KEGG ORTHOLOGY: K01116

GO:

Genes

HSA:	5335(PLCG1)
PTR:	458253(PLCG1)
PPS:	100995010(PLCG1)
GGO:	101135199(PLCG1)
PON:	100450941(PLCG1)
NLE:	100591458(PLCG1)
MCC:	697069(PLCG1)
MCF:	102138726(PLCG1)
CSAB:	103245987(PLCG1)
RRO:	104672220(PLCG1)
CJC:	100397497(PLCG1)
SBQ:	101046976(PLCG1)
MMU:	18803(Plcg1)
RNO:	25738(Plcg1)
CGE:	100769697(Plcg1)
NGI:	103747244(Plcg1)
HGL:	101705192(Plcg1)
CCAN:	109683399(Plcg1)
OCU:	100349958(PLCG1)
TUP:	102469651(PLCG1)
CFA:	485874(PLCG1)
AML:	100480586(PLCG1)
UMR:	103669754(PLCG1)
FCA:	101092925(PLCG1)
PTG:	102952137(PLCG1)
AJU:	106974495(PLCG1)
BTA:	281987(PLCG1)
BOM:	102265099(PLCG1)
BIU:	109567698(PLCG1)
PHD:	102324368(PLCG1)
CHX:	102181878(PLCG1)
OAS:	101103341(PLCG1)
SSC:	100152497(PLCG1)
CFR:	102524452(PLCG1)
BACU:	103016663(PLCG1)
LVE:	103068930(PLCG1)
ECB:	100070545(PLCG1)
MYB:	102248243(PLCG1)
MYD:	102756475(PLCG1)
HAI:	109379925(PLCG1)
RSS:	109456634(PLCG1)
PALE:	102896228(PLCG1)
LAV:	100677739(PLCG1)
MDO:	100032696(PLCG1)
SHR:	100923119(PLCG1)
OAA:	100078757(PLCG1)
GGA:	419175(PLCG1) 776273
MGP:	100542272 100548670(PLCG1)
CJO:	107310620 107322901(PLCG1)
APLA:	101792010 101798692(PLCG1)
ACYG:	106042207 106043486(PLCG1)
TGU:	100220070(PLCG1) 100222362
GFR:	102032882(PLCG1) 102038983
FAB:	101806517(PLCG1) 101820005
PHI:	102100949 102114427(PLCG1)
CCW:	104687887(PLCG1) 104692596
FPG:	101912447(PLCG1) 101918282
FCH:	102046961 102057302(PLCG1)
CLV:	102098341(PLCG1) 102098590
AAM:	106488145(PLCG1) 106494802
ASN:	102368895 102369875(PLCG1)
AMJ:	102563626(PLCG1) 102574067
PSS:	102459944(PLCG1) 102461099
CMY:	102944142(PLCG1) 102946940
CPIC:	101930905 101935550(PLCG1)
ACS:	100559347(plcg1) 100566976 103281908
PBI:	103062888 103064933(PLCG1)
GJA:	107107624 107109685(PLCG1) 107121439
XLA:	108702812 108719445 398359(plcg1.L) 398360(plcg1.S)
XTR:	100496658 100496674(plcg1)
NPR:	108786812(PLCG1) 108789042
DRE:	373867(plcg1)
SRX:	107713547 107723006 107747732
SANH:	107663201(plcg1) 107703619
SGH:	107557477 107562619
IPU:	108275796(plcg1)
TRU:	101065481 101069039(plcg1)
TNG:	GSTEN00000204G001 GSTEN00006212G001 GSTEN00011828G001
LCO:	104925092(plcg1) 104927718
NCC:	104943867 104954784 104964925(plcg1)
MZE:	101470576(plcg1) 101473405
OLA:	101163005(plcg1) 101167946
XMA:	102217766(plcg1) 102229810
CSEM:	103385539(plcg1) 103399890
LCF:	108877896(plcg1) 108879537
SASA:	106560399 106566556(plcg1)
ELS:	105011953 105013964(plcg1)
SFM:	108926447 108932641 108932661 108936962(plcg1)
LCM:	102352804 102362442(PLCG1)
CMK:	103172407 103173857 103186275(plcg1) 103191121
BFO:	BRAFLDRAFT_205043
CIN:	100178711
SPU:	579102
SKO:	100377901
DME:	Dmel_CG4200(sl)
DPO:	Dpse_GA18024(Dpse_small-wing)
DAN:	Dana_GF19146
DER:	Dere_GG17956
DPE:	Dper_GL15831
DSE:	Dsec_GM13428
DSI:	Dsimw501_GD17281(Dsim_GD17281)
DWI:	Dwil_GK25059
DYA:	Dyak_GE17264
DGR:	Dgri_GH12692
DMO:	Dmoj_GI14457
DVI:	Dvir_GJ18791(Dvir_small-wing)
MDE:	101900328
AGA:	AgaP_AGAP011152
AAG:	AaeL_AAEL004431
CQU:	CpipJ_CPIJ008193
AME:	551709(sl)
BIM:	100748682
BTER:	100647687
SOC:	105196430 105206257
AEC:	105144421
ACEP:	105624086
PBAR:	105431231
HST:	105188458
CFO:	105257806
LHU:	105673001
NVI:	100123217
TCA:	660210
DPA:	109537047
NVL:	108561344
BMOR:	100329155(PLCg)
PXY:	105381166
API:	100166969
DNX:	107163682
PHU:	Phum_PHUM019460
DPX:	DAPPUDRAFT_204745 DAPPUDRAFT_236642 DAPPUDRAFT_253811
ISC:	IscW_ISCW015942
TUT:	107359684
CEL:	CELE_T01E8.3(plc-3)
CBR:	CBG18715(Cbr-plc-3)
NAI:	NECAME_11673
BMY:	Bm1_42205
LOA:	LOAG_00547
TSP:	Tsp_10563
HRO:	HELRODRAFT_88112
LGI:	LOTGIDRAFT_234838
CRG:	105340725
OBI:	106874041
NVE:	NEMVE_v1g124290
ADF:	107357605
HMG:	100212273
AQU:	100633163 109583910
SRE:	PTSG_03830

Reference

PMID:18593525

Authors

Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH

Title

Multiple roles of phosphoinositide-specific phospholipase C isozymes.

Journal

BMB Rep 41:415-34 (2008)

Reference

PMID:10579907

Authors

Carpenter G, Ji Q

Title

Phospholipase C-gamma as a signal-transducing element.

Journal

Exp Cell Res 253:15-24 (1999)
DOI:10.1006/excr.1999.4671

Reference

PMID:2167438

Authors

Burgess WH, Dionne CA, Kaplow J, Mudd R, Friesel R, Zilberstein A, Schlessinger J, Jaye M

Title

Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.

