KEGG ORTHOLOGY: K01108

Genes

HSA:	4534(MTM1)
PTR:	465904(MTM1)
PPS:	100995776(MTM1)
GGO:	101127158(MTM1)
PON:	100174495(MTM1)
NLE:	100587311(MTM1)
MCC:	703131(MTM1)
MCF:	102117369(MTM1)
CSAB:	103232739(MTM1)
RRO:	104663197(MTM1)
CJC:	100387480(MTM1)
SBQ:	101034305(MTM1)
MMU:	17772(Mtm1)
RNO:	288762(Mtm1)
CGE:	100761567 107980426(Mtm1)
NGI:	103731164(Mtm1)
HGL:	101698768(Mtm1)
CCAN:	109700327(Mtm1)
OCU:	100350857(MTM1)
TUP:	102501573(MTM1)
CFA:	612385(MTM1)
AML:	100470283(MTM1)
UMR:	103662562(MTM1)
FCA:	101093757(MTM1)
PTG:	102949457(MTM1)
AJU:	106985747(MTM1)
BTA:	533622(MTM1)
BOM:	102272810(MTM1)
BIU:	109555381(MTM1)
PHD:	102323553(MTM1)
CHX:	102191778(MTM1)
OAS:	101114846(MTM1)
SSC:	100516892(MTM1)
CFR:	102512516(MTM1)
BACU:	103001571(MTM1)
LVE:	103082658(MTM1)
ECB:	100069680(MTM1)
MYB:	102244493(MTM1)
MYD:	102759418(MTM1)
HAI:	109396239(MTM1)
RSS:	109459203(MTM1)
PALE:	102891982(MTM1)
LAV:	100664603(MTM1)
MDO:	100015113(MTM1)
SHR:	100930917(MTM1)
OAA:	100081312(MTM1)
GGA:	422388(MTM1)
MGP:	100547482(MTM1)
CJO:	107312926(MTM1)
APLA:	101803703(MTM1)
ACYG:	106037723(MTM1)
TGU:	100227491(MTM1)
GFR:	102044014(MTM1)
FAB:	101819090(MTM1)
PHI:	102102968(MTM1)
CCW:	104691682(MTM1)
FPG:	101917168(MTM1)
FCH:	102055474(MTM1)
CLV:	102085828(MTM1)
AAM:	106487576(MTM1)
ASN:	102371219(MTM1)
AMJ:	102564445(MTM1)
PSS:	102444590(MTM1)
CMY:	102932290(MTM1)
CPIC:	101944474(MTM1)
ACS:	100564867(mtm1)
PBI:	103052336(MTM1)
GJA:	107112040(MTM1)
XLA:	108698426(mtm1.L) 734460(mtm1.S)
XTR:	548545(mtm1)
NPR:	108783896(MTM1)
DRE:	560881(mtm1)
SRX:	107749798 107750584
SANH:	107668296(mtm1) 107677984
SGH:	107563032 107593873
IPU:	108267553(mtm1)
TRU:	101072251(mtm1)
TNG:	GSTEN00010495G001
LCO:	104939418(mtm1)
NCC:	104965672
MZE:	101476994(mtm1)
OLA:	101168528(mtm1)
XMA:	102223974(mtm1)
CSEM:	103392128
LCF:	108879698 108895246
SASA:	100380488(mtm1) 106577925
ELS:	105027660(mtm1)
SFM:	108922995 108934420
LCM:	102351041(MTM1)
CMK:	103178361(mtm1)
TET:	TTHERM_00293460
SMIN:	v1.2.011730.t1(symbB.v1.2.011730.t1)
AAF:	AURANDRAFT_1309
GTT:	GUITHDRAFT_103752 GUITHDRAFT_89063

Reference

PMID:10900271

Authors

Taylor GS, Maehama T, Dixon JE

Title

Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate.

Journal

Proc Natl Acad Sci U S A 97:8910-5 (2000)
DOI:10.1073/pnas.160255697

All links

Ontology (5)   
   KEGG BRITE (3)   
   GO (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (6)   
   KEGG ENZYME (2)   
   KEGG REACTION (3)   
   KEGG RCLASS (1)   
Gene (229)   
   KEGG GENES (103)   
   KEGG MGENES (81)   
   RefGene (29)   
   EGENES (13)   
   OC (3)   
Protein sequence (33)   
   UniProt (26)   
   SWISS-PROT (7)   
Literature (1)   
   PubMed (1)   
All databases (281)   

Download RDF

ORTHOLOGY: K18081

Entry

K18081 KO

Name

MTMR1_2

Definition

myotubularin-related protein 1/2 [EC:3.1.3.64 3.1.3.95]

Pathway

ko00562	Inositol phosphate metabolism
ko04070	Phosphatidylinositol signaling system

Disease

H00264

Charcot-Marie-Tooth disease (CMT)

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K18081  MTMR1_2; myotubularin-related protein 1/2
Environmental Information Processing
  Signal transduction
   04070 Phosphatidylinositol signaling system
    K18081  MTMR1_2; myotubularin-related protein 1/2
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.64  phosphatidylinositol-3-phosphatase
     K18081  MTMR1_2; myotubularin-related protein 1/2
    3.1.3.95  phosphatidylinositol-3,5-bisphosphate 3-phosphatase
     K18081  MTMR1_2; myotubularin-related protein 1/2
Protein phosphatases and associated proteins [BR:ko01009]
Protein Tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Myotubularins
    K18081  MTMR1_2; myotubularin-related protein 1/2

Other DBs

GO:

Genes

HSA:	8776(MTMR1) 8898(MTMR2)
PTR:	451498(MTMR2) 465905(MTMR1)
PPS:	100969994(MTMR1) 100977094(MTMR2)
GGO:	101127773(MTMR1) 101149089(MTMR2)
PON:	100174264(MTMR2) 100443993(MTMR1) 100450380
NLE:	100587643(MTMR1) 100601635(MTMR2)
MCC:	699703(MTMR2) 708892(MTMR1)
MCF:	101866399(MTMR2) 101925490(MTMR1)
CSAB:	103232740(MTMR1) 103248282(MTMR2)
RRO:	104663196(MTMR1) 104671805(MTMR2)
CJC:	100388332(MTMR1) 100404569(MTMR2)
SBQ:	101034908(MTMR2) 101038633(MTMR1)
MMU:	53332(Mtmr1) 77116(Mtmr2)
RNO:	315422(Mtmr2) 317296(Mtmr1)
CGE:	100762316(Mtmr2) 100770104(Mtmr1)
NGI:	103731165(Mtmr1) 103748247(Mtmr2)
HGL:	101699372(Mtmr1) 101718842(Mtmr2)
CCAN:	109688151 109688153(Mtmr1) 109699464(Mtmr2)
OCU:	100352381(MTMR2) 100354324(MTMR1)
TUP:	102497909(MTMR2) 102499371(MTMR1)
CFA:	492211(MTMR1) 606918(MTMR2)
AML:	100470028(MTMR1) 100473901(MTMR2)
UMR:	103660720(MTMR2) 103662580(MTMR1)
FCA:	101080478(MTMR2) 101098208(MTMR1)
PTG:	102949757(MTMR1) 102968938(MTMR2)
AJU:	106970759(MTMR2) 106985749(MTMR1)
BTA:	536810(MTMR2) 541155(MTMR1)
BOM:	102272519(MTMR1) 102282843(MTMR2)
BIU:	109555122(MTMR1) 109569725(MTMR2)
PHD:	102318197(MTMR2) 102323899(MTMR1)
CHX:	102168613(MTMR1) 102180779(MTMR2)
OAS:	101107677(MTMR1) 101123404(MTMR2)
SSC:	100517258(MTMR1) 100518140(MTMR2)
CFR:	102512989(MTMR1) 102521416(MTMR2)
BACU:	103000889(MTMR2) 103001831(MTMR1)
LVE:	103078352(MTMR2) 103083116(MTMR1)
ECB:	100067900(MTMR2) 100069653(MTMR1)
MYB:	102244753(MTMR2) 102244995(MTMR1)
MYD:	102758041(MTMR1) 102761693(MTMR2)
HAI:	109390549(MTMR2) 109396233(MTMR1)
RSS:	109450331(MTMR2) 109459198(MTMR1)
PALE:	102880648(MTMR2) 102891579(MTMR1)
LAV:	100657088(MTMR2) 100668300(MTMR1)
MDO:	100013067(MTMR2) 100617772(MTMR1)
SHR:	100920455(MTMR2) 100933524(MTMR1)
OAA:	100080246(MTMR2) 100082050(MTMR1)
GGA:	418992(MTMR2) 422387(MTMR1)
MGP:	100546486(MTMR2) 100547943(MTMR1)
CJO:	107308419(MTMR2) 107312925(MTMR1)
APLA:	101803235(MTMR1) 101804435(MTMR2)
ACYG:	106034155(MTMR2) 106037722(MTMR1)
TGU:	100222676(MTMR1) 100225316(MTMR2)
GFR:	102032651(MTMR2) 102043729(MTMR1)
FAB:	101818420(MTMR2) 101819675(MTMR1)
PHI:	102103157(MTMR1) 102108667(MTMR2)
CCW:	104690075(MTMR2) 104691681(MTMR1)
FPG:	101917345(MTMR1) 101922927(MTMR2)
FCH:	102048548(MTMR2) 102055182(MTMR1)
CLV:	102086136(MTMR1) 102096489(MTMR2)
AAM:	106487566(MTMR1) 106495539(MTMR2)
ASN:	102370473(MTMR1) 102380001(MTMR2)
AMJ:	102564682(MTMR2) 106737108(MTMR1)
PSS:	102444807(MTMR1) 102447518(MTMR2)
CMY:	102932512(MTMR1) 102941323(MTMR2)
CPIC:	101930881(MTMR2) 101931312(MTMR1)
ACS:	100556577(mtmr2) 100564667(mtmr1)
PBI:	103052721(MTMR1) 103060397(MTMR2)
GJA:	107112098(MTMR1) 107116842(MTMR2)
XLA:	108698427 108700127 108708743(mtmr2.L) 108710008(mtmr2.S)
XTR:	100494494(mtmr2) 734091(mtmr1)
NPR:	108783903(MTMR1) 108784202(MTMR2)
DRE:	30644(mtmr2) 541517(mtmr1b) 553750(mtmr1a)
SRX:	107713197 107727267 107732604 107747813 107750582
SANH:	107661603 107661737 107668235 107677993 107680397 107687656
SGH:	107561958 107581988 107587235 107587278 107592277 107593835 107597225
IPU:	108259814(mtmr2) 108261680 108267552(mtmr1)
TRU:	101065083(mtmr2) 101072034(mtmr1)
TNG:	GSTEN00007439G001 GSTEN00009054G001 GSTEN00022168G001
LCO:	104919737(mtmr2) 104937744(mtmr1)
NCC:	104954632(mtmr2) 104966346
MZE:	101464973(mtmr2) 101475552
OLA:	101157315(mtmr2) 101157977
XMA:	102222634(mtmr2) 102235299
CSEM:	103395432
LCF:	108893812(mtmr2) 108895232
SASA:	100306801(mtmr2) 106567844 106577923 106608928
ELS:	105025988(mtmr2) 105027659(mtmr1)
SFM:	108932391(mtmr2) 108934369(mtmr1)
LCM:	102352382(MTMR1) 102366435(MTMR2)
CMK:	103178360(mtmr1) 103184098(mtmr2)
BFO:	BRAFLDRAFT_121921
CIN:	100182371
SPU:	583980
SKO:	100313661
DME:	Dmel_CG9115(mtm)
DPO:	Dpse_GA21553
DAN:	Dana_GF14283
DER:	Dere_GG10145
DPE:	Dper_GL19086
DSE:	Dsec_GM17969 Dsec_GM17970
DSI:	Dsimw501_GD22607(Dsim_GD22607)
DWI:	Dwil_GK15399
DYA:	Dyak_GE18955
DGR:	Dgri_GH10708
DMO:	Dmoj_GI11288
DVI:	Dvir_GJ12474
MDE:	101899399
AGA:	AgaP_AGAP009563
AAG:	AaeL_AAEL005367
CQU:	CpipJ_CPIJ006851
AME:	411563(MTMR2)
BIM:	100741387
BTER:	100645314
SOC:	105202084
AEC:	105146176
ACEP:	105623045
PBAR:	105425523
HST:	105192679
CFO:	105253355
LHU:	105678030
NVI:	100121534
TCA:	663698
DPA:	109542826
NVL:	108557168
BMOR:	101736147
PXY:	105381058 105394827
API:	100160591
DNX:	107172966
PHU:	Phum_PHUM213020
DPX:	DAPPUDRAFT_299527
ISC:	IscW_ISCW009978
TUT:	107367748
CEL:	CELE_Y110A7A.5(mtm-1)
CBR:	CBG10832(Cbr-mtm-1) CBG22220
NAI:	NECAME_06007
BMY:	Bm1_27530
LOA:	LOAG_10137
TSP:	Tsp_00892
HRO:	HELRODRAFT_188680
LGI:	LOTGIDRAFT_168891
CRG:	105348463
OBI:	106881300
SMM:	Smp_083540
OVI:	T265_00177
NVE:	NEMVE_v1g241000
ADF:	107331058 107331875 107342898
HMG:	100215007
TAD:	TRIADDRAFT_38469
AQU:	100632035 100636439 100638833 100638989
ATH:	AT3G10550(MTM1) AT5G04540(MTM2)
ALY:	ARALYDRAFT_317855 ARALYDRAFT_343046 ARALYDRAFT_487236
CRB:	CARUB_v10000224mg CARUB_v10013103mg
EUS:	EUTSA_v10012689mg EUTSA_v10020062mg
BRP:	103847280 103847443 103850551
BNA:	106372501 106381187 106406872 106422587 106425271 106425276 106433131 106434589
THJ:	104816452 104823194
CIT:	102608799 102627970 102628265
CIC:	CICLE_v100317281m
TCC:	18586627
GRA:	105763609 105785321
GHI:	107919767 107922039 107945436 107960317
EGR:	104421745
GMX:	100781842 100789349
PVU:	PHAVU_007G105800g
VRA:	106772055
VAR:	108326121
CCAJ:	109789435 109789438
MTR:	MTR_1g092570 MTR_1g492590
CAM:	101510463
ADU:	107466695
AIP:	107617891
LJA:	Lj5g3v1737120.1(Lj5g3v1737120.1) Lj5g3v1737130.1(Lj5g3v1737130.1)
LANG:	109336030 109340089
FVE:	101303170
PPER:	18785424
PMUM:	103331199
MDM:	103402788 103407351 103410117 103416625 103418466
PXB:	103951724
ZJU:	107413081
CSV:	101204839
CMO:	103496486
RCU:	8263587
JCU:	105648328
POP:	POPTR_0008s02720g POPTR_0010s23980g(POPTRDRAFT_228298)
VVI:	100252361
SLY:	101255550
SPEN:	107004882
SOT:	102582140
INI:	109148110
SIND:	105179696
BVG:	104906669
NNU:	104587444 104612520
OSA:	4346290
DOSA:	Os08t0556700-01(Os08g0556700)
OBR:	102706122
BDI:	100833495
ATS:	F775_09035
ZMA:	103627995 103643201
SITA:	101768844
PDA:	103723836
EGU:	105038188
MUS:	103996633
ATR:	18441473
SMO:	SELMODRAFT_437478
PPP:	PHYPADRAFT_12645 PHYPADRAFT_71628
SRE:	PTSG_09234
DDI:	DDB_G0271610 DDB_G0288731
DPP:	DICPUDRAFT_158764 DICPUDRAFT_6017 DICPUDRAFT_97178
DFA:	DFA_07597 DFA_10009
EHI:	EHI_070120(383.t00005)
EDI:	EDI_017270
EIV:	EIN_054860 EIN_065260 EIN_162560 EIN_525580
ACAN:	ACA1_000330 ACA1_015100 ACA1_054610 ACA1_062240 ACA1_066600 ACA1_066810 ACA1_070610 ACA1_070620 ACA1_088650 ACA1_194960 ACA1_214010 ACA1_367320 ACA1_367330
TET:	TTHERM_00068150
PTM:	GSPATT00016054001 GSPATT00026750001
SMIN:	v1.2.030246.t1(symbB.v1.2.030246.t1)
FCY:	FRACYDRAFT_182698
AAF:	AURANDRAFT_11784 AURANDRAFT_22249 AURANDRAFT_25339 AURANDRAFT_25625 AURANDRAFT_34751
PIF:	PITG_00440 PITG_03864 PITG_06319 PITG_06929 PITG_11157 PITG_15883 PITG_18372
PSOJ:	PHYSODRAFT_311351 PHYSODRAFT_316113 PHYSODRAFT_471429 PHYSODRAFT_481864 PHYSODRAFT_508901 PHYSODRAFT_535974 PHYSODRAFT_555387 PHYSODRAFT_558210 PHYSODRAFT_563284
SPAR:	SPRG_01841 SPRG_03597 SPRG_05166 SPRG_07559 SPRG_13066 SPRG_14635 SPRG_15527 SPRG_16905 SPRG_20770
EHX:	EMIHUDRAFT_41894
GTT:	GUITHDRAFT_75440
NGR:	NAEGRDRAFT_58398 NAEGRDRAFT_78325

