CB)
FCA: 
101091892(PIK3CB) 101094274(PIK3CD) 101096215(PIK3CG) 101097413(PIK3CA)
PTG: 
102953082(PIK3CD) 102953306(PIK3CG) 102965070(PIK3CA) 102972487(PIK3CB)
AJU: 
106973880(PIK3CA) 106984265(PIK3CB) 106984896(PIK3CD) 106987833(PIK3CG)
BTA: 
282306(PIK3CA) 504531(PIK3CD) 517948(PIK3CB) 530001(PIK3CG)
BOM: 
102274461(PIK3CD) 102274553(PIK3CA) 102277419(PIK3CG) 102277548(PIK3CB)
BIU: 
109557383(PIK3CG) 109557823(PIK3CA) 109559805(PIK3CB) 109570415(PIK3CD)
PHD: 
102320516(PIK3CB) 102321231(PIK3CA) 102333324(PIK3CD) 102342662(PIK3CG)
CHX: 
102168391(PIK3CA) 102173256(PIK3CG) 102177551(PIK3CD) 102185042(PIK3CB)
OAS: 
101102896(PIK3CG) 101109759(PIK3CB) 101110015(PIK3CA) 101117348(PIK3CD)
SSC: 
100518131(PIK3CD) 100621789(PIK3CA) 396979(PIK3CG)
CFR: 
102503674(PIK3CG) 102518643(PIK3CD) 102519994(PIK3CB) 102523502(PIK3CA)
BACU: 
103004888(PIK3CG) 103012691(PIK3CA) 103012931(PIK3CB) 103014043(PIK3CD)
LVE: 
103069455(PIK3CG) 103085303(PIK3CA) 103088756(PIK3CB) 103089257(PIK3CD)
ECB: 
100050532(PIK3CG) 100051623(PIK3CD) 100051753(PIK3CB) 100058141(PIK3CA)
MYB: 
102239669(PIK3CA) 102241723(PIK3CG) 102252921(PIK3CD) 102260487(PIK3CB)
MYD: 
102758951(PIK3CA) 102764343(PIK3CB) 102766356(PIK3CD) 102773870(PIK3CG)
HAI: 
109372681(PIK3CA) 109375969(PIK3CG) 109381238(PIK3CD) 109394108(PIK3CB)
RSS: 
109454601(PIK3CG) 109455259(PIK3CD) 109455777(PIK3CB) 109458390(PIK3CA)
PALE: 
102880320(PIK3CB) 102884972(PIK3CG) 102889227(PIK3CA) 102889576(PIK3CD)
LAV: 
100657948(PIK3CA) 100658340(PIK3CB) 100666266(PIK3CD) 100673566(PIK3CG)
MDO: 
100009879(PIK3CG) 100010412(PIK3CA) 100017332(PIK3CB) 100024769(PIK3CD)
SHR: 
100925455(PIK3CG) 100929811(PIK3CB) 100932099(PIK3CA)
OAA: 
100073788(PIK3CA) 100074273(PIK3CD) 100078046(PIK3CG) 100086270(PIK3CB)
GGA: 
417706(PIK3CG) 419444(PIK3CD) 424826(PIK3CB) 424971(PIK3CA)
MGP: 
100543492(PIK3CD) 100546867(PIK3CA) 104914241
CJO: 
107306688(PIK3CG) 107317945(PIK3CB) 107318114(PIK3CA) 107323497(PIK3CD)
APLA: 
101796183(PIK3CA) 101796856(PIK3CG) 101800900(PIK3CB) 101802796(PIK3CD)
ACYG: 
106032026(PIK3CA) 106040311(PIK3CB) 106042023(PIK3CG) 106044285(PIK3CD)
TGU: 
100219602(PIK3CB) 100224188(PIK3CD) 100229232(PIK3CG) 100229768(PIK3CA)
GFR: 
102040845(PIK3CB) 102040853(PIK3CD) 102042284(PIK3CA) 102044692(PIK3CG)
FAB: 
101811117(PIK3CG) 101811931(PIK3CD) 101814811(PIK3CA) 101821801(PIK3CB)
PHI: 
102099156(PIK3CA) 102102611(PIK3CG) 102103635(PIK3CD) 102106643(PIK3CB)
CCW: 
104686866(PIK3CG) 104688020(PIK3CA) 104693039(PIK3CB) 104693336(PIK3CD)
FPG: 
101910831(PIK3CG) 101911441(PIK3CA) 101919202(PIK3CD) 101923805(PIK3CB)
FCH: 
102049197(PIK3CA) 102049812(PIK3CD) 102051392(PIK3CG) 102057414(PIK3CB)
CLV: 
102083735(PIK3CB) 102084293(PIK3CA) 102090627(PIK3CG) 102095297(PIK3CD)
AAM: 
106482245(PIK3CA) 106487739(PIK3CG) 106496183(PIK3CB) 106499152(PIK3CD)
ASN: 
102372482(PIK3CB) 102381149(PIK3CG) 102387818(PIK3CA) 102388304(PIK3CD)
AMJ: 
102559272(PIK3CG) 102564312(PIK3CD) 102571877(PIK3CB) 106737094(PIK3CA)
PSS: 
102448624(PIK3CA) 102459577(PIK3CD) 102460136(PIK3CG) 102461096(PIK3CB) 102462482
CMY: 