Journal

Mol Cell Biol 10:4770-7 (1990)
DOI:10.1128/MCB.10.9.4770

Sequence

[hsa:5335]

All links

Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (69)   
   KEGG PATHWAY (68)   
   KEGG MODULE (1)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (2)   
Gene (713)   
   KEGG GENES (204)   
   KEGG MGENES (403)   
   RefGene (82)   
   EGENES (18)   
   OC (6)   
Protein sequence (52)   
   UniProt (47)   
   SWISS-PROT (5)   
Literature (3)   
   PubMed (3)   
All databases (848)   

Download RDF

ORTHOLOGY: K05857

Entry

K05857 KO

Name

PLCD

Definition

phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]

Pathway

ko00562	Inositol phosphate metabolism
ko04020	Calcium signaling pathway
ko04070	Phosphatidylinositol signaling system
ko04919	Thyroid hormone signaling pathway
ko04933	AGE-RAGE signaling pathway in diabetic complications

Module

M00130

Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4

Disease

H01307

Nonsyndromic congenital nail disorder (NDNC)

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
Environmental Information Processing
  Signal transduction
   04020 Calcium signaling pathway
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
   04070 Phosphatidylinositol signaling system
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
Organismal Systems
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
Human Diseases
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
KEGG modules [BR:ko00002]
Pathway module
  Carbohydrate and lipid metabolism
   Lipid metabolism
    M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
     K05857  PLCD; phosphatidylinositol phospholipase C, delta
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05857  PLCD; phosphatidylinositol phospholipase C, delta
Membrane trafficking [BR:ko04131]
Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
Endocytosis
  Macropinocytosis
   Phospholipase C
    K05857  PLCD; phosphatidylinositol phospholipase C, delta

Other DBs

RN:

GO:

Genes

HSA:	113026(PLCD3) 5333(PLCD1) 84812(PLCD4)
PTR:	460267(PLCD1) 468279(PLCD3) 470647(PLCD4)
PPS:	100969236(PLCD1) 100980795(PLCD3) 100988032(PLCD4)
GGO:	101136081(PLCD4) 101139984(PLCD1) 101142984(PLCD3) 109025954
PON:	100171640(PLCD4) 100443819(PLCD3) 100462440(PLCD1)
NLE:	100596702(PLCD1) 100598366(PLCD4) 100604799(PLCD3)
MCC:	696860(PLCD1) 699569(PLCD4) 715924(PLCD3)
MCF:	101866682(PLCD1) 102122144(PLCD4) 102138566(PLCD3)
CSAB:	103217873(PLCD4) 103221069(PLCD1) 103243297(PLCD3)
RRO:	104654736(PLCD3) 104657452(PLCD1) 104660025(PLCD4)
CJC:	100395085(PLCD3) 100408539(PLCD4) 100408597(PLCD1)
SBQ:	101030401(PLCD4) 101045153(PLCD3) 101053112(PLCD1)
MMU:	18799(Plcd1) 18802(Plcd4) 72469(Plcd3)
RNO:	140693(Plcd4) 24655(Plcd1) 287745(Plcd3)
CGE:	100751509(Plcd1) 100751872(Plcd4) 100759620(Plcd3)
NGI:	103727720(Plcd4) 103738313(Plcd3) 103751602(Plcd1)
HGL:	101704621(Plcd3) 101704999(Plcd4) 101715010(Plcd1)
CCAN:	109678350(Plcd4) 109691551(Plcd3) 109698346(Plcd1)
OCU:	100347485(PLCD4) 100352032(PLCD3) 103347252(PLCD1)
TUP:	102468499(PLCD3) 102475249(PLCD4) 102500184(PLCD1)
CFA:	478910(PLCD4) 485586(PLCD1) 490929(PLCD3)
AML:	100469148(PLCD4) 100471021(PLCD3) 100476035(PLCD1)
UMR:	103662760(PLCD4) 103665878(PLCD3) 103682206(PLCD1)
FCA:	101086518(PLCD3) 101087777(PLCD1) 101090455(PLCD4)
PTG:	102952633(PLCD1) 102956201(PLCD4) 102963235(PLCD3)
AJU:	106966690(PLCD1) 106970106(PLCD4) 106988142(PLCD3)
BTA:	281986(PLCD1) 513057(PLCD3) 540771(PLCD4)
BOM:	102269641(PLCD3) 102270277 102273490(PLCD4) 106701107(PLCD1)
BIU:	109570636(PLCD4) 109573523(PLCD3) 109576386 109576389
PHD:	102321405(PLCD1) 102324981(PLCD3) 102328353(PLCD4)
CHX:	102169343(PLCD4) 102184479(PLCD1) 102190639(PLCD3)
OAS:	101110367(PLCD1) 101111344(PLCD4) 101118035(PLCD3)
SSC:	100521111(PLCD3) 100627099(PLCD1) 397119(PLCD4)
CFR:	102506571(PLCD3) 102507363(PLCD1) 102515536(PLCD4)
BACU:	103014054(PLCD1) 103014562(PLCD3) 103019165(PLCD4)
LVE:	103073047(PLCD1) 103080679(PLCD3) 103081712(PLCD4)
ECB:	100054233(PLCD1) 100058665(PLCD4) 100064142(PLCD3)
MYB:	102241313(PLCD3) 102252971(PLCD4) 102262661(PLCD1)
MYD:	102758829(PLCD4) 102760213(PLCD3) 102760355(PLCD1)
HAI:	109380562(PLCD4) 109385184(PLCD1) 109394976(PLCD3)
RSS:	109440363 109440549 109440574 109441747 109445340(PLCD1) 109452690(PLCD4) 109458499(PLCD3)
PALE:	102878454(PLCD1) 102884893(PLCD4) 102896686(PLCD3)
LAV:	100656701(PLCD3) 100660015(PLCD1) 100676480(PLCD4)
MDO:	100011291(PLCD4) 100024144(PLCD3)
SHR:	100916816(PLCD3) 100919591(PLCD4) 100933386(PLCD1)
OAA:	100083809(PLCD1)
GGA:	420416(PLCD1) 424214 428279(PLCD3)
MGP:	100540750(PLCD4) 100542227(PLCD1) 100551436(PLCD3)
CJO:	107308792(PLCD1) 107316914(PLCD4) 107325007(PLCD3)
APLA:	101796325(PLCD1) 101796880(PLCD3) 101804382(PLCD4)
ACYG:	106036853(PLCD1) 106039320(PLCD4) 106046916(PLCD3)
TGU:	100224924 100227504(PLCD4) 100229323(PLCD1)
GFR:	102034984(PLCD4) 102040502(PLCD1) 102041993(PLCD3)
FAB:	101809831(PLCD3) 101816161(PLCD1) 101817537(PLCD4)
PHI:	102100115(PLCD4) 102100695(PLCD3) 102108822(PLCD1)
CCW:	104686410(PLCD1) 104693970(PLCD4) 104698537(PLCD3)
FPG:	101911097(PLCD3) 101919734(PLCD1) 101920700(PLCD4)
FCH:	102049427(PLCD1) 102050720(PLCD3) 102054061(PLCD4)
CLV:	102083893(PLCD4) 102086985(PLCD1) 102096927(PLCD3)
AAM:	106494848(PLCD1) 106495647(PLCD3) 106499321
ASN:	102368121(PLCD1) 102387019(PLCD3)
AMJ:	102575027(PLCD3) 102576343(PLCD1)
PSS:	102455868(PLCD1) 102459349(PLCD4)
CMY:	102932314(PLCD1) 102935898(PLCD4) 102944425(PLCD3)
CPIC:	101933267(PLCD3) 101941573(PLCD1) 101944484(PLCD4)
ACS:	100552636(plcd4) 100559401(plcd3) 100567266(plcd1) 103282571
PBI:	103051665(PLCD4) 103053551(PLCD3) 103056024(PLCD1)
GJA:	107115054 107116964(PLCD4) 107120612(PLCD3) 107121463
XLA:	108700851(plcd3.L) 108702553(plcd3.S) 108702938(plcd4.S) 108718712(plcd1.L) 108719811(plcd1.S) 735225(plcd4.L)
XTR:	100379715(plcd4) 100488677(plcd1) 100497993(plcd3)
NPR:	108784616(PLCD1) 108785980(PLCD3)
DRE:	337489(plcd1b) 555443(plcd1a) 562569(plcd3b) 565669(plcd4a) 569040(plcd3a)
SRX:	107714237 107718154 107720035(plcd3) 107722543 107738025 107739328 107741014 107741909 107744333 107751666 107754248 107754249
SANH:	107653530 107654535 107660629 107662566 107670428 107673750 107674588 107683256 107687884 107688433 107689396 107701657
SGH:	107555902 107561636 107579600 107581738 107584946 107585437 107586990 107589883 107591255 107591554 107596071 107600964
IPU:	108256573(plcd1) 108259491 108259894(plcd3) 108266487(plcd4) 108273813 108280636
TRU:	101062624(plcd1) 101066005 101076189(plcd3) 101077179(plcd4) 101078575
TNG:	GSTEN00015123G001 GSTEN00019817G001 GSTEN00023915G001 GSTEN00027101G001 GSTEN00027858G001
LCO:	104926417 104927956 104930729 104935185 104936009(plcd4) 104937066 109140514(plcd1)
NCC:	104946859(plcd3) 104954046 104955628 104955629 104956409 104957849 104958258 104961884 104963179 104963181
MZE:	101466745(plcd4) 101468079 101469784 101473979(plcd1) 101477371 106674672
OLA:	101156540(plcd4) 101163204 101166226(plcd3) 101167907 101172720 101172964 101173208 101175056 105357398
XMA:	102216385 102217197 102228874(plcd1) 102229997(plcd4) 102233270 102236784
CSEM:	103377214(plcd1) 103382183 103389737 103392383(plcd4) 103392750 103396221
LCF:	108872744 108876760 108881708(plcd1) 108883910 108897205(plcd4) 108902591
SASA:	100380422(plcd4) 106569808 106574281 106575211 106579107 106579767 106586132 106590697(plcd1) 106592034 106594992 106600791 106607244
ELS:	105007252 105010329(plcd1) 105016179(plcd4) 105022523 105022998 105028902 105030417
SFM:	108919945(plcd3) 108924218(plcd4) 108928009 108934038(plcd1) 108941601
LCM:	102347797(PLCD1) 102348562(PLCD3) 102349822 102354402(PLCD4)
CMK:	103172669 103173793 103189707 103189708 103189804(plcd4)
BFO:	BRAFLDRAFT_115415 BRAFLDRAFT_223817 BRAFLDRAFT_241494 BRAFLDRAFT_281182 BRAFLDRAFT_285727
CIN:	100185660
SPU:	100891267(PLCdsu) 494023(plcd)
SKO:	102802106 102804539
DPX:	DAPPUDRAFT_100827 DAPPUDRAFT_237502 DAPPUDRAFT_313504 DAPPUDRAFT_317364 DAPPUDRAFT_54889 DAPPUDRAFT_61075
ISC:	IscW_ISCW014053 IscW_ISCW020642
TUT:	107366993
CEL:	CELE_R05G6.8(plc-4)
CBR:	CBG05896(Cbr-plc-4)
NAI:	NECAME_13574
BMY:	Bm1_31705
LOA:	LOAG_02789
TSP:	Tsp_07594
HRO:	HELRODRAFT_62499 HELRODRAFT_94839
LGI:	LOTGIDRAFT_142432
CRG:	105342681
OBI:	106880478
NVE:	NEMVE_v1g114299 NEMVE_v1g136833
ADF:	107333500 107346860
HMG:	100198602
TAD:	TRIADDRAFT_29799
ATH:	AT2G40116 AT3G08510(PLC2) AT3G55940 AT4G38530(PLC1) AT5G58670(PLC1) AT5G58690(PLC5) AT5G58700(PLC4)
ALY:	ARALYDRAFT_486035 ARALYDRAFT_490617 ARALYDRAFT_495989 ARALYDRAFT_495993 ARALYDRAFT_671640 ARALYDRAFT_685532 ARALYDRAFT_903282
CRB:	CARUB_v10007023mg CARUB_v10013310mg CARUB_v10016918mg CARUB_v10018550mg CARUB_v10024587mg CARUB_v10026125mg CARUB_v10026144mg CARUB_v10026170mg
EUS:	EUTSA_v10010330mg EUTSA_v10013042mg EUTSA_v10013061mg EUTSA_v10013134mg EUTSA_v10016400mg EUTSA_v10020359mg EUTSA_v10024782mg
BRP:	103828094 103841495 103845299 103845301 103845302 103848861 103851627 103856668 103857907 103863617 103866016 103866980 103870613
BNA:	106349466 106359635 106364955 106383590 106387397 106387427 106388063 106388090 106388407 106395165 106400157 106401032 106401409 106411102 106420251 106420273 106420503 106420706 106427003 106427964(PLC) 106430919 106430929 106440574 106440577 106441571 106443579 106450263 106452856 106454594
THJ:	104799392 104810099 104810100 104810710 104810768 104814915
CIT:	102623592 102623883 102624539 102629782 102630072
CIC:	CICLE_v10028054mg CICLE_v10028080mg CICLE_v10028087mg CICLE_v10031019mg CICLE_v10031029mg
TCC:	18585851 18585852 18590488 18590489 18590491
GRA:	105768302 105770227 105770228 105771549 105773437 105777827 105780353 105799161