Reference

PMID:12847286

Authors

Nandurkar HH, Layton M, Laporte J, Selan C, Corcoran L, Caldwell KK, Mochizuki Y, Majerus PW, Mitchell CA

Title

Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP.

Journal

Proc Natl Acad Sci U S A 100:8660-5 (2003)
DOI:10.1073/pnas.1033097100

Sequence

[hsa:8776]

All links

Ontology (5)   
   KEGG BRITE (3)   
   GO (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Gene (1013)   
   KEGG GENES (423)   
   KEGG MGENES (481)   
   RefGene (94)   
   OC (15)   
Protein sequence (185)   
   UniProt (174)   
   SWISS-PROT (11)   
Literature (1)   
   PubMed (1)   
All databases (1213)   

Download RDF

ORTHOLOGY: K18082

Entry

K18082 KO

Name

MTMR3_4, ZFYVE10_11

Definition

myotubularin-related protein 3/4 [EC:3.1.3.48 3.1.3.64 3.1.3.95]

Pathway

ko00562	Inositol phosphate metabolism
ko04070	Phosphatidylinositol signaling system
ko04140	Autophagy - animal

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K18082  MTMR3_4, ZFYVE10_11; myotubularin-related protein 3/4
Environmental Information Processing
  Signal transduction
   04070 Phosphatidylinositol signaling system
    K18082  MTMR3_4, ZFYVE10_11; myotubularin-related protein 3/4
Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    K18082  MTMR3_4, ZFYVE10_11; myotubularin-related protein 3/4
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K18082  MTMR3_4, ZFYVE10_11; myotubularin-related protein 3/4
    3.1.3.64  phosphatidylinositol-3-phosphatase
     K18082  MTMR3_4, ZFYVE10_11; myotubularin-related protein 3/4
    3.1.3.95  phosphatidylinositol-3,5-bisphosphate 3-phosphatase
     K18082  MTMR3_4, ZFYVE10_11; myotubularin-related protein 3/4
Protein phosphatases and associated proteins [BR:ko01009]
Protein Tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Myotubularins
    K18082  MTMR3_4, ZFYVE10_11; myotubularin-related protein 3/4

Other DBs

GO:

0004725 0004438 0052629

Genes

HSA:	8897(MTMR3) 9110(MTMR4)
PTR:	455157(MTMR4) 458748(MTMR3)
PPS:	100969607(MTMR3) 100988025(MTMR4)
GGO:	101133900(MTMR3) 101137563(MTMR4)
PON:	100173446(MTMR3) 100460579(MTMR4)
NLE:	100579744(MTMR4) 100597273(MTMR3)
MCC:	714621(MTMR4) 715214(MTMR3)
MCF:	102130837(MTMR3) 102134403(MTMR4)
CSAB:	103223153(MTMR3) 103242843(MTMR4)
RRO:	104659413(MTMR3) 104668437(MTMR4)
CJC:	100386598(MTMR3) 100413559(MTMR4)
SBQ:	101043320(MTMR4) 101045305(MTMR3)
MMU:	170749(Mtmr4) 74302(Mtmr3)
RNO:	287607(Mtmr4) 305482(Mtmr3)
CGE:	100750781(Mtmr3) 100753422(Mtmr4)
NGI:	103740456(Mtmr3) 103741780(Mtmr4)
HGL:	101710657(Mtmr3) 101712041(Mtmr4)
CCAN:	109696559(Mtmr4) 109697277(Mtmr3)
OCU:	100340433(MTMR4) 100341987(MTMR3)
TUP:	102476361(MTMR4) 102496235(MTMR3)
CFA:	100856311(MTMR3) 480570(MTMR4)
AML:	100472144(MTMR4) 100484172(MTMR3)
UMR:	103659251(MTMR3) 103667349(MTMR4)
FCA:	101082607(MTMR4) 101089469(MTMR3)
PTG:	102953897(MTMR4) 102965393(MTMR3)
AJU:	106985452(MTMR3) 106989945(MTMR4)
BTA:	535099(MTMR3) 782743(MTMR4)
BOM:	102268447(MTMR4) 102275751(MTMR3)
BIU:	109571113(MTMR3) 109574023(MTMR4)
PHD:	102321908(MTMR3) 102337237(MTMR4)
CHX:	102186335(MTMR4) 102187423(MTMR3)
OAS:	101105343(MTMR4) 101109302(MTMR3)
SSC:	100157292(MTMR3) 100517493(MTMR4)
CFR:	102503973(MTMR3) 102518514(MTMR4)
BACU:	103003249(MTMR3) 103003443(MTMR4)
LVE:	103084830(MTMR4) 103086469(MTMR3)
ECB:	100058825(MTMR3) 100070938(MTMR4)
MYB:	102241894(MTMR4) 102257312(MTMR3)
MYD:	102772830(MTMR4) 102773236(MTMR3)
HAI:	109379770(MTMR4) 109383054(MTMR3)
RSS:	109449759(MTMR4) 109453388(MTMR3)
PALE:	102884551(MTMR4) 102888211(MTMR3)
LAV:	100661164(MTMR4) 100662519(MTMR3)
MDO:	100012210(MTMR4) 100030849(MTMR3)
SHR:	100917511(MTMR4) 100933801(MTMR3)
OAA:	100078009(MTMR4) 100090153(MTMR3)
GGA:	417015(MTMR3) 417472(MTMR4)
MGP:	100548510(MTMR3) 100549025(MTMR4)
CJO:	107321254(MTMR3) 107322630(MTMR4)
APLA:	101793168(MTMR3) 101802164(MTMR4)
ACYG:	106041058(MTMR4) 106049047(MTMR3)
TGU:	100220519(MTMR3) 100223363(MTMR4)
GFR:	102037328(MTMR4) 102041698(MTMR3)
FAB:	101815162(MTMR4) 101816909(MTMR3)
PHI:	102101780(MTMR4) 102110973(MTMR3)
CCW:	104695032(MTMR3) 104695802(MTMR4)
FPG:	101911214(MTMR4) 101915031(MTMR3)
FCH:	102049664(MTMR3) 102060136(MTMR4)
CLV:	102094353(MTMR3) 102097791(MTMR4)
AAM:	106484674(MTMR4) 106494532(MTMR3)
ASN:	102368917(MTMR3) 102372670(MTMR4)
AMJ:	102565909(MTMR3) 102573738(MTMR4)
PSS:	102443507(MTMR4) 102444511(MTMR3)
CMY:	102934887(MTMR4) 102945904
CPIC:	101939749(MTMR3) 101951257(MTMR4)
ACS:	100567629 103282853
PBI:	103054857(MTMR3) 103061439(MTMR4)
GJA:	107112431(MTMR4) 107122295(MTMR3)
XLA:	108705035 108709322(mtmr4.S) 379701(mtmr3) 379965(mtmr4.L) 494749(mtmr3.L)
XTR:	100151726(mtmr4) 100494490(mtmr3)
NPR:	108786260(MTMR3) 108790885(MTMR4)
DRE:	100333801 393584(mtmr4) 393838(mtmr3)
SRX:	107715150 107715154 107719345 107734350(mtmr4) 107734413 107735898 107743064 107745942 107754413
SANH:	107654282(mtmr4) 107666797 107671008 107691163 107698017 107699659
SGH:	107552187 107553046(mtmr3) 107563431(mtmr4) 107563440 107577910 107591495
IPU:	108260270 108260292(mtmr4) 108265535(mtmr3)
TRU:	101072360(mtmr3) 101074389 101078028
TNG:	GSTEN00016272G001 GSTEN00021609G001
LCO:	104926364(mtmr3) 104928772(mtmr4)
NCC:	104949319(mtmr4) 104956632
MZE:	101478413(mtmr4) 101480346(mtmr3)
OLA:	101168809(mtmr4) 101170277(mtmr3)
XMA:	102230461(mtmr3) 102232025(mtmr4)
CSEM:	103395170(mtmr4) 103397032 103397431
LCF:	108878266(mtmr3) 108893658(mtmr4)
SASA:	106567397(mtmr4) 106579950 106585478 106603952 106603956
ELS:	105014193(mtmr3) 106023667(mtmr4)
SFM:	108921496(mtmr4) 108921909 108932977
LCM:	102352617(MTMR3) 102364350(MTMR4)
CMK:	103180496(mtmr4) 103184352(mtmr3)
BFO:	BRAFLDRAFT_219160
SPU:	585727
SKO:	100371745
DME:	Dmel_CG3632
DPO:	Dpse_GA22870
DAN:	Dana_GF19035
DER:	Dere_GG17949
DPE:	Dper_GL21339
DSE:	Dsec_GM13419
DSI:	Dsimw501_GD17273(Dsim_GD17273)
DWI:	Dwil_GK25720
DYA:	Dyak_GE11013
DGR:	Dgri_GH12561
DMO:	Dmoj_GI11214
DVI:	Dvir_GJ18508
MDE:	101897750
AGA:	AgaP_AGAP001604
AAG:	AaeL_AAEL000564
CQU:	CpipJ_CPIJ007313
AME:	413663
BIM:	100747122
BTER:	100642665
SOC:	105199451
AEC:	105154153
ACEP:	105622789 105625373
PBAR:	105424785
HST:	105187983
CFO:	105256703
LHU:	105673649
NVI:	100116110
TCA:	657269
DPA:	109533697
NVL:	108556797
BMOR:	101740354
PXY:	105380596
API:	100167896
DNX:	107161735
PHU:	Phum_PHUM607650 Phum_PHUM607660
DPX:	DAPPUDRAFT_226406
ISC:	IscW_ISCW014883 IscW_ISCW014885
TUT:	107364009
CEL:	CELE_T24A11.1(mtm-3)
CBR:	CBG09227(Cbr-mtm-3)
NAI:	NECAME_03521 NECAME_14201
BMY:	Bm1_08130
LOA:	LOAG_18267
TSP:	Tsp_14073
HRO:	HELRODRAFT_62273
LGI:	LOTGIDRAFT_81473
CRG:	105321837
OBI:	106875841
OVI:	T265_12726
NVE:	NEMVE_v1g20426
ADF:	107351736
HMG:	101236024
TAD:	TRIADDRAFT_64213
AQU:	100640426
NGD:	NGA_0134600

Reference

PMID:11676921

Authors

Walker DM, Urbe S, Dove SK, Tenza D, Raposo G, Clague MJ

Title

Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity.

Journal

Curr Biol 11:1600-5 (2001)
DOI:10.1016/S0960-9822(01)00501-2

Sequence

[hsa:8897]

Reference

PMID:11302699

Authors

Zhao R, Qi Y, Chen J, Zhao ZJ

Title

FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate.

Journal

Exp Cell Res 265:329-38 (2001)
DOI:10.1006/excr.2001.5185

Sequence

[hsa:9110]

All links

Ontology (6)   
   KEGG BRITE (3)   
   GO (3)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical reaction (3)   
   KEGG ENZYME (3)   
Gene (901)   
   KEGG GENES (268)   
   KEGG MGENES (540)   
   RefGene (88)   
   OC (5)   
Protein sequence (74)   
   UniProt (68)   
   SWISS-PROT (6)   
Literature (2)   
   PubMed (2)   
All databases (994)   

Download RDF

ORTHOLOGY: K18083

Entry

K18083 KO

Name

MTMR6_7_8

Definition

myotubularin-related protein 6/7/8 [EC:3.1.3.64 3.1.3.95]

Pathway

ko00562	Inositol phosphate metabolism
ko04070	Phosphatidylinositol signaling system
ko04138	Autophagy - yeast

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K18083  MTMR6_7_8; myotubularin-related protein 6/7/8
Environmental Information Processing
  Signal transduction
   04070 Phosphatidylinositol signaling system
    K18083  MTMR6_7_8; myotubularin-related protein 6/7/8
Cellular Processes
  Transport and catabolism
   04138 Autophagy - yeast
    K18083  MTMR6_7_8; myotubularin-related protein 6/7/8
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.64  phosphatidylinositol-3-phosphatase
     K18083  MTMR6_7_8; myotubularin-related protein 6/7/8
    3.1.3.95  phosphatidylinositol-3,5-bisphosphate 3-phosphatase
     K18083  MTMR6_7_8; myotubularin-related protein 6/7/8
Protein phosphatases and associated proteins [BR:ko01009]
Protein Tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Myotubularins
    K18083  MTMR6_7_8; myotubularin-related protein 6/7/8

Other DBs

GO:

Genes

HSA:	55613(MTMR8) 9107(MTMR6) 9108(MTMR7)
PTR:	452496(MTMR6) 464007(MTMR7) 465670(MTMR8)
PPS:	100968047(MTMR7) 100984785(MTMR8) 100987222(MTMR6)
GGO:	101127088(MTMR6) 101130652(MTMR8) 101144360(MTMR7) 109025484
PON:	100173546(MTMR7) 100173697(MTMR6) 100451447(MTMR8)
NLE:	100583868(MTMR6) 100597684(MTMR8) 100605375(MTMR7)
MCC:	708037(MTMR8) 709118(MTMR6) 710278(MTMR7)
MCF:	102125803(MTMR6) 102137742(MTMR8) 102141092(MTMR7)
CSAB:	103215386(MTMR7) 103232084(MTMR8) 103249032(MTMR6)
RRO:	104659978(MTMR6) 104670768 104671073(MTMR7) 104673822
CJC:	100385223(MTMR6) 100394595(MTMR8) 100414691(MTMR7)
SBQ:	101035968(MTMR8) 101041030(MTMR7) 101044757(MTMR6)
MMU:	219135(Mtmr6) 54384(Mtmr7)
RNO:	305935(Mtmr6) 306490(Mtmr7)
CGE:	100751422(Mtmr7) 100766683(Mtmr6)
NGI:	103727180(Mtmr6) 103743276(Mtmr7)
HGL:	101697627(Mtmr8) 101699227(Mtmr7) 101723145(Mtmr6)
CCAN:	109675599 109695560(Mtmr6) 109698044(Mtmr7)
OCU:	100338397(MTMR6) 100339959(MTMR7) 100355823(MTMR8)
TUP:	102495236(MTMR6) 102497246(MTMR7)
CFA:	475612(MTMR7) 477336(MTMR6)
AML:	100467164(MTMR6) 100473804(MTMR7)
UMR:	103664301(MTMR6) 103681375(MTMR7)
FCA:	101080528(MTMR7) 101085092(MTMR6)
PTG:	102960384(MTMR6) 102964903(MTMR7)
AJU:	106972637(MTMR7) 106983162(MTMR8) 106988930(MTMR6)
BTA:	104968449(MTMR8) 513986(MTMR7) 540589(MTMR6)
BOM:	102271970(MTMR8) 102280070(MTMR6) 102286699(MTMR7)
BIU:	109553417(MTMR7) 109555533(MTMR8) 109567042(MTMR6)
PHD:	102317432(MTMR8) 102323352(MTMR7) 102334673(MTMR6)
CHX:	102170298(MTMR7) 102177151(MTMR8) 102191808(MTMR6) 108634298
OAS:	101104812(MTMR8) 101111072(MTMR7) 101116065(MTMR6)
SSC:	100514555(MTMR8) 100516469(MTMR7)
CFR:	102506862(MTMR6) 102521704(MTMR8) 102522961(MTMR7)
BACU:	102999465(MTMR6) 103001617(MTMR8) 103010746(MTMR7)
LVE:	103079655(MTMR8) 103085136(MTMR6) 103089545(MTMR7)
ECB:	100053655(MTMR7) 100054675(MTMR8) 100058883(MTMR6)
MYB:	102252475(MTMR6) 102256368(MTMR8) 102260492(MTMR7)
MYD:	102754942(MTMR6) 102771673(MTMR7)
HAI:	109387515(MTMR6) 109390071(MTMR8) 109394579(MTMR7)
RSS:	109438790 109449860(MTMR6) 109450544(MTMR7)
PALE:	102887092(MTMR7) 102894255(MTMR6) 102896812(MTMR8)
LAV:	100657643(MTMR7) 100664954(MTMR6) 100673681(MTMR8)
MDO:	100021656(MTMR7) 100024556(MTMR6) 100028310(MTMR8)
SHR:	100922040(MTMR6) 100928660(MTMR7) 100929880(MTMR8)
OAA:	100090086(MTMR6)
GGA:	418938(MTMR6) 422312(MTMR8) 422731(MTMR7)
MGP:	100547050(MTMR6) 100547739(MTMR8) 100551000
CJO:	107308302(MTMR6) 107312838(MTMR8) 107313730(MTMR7)
APLA:	101792832(MTMR8) 101799934(MTMR6) 101805213(MTMR7)
ACYG:	106035123(MTMR7) 106040394(MTMR6) 106047494(MTMR8)
TGU:	100219323(MTMR7) 100227284(MTMR6) 100231272(MTMR8)
GFR:	102032136(MTMR8) 102041380(MTMR6) 102044715(MTMR7)
FAB:	101811909(MTMR8) 101812336(MTMR6) 101821855(MTMR7)
PHI:	102102606(MTMR7) 102104801(MTMR6) 102108094(MTMR8)
CCW:	104690010(MTMR6) 104690603(MTMR7) 104691604(MTMR8)
FPG:	101911389(MTMR8) 101912718(MTMR6) 101916945(MTMR7)
FCH:	102046191(MTMR7) 102046774(MTMR8) 102050829(MTMR6)
CLV:	102084511(MTMR7) 102084631(MTMR8) 102093428(MTMR6)
AAM:	106489827(MTMR8) 106490077(MTMR7) 106500434(MTMR6)
ASN:	102368884(MTMR8) 102380372(MTMR7) 102380613(MTMR6)
AMJ:	102564229(MTMR7) 102574139(MTMR8) 106736685(MTMR6)
PSS:	102443874(MTMR8) 102450271(MTMR7) 102451171(MTMR6)
CMY:	102930575(MTMR7) 102931303(MTMR8) 102931382(MTMR6)
CPIC:	101932567(MTMR6) 101948247(MTMR7) 101949926(MTMR8)
ACS:	100553091(mtmr8) 100554881(mtmr7) 100556135(mtmr6)
PBI:	103049623(MTMR6) 103051409(MTMR7) 103056450(MTMR8)
GJA:	107106958(MTMR8) 107108733(MTMR7) 107117269(MTMR6)
XLA:	108698369 108698621 108706606 108706607 108708714(mtmr6.L)
XTR:	100485851(mtmr7) 100489239(mtmr8) 100497758(mtmr6)
NPR:	108785687(MTMR7) 108789931(MTMR8) 108794125 108795176(MTMR6)
DRE:	327346(mtmr6) 393365(mtmr8) 559198(mtmr7b) 678558(mtmr7a)
SRX:	107705267 107707226 107721424 107721921 107722025 107741196 107746239 107747392 107751936
SANH:	107656498 107658049 107661412 107663233 107663672(mtmr6) 107672736 107682766 107682777 107702332
SGH:	107554389 107557114 107561341 107562927 107565722 107578176 107586719 107590218 107597259
IPU:	108256582(mtmr6) 108260298(mtmr8) 108260771(mtmr7) 108268392(MTMR7)
TRU:	101071974 101074636(mtmr6) 101077117(mtmr7)
TNG:	GSTEN00007051G001 GSTEN00010499G001
LCO:	104917798 104920586(mtmr7) 104933246(mtmr6)
NCC:	104946356(mtmr7) 104951661 104951663 104955011 104956392
MZE:	101465793 101479475(mtmr7) 101486188(mtmr6)
OLA:	101157342 101161735 101165600(mtmr6)
XMA:	102227567 102229271(mtmr7) 102231068(mtmr6)
CSEM:	103376906(mtmr6) 103384313 103391312
LCF:	108882734(mtmr7) 108900794(mtmr6)
SASA:	100380604(mtmr6) 106590572 106590584 106602191 106603315 106610400 106610403 106612032
ELS:	105006454(mtmr8) 105021026 105025643(mtmr6) 105026550(mtmr7)
SFM:	108919961 108924598(mtmr7) 108939546
LCM:	102350800(MTMR7) 102357589(MTMR6) 102367128(MTMR8)
CMK:	103178229(mtmr7) 103178658(mtmr8) 103183266(mtmr6)
BFO:	BRAFLDRAFT_128725
CIN:	100186111
SPU:	585290
SKO:	100370630
DME:	Dmel_CG3530
DPO:	Dpse_GA17504
DAN:	Dana_GF11853
DER:	Dere_GG20035
DPE:	Dper_GL17566
DSE:	Dsec_GM13033 Dsec_GM15548
DSI:	Dsimw501_GD25052(Dsim_GD25052)
DWI:	Dwil_GK23060
DYA:	Dyak_GE11572
DGR:	Dgri_GH20661
DMO:	Dmoj_GI19024
DVI:	Dvir_GJ19990
MDE:	101898537
AGA:	AgaP_AGAP005341
AAG:	AaeL_AAEL003083
CQU:	CpipJ_CPIJ000006
AME:	727030
BIM:	100749527
BTER:	100643350
SOC:	105199109
AEC:	105150652
ACEP:	105617255
PBAR:	105433477
HST:	105182249
CFO:	105251389
LHU:	105668290
NVI:	100121701
TCA:	662636
DPA:	109540393
NVL:	108568061
BMOR:	101736509
PXY:	105384814 105398233 105398235
API:	100169408
DNX:	107169027
PHU:	Phum_PHUM060700
DPX:	DAPPUDRAFT_316434
ISC:	IscW_ISCW018501
TUT:	107360724
CEL:	CELE_F53A2.8(mtm-6)
CBR:	CBG24732(Cbr-mtm-6)
NAI:	NECAME_12087
BMY:	Bm1_06990
LOA:	LOAG_17492
TSP:	Tsp_01469
HRO:	HELRODRAFT_91412
LGI:	LOTGIDRAFT_125960
CRG:	105318437
OBI:	106880692
SMM:	Smp_180520
OVI:	T265_09881
NVE:	NEMVE_v1g235730
ADF:	107330184 107355402
HMG:	100205727(mtmr6)
TAD:	TRIADDRAFT_34687 TRIADDRAFT_56124
AQU:	100640623
SCE:	YJR110W(YMR1)
AGO:	AGOS_ABR152C
ERC:	Ecym_7181
KLA:	KLLA0E05853g
LTH:	KLTH0E01584g
VPO:	Kpol_1013p67
ZRO:	ZYRO0G18062g
CGR:	CAGL0C04895g
NCS:	NCAS_0H00430(NCAS0H00430)
NDI:	NDAI_0D00380(NDAI0D00380)
TPF:	TPHA_0I02940(TPHA0I02940)
TBL:	TBLA_0F02770(TBLA0F02770)
TDL:	TDEL_0C03540(TDEL0C03540)
PPA:	PAS_chr3_0354
DHA:	DEHA2B10802g
PIC:	PICST_82137(YMR1)
PGU:	PGUG_01706
SPAA:	SPAPADRAFT_139029
LEL:	LELG_00433
CAL:	CAALFM_C108860CA(CaO19.4744)
CTP:	CTRG_03237
COT:	CORT_0A05240
CDU:	CD36_08360
CTEN:	CANTEDRAFT_123868
YLI:	YALI0E23738g
CLU:	CLUG_00819
CAUR:	QG37_06929
NCR:	NCU11185
NTE:	NEUTE1DRAFT82509(NEUTE1DRAFT_82509)
SMP:	SMAC_01920
PAN:	PODANSg5062
TTT:	THITE_2118463
MTM:	MYCTH_101588
CTHR:	CTHT_0026370
MGR:	MGG_16443
TMN:	UCRPA7_6354
FGR:	FGSG_05432
FPU:	FPSE_03575
FVR:	FVEG_07095
FOX:	FOXG_09466
NHE:	NECHADRAFT_95611
TRE:	TRIREDRAFT_119854
MAW:	MAC_08346
MAJ:	MAA_03578
CMT:	CCM_07402
VAL:	VDBG_08718
VDA:	VDAG_06379
CFJ:	CFIO01_03337
ELA:	UCREL1_8935
PFY:	PFICI_12960
SSL:	SS1G_07121
BFU:	BC1G_10190
MBE:	MBM_02151
PSCO:	LY89DRAFT_622607
GLZ:	GLAREA_07605
AFM:	AFUA_1G05640
AOR:	AOR_1_620184(AO090009000376)
ANG:	ANI_1_424164(An18g03320)
AFV:	AFLA_050960
ACT:	ACLA_028990
NFI:	NFIA_019110
PCS:	Pc18g02100
PDP:	PDIP_73810
CIM:	CIMG_03902
CPW:	CPC735_004420
PBL:	PAAG_01784
PBN:	PADG_01408
ABE:	ARB_05638
TVE:	TRV_05539
AJE:	HCAG_00213
PNO:	SNOG_11728
PTE:	PTT_07513
BZE:	COCCADRAFT_37906
BSC:	COCSADRAFT_98941
BOR:	COCMIDRAFT_23430
ZTR:	MYCGRDRAFT_21242
PFJ:	MYCFIDRAFT_127850
BCOM:	BAUCODRAFT_34931
NPA:	UCRNP2_1762
SPO:	SPAC19A8.03
CNE:	CNA03790
CNB:	CNBA3590
CGI:	CGB_A3520W
TMS:	TREMEDRAFT_70913
TVS:	TRAVEDRAFT_165027
DSQ:	DICSQDRAFT_98235
PCO:	PHACADRAFT_208612
SHS:	STEHIDRAFT_73786
HIR:	HETIRDRAFT_457720
PSQ:	PUNSTDRAFT_89339
ADL:	AURDEDRAFT_152237
FME:	FOMMEDRAFT_118876
GTR:	GLOTRDRAFT_114539
LBC:	LACBIDRAFT_143319
MRR:	Moror_10782
CCI:	CC1G_01220
SCM:	SCHCODRAFT_81454
ABP:	AGABI1DRAFT52558(AGABI1DRAFT_52558)
ABV:	AGABI2DRAFT215827(AGABI2DRAFT_215827)
CPUT:	CONPUDRAFT_97388
SLA:	SERLADRAFT_357783
WSE:	WALSEDRAFT_60201
WIC:	J056_004627
UMA:	UMAG_05646
PFP:	PFL1_06624
MGL:	MGL_2222
PGR:	PGTG_11730
MLR:	MELLADRAFT_40285
SRE:	PTSG_01664
EIV:	EIN_398190

Reference

PMID:16847315

Authors

Srivastava S, Ko K, Choudhury P, Li Z, Johnson AK, Nadkarni V, Unutmaz D, Coetzee WA, Skolnik EY

Title

Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells.