102929971(PIK3CA) 102932183(PIK3CD) 102936956(PIK3CB) 102945282(PIK3CG)
CPIC: 
101934126(PIK3CD) 101935421(PIK3CA) 101940315(PIK3CB) 101943751 101948128(PIK3CG) 101952320
ACS: 
100561444(pik3cg) 100562345(pik3ca) 100567254(pik3cb) 100567364 100568252(pik3cd)
PBI: 
103049546(PIK3CB) 103050043(PIK3CA) 103057875(PIK3CG) 103061550(PIK3CD) 103063682
GJA: 
107107376(PIK3CD) 107108982(PIK3CG) 107110507(PIK3CB) 107110982(PIK3CA) 107118085
XLA: 
108711184 108713077(pik3cg.S) 108717120(pik3cb.L) 108718090 108718190(pik3cb.S) 373752(pik3ca.L)
XTR: 
100144924(pik3ca) 100158519(pik3cg) 780390(pik3cb)
NPR: 
108785765(PIK3CA) 108796670(PIK3CB) 108797066(PIK3CG) 108798423(PIK3CD)
DRE: 
100002263(pik3cb) 394174(pik3cd) 406598(pik3cg) 561737(pik3ca) 564261(si:rp71-17i16.5)
SRX: 
107705338 107708832 107712701 107715769 107718208(pik3ca) 107718546 107718809 107719529 107726123 107736520 107747314 107757304
SANH: 
107653898 107655300 107656384 107658948 107671515 107677508(pik3ca) 107681979 107685965 107695767 107699595
SGH: 
107551780 107567258 107571428 107571432 107571564 107574159 107577515 107583938 107584052 107586517(pik3cd) 107590535 107593445 107598784
IPU: 
108271155(pik3ca) 108275608 108276156(pik3cd) 108276435 108279798(pik3cg) 108280664(pik3cb)
TRU: 
101066166 101067191 101068840(pik3cb) 101071229(pik3cg) 101072152 101075343 101076867(pik3cd)
TNG: 
GSTEN00004055G001 GSTEN00006075G001 GSTEN00013008G001 GSTEN00013245G001 GSTEN00014961G001 GSTEN00026768G001 GSTEN00028231G001
LCO: 
104919391(pik3cb) 104921281 104927097(pik3cd) 104931247 104933235(pik3cg) 104933269(pik3ca) 104934900
NCC: 
104952370 104956376 104960975(pik3ca) 104967044(pik3cg) 104967097 104967189 104967191
MZE: 
101466374(pik3cb) 101469095(pik3cd) 101471620 101473981 101474114 101474181(pik3cg) 101487871(pik3ca)
OLA: 
101159013 101161626(pik3ca) 101161887(pik3cd) 101165660(pik3cb) 101168152 101173828(pik3cg)
XMA: 
102218230 102225882 102225994 102226157 102229099(pik3cg) 102230257(pik3cb) 102231707(pik3cd)
CSEM: 
103378227(pik3cb) 103383124(pik3cg) 103384699 103385041(pik3cd) 103396148 103396566(pik3ca) 107988201
LCF: 
108876542(pik3cd) 108880106 108882207 108883763 108884757 108888220(pik3cb) 108888339(pik3cg) 108892325
SASA: 
106568747 106572046(pik3cd) 106572104 106576084 106581359 106598808 106609208 106613172 106613931(pik3ca)
ELS: 
105009967 105025656(pik3cg) 105025897(pik3ca) 105026926(pik3cd) 105027772 105028918 105029118(pik3cb) 106024560
SFM: 
108918751(pik3cg) 108921677 108923074 108925594 108932407(pik3cb) 108933929(pik3cd) 108937366
LCM: 
102350948(PIK3CA) 102351332 102351622(PIK3CD) 102353565(PIK3CG) 102359335(PIK3CB) 102362971
CMK: 
103175241(pik3cb) 103175665 103175843(pik3ca) 103176691(pik3cg) 103184230(pik3cd)
BFO: 
BRAFLDRAFT_228095 BRAFLDRAFT_94886
CIN: 
100180112(pik3cg) 100180252 100183611
SPU: 
100887922 588097 754280
SKO: 
100377266 100377675
DME: 
Dmel_CG4141(Pi3K92E)
DPO: 
Dpse_GA17984
DAN: 
Dana_GF18327
DER: 
Dere_GG15290
DPE: 
Dper_GL27142
DSE: 
Dsec_GM23175
DSI: 
Dsimw501_GD20048(Dsim_GD20048)
DWI: 
Dwil_GK22711
DYA: 