GHI:	107889062 107891618 107900444 107900445 107906622 107906624 107906625 107931804 107959192 107959193 107959194 107959195 107960006
EGR:	104421075 104421076 104421083 104422365 104422367 104422368 104432644 104454389
GMX:	100037460 100776483 100777010 100784534 100786997 100788788 100799027 100803394 100817915 100820253 547863 547864 547865
PVU:	PHAVU_001G243100g PHAVU_001G243200g PHAVU_001G243300g PHAVU_008G224000g PHAVU_008G224100g PHAVU_008G224200g PHAVU_008G261100g
VRA:	106757766 106757865(PLC1) 106764143 106764604(PLC2) 106764606 106764607
VAR:	108326859 108327843 108329771 108337111 108337350 108337572 108338381
CCAJ:	109790806 109790807 109791083 109797332 109803749 109807238 109811219
MTR:	MTR_3g069280 MTR_3g070560 MTR_3g070710 MTR_3g070720 MTR_5g071010 MTR_5g071040 MTR_5g082580 MTR_5g082590 MTR_5g082620
CAM:	101499071 101499385 101502612 101502929 101503581 101504327 101504660
ADU:	107457672 107457704 107457717 107458352 107458360 107469474 107469481 107469492
AIP:	107606651 107608057 107609151 107609560 107609693 107622996 107623420 107624328
LJA:	Lj0g3v0130579.1(Lj0g3v0130579.1) Lj0g3v0130589.1(Lj0g3v0130589.1) Lj0g3v0148389.1(Lj0g3v0148389.1) Lj0g3v0189439.1(Lj0g3v0189439.1) Lj0g3v0189439.2(Lj0g3v0189439.2) Lj2g3v2256390.1(Lj2g3v2256390.1) Lj2g3v2256400.1(Lj2g3v2256400.1) Lj2g3v2747660.1(Lj2g3v2747660.1) Lj2g3v2747660.2(Lj2g3v2747660.2) Lj2g3v2748690.1(Lj2g3v2748690.1) Lj6g3v0521600.1(Lj6g3v0521600.1) Lj6g3v0521600.2(Lj6g3v0521600.2) Lj6g3v0521600.3(Lj6g3v0521600.3) Lj6g3v0521670.1(Lj6g3v0521670.1)
LANG:	109326813 109328447 109328448 109340327 109340384 109356693 109356694 109356756 109357350 109360697
FVE:	101302205 101302496 101303890 101304756 101311837
PPER:	18772015 18773491 18774669 18785127 18785526
PMUM:	103320887 103320896 103320905 103332782 103332783
MDM:	103406415 103418706 103432827 103432829 103437320 103438122 103447387
PXB:	103936781 103936790 103938929 103938930 103958605 103958607
ZJU:	107410786 107410802 107413847 107413865
CSV:	101203631 101204232 101209542 101212421
CMO:	103485573 103497077 103497078 103501442
RCU:	8277605 8277606 8285994 8286460 8286461 8286462
JCU:	105628146 105630259 105630267 105630282 105630315 105630322 105646265 105646272
POP:	POPTR_0001s25910g(POPTRDRAFT_815304) POPTR_0001s25930g(POPTRDRAFT_752026) POPTR_0008s06830g(POPTRDRAFT_803315) POPTR_0008s06840g(POPTRDRAFT_564023) POPTR_0009s05130g(POPTRDRAFT_875869) POPTR_0010s19610g(POPTRDRAFT_567270) POPTR_0010s19620g(POPTRDRAFT_805439)
VVI:	100241574 100243703 100246006 100248420 100255373 100267383 100853282
SLY:	100301919(PLC5) 100301920 100301921 100301922 100301923 100301941 101261499(PLC7)
SPEN:	107002343 107012970 107020453 107021827 107022350 107023791
SOT:	102583742(PLC1) 102588383(plc3) 102590316 102596402 102602093(plc2) 102603424
INI:	109173625 109173626 109181610 109182836 109186825
SIND:	105160885 105160886 105161539 105167050
BVG:	104891635 104899948 104899949 104899950 104899951 104903334 104903337
NNU:	104594891 104595046 104602598
OSA:	4332497 4337686 4344391(P0627E10.3) 4352524
DOSA:	Os03t0289300-00(Os03g0289300) Os05t0127200-01(Os05g0127200) Os07t0694000-01(Os07g0694000) Os12t0562400-00(Os12g0562400)
OBR:	102702115 102703305 102706922 102707180
BDI:	100831986 100835224 100839274 100840369
ATS:	F775_10271 F775_14422 F775_32754
SBI:	8084994
ZMA:	100136827 100191466 100191939 103626494 542162(PLC)
SITA:	101756981 101770957 101774810 101782785
PDA:	103706677 103706679 103709636 103718431 103718441 103718899
EGU:	105044613 105044614 105045827 105045828 105057087(PIPLC) 105057088
MUS:	103969012 103969014 103972891 103974417 103984258 103986180
ATR:	18433394 18433395
SMO:	SELMODRAFT_109775 SELMODRAFT_158000 SELMODRAFT_180165 SELMODRAFT_75628
PPP:	PHYPADRAFT_110278(PLC2) PHYPADRAFT_133245(PLC3) PHYPADRAFT_154928(PLC7) PHYPADRAFT_202996(PLC4) PHYPADRAFT_221032(PLC5) PHYPADRAFT_228841(PLC6)
CRE:	CHLREDRAFT_142126
OLU:	OSTLU_50249
OTA:	Ot08g01240
BPG:	Bathy04g01280
MIS:	MICPUN_51586
MPP:	MICPUCDRAFT_55672
CCP:	CHC_T00005154001
SCE:	YPL268W(PLC1)
AGO:	AGOS_ACR024W
ERC:	Ecym_3005
KLA:	KLLA0D00638g
LTH:	KLTH0C11660g
VPO:	Kpol_449p13
ZRO:	ZYRO0F00352g
CGR:	CAGL0A01177g
NCS:	NCAS_0D02230(NCAS0D02230)
NDI:	NDAI_0I02690(NDAI0I02690)
TPF:	TPHA_0J00210(TPHA0J00210)
TBL:	TBLA_0A07020(TBLA0A07020)
TDL:	TDEL_0G04680(TDEL0G04680)
KAF:	KAFR_0B06460(KAFR0B06460)
PPA:	PAS_chr4_0700
DHA:	DEHA2A04510g
PIC:	PICST_42966(PLC1)
PGU:	PGUG_00206
SPAA:	SPAPADRAFT_73417
LEL:	LELG_05130
CAL:	CAALFM_C703710CA(PLC1)
CTP:	CTRG_05145
COT:	CORT_0G03510
CDU:	CD36_73380(PLC1)
CTEN:	CANTEDRAFT_105288
YLI:	YALI0C04180g
CLU:	CLUG_03263
NCR:	NCU01266
NTE:	NEUTE1DRAFT127609(NEUTE1DRAFT_127609)
SMP:	SMAC_03962
PAN:	PODANSg8027
TTT:	THITE_2106937
MTM:	MYCTH_2300779
CTHR:	CTHT_0066170
MGR:	MGG_02444
TMN:	UCRPA7_5786
FGR:	FGSG_02980 FGSG_05898
FPU:	FPSE_02260 FPSE_12239
FVR:	FVEG_04539 FVEG_16850
FOX:	FOXG_06598 FOXG_06661 FOXG_07102 FOXG_07227 FOXG_07611 FOXG_12081 FOXG_14448 FOXG_15032
NHE:	NECHADRAFT_75847 NECHADRAFT_85080
TRE:	TRIREDRAFT_60194
MAW:	MAC_06035
MAJ:	MAA_06168
CMT:	CCM_07897
VAL:	VDBG_03354
VDA:	VDAG_09958
CFJ:	CFIO01_12970
ELA:	UCREL1_8660
PFY:	PFICI_11085
SSL:	SS1G_05754
BFU:	BC1G_01559
MBE:	MBM_09817
PSCO:	LY89DRAFT_698179
GLZ:	GLAREA_07735
ANI:	AN0664.2
AFM:	AFUA_1G13250
AOR:	AOR_1_976194(AO090012000557)
ANG:	ANI_1_884074(An08g06320)
AFV:	AFLA_018170
ACT:	ACLA_022180
NFI:	NFIA_012260
PCS:	Pc13g12130
PDP:	PDIP_26340
CIM:	CIMG_06831
CPW:	CPC735_032410
PBL:	PAAG_07722
PBN:	PADG_02814
URE:	UREG_03646
ABE:	ARB_06692
TVE:	TRV_04036
AJE:	HCAG_00760 HCAG_00761
PNO:	SNOG_10714
PTE:	PTT_08861
BZE:	COCCADRAFT_5314
BSC:	COCSADRAFT_262210
BOR:	COCMIDRAFT_21499
ZTR:	MYCGRDRAFT_66273
PFJ:	MYCFIDRAFT_148132(PLC)
BCOM:	BAUCODRAFT_120631
NPA:	UCRNP2_6478
TML:	GSTUM_00002161001
SPO:	SPAC22F8.11(plc1)
CNE:	CNC04820
CNB:	CNBC2360
CGI:	CGB_C7130W
TMS:	TREMEDRAFT_38681
TVS:	TRAVEDRAFT_136210
DSQ:	DICSQDRAFT_64218
PCO:	PHACADRAFT_254611
SHS:	STEHIDRAFT_146709 STEHIDRAFT_99869
HIR:	HETIRDRAFT_174607 HETIRDRAFT_235382
PSQ:	PUNSTDRAFT_81102
ADL:	AURDEDRAFT_169456
FME:	FOMMEDRAFT_124022
GTR:	GLOTRDRAFT_140049 GLOTRDRAFT_50083
LBC:	LACBIDRAFT_233152 LACBIDRAFT_315547 LACBIDRAFT_329174
MPR:	MPER_02532 MPER_08907
MRR:	Moror_139 Moror_17332
CCI:	CC1G_07213 CC1G_07975 CC1G_09463
SCM:	SCHCODRAFT_109536 SCHCODRAFT_79892 SCHCODRAFT_82573
ABP:	AGABI1DRAFT129320(AGABI1DRAFT_129320) AGABI1DRAFT72480(AGABI1DRAFT_72480)
ABV:	AGABI2DRAFT120986(AGABI2DRAFT_120986) AGABI2DRAFT212030(AGABI2DRAFT_212030)
CPUT:	CONPUDRAFT_131189
SLA:	SERLADRAFT_471357 SERLADRAFT_480572
WSE:	WALSEDRAFT_11682 WALSEDRAFT_69643
WIC:	J056_000494
UMA:	UMAG_02982
PFP:	PFL1_05016
MGL:	MGL_2569
PGR:	PGTG_13407
MLR:	MELLADRAFT_112249
MBR:	MONBRDRAFT_34469
SRE:	PTSG_02362
DDI:	DDB_G0292736(plc)
DPP:	DICPUDRAFT_96532
DFA:	DFA_07345 DFA_07346(plc)
ACAN:	ACA1_368260
TAN:	TA06965
TPV:	TP01_0775
TOT:	TOT_010000726
BEQ:	BEWA_038560
BBO:	BBOV_IV011070(23.m06338)
CPV:	cgd4_2560
CHO:	Chro.40288
TET:	TTHERM_00238850
PTM:	GSPATT00008002001 GSPATT00029973001 GSPATT00030070001 GSPATT00031253001 GSPATT00031342001 GSPATT00034681001
SMIN:	v1.2.010004.t1(symbB.v1.2.010004.t1) v1.2.033641.t1(symbB.v1.2.033641.t1)
PTI:	PHATRDRAFT_42683(PLC-delta) PHATRDRAFT_bd1000 PHATRDRAFT_bd1611
FCY:	FRACYDRAFT_186252 FRACYDRAFT_193320 FRACYDRAFT_203452
TPS:	THAPS_263246
AAF:	AURANDRAFT_18506(PLC1) AURANDRAFT_21478 AURANDRAFT_54465
SPAR:	SPRG_04373
EHX:	EMIHUDRAFT_100814 EMIHUDRAFT_107969 EMIHUDRAFT_113919 EMIHUDRAFT_116213 EMIHUDRAFT_219576 EMIHUDRAFT_467823 EMIHUDRAFT_99535
TBR:	Tb11.02.3780
TCR:	504149.160
LMA:	LMJF_22_1680 LMJF_30_2950
LIF:	LINJ_22_1530 LINJ_30_2970
LDO:	LDBPK_221530 LDBPK_302970
LMI:	LMXM_29_2950
LBZ:	LBRM_22_1590
NGR:	NAEGRDRAFT_1225 NAEGRDRAFT_59073 NAEGRDRAFT_80564