Journal

Mol Cell Biol 26:5595-602 (2006)
DOI:10.1128/MCB.00352-06

Sequence

[hsa:9107]

All links

Ontology (5)   
   KEGG BRITE (3)   
   GO (2)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Gene (740)   
   KEGG GENES (462)   
   KEGG MGENES (222)   
   RefGene (46)   
   OC (10)   
Protein sequence (195)   
   UniProt (184)   
   SWISS-PROT (11)   
Literature (1)   
   PubMed (1)   
All databases (951)   

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ORTHOLOGY: K18086

Entry

K18086 KO

Name

MTMR14

Definition

myotubularin-related protein 14 [EC:3.1.3.64 3.1.3.95]

Pathway

ko00562	Inositol phosphate metabolism
ko04070	Phosphatidylinositol signaling system
ko04140	Autophagy - animal

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K18086  MTMR14; myotubularin-related protein 14
Environmental Information Processing
  Signal transduction
   04070 Phosphatidylinositol signaling system
    K18086  MTMR14; myotubularin-related protein 14
Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    K18086  MTMR14; myotubularin-related protein 14
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.64  phosphatidylinositol-3-phosphatase
     K18086  MTMR14; myotubularin-related protein 14
    3.1.3.95  phosphatidylinositol-3,5-bisphosphate 3-phosphatase
     K18086  MTMR14; myotubularin-related protein 14
Protein phosphatases and associated proteins [BR:ko01009]
Protein Tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Myotubularins
    K18086  MTMR14; myotubularin-related protein 14

Other DBs

GO:

Genes

HSA:	64419(MTMR14)
PTR:	460149(MTMR14)
PPS:	100991819(MTMR14)
GGO:	101134886(MTMR14)
PON:	100435473(MTMR14)
NLE:	100594364(MTMR14)
MCC:	703936(MTMR14)
MCF:	102143610(MTMR14)
CSAB:	103227971(MTMR14)
RRO:	104667167(MTMR14)
CJC:	100397575(MTMR14)
SBQ:	101045778(MTMR14)
MMU:	97287(Mtmr14)
RNO:	312634(Mtmr14)
CGE:	100754286(Mtmr14)
NGI:	103751415(Mtmr14)
HGL:	101724817(Mtmr14)
CCAN:	109686991(Mtmr14)
OCU:	100348191(MTMR14)
TUP:	102488403(MTMR14)
CFA:	484668(MTMR14)
AML:	100474479(MTMR14)
UMR:	103669649(MTMR14)
FCA:	101083154(MTMR14)
PTG:	102971939(MTMR14)
AJU:	106972336(MTMR14)
BTA:	514596(MTMR14)
BOM:	102269780(MTMR14)
BIU:	109576236(MTMR14)
PHD:	102321531(MTMR14)
CHX:	102184563(MTMR14)
OAS:	101102342(MTMR14)
SSC:	100157480(MTMR14)
CFR:	102519969(MTMR14)
BACU:	103020754(MTMR14)
LVE:	103073483(MTMR14)
ECB:	100058531(MTMR14)
MYB:	102256907(MTMR14)
MYD:	102767087(MTMR14)
HAI:	109387291(MTMR14)
RSS:	109456171(MTMR14)
PALE:	102882988(MTMR14)
LAV:	100658106(MTMR14)
MDO:	100014047(MTMR14)
SHR:	100928957(MTMR14)
OAA:	100075535(MTMR14)
GGA:	416048(MTMR14)
MGP:	100542441(MTMR14)
CJO:	107319801(MTMR14)
APLA:	101800837(MTMR14)
ACYG:	106045072(MTMR14)
TGU:	100224025(MTMR14)
GFR:	102041338(MTMR14)
FAB:	101807592(MTMR14)
PHI:	102106615(MTMR14)
CCW:	104683318(MTMR14)
FPG:	101911308(MTMR14)
FCH:	102059156(MTMR14)
CLV:	102095343(MTMR14)
AAM:	106498998(MTMR14)
ASN:	102370505(MTMR14)
AMJ:	102568445(MTMR14)
PSS:	102446720 102462566
CMY:	102939454(MTMR14)
CPIC:	101940028(MTMR14)
ACS:	100554543(mtmr14)
PBI:	103068280(MTMR14)
GJA:	107111938 107119095
XLA:	734951(mtmr14.S)
XTR:	100036693(mtmr14)
NPR:	108788242(MTMR14)
DRE:	323929(mtmr14)
SRX:	107710166 107716897
SANH:	107688805(mtmr14) 107691493 107694900
SGH:	107569464 107586366
IPU:	108272090(mtmr14)
TRU:	101077753(mtmr14)
TNG:	GSTEN00004651G001
LCO:	104934550(mtmr14)
NCC:	104945404(mtmr14)
MZE:	101477870(mtmr14)
OLA:	105354120(mtmr14)
XMA:	102221740(mtmr14)
CSEM:	103386626(mtmr14)
LCF:	108877482(mtmr14) 108879963 108880075
SASA:	106565250(mtmr14) 106583633 106596434 106596691
ELS:	105024794(mtmr14)
SFM:	108918301(mtmr14)
LCM:	102360413(MTMR14)
CMK:	103176603(mtmr14)
BFO:	BRAFLDRAFT_87681
CIN:	100186380
SPU:	577354
SKO:	102808735
DME:	Dmel_CG6542(EDTP)
DPO:	Dpse_GA19672
DAN:	Dana_GF11784
DER:	Dere_GG22197
DPE:	Dper_GL10664
DSE:	Dsec_GM19983
DSI:	Dsimw501_GD25480(Dsim_GD25480)
DWI:	Dwil_GK23304
DYA:	Dyak_GE14194
DGR:	Dgri_GH20487
DMO:	Dmoj_GI21030
DVI:	Dvir_GJ21957
MDE:	101901021
AGA:	AgaP_AGAP009826
AAG:	AaeL_AAEL002370
CQU:	CpipJ_CPIJ000895
AME:	413411(EDTP)
BIM:	100746416
BTER:	100642640
SOC:	105197704
AEC:	105152363
ACEP:	105626425
PBAR:	105431463
HST:	105187884
CFO:	105255945
LHU:	105667801
NVI:	100120254
DPA:	109537168
NVL:	108558935
API:	100163933
DNX:	107169000
ISC:	IscW_ISCW018312
HRO:	HELRODRAFT_190283
LGI:	LOTGIDRAFT_173287
CRG:	105345000
OBI:	106871204
SMM:	Smp_075440.1 Smp_075440.3
OVI:	T265_08371
NVE:	NEMVE_v1g50340
ADF:	107330431 107342002
TAD:	TRIADDRAFT_52465
AQU:	100641184
MBR:	MONBRDRAFT_21963
SRE:	PTSG_05869
DDI:	DDB_G0289807
DPP:	DICPUDRAFT_153793
DFA:	DFA_02288
ACAN:	ACA1_389600

Reference

PMID:20595810

Authors

Gibbs EM, Feldman EL, Dowling JJ

Title

The role of MTMR14 in autophagy and in muscle disease.

Journal

Autophagy 6:819-20 (2010)
DOI:10.4161/auto.6.6.12624

Sequence

[hsa:64419] [dre:323929]

Reference

PMID:17008356

Authors

Tosch V, Rohde HM, Tronchere H, Zanoteli E, Monroy N, Kretz C, Dondaine N, Payrastre B, Mandel JL, Laporte J

Title

A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy.

Journal

Hum Mol Genet 15:3098-106 (2006)
DOI:10.1093/hmg/ddl250

Sequence

[hsa:64419]

All links

Ontology (5)   
   KEGG BRITE (3)   
   GO (2)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Gene (384)   
   KEGG GENES (155)   
   KEGG MGENES (198)   
   RefGene (28)   
   OC (3)   
Protein sequence (56)   
   UniProt (54)   
   SWISS-PROT (2)   
Literature (2)   
   PubMed (2)   
All databases (457)   

Download RDF

ENZYME: 3.1.3.95

Entry

EC 3.1.3.95 Enzyme

Name

phosphatidylinositol-3,5-bisphosphate 3-phosphatase;
MTMR;
PtdIns-3,5-P2 3-Ptase

Class

Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases

Sysname

1-phosphatidyl-1D-myo-inositol-3,5-bisphosphate 3-phosphohydrolase

Reaction(IUBMB)

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate [RN:R10928]

Reaction(KEGG)

R10928

Substrate

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [CPD:C11556];
H2O [CPD:C00001]

Product

1-phosphatidyl-1D-myo-inositol 5-phosphate [CPD:C11557];
phosphate [CPD:C00009]

Comment

The enzyme is found in both plants and animals. It also has the activity of EC 3.1.3.64 (phosphatidylinositol-3-phosphatase).

History

EC 3.1.3.95 created 2014

Pathway

ec00562

Inositol phosphate metabolism

Orthology

K01108	myotubularin
K18081	myotubularin-related protein 1/2
K18082	myotubularin-related protein 3/4
K18083	myotubularin-related protein 6/7/8
K18086	myotubularin-related protein 14