Dyak_GE25053
DGR: 
Dgri_GH16124
DMO: 
Dmoj_GI22170
DVI: 
Dvir_GJ24290
MDE: 
101900071
AGA: 
AgaP_AGAP000018
AAG: 
AaeL_AAEL002903
CQU: 
CpipJ_CPIJ005543
AME: 
551500
BIM: 
100748255
BTER: 
100646352
SOC: 
105205485
AEC: 
105149725
ACEP: 
105620083
PBAR: 
105432118
HST: 
105189236
CFO: 
105253109
LHU: 
105678402
NVI: 
100115810(Pik3cb)
TCA: 
657286
DPA: 
109538758
NVL: 
108565087
BMOR: 
101741278
PXY: 
105394660
API: 
100160001
DNX: 
107164340
PHU: 
Phum_PHUM169940
DPX: 
DAPPUDRAFT_117886 DAPPUDRAFT_300912 DAPPUDRAFT_333863
ISC: 
IscW_ISCW010469 IscW_ISCW014229
TUT: 
107362674 107364432
CEL: 
CELE_B0334.8(age-1)
CBR: 
CBG02868(Cbr-age-1)
NAI: 
NECAME_14812
BMY: 
Bm1_55680
LOA: 
LOAG_16863
HRO: 
HELRODRAFT_155850 HELRODRAFT_96068
LGI: 
LOTGIDRAFT_179045 LOTGIDRAFT_205708
CRG: 
105320169 105346575
OBI: 
106874488 106883036
SMM: 
Smp_164960
OVI: 
T265_11834
NVE: 
NEMVE_v1g242402
ADF: 
107327044
HMG: 
100210375 101235289
TAD: 
TRIADDRAFT_26293
AQU: 
100637686 100638758 100640192 100641746
MBR: 
MONBRDRAFT_18656(PI3K-CA_alpha)
SRE: 
PTSG_02075 PTSG_12633
DDI: 
DDB_G0268548(pikF) DDB_G0275011(pikC) DDB_G0278727(pikA) DDB_G0282625(pikG) DDB_G0283081(pikB)
DPP: 
DICPUDRAFT_149892 DICPUDRAFT_35373 DICPUDRAFT_38568 DICPUDRAFT_52203 DICPUDRAFT_58194
DFA: 
DFA_00682 DFA_02787(pikB) DFA_06196(pikC) DFA_10225(pikF) DFA_11886(pikA)
EHI: 
EHI_006130(83.t00026) EHI_095130(269.t00003) EHI_188970(67.t00015)
EDI: 
EDI_013060 EDI_083720 EDI_198920
EIV: 
EIN_082310 EIN_133870 EIN_151380 EIN_229690 EIN_249470
ACAN: 
ACA1_065770 ACA1_078600 ACA1_155440 ACA1_181940 ACA1_199620 ACA1_208110 ACA1_360410
TET: 
TTHERM_00951960
PTM: 
GSPATT00012877001 GSPATT00018694001 GSPATT00019938001 GSPATT00027505001 GSPATT00039649001
AAF: 
AURANDRAFT_39233 AURANDRAFT_61515
PIF: 
PITG_00569 PITG_07286 PITG_07289
PSOJ: 
PHYSODRAFT_286362 PHYSODRAFT_354120 PHYSODRAFT_354122
SPAR: 
SPRG_01338 SPRG_03711 SPRG_03714 SPRG_03720 SPRG_03722 SPRG_18804
EHX: 
EMIHUDRAFT_632222(PI3K1)
TCR: 
508859.90 510167.10
LIF: 
LINJ_14_0020
LDO: 
LDBPK_140020
LMI: 
LMXM_14_0020
NGR: 
NAEGRDRAFT_48457 NAEGRDRAFT_81057
TVA: 
TVAG_284350
GLA: 
GL50803_14855
 » show all
Taxonomy
Reference
1  [PMID:11395417]
  Authors
Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, Waterfield MD.
  Title
Synthesis and function of 3-phosphorylated inositol lipids.
  Journal
Annu. Rev. Biochem. 70 (2001) 535-602.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
103843-30-7
KEGG   REACTION: R04545Help
Entry
R04545                      Reaction                               

Name
ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase
Definition
ATP + 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate <=> ADP + Phosphatidylinositol-3,4,5-trisphosphate
Equation
Reaction class
C00002_C00008
C04637_C05981
Enzyme
Pathway
Inositol phosphate metabolism
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649  
phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K21289  
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153]
Other DBs
RHEA: 
DBGET integrated database retrieval system