Reference

PMID:18593525

Authors

Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH

Title

Multiple roles of phosphoinositide-specific phospholipase C isozymes.

Journal

BMB Rep 41:415-34 (2008)

All links

Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (13)   
   KEGG PATHWAY (12)   
   KEGG MODULE (1)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (2)   
Gene (1942)   
   KEGG GENES (976)   
   KEGG MGENES (340)   
   RefGene (82)   
   EGENES (526)   
   OC (18)   
Protein sequence (410)   
   UniProt (385)   
   SWISS-PROT (25)   
Literature (1)   
   PubMed (1)   
All databases (2378)   

Download RDF

ORTHOLOGY: K05858

Entry

K05858 KO

Name

PLCB

Definition

phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]

Pathway

ko00562	Inositol phosphate metabolism
ko04015	Rap1 signaling pathway
ko04020	Calcium signaling pathway
ko04022	cGMP-PKG signaling pathway
ko04062	Chemokine signaling pathway
ko04070	Phosphatidylinositol signaling system
ko04071	Sphingolipid signaling pathway
ko04072	Phospholipase D signaling pathway
ko04261	Adrenergic signaling in cardiomyocytes
ko04270	Vascular smooth muscle contraction
ko04310	Wnt signaling pathway
ko04371	Apelin signaling pathway
ko04540	Gap junction
ko04611	Platelet activation
ko04621	NOD-like receptor signaling pathway
ko04713	Circadian entrainment
ko04720	Long-term potentiation
ko04723	Retrograde endocannabinoid signaling
ko04724	Glutamatergic synapse
ko04725	Cholinergic synapse
ko04726	Serotonergic synapse
ko04728	Dopaminergic synapse
ko04730	Long-term depression
ko04745	Phototransduction - fly
ko04750	Inflammatory mediator regulation of TRP channels
ko04911	Insulin secretion
ko04912	GnRH signaling pathway
ko04915	Estrogen signaling pathway
ko04916	Melanogenesis
ko04918	Thyroid hormone synthesis
ko04919	Thyroid hormone signaling pathway
ko04921	Oxytocin signaling pathway
ko04922	Glucagon signaling pathway
ko04924	Renin secretion
ko04925	Aldosterone synthesis and secretion
ko04933	AGE-RAGE signaling pathway in diabetic complications
ko04961	Endocrine and other factor-regulated calcium reabsorption
ko04970	Salivary secretion
ko04971	Gastric acid secretion
ko04972	Pancreatic secretion
ko05010	Alzheimer's disease
ko05016	Huntington's disease
ko05142	Chagas disease (American trypanosomiasis)
ko05143	African trypanosomiasis
ko05146	Amoebiasis
ko05200	Pathways in cancer