Genes

HSA:	4534(MTM1) 55613(MTMR8) 64419(MTMR14) 8776(MTMR1) 8897(MTMR3) 8898(MTMR2) 9107(MTMR6) 9108(MTMR7) 9110(MTMR4)
PTR:	451498(MTMR2) 452496(MTMR6) 455157(MTMR4) 458748(MTMR3) 460149(MTMR14) 464007(MTMR7) 465670(MTMR8) 465904(MTM1) 465905(MTMR1)
PPS:	100968047(MTMR7) 100969607(MTMR3) 100969994(MTMR1) 100977094(MTMR2) 100984785(MTMR8) 100987222(MTMR6) 100988025(MTMR4) 100991819(MTMR14) 100995776(MTM1)
GGO:	101127088(MTMR6) 101127158(MTM1) 101127773(MTMR1) 101130652(MTMR8) 101133900(MTMR3) 101134886(MTMR14) 101137563(MTMR4) 101144360(MTMR7) 101149089(MTMR2) 109025484
PON:	100173446(MTMR3) 100173546(MTMR7) 100173697(MTMR6) 100174264(MTMR2) 100174495(MTM1) 100435473(MTMR14) 100443993(MTMR1) 100450380 100451447(MTMR8) 100460579(MTMR4)
NLE:	100579744(MTMR4) 100583868(MTMR6) 100587311(MTM1) 100587643(MTMR1) 100594364(MTMR14) 100597273(MTMR3) 100597684(MTMR8) 100601635(MTMR2) 100605375(MTMR7)
MCC:	699703(MTMR2) 703131(MTM1) 703936(MTMR14) 708037(MTMR8) 708892(MTMR1) 709118(MTMR6) 710278(MTMR7) 714621(MTMR4) 715214(MTMR3)
MCF:	101866399(MTMR2) 101925490(MTMR1) 102117369(MTM1) 102125803(MTMR6) 102130837(MTMR3) 102134403(MTMR4) 102137742(MTMR8) 102141092(MTMR7) 102143610(MTMR14)
CSAB:	103215386(MTMR7) 103223153(MTMR3) 103227971(MTMR14) 103232084(MTMR8) 103232739(MTM1) 103232740(MTMR1) 103242843(MTMR4) 103248282(MTMR2) 103249032(MTMR6)
RRO:	104659413(MTMR3) 104659978(MTMR6) 104663196(MTMR1) 104663197(MTM1) 104667167(MTMR14) 104668437(MTMR4) 104670768 104671073(MTMR7) 104671805(MTMR2) 104673822
CJC:	100385223(MTMR6) 100386598(MTMR3) 100387480(MTM1) 100388332(MTMR1) 100394595(MTMR8) 100397575(MTMR14) 100404569(MTMR2) 100413559(MTMR4) 100414691(MTMR7)
SBQ:	101034305(MTM1) 101034908(MTMR2) 101035968(MTMR8) 101038633(MTMR1) 101041030(MTMR7) 101043320(MTMR4) 101044757(MTMR6) 101045305(MTMR3) 101045778(MTMR14)
MMU:	170749(Mtmr4) 17772(Mtm1) 219135(Mtmr6) 53332(Mtmr1) 54384(Mtmr7) 74302(Mtmr3) 77116(Mtmr2) 97287(Mtmr14)
RNO:	287607(Mtmr4) 288762(Mtm1) 305482(Mtmr3) 305935(Mtmr6) 306490(Mtmr7) 312634(Mtmr14) 315422(Mtmr2) 317296(Mtmr1)
CGE:	100750781(Mtmr3) 100751422(Mtmr7) 100753422(Mtmr4) 100754286(Mtmr14) 100761567 100762316(Mtmr2) 100766683(Mtmr6) 100770104(Mtmr1) 107980426(Mtm1)
NGI:	103727180(Mtmr6) 103731164(Mtm1) 103731165(Mtmr1) 103740456(Mtmr3) 103741780(Mtmr4) 103743276(Mtmr7) 103748247(Mtmr2) 103751415(Mtmr14)
HGL:	101697627(Mtmr8) 101698768(Mtm1) 101699227(Mtmr7) 101699372(Mtmr1) 101710657(Mtmr3) 101712041(Mtmr4) 101718842(Mtmr2) 101723145(Mtmr6) 101724817(Mtmr14)
CCAN:	109675599 109686991(Mtmr14) 109688151 109688153(Mtmr1) 109695560(Mtmr6) 109696559(Mtmr4) 109697277(Mtmr3) 109698044(Mtmr7) 109699464(Mtmr2) 109700327(Mtm1)
OCU:	100338397(MTMR6) 100339959(MTMR7) 100340433(MTMR4) 100341987(MTMR3) 100348191(MTMR14) 100350857(MTM1) 100352381(MTMR2) 100354324(MTMR1) 100355823(MTMR8)
TUP:	102476361(MTMR4) 102488403(MTMR14) 102495236(MTMR6) 102496235(MTMR3) 102497246(MTMR7) 102497909(MTMR2) 102499371(MTMR1) 102501573(MTM1)
CFA:	100856311(MTMR3) 475612(MTMR7) 477336(MTMR6) 480570(MTMR4) 484668(MTMR14) 492211(MTMR1) 606918(MTMR2) 612385(MTM1)
AML:	100467164(MTMR6) 100470028(MTMR1) 100470283(MTM1) 100472144(MTMR4) 100473804(MTMR7) 100473901(MTMR2) 100474479(MTMR14) 100484172(MTMR3)
UMR:	103659251(MTMR3) 103660720(MTMR2) 103662562(MTM1) 103662580(MTMR1) 103664301(MTMR6) 103667349(MTMR4) 103669649(MTMR14) 103681375(MTMR7)
FCA:	101080478(MTMR2) 101080528(MTMR7) 101082607(MTMR4) 101083154(MTMR14) 101085092(MTMR6) 101089469(MTMR3) 101093757(MTM1) 101098208(MTMR1)
PTG:	102949457(MTM1) 102949757(MTMR1) 102953897(MTMR4) 102960384(MTMR6) 102964903(MTMR7) 102965393(MTMR3) 102968938(MTMR2) 102971939(MTMR14)
AJU:	106970759(MTMR2) 106972336(MTMR14) 106972637(MTMR7) 106983162(MTMR8) 106985452(MTMR3) 106985747(MTM1) 106985749(MTMR1) 106988930(MTMR6) 106989945(MTMR4)
BTA:	104968449(MTMR8) 513986(MTMR7) 514596(MTMR14) 533622(MTM1) 535099(MTMR3) 536810(MTMR2) 540589(MTMR6) 541155(MTMR1) 782743(MTMR4)
BOM:	102268447(MTMR4) 102269780(MTMR14) 102271970(MTMR8) 102272519(MTMR1) 102272810(MTM1) 102275751(MTMR3) 102280070(MTMR6) 102282843(MTMR2) 102286699(MTMR7)
BIU:	109553417(MTMR7) 109555122(MTMR1) 109555381(MTM1) 109555533(MTMR8) 109567042(MTMR6) 109569725(MTMR2) 109571113(MTMR3) 109574023(MTMR4) 109576236(MTMR14)
PHD:	102317432(MTMR8) 102318197(MTMR2) 102321531(MTMR14) 102321908(MTMR3) 102323352(MTMR7) 102323553(MTM1) 102323899(MTMR1) 102334673(MTMR6) 102337237(MTMR4)
CHX:	102168613(MTMR1) 102170298(MTMR7) 102177151(MTMR8) 102180779(MTMR2) 102184563(MTMR14) 102186335(MTMR4) 102187423(MTMR3) 102191778(MTM1) 102191808(MTMR6) 108634298
OAS:	101102342(MTMR14) 101104812(MTMR8) 101105343(MTMR4) 101107677(MTMR1) 101109302(MTMR3) 101111072(MTMR7) 101114846(MTM1) 101116065(MTMR6) 101123404(MTMR2)
SSC:	100157292(MTMR3) 100157480(MTMR14) 100514555(MTMR8) 100516469(MTMR7) 100516892(MTM1) 100517258(MTMR1) 100517493(MTMR4) 100518140(MTMR2)
CFR:	102503973(MTMR3) 102506862(MTMR6) 102512516(MTM1) 102512989(MTMR1) 102518514(MTMR4) 102519969(MTMR14) 102521416(MTMR2) 102521704(MTMR8) 102522961(MTMR7)
BACU:	102999465(MTMR6) 103000889(MTMR2) 103001571(MTM1) 103001617(MTMR8) 103001831(MTMR1) 103003249(MTMR3) 103003443(MTMR4) 103010746(MTMR7) 103020754(MTMR14)
LVE:	103073483(MTMR14) 103078352(MTMR2) 103079655(MTMR8) 103082658(MTM1) 103083116(MTMR1) 103084830(MTMR4) 103085136(MTMR6) 103086469(MTMR3) 103089545(MTMR7)
ECB:	100053655(MTMR7) 100054675(MTMR8) 100058531(MTMR14) 100058825(MTMR3) 100058883(MTMR6) 100067900(MTMR2) 100069653(MTMR1) 100069680(MTM1) 100070938(MTMR4)
MYB:	102241894(MTMR4) 102244493(MTM1) 102244753(MTMR2) 102244995(MTMR1) 102252475(MTMR6) 102256368(MTMR8) 102256907(MTMR14) 102257312(MTMR3) 102260492(MTMR7)
MYD:	102754942(MTMR6) 102758041(MTMR1) 102759418(MTM1) 102761693(MTMR2) 102767087(MTMR14) 102771673(MTMR7) 102772830(MTMR4) 102773236(MTMR3)
HAI:	109379770(MTMR4) 109383054(MTMR3) 109387291(MTMR14) 109387515(MTMR6) 109390071(MTMR8) 109390549(MTMR2) 109394579(MTMR7) 109396233(MTMR1) 109396239(MTM1)
RSS:	109438790 109449759(MTMR4) 109449860(MTMR6) 109450331(MTMR2) 109450544(MTMR7) 109453388(MTMR3) 109456171(MTMR14) 109459198(MTMR1) 109459203(MTM1)
PALE:	102880648(MTMR2) 102882988(MTMR14) 102884551(MTMR4) 102887092(MTMR7) 102888211(MTMR3) 102891579(MTMR1) 102891982(MTM1) 102894255(MTMR6) 102896812(MTMR8)
LAV:	100657088(MTMR2) 100657643(MTMR7) 100658106(MTMR14) 100661164(MTMR4) 100662519(MTMR3) 100664603(MTM1) 100664954(MTMR6) 100668300(MTMR1) 100673681(MTMR8)
MDO:	100012210(MTMR4) 100013067(MTMR2) 100014047(MTMR14) 100015113(MTM1) 100021656(MTMR7) 100024556(MTMR6) 100028310(MTMR8) 100030849(MTMR3) 100617772(MTMR1)
SHR:	100917511(MTMR4) 100920455(MTMR2) 100922040(MTMR6) 100928660(MTMR7) 100928957(MTMR14) 100929880(MTMR8) 100930917(MTM1) 100933524(MTMR1) 100933801(MTMR3)
OAA:	100075535(MTMR14) 100078009(MTMR4) 100080246(MTMR2) 100081312(MTM1) 100082050(MTMR1) 100090086(MTMR6) 100090153(MTMR3)
GGA:	416048(MTMR14) 417015(MTMR3) 417472(MTMR4) 418938(MTMR6) 418992(MTMR2) 422312(MTMR8) 422387(MTMR1) 422388(MTM1) 422731(MTMR7)
MGP:	100542441(MTMR14) 100546486(MTMR2) 100547050(MTMR6) 100547482(MTM1) 100547739(MTMR8) 100547943(MTMR1) 100548510(MTMR3) 100549025(MTMR4) 100551000
CJO:	107308302(MTMR6) 107308419(MTMR2) 107312838(MTMR8) 107312925(MTMR1) 107312926(MTM1) 107313730(MTMR7) 107319801(MTMR14) 107321254(MTMR3) 107322630(MTMR4)
APLA:	101792832(MTMR8) 101793168(MTMR3) 101799934(MTMR6) 101800837(MTMR14) 101802164(MTMR4) 101803235(MTMR1) 101803703(MTM1) 101804435(MTMR2) 101805213(MTMR7)
ACYG:	106034155(MTMR2) 106035123(MTMR7) 106037722(MTMR1) 106037723(MTM1) 106040394(MTMR6) 106041058(MTMR4) 106045072(MTMR14) 106047494(MTMR8) 106049047(MTMR3)
TGU:	100219323(MTMR7) 100220519(MTMR3) 100222676(MTMR1) 100223363(MTMR4) 100224025(MTMR14) 100225316(MTMR2) 100227284(MTMR6) 100227491(MTM1) 100231272(MTMR8)
GFR:	102032136(MTMR8) 102032651(MTMR2) 102037328(MTMR4) 102041338(MTMR14) 102041380(MTMR6) 102041698(MTMR3) 102043729(MTMR1) 102044014(MTM1) 102044715(MTMR7)
FAB:	101807592(MTMR14) 101811909(MTMR8) 101812336(MTMR6) 101815162(MTMR4) 101816909(MTMR3) 101818420(MTMR2) 101819090(MTM1) 101819675(MTMR1) 101821855(MTMR7)
PHI:	102101780(MTMR4) 102102606(MTMR7) 102102968(MTM1) 102103157(MTMR1) 102104801(MTMR6) 102106615(MTMR14) 102108094(MTMR8) 102108667(MTMR2) 102110973(MTMR3)
CCW:	104683318(MTMR14) 104690010(MTMR6) 104690075(MTMR2) 104690603(MTMR7) 104691604(MTMR8) 104691681(MTMR1) 104691682(MTM1) 104695032(MTMR3) 104695802(MTMR4)
FPG:	101911214(MTMR4) 101911308(MTMR14) 101911389(MTMR8) 101912718(MTMR6) 101915031(MTMR3) 101916945(MTMR7) 101917168(MTM1) 101917345(MTMR1) 101922927(MTMR2)
FCH:	102046191(MTMR7) 102046774(MTMR8) 102048548(MTMR2) 102049664(MTMR3) 102050829(MTMR6) 102055182(MTMR1) 102055474(MTM1) 102059156(MTMR14) 102060136(MTMR4)
CLV:	102084511(MTMR7) 102084631(MTMR8) 102085828(MTM1) 102086136(MTMR1) 102093428(MTMR6) 102094353(MTMR3) 102095343(MTMR14) 102096489(MTMR2) 102097791(MTMR4)
AAM:	106484674(MTMR4) 106487566(MTMR1) 106487576(MTM1) 106489827(MTMR8) 106490077(MTMR7) 106494532(MTMR3) 106495539(MTMR2) 106498998(MTMR14) 106500434(MTMR6)
ASN:	102368884(MTMR8) 102368917(MTMR3) 102370473(MTMR1) 102370505(MTMR14) 102371219(MTM1) 102372670(MTMR4) 102380001(MTMR2) 102380372(MTMR7) 102380613(MTMR6)
AMJ:	102564229(MTMR7) 102564445(MTM1) 102564682(MTMR2) 102565909(MTMR3) 102568445(MTMR14) 102573738(MTMR4) 102574139(MTMR8) 106736685(MTMR6) 106737108(MTMR1)
PSS:	102443507(MTMR4) 102443874(MTMR8) 102444511(MTMR3) 102444590(MTM1) 102444807(MTMR1) 102446720 102447518(MTMR2) 102450271(MTMR7) 102451171(MTMR6) 102462566
CMY:	102930575(MTMR7) 102931303(MTMR8) 102931382(MTMR6) 102932290(MTM1) 102932512(MTMR1) 102934887(MTMR4) 102939454(MTMR14) 102941323(MTMR2) 102945904
CPIC:	101930881(MTMR2) 101931312(MTMR1) 101932567(MTMR6) 101939749(MTMR3) 101940028(MTMR14) 101944474(MTM1) 101948247(MTMR7) 101949926(MTMR8) 101951257(MTMR4)
ACS:	100553091(mtmr8) 100554543(mtmr14) 100554881(mtmr7) 100556135(mtmr6) 100556577(mtmr2) 100564667(mtmr1) 100564867(mtm1) 100567629 103282853
PBI:	103049623(MTMR6) 103051409(MTMR7) 103052336(MTM1) 103052721(MTMR1) 103054857(MTMR3) 103056450(MTMR8) 103060397(MTMR2) 103061439(MTMR4) 103068280(MTMR14)
GJA:	107106958(MTMR8) 107108733(MTMR7) 107111938 107112040(MTM1) 107112098(MTMR1) 107112431(MTMR4) 107116842(MTMR2) 107117269(MTMR6) 107119095 107122295(MTMR3)
XLA:	108698369 108698426(mtm1.L) 108698427 108698621 108700127 108705035 108706606 108706607 108708714(mtmr6.L) 108708743(mtmr2.L) 108709322(mtmr4.S) 108710008(mtmr2.S) 379701(mtmr3) 379965(mtmr4.L) 494749(mtmr3.L) 734460(mtm1.S) 734951(mtmr14.S)
XTR:	100036693(mtmr14) 100151726(mtmr4) 100485851(mtmr7) 100489239(mtmr8) 100494490(mtmr3) 100494494(mtmr2) 100497758(mtmr6) 548545(mtm1) 734091(mtmr1)
NPR:	108783896(MTM1) 108783903(MTMR1) 108784202(MTMR2) 108785687(MTMR7) 108786260(MTMR3) 108788242(MTMR14) 108789931(MTMR8) 108790885(MTMR4) 108794125 108795176(MTMR6)
DRE:	100333801 30644(mtmr2) 323929(mtmr14) 327346(mtmr6) 393365(mtmr8) 393584(mtmr4) 393838(mtmr3) 541517(mtmr1b) 553750(mtmr1a) 559198(mtmr7b) 560881(mtm1) 678558(mtmr7a)
SRX:	107705267 107707226 107710166 107713197 107715150 107715154 107716897 107719345 107721424 107721921 107722025 107727267 107732604 107734350(mtmr4) 107734413 107735898 107741196 107743064 107745942 107746239 107747392 107747813 107749798 107750582 107750584 107751936 107754413
SANH:	107654282(mtmr4) 107656498 107658049 107661412 107661603 107661737 107663233 107663672(mtmr6) 107666797 107668235 107668296(mtm1) 107671008 107672736 107677984 107677993 107680397 107682766 107682777 107687656 107688805(mtmr14) 107691163 107691493 107694900 107698017 107699659 107702332
SGH:	107552187 107553046(mtmr3) 107554389 107557114 107561341 107561958 107562927 107563032 107563431(mtmr4) 107563440 107565722 107569464 107577910 107578176 107581988 107586366 107586719 107587235 107587278 107590218 107591495 107592277 107593835 107593873 107597225 107597259
IPU:	108256582(mtmr6) 108259814(mtmr2) 108260270 108260292(mtmr4) 108260298(mtmr8) 108260771(mtmr7) 108261680 108265535(mtmr3) 108267552(mtmr1) 108267553(mtm1) 108268392(MTMR7) 108272090(mtmr14)
TRU:	101065083(mtmr2) 101071974 101072034(mtmr1) 101072251(mtm1) 101072360(mtmr3) 101074389 101074636(mtmr6) 101077117(mtmr7) 101077753(mtmr14) 101078028
TNG:	GSTEN00004651G001 GSTEN00007051G001 GSTEN00007439G001 GSTEN00009054G001 GSTEN00010495G001 GSTEN00010499G001 GSTEN00016272G001 GSTEN00021609G001 GSTEN00022168G001
LCO:	104917798 104919737(mtmr2) 104920586(mtmr7) 104926364(mtmr3) 104928772(mtmr4) 104933246(mtmr6) 104934550(mtmr14) 104937744(mtmr1) 104939418(mtm1)
NCC:	104945404(mtmr14) 104946356(mtmr7) 104949319(mtmr4) 104951661 104951663 104954632(mtmr2) 104955011 104956392 104956632 104965672 104966346
MZE:	101464973(mtmr2) 101465793 101475552 101476994(mtm1) 101477870(mtmr14) 101478413(mtmr4) 101479475(mtmr7) 101480346(mtmr3) 101486188(mtmr6)
OLA:	101157315(mtmr2) 101157342 101157977 101161735 101165600(mtmr6) 101168528(mtm1) 101168809(mtmr4) 101170277(mtmr3) 105354120(mtmr14)
XMA:	102221740(mtmr14) 102222634(mtmr2) 102223974(mtm1) 102227567 102229271(mtmr7) 102230461(mtmr3) 102231068(mtmr6) 102232025(mtmr4) 102235299
CSEM:	103376906(mtmr6) 103384313 103386626(mtmr14) 103391312 103392128 103395170(mtmr4) 103395432 103397032 103397431
LCF:	108877482(mtmr14) 108878266(mtmr3) 108879698 108879963 108880075 108882734(mtmr7) 108893658(mtmr4) 108893812(mtmr2) 108895232 108895246 108900794(mtmr6)
SASA:	100306801(mtmr2) 100380488(mtm1) 100380604(mtmr6) 106565250(mtmr14) 106567397(mtmr4) 106567844 106577923 106577925 106579950 106583633 106585478 106590572 106590584 106596434 106596691 106602191 106603315 106603952 106603956 106608928 106610400 106610403 106612032
ELS:	105006454(mtmr8) 105014193(mtmr3) 105021026 105024794(mtmr14) 105025643(mtmr6) 105025988(mtmr2) 105026550(mtmr7) 105027659(mtmr1) 105027660(mtm1) 106023667(mtmr4)
SFM:	108918301(mtmr14) 108919961 108921496(mtmr4) 108921909 108922995 108924598(mtmr7) 108932391(mtmr2) 108932977 108934369(mtmr1) 108934420 108939546
LCM:	102350800(MTMR7) 102351041(MTM1) 102352382(MTMR1) 102352617(MTMR3) 102357589(MTMR6) 102360413(MTMR14) 102364350(MTMR4) 102366435(MTMR2) 102367128(MTMR8)
CMK:	103176603(mtmr14) 103178229(mtmr7) 103178360(mtmr1) 103178361(mtm1) 103178658(mtmr8) 103180496(mtmr4) 103183266(mtmr6) 103184098(mtmr2) 103184352(mtmr3)
BFO:	BRAFLDRAFT_121921 BRAFLDRAFT_128725 BRAFLDRAFT_219160 BRAFLDRAFT_87681
CIN:	100182371 100186111 100186380
SPU:	577354 583980 585290 585727
SKO:	100313661 100370630 100371745 102808735
DME:	Dmel_CG3530 Dmel_CG3632 Dmel_CG6542(EDTP) Dmel_CG9115(mtm)
DPO:	Dpse_GA17504 Dpse_GA19672 Dpse_GA21553 Dpse_GA22870
DAN:	Dana_GF11784 Dana_GF11853 Dana_GF14283 Dana_GF19035
DER:	Dere_GG10145 Dere_GG17949 Dere_GG20035 Dere_GG22197
DPE:	Dper_GL10664 Dper_GL17566 Dper_GL19086 Dper_GL21339
DSE:	Dsec_GM13033 Dsec_GM13419 Dsec_GM15548 Dsec_GM17969 Dsec_GM17970 Dsec_GM19983
DSI:	Dsimw501_GD17273(Dsim_GD17273) Dsimw501_GD22607(Dsim_GD22607) Dsimw501_GD25052(Dsim_GD25052) Dsimw501_GD25480(Dsim_GD25480)
DWI:	Dwil_GK15399 Dwil_GK23060 Dwil_GK23304 Dwil_GK25720
DYA:	Dyak_GE11013 Dyak_GE11572 Dyak_GE14194 Dyak_GE18955
DGR:	Dgri_GH10708 Dgri_GH12561 Dgri_GH20487 Dgri_GH20661
DMO:	Dmoj_GI11214 Dmoj_GI11288 Dmoj_GI19024 Dmoj_GI21030
DVI:	Dvir_GJ12474 Dvir_GJ18508 Dvir_GJ19990 Dvir_GJ21957
MDE:	101897750 101898537 101899399 101901021
AGA:	AgaP_AGAP001604 AgaP_AGAP005341 AgaP_AGAP009563 AgaP_AGAP009826
AAG:	AaeL_AAEL000564 AaeL_AAEL002370 AaeL_AAEL003083 AaeL_AAEL005367
CQU:	CpipJ_CPIJ000006 CpipJ_CPIJ000895 CpipJ_CPIJ006851 CpipJ_CPIJ007313
AME:	411563(MTMR2) 413411(EDTP) 413663 727030
BIM:	100741387 100746416 100747122 100749527
BTER:	100642640 100642665 100643350 100645314
SOC:	105197704 105199109 105199451 105202084
AEC:	105146176 105150652 105152363 105154153
ACEP:	105617255 105622789 105623045 105625373 105626425
PBAR:	105424785 105425523 105431463 105433477
HST:	105182249 105187884 105187983 105192679
CFO:	105251389 105253355 105255945 105256703
LHU:	105667801 105668290 105673649 105678030
NVI:	100116110 100120254 100121534 100121701
TCA:	657269 662636 663698
DPA:	109533697 109537168 109540393 109542826
NVL:	108556797 108557168 108558935 108568061
BMOR:	101736147 101736509 101740354
PXY:	105380596 105381058 105384814 105394827 105398233 105398235
API:	100160591 100163933 100167896 100169408
DNX:	107161735 107169000 107169027 107172966
PHU:	Phum_PHUM060700 Phum_PHUM213020 Phum_PHUM607650 Phum_PHUM607660
DPX:	DAPPUDRAFT_226406 DAPPUDRAFT_299527 DAPPUDRAFT_316434
ISC:	IscW_ISCW009978 IscW_ISCW014883 IscW_ISCW014885 IscW_ISCW018312 IscW_ISCW018501
TUT:	107360724 107364009 107367748
CEL:	CELE_F53A2.8(mtm-6) CELE_T24A11.1(mtm-3) CELE_Y110A7A.5(mtm-1)
CBR:	CBG09227(Cbr-mtm-3) CBG10832(Cbr-mtm-1) CBG22220 CBG24732(Cbr-mtm-6)
NAI:	NECAME_03521 NECAME_06007 NECAME_12087 NECAME_14201
BMY:	Bm1_06990 Bm1_08130 Bm1_27530
LOA:	LOAG_10137 LOAG_17492 LOAG_18267
TSP:	Tsp_00892 Tsp_01469 Tsp_14073
HRO:	HELRODRAFT_188680 HELRODRAFT_190283 HELRODRAFT_62273 HELRODRAFT_91412
LGI:	LOTGIDRAFT_125960 LOTGIDRAFT_168891 LOTGIDRAFT_173287 LOTGIDRAFT_81473
CRG:	105318437 105321837 105345000 105348463
OBI:	106871204 106875841 106880692 106881300
SMM:	Smp_075440.1 Smp_075440.3 Smp_083540 Smp_180520
OVI:	T265_00177 T265_08371 T265_09881 T265_12726
NVE:	NEMVE_v1g20426 NEMVE_v1g235730 NEMVE_v1g241000 NEMVE_v1g50340
ADF:	107330184 107330431 107331058 107331875 107342002 107342898 107351736 107355402
HMG:	100205727(mtmr6) 100215007 101236024
TAD:	TRIADDRAFT_34687 TRIADDRAFT_38469 TRIADDRAFT_52465 TRIADDRAFT_56124 TRIADDRAFT_64213
AQU:	100632035 100636439 100638833 100638989 100640426 100640623 100641184
ATH:	AT3G10550(MTM1) AT5G04540(MTM2)
ALY:	ARALYDRAFT_317855 ARALYDRAFT_343046 ARALYDRAFT_487236
CRB:	CARUB_v10000224mg CARUB_v10013103mg
EUS:	EUTSA_v10012689mg EUTSA_v10020062mg
BRP:	103847280 103847443 103850551
BNA:	106372501 106381187 106406872 106422587 106425271 106425276 106433131 106434589
THJ:	104816452 104823194
CIT:	102608799 102627970 102628265
CIC:	CICLE_v100317281m
TCC:	18586627
GRA:	105763609 105785321
GHI:	107919767 107922039 107945436 107960317
EGR:	104421745
GMX:	100781842 100789349
PVU:	PHAVU_007G105800g
VRA:	106772055
VAR:	108326121
CCAJ:	109789435 109789438
MTR:	MTR_1g092570 MTR_1g492590
CAM:	101510463
ADU:	107466695
AIP:	107617891
LJA:	Lj5g3v1737120.1(Lj5g3v1737120.1) Lj5g3v1737130.1(Lj5g3v1737130.1)
LANG:	109336030 109340089
FVE:	101303170
PPER:	18785424
PMUM:	103331199
MDM:	103402788 103407351 103410117 103416625 103418466
PXB:	103951724
ZJU:	107413081
CSV:	101204839
CMO:	103496486
RCU:	8263587
JCU:	105648328
POP:	POPTR_0008s02720g POPTR_0010s23980g(POPTRDRAFT_228298)
VVI:	100252361
SLY:	101255550
SPEN:	107004882
SOT:	102582140
INI:	109148110
SIND:	105179696
BVG:	104906669
NNU:	104587444 104612520
OSA:	4346290
DOSA:	Os08t0556700-01(Os08g0556700)
OBR:	102706122
BDI:	100833495
ATS:	F775_09035
ZMA:	103627995 103643201
SITA:	101768844
PDA:	103723836
EGU:	105038188
MUS:	103996633
ATR:	18441473
SMO:	SELMODRAFT_437478
PPP:	PHYPADRAFT_12645 PHYPADRAFT_71628
SCE:	YJR110W(YMR1)
AGO:	AGOS_ABR152C
ERC:	Ecym_7181
KLA:	KLLA0E05853g
LTH:	KLTH0E01584g
VPO:	Kpol_1013p67
ZRO:	ZYRO0G18062g
CGR:	CAGL0C04895g
NCS:	NCAS_0H00430(NCAS0H00430)
NDI:	NDAI_0D00380(NDAI0D00380)
TPF:	TPHA_0I02940(TPHA0I02940)
TBL:	TBLA_0F02770(TBLA0F02770)
TDL:	TDEL_0C03540(TDEL0C03540)
PPA:	PAS_chr3_0354
DHA:	DEHA2B10802g
PIC:	PICST_82137(YMR1)
PGU:	PGUG_01706
SPAA:	SPAPADRAFT_139029
LEL:	LELG_00433
CAL:	CAALFM_C108860CA(CaO19.4744)
CTP:	CTRG_03237
COT:	CORT_0A05240
CDU:	CD36_08360
CTEN:	CANTEDRAFT_123868
YLI:	YALI0E23738g
CLU:	CLUG_00819
CAUR:	QG37_06929
NCR:	NCU11185
NTE:	NEUTE1DRAFT82509(NEUTE1DRAFT_82509)
SMP:	SMAC_01920
PAN:	PODANSg5062
TTT:	THITE_2118463
MTM:	MYCTH_101588
CTHR:	CTHT_0026370
MGR:	MGG_16443
TMN:	UCRPA7_6354
FGR:	FGSG_05432
FPU:	FPSE_03575
FVR:	FVEG_07095
FOX:	FOXG_09466
NHE:	NECHADRAFT_95611
TRE:	TRIREDRAFT_119854
MAW:	MAC_08346
MAJ:	MAA_03578
CMT:	CCM_07402
VAL:	VDBG_08718
VDA:	VDAG_06379
CFJ:	CFIO01_03337
ELA:	UCREL1_8935
PFY:	PFICI_12960
SSL:	SS1G_07121
BFU:	BC1G_10190
MBE:	MBM_02151
PSCO:	LY89DRAFT_622607
GLZ:	GLAREA_07605
AFM:	AFUA_1G05640
AOR:	AOR_1_620184(AO090009000376)
ANG:	ANI_1_424164(An18g03320)
AFV:	AFLA_050960
ACT:	ACLA_028990
NFI:	NFIA_019110
PCS:	Pc18g02100
PDP:	PDIP_73810
CIM:	CIMG_03902
CPW:	CPC735_004420
PBL:	PAAG_01784
PBN:	PADG_01408
ABE:	ARB_05638
TVE:	TRV_05539
AJE:	HCAG_00213
PNO:	SNOG_11728
PTE:	PTT_07513
BZE:	COCCADRAFT_37906
BSC:	COCSADRAFT_98941
BOR:	COCMIDRAFT_23430
ZTR:	MYCGRDRAFT_21242
PFJ:	MYCFIDRAFT_127850
BCOM:	BAUCODRAFT_34931
NPA:	UCRNP2_1762
SPO:	SPAC19A8.03
CNE:	CNA03790
CNB:	CNBA3590
CGI:	CGB_A3520W
TMS:	TREMEDRAFT_70913
TVS:	TRAVEDRAFT_165027
DSQ:	DICSQDRAFT_98235
PCO:	PHACADRAFT_208612
SHS:	STEHIDRAFT_73786
HIR:	HETIRDRAFT_457720
PSQ:	PUNSTDRAFT_89339
ADL:	AURDEDRAFT_152237
FME:	FOMMEDRAFT_118876
GTR:	GLOTRDRAFT_114539
LBC:	LACBIDRAFT_143319
MRR:	Moror_10782
CCI:	CC1G_01220
SCM:	SCHCODRAFT_81454
ABP:	AGABI1DRAFT52558(AGABI1DRAFT_52558)
ABV:	AGABI2DRAFT215827(AGABI2DRAFT_215827)
CPUT:	CONPUDRAFT_97388
SLA:	SERLADRAFT_357783
WSE:	WALSEDRAFT_60201
WIC:	J056_004627
UMA:	UMAG_05646
PFP:	PFL1_06624
MGL:	MGL_2222
PGR:	PGTG_11730
MLR:	MELLADRAFT_40285
MBR:	MONBRDRAFT_21963
SRE:	PTSG_01664 PTSG_05869 PTSG_09234
DDI:	DDB_G0271610 DDB_G0288731 DDB_G0289807
DPP:	DICPUDRAFT_153793 DICPUDRAFT_158764 DICPUDRAFT_6017 DICPUDRAFT_97178
DFA:	DFA_02288 DFA_07597 DFA_10009
EHI:	EHI_070120(383.t00005)
EDI:	EDI_017270
EIV:	EIN_054860 EIN_065260 EIN_162560 EIN_398190 EIN_525580
ACAN:	ACA1_000330 ACA1_015100 ACA1_054610 ACA1_062240 ACA1_066600 ACA1_066810 ACA1_070610 ACA1_070620 ACA1_088650 ACA1_194960 ACA1_214010 ACA1_367320 ACA1_367330 ACA1_389600
TET:	TTHERM_00068150 TTHERM_00293460
PTM:	GSPATT00016054001 GSPATT00026750001
SMIN:	v1.2.011730.t1(symbB.v1.2.011730.t1) v1.2.030246.t1(symbB.v1.2.030246.t1)
FCY:	FRACYDRAFT_182698
AAF:	AURANDRAFT_11784 AURANDRAFT_1309 AURANDRAFT_22249 AURANDRAFT_25339 AURANDRAFT_25625 AURANDRAFT_34751
NGD:	NGA_0134600
PIF:	PITG_00440 PITG_03864 PITG_06319 PITG_06929 PITG_11157 PITG_15883 PITG_18372
PSOJ:	PHYSODRAFT_311351 PHYSODRAFT_316113 PHYSODRAFT_471429 PHYSODRAFT_481864 PHYSODRAFT_508901 PHYSODRAFT_535974 PHYSODRAFT_555387 PHYSODRAFT_558210 PHYSODRAFT_563284
SPAR:	SPRG_01841 SPRG_03597 SPRG_05166 SPRG_07559 SPRG_13066 SPRG_14635 SPRG_15527 SPRG_16905 SPRG_20770
EHX:	EMIHUDRAFT_41894
GTT:	GUITHDRAFT_103752 GUITHDRAFT_75440 GUITHDRAFT_89063
NGR:	NAEGRDRAFT_58398 NAEGRDRAFT_78325