Module

M00130

Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4

Disease

H00606	Early infantile epileptic encephalopathy
H01815	Malignant migrating partial seizures in infancy
H01884	Auriculocondylar syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04310 Wnt signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04371 Apelin signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04020 Calcium signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04070 Phosphatidylinositol signaling system
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04072 Phospholipase D signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04071 Sphingolipid signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04022 cGMP - PKG signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
Organismal Systems
  Immune system
   04611 Platelet activation
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04621 NOD-like receptor signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04062 Chemokine signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Endocrine system
   04911 Insulin secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04922 Glucagon signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04912 GnRH signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04915 Estrogen signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04921 Oxytocin signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04918 Thyroid hormone synthesis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04919 Thyroid hormone signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04916 Melanogenesis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04924 Renin secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04925 Aldosterone synthesis and secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04270 Vascular smooth muscle contraction
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Digestive system
   04970 Salivary secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04971 Gastric acid secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04972 Pancreatic secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Nervous system
   04724 Glutamatergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04725 Cholinergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04728 Dopaminergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04726 Serotonergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04720 Long-term potentiation
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04730 Long-term depression
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04723 Retrograde endocannabinoid signaling
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Sensory system
   04745 Phototransduction - fly
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04750 Inflammatory mediator regulation of TRP channels
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Environmental adaptation
   04713 Circadian entrainment
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
Human Diseases
  Cancers
   05200 Pathways in cancer
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05016 Huntington's disease
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  Infectious diseases
   05146 Amoebiasis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05142 Chagas disease (American trypanosomiasis)
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05143 African trypanosomiasis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
KEGG modules [BR:ko00002]
Pathway module
  Carbohydrate and lipid metabolism
   Lipid metabolism
    M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
     K05858  PLCB; phosphatidylinositol phospholipase C, beta
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05858  PLCB; phosphatidylinositol phospholipase C, beta
Membrane trafficking [BR:ko04131]
Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
Endocytosis
  Macropinocytosis
   Phospholipase C
    K05858  PLCB; phosphatidylinositol phospholipase C, beta

Other DBs

RN:

GO:

Genes

HSA:	23236(PLCB1) 5330(PLCB2) 5331(PLCB3) 5332(PLCB4)
PTR:	451290(PLCB3) 453330(PLCB2) 458093(PLCB4) 469875(PLCB1)
PPS:	100969344(PLCB2) 100969660(PLCB1) 100978643(PLCB4) 100987524(PLCB3)
GGO:	101129357(PLCB3) 101140350(PLCB2) 101153613(PLCB1) 101154323(PLCB4) 109024863
PON:	100434502(PLCB1) 100458716(PLCB2) 100460060(PLCB3) 100461961(PLCB4)
NLE:	100597115(PLCB1) 100600507(PLCB4) 100600865(PLCB3) 100606558(PLCB2)
MCC:	701951(PLCB2) 717764(PLCB3) 718387(PLCB1) 718418(PLCB4)
MCF:	101925220(PLCB4) 102123165(PLCB3) 102136896(PLCB2) 102140615(PLCB1)
CSAB:	103233299(PLCB3) 103245842(PLCB2) 103246591(PLCB4) 103246657(PLCB1)
RRO:	104655777(PLCB4) 104659669(PLCB2) 104668296(PLCB1) 104673127(PLCB3)
CJC:	100386921(PLCB2) 100400803(PLCB3) 100409716(PLCB1) 100410075(PLCB4)
SBQ:	101029401(PLCB3) 101046851(PLCB4) 101047168(PLCB1) 101052271(PLCB2)
MMU:	18795(Plcb1) 18796(Plcb2) 18797(Plcb3) 18798(Plcb4)
RNO:	24654(Plcb1) 25031(Plcb4) 29322(Plcb3) 85240(Plcb2)
CGE:	100751979(Plcb1) 100760134(Plcb3) 100760731(Plcb2) 100770957(Plcb4)
NGI:	103728414 103735195(Plcb1) 103738797(Plcb3) 103741502(Plcb2)
HGL:	101696454(Plcb4) 101697744(Plcb3) 101708380(Plcb2) 101725860(Plcb1)
CCAN:	109683253 109683285(Plcb3) 109684223(Plcb1) 109688859 109688860 109688861 109688862 109701244(Plcb2)
OCU:	100341512(PLCB1) 100348672(PLCB2) 100350395(PLCB4)
TUP:	102472532(PLCB3) 102476196(PLCB4) 102477438(PLCB1) 102492903(PLCB2)
CFA:	100856190(PLCB2) 476034(PLCB3) 477160(PLCB4) 485773(PLCB1)
AML:	100465232(PLCB3) 100474779(PLCB2) 100480603(PLCB4) 100481755(PLCB1)
UMR:	103673552(PLCB2) 103674425(PLCB1) 103674426(PLCB4) 103679549(PLCB3)
FCA:	101090005(PLCB4) 101090942 101092262(PLCB1) 101092961(PLCB3) 102899339(PLCB2)
PTG:	102959485(PLCB2) 102960646(PLCB4) 102961121(PLCB1) 102961437(PLCB3)
AJU:	106968579(PLCB2) 106976431(PLCB4) 106976432(PLCB1) 106981698(PLCB3)
BTA:	281985(PLCB4) 287026(PLCB1) 508888(PLCB2) 515669(PLCB3)
BOM:	102264989(PLCB4) 102273347(PLCB1) 102276260(PLCB3) 102278948(PLCB2)
BIU:	109554384(PLCB3) 109564927(PLCB2) 109567852(PLCB1) 109567854(PLCB4)
PHD:	102318466(PLCB4) 102333745(PLCB2) 102337250(PLCB3) 102342417(PLCB1)
CHX:	102169966(PLCB2) 102180505(PLCB4) 102188148(PLCB1) 102189653(PLCB3)
OAS:	101103585(PLCB1) 101106864(PLCB4) 101113074(PLCB2) 101116105(PLCB3)
SSC:	100152679(PLCB1) 100157641(PLCB2) 100516581(PLCB4) 100525148(PLCB3)
CFR:	102505338(PLCB3) 102509058(PLCB2) 102513431(PLCB4) 102513996(PLCB1)
BACU:	102997432(PLCB4) 103006361(PLCB3) 103007077(PLCB2) 103020805(PLCB1)
LVE:	103078639(PLCB4) 103079287(PLCB1) 103083884(PLCB3) 103086280(PLCB2)
ECB:	100051485(PLCB4) 100051558(PLCB1) 100055407(PLCB3) 100057315(PLCB2)
MYB:	102238655(PLCB3) 102240650(PLCB1) 102241255(PLCB4) 102254054(PLCB2)
MYD:	102751685(PLCB1) 102751959(PLCB4) 102755123(PLCB3) 102760520(PLCB2)
HAI:	109378976(PLCB4) 109378977(PLCB1) 109383976(PLCB2) 109384329(PLCB3)
RSS:	109444239(PLCB2) 109449030(PLCB4) 109449033(PLCB1) 109450510(PLCB3)
PALE:	102879238(PLCB3) 102885207(PLCB4) 102885781(PLCB1) 102885953(PLCB2)
LAV:	100663829(PLCB3) 100668575(PLCB2) 100670617(PLCB4) 100672435(PLCB1)
MDO:	100031263(PLCB3) 100031660(PLCB1) 100031869(PLCB2) 100033281(PLCB4)
SHR:	100922938(PLCB3) 100929015(PLCB2) 100934049(PLCB4) 100934311(PLCB1)
OAA:	100078508(PLCB1) 100081349 100084272(PLCB4)
GGA:	416730(PLCB4) 423014(PLCB2) 427687(PLCB1)
MGP:	100547667(PLCB4) 100548128 664713(PLCB2)
CJO:	107307599 107310934(PLCB4) 107310953(PLCB1) 107314230(PLCB2)
APLA:	101790966(PLCB1) 101804447(PLCB2) 101805172(PLCB4)
ACYG:	106036606(PLCB4) 106036632(PLCB1) 106047056(PLCB2)
TGU:	100219122(PLCB1) 100221959(PLCB4) 100229635(PLCB2)
GFR:	102031336(PLCB4) 102037268(PLCB1) 102045029(PLCB2)
FAB:	101806047(PLCB2) 101812094(PLCB4) 101816169(PLCB1)
PHI:	102100609(PLCB4) 102105081(PLCB2) 102113003(PLCB1) 106629033 106629087
CCW:	104691519(PLCB1) 104691520(PLCB4) 104692980(PLCB2)
FPG:	101912415(PLCB2) 101916711(PLCB4) 101922366(PLCB1)
FCH:	102048018(PLCB2) 102048448(PLCB1) 102054421(PLCB4)
CLV:	102096635(PLCB2) 102097554(PLCB4) 102098150(PLCB1)
AAM:	106486714(PLCB2) 106490470(PLCB4) 106490480(PLCB1)
ASN:	102371353(PLCB3) 102379390(PLCB4) 102381048(PLCB2) 102381939(PLCB1)
AMJ:	102560430(PLCB4) 102566880(PLCB1) 102572359(PLCB2) 102576994(PLCB3) 109282420
PSS:	102449462(PLCB3) 102455767(PLCB4) 102460883(PLCB1) 102461092(PLCB2)
CMY:	102931046(PLCB2) 102932254(PLCB3) 102942020(PLCB1) 102942246(PLCB4)
CPIC:	101930785(PLCB2) 101931546(PLCB4) 101932753(PLCB1) 101940400(PLCB3)
ACS:	100551754(plcb2) 100560758(plcb4) 100566853(plcb1) 100567752(plcb3)
PBI:	103055449(PLCB2) 103057663(PLCB4) 103062216(PLCB1) 103064298 103066383
GJA:	107106753(PLCB1) 107115177(PLCB3) 107119642(PLCB2) 107123869 107123894(PLCB4)
XLA:	108699254(plcb2.L) 108716399(plcb4.L) 108716400 397692(plcb3.L) 445848(plcb4.S) 733258(plcb1.S)
XTR:	100125098(plcb4) 100487267(plcb3) 101734935(plcb2) 780394(plcb1)
NPR:	108789286(PLCB2) 108793965(PLCB3) 108795338(PLCB4) 108795563(PLCB1)
DRE:	100001532(plcb3) 100537538 407700(plcb4) 569376(plcb2)
SRX:	107707789 107712192 107712202(plcb4) 107716052 107721661 107726572 107728313 107728323 107737900 107740752 107744270 107757379
SANH:	107659797 107659823 107661090 107661968 107663134 107663155 107663156 107678713(plcb2) 107678738 107682610
SGH:	107552867 107552868 107552879 107552896 107557888 107557900 107557901 107560167(plcb2) 107564330 107564333 107569311 107578054 107583283 107594127 107594128
IPU:	108258041(PLCB4) 108258091(PLCB1) 108267602(PLCB3) 108269611(plcb2) 108270307(plcb1) 108270308
TRU:	101065367(plcb1) 101069591 101073102(plcb3) 101076025(plcb2) 101078708(plcb4)
TNG:	GSTEN00002207G001 GSTEN00003549G001 GSTEN00018741G001 GSTEN00020280G001 GSTEN00020281G001 GSTEN00020282G001 GSTEN00020283G001 GSTEN00032419G001
LCO:	104919801(plcb4) 104920858(plcb1) 104924817(plcb2) 104928901(plcb3) 104935685 109138593 109140342
NCC:	104946378(plcb4) 104947200(plcb2) 104948204(plcb3) 104950405 104951799(plcb1) 104964222
MZE:	101464832(plcb4) 101465812(plcb1) 101474135(plcb3) 101475994(plcb2) 101478971
OLA:	100049465(plcb2) 100049529 100049535(plcb4) 101166030 101172698(plcb1) 101175365
XMA:	102217878 102219479 102223820(plcb4) 102224078(plcb1) 102230660(plcb2)
CSEM:	103381058(plcb1) 103381059(plcb4) 103384259 103385127(plcb3) 103387749 103389807(plcb2) 103399084
LCF:	108872939 108892548(plcb2) 108893282 108896906(plcb4) 108896922(plcb1)
SASA:	106571556 106571557(plcb4) 106571738 106578106 106591031 106592886 106593689 106595124 106599624 106608040 106608052 106608062 106608063 106608066 106610872(plcb2) 106610916
ELS:	105007096(plcb3) 105015712(plcb2) 105017520(plcb1) 105017521(plcb4) 105031658
SFM:	108919358(plcb2) 108922946 108925497(plcb3) 108929291 108929356(plcb4)
LCM:	102345855(PLCB1) 102346126 102348275(PLCB4) 102362364(PLCB2) 102363030 102365542(PLCB3)
CMK:	103171709 103186433(plcb4) 103187499(plcb2) 103187635(plcb1) 103191092 103191382
BFO:	BRAFLDRAFT_170074 BRAFLDRAFT_202613 BRAFLDRAFT_202677
CIN:	100182086 100186259(plcb4)
SPU:	100888919 587412(plcb4)
SKO:	100376870 100377106
DME:	Dmel_CG3620(norpA) Dmel_CG4574(Plc21C)
DPO:	Dpse_GA17564 Dpse_GA18269
DAN:	Dana_GF19456 Dana_GF20639
DER:	Dere_GG18703 Dere_GG24713
DPE:	Dper_GL14297 Dper_GL18869
DSE:	Dsec_GM12340 Dsec_GM16735
DSI:	Dsimw501_GD16687(Dsim_GD16687) Dsimw501_GD23017(Dsim_GD23017)
DWI:	Dwil_GK15712 Dwil_GK23786
DYA:	Dyak_GE16341 Dyak_GE16747(Dyak_Plc21C)
DGR:	Dgri_GH10584 Dgri_GH24286
DMO:	Dmoj_GI16411 Dmoj_GI23110
DVI:	Dvir_GJ17032 Dvir_GJ23620
MDE:	101890926 101896046
AGA:	AgaP_AGAP001936 AgaP_AGAP009115
AAG:	AaeL_AAEL009380 AaeL_AAEL010124 AaeL_AAEL017393
CQU:	CpipJ_CPIJ000778 CpipJ_CPIJ008403
AME:	408791(Plc) 408996(norpA2)
BIM:	100740167 100741416 100745742
BTER:	100642628 100644023 100649981
SOC:	105193187 105194901 105200207
AEC:	105143133 105153332 105153367
ACEP:	105617321 105620891 105621470
PBAR:	105423419 105433233 105434284
HST:	105182692 105184531 105189361
CFO:	105249554 105250162 105254466 105255784
LHU:	105670772 105671798 105674793
NVI:	100115054 100120894 100122708
TCA:	659062 662602
DPA:	109533383 109534788 109536412 109539915 109539926 109541674
NVL:	108558941 108562170
BMOR:	100329153(PLCb1) 100329154(PLCb4)
PXY:	105384635 105388539 105389487 105394759 105396020
API:	100162131 100166756
DNX:	107162504 107163546
PHU:	Phum_PHUM231170 Phum_PHUM447590 Phum_PHUM602870
DPX:	DAPPUDRAFT_206341(Plcb2) DAPPUDRAFT_226357(Plcb1)
ISC:	IscW_ISCW001177 IscW_ISCW001178
TUT:	107360466 107362492
CEL:	CELE_B0348.4(egl-8)
CBR:	CBG06373(Cbr-egl-8)
NAI:	NECAME_13344
BMY:	Bm1_51505
LOA:	LOAG_16338 LOAG_16339
TSP:	Tsp_02482 Tsp_02544 Tsp_13132
HRO:	HELRODRAFT_109918 HELRODRAFT_189171 HELRODRAFT_92027
LGI:	LOTGIDRAFT_107866 LOTGIDRAFT_123959
CRG:	105318640 105335651 105343409
OBI:	106870488 106884061
SMM:	Smp_146330
OVI:	T265_05106
NVE:	NEMVE_v1g101739 NEMVE_v1g174
ADF:	107328601 107341838 107341839
HMG:	100189549(plcbh1) 100200484
TAD:	TRIADDRAFT_61893 TRIADDRAFT_61894
AQU:	100641378
MBR:	MONBRDRAFT_21166
SRE:	PTSG_09606
EHX:	EMIHUDRAFT_121888