Reference

1 [PMID:11676921]

Authors

Walker DM, Urbe S, Dove SK, Tenza D, Raposo G, Clague MJ

Title

Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity.

Journal

Curr. Biol. 11 (2001) 1600-5.

Sequence

[hsa:8897]

Reference

2 [PMID:12045210]

Authors

Berger P, Bonneick S, Willi S, Wymann M, Suter U

Title

Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1.

Journal

Hum. Mol. Genet. 11 (2002) 1569-79.

Sequence

[mmu:77116]

Reference

3 [PMID:19901554]

Authors

Ding Y, Lapko H, Ndamukong I, Xia Y, Al-Abdallat A, Lalithambika S, Sadder M, Saleh A, Fromm M, Riethoven JJ, Lu G, Avramova Z

Title

The Arabidopsis chromatin modifier ATX1, the myotubularin-like AtMTM and the response to drought.

Journal

Plant. Signal. Behav. 4 (2009) 1049-58.

Sequence

[ath:AT3G10550]

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

BRENDA, the Enzyme Database:

All links

Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (3223)   
   KEGG ORTHOLOGY (5)   
   KEGG GENES (1411)   
   KEGG MGENES (1522)   
   RefGene (285)   
Protein sequence (73)   
   UniProt (22)   
   SWISS-PROT (22)   
   RefSeq(pep) (29)   
DNA sequence (32)   
   RefSeq(nuc) (32)   
All databases (3338)   

Download RDF

REACTION: R10928

Entry

R10928 Reaction

Name

1-phosphatidyl-1D-myo-inositol-3,5-bisphosphate 3-phosphohydrolase

Definition

1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O <=> 1-Phosphatidyl-1D-myo-inositol 5-phosphate + Orthophosphate

Equation

C11556 + C00001 <=> C11557 + C00009

Reaction class

RC00078

C11556_C11557

Enzyme