Reference

PMID:11118617

Authors

Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC

Title

Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1).

Journal

Biochim Biophys Acta 1517:63-72 (2000)
DOI:10.1016/S0167-4781(00)00260-8

Sequence

[hsa:23236]

Reference

PMID:1644792

Authors

Park D, Jhon DY, Kriz R, Knopf J, Rhee SG

Title

Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2.

Journal

J Biol Chem 267:16048-55 (1992)

Sequence

[hsa:5330]

Reference

PMID:1333955

Authors

Carozzi AJ, Kriz RW, Webster C, Parker PJ

Title

Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily.

Journal

Eur J Biochem 210:521-9 (1992)
DOI:10.1111/j.1432-1033.1992.tb17450.x

Sequence

[hsa:5331]

Reference

PMID:8530101

Authors

Alvarez RA, Ghalayini AJ, Xu P, Hardcastle A, Bhattacharya S, Rao PN, Pettenati MJ, Anderson RE, Baehr W

Title

cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4).

Journal

Genomics 29:53-61 (1995)
DOI:10.1006/geno.1995.1214

Sequence

[hsa:5332]

All links

Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (95)   
   KEGG PATHWAY (94)   
   KEGG MODULE (1)   
Disease (3)   
   KEGG DISEASE (3)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (2)   
Gene (1863)   
   KEGG GENES (560)   
   KEGG MGENES (1016)   
   RefGene (242)   
   EGENES (34)   
   OC (11)   
Protein sequence (140)   
   UniProt (127)   
   SWISS-PROT (13)   
Literature (4)   
   PubMed (4)   
All databases (2116)   

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ORTHOLOGY: K05859

Entry

K05859 KO

Name

PLCG2

Definition

phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]

Pathway

ko00562	Inositol phosphate metabolism
ko01521	EGFR tyrosine kinase inhibitor resistance
ko04012	ErbB signaling pathway
ko04014	Ras signaling pathway
ko04020	Calcium signaling pathway
ko04064	NF-kappa B signaling pathway
ko04066	HIF-1 signaling pathway
ko04070	Phosphatidylinositol signaling system
ko04072	Phospholipase D signaling pathway
ko04360	Axon guidance
ko04370	VEGF signaling pathway
ko04380	Osteoclast differentiation
ko04611	Platelet activation
ko04650	Natural killer cell mediated cytotoxicity
ko04662	B cell receptor signaling pathway
ko04664	Fc epsilon RI signaling pathway
ko04666	Fc gamma R-mediated phagocytosis
ko04670	Leukocyte transendothelial migration
ko04722	Neurotrophin signaling pathway
ko04750	Inflammatory mediator regulation of TRP channels
ko04919	Thyroid hormone signaling pathway
ko04933	AGE-RAGE signaling pathway in diabetic complications
ko05110	Vibrio cholerae infection
ko05120	Epithelial cell signaling in Helicobacter pylori infection
ko05167	Kaposi's sarcoma-associated herpesvirus infection
ko05169	Epstein-Barr virus infection
ko05200	Pathways in cancer
ko05205	Proteoglycans in cancer
ko05206	MicroRNAs in cancer
ko05214	Glioma
ko05223	Non-small cell lung cancer

Module

M00130

Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4

Disease

H01743

Autoinflammation and PLCG2-associated antibody deficiency and immune dysregulation (APLAID)

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04012 ErbB signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04370 VEGF signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04064 NF-kappa B signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04066 HIF-1 signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04020 Calcium signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04070 Phosphatidylinositol signaling system
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04072 Phospholipase D signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Organismal Systems
  Immune system
   04611 Platelet activation
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04650 Natural killer cell mediated cytotoxicity
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04662 B cell receptor signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04664 Fc epsilon RI signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04666 Fc gamma R-mediated phagocytosis
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04670 Leukocyte transendothelial migration
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  Nervous system
   04722 Neurotrophin signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  Development
   04360 Axon guidance
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04380 Osteoclast differentiation
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Human Diseases
  Cancers
   05200 Pathways in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05206 MicroRNAs in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05205 Proteoglycans in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05214 Glioma
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05223 Non-small cell lung cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  Infectious diseases
   05110 Vibrio cholerae infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05169 Epstein-Barr virus infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
KEGG modules [BR:ko00002]
Pathway module
  Carbohydrate and lipid metabolism
   Lipid metabolism
    M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
     K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Membrane trafficking [BR:ko04131]
Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Endocytosis
  Macropinocytosis
   Phospholipase C
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2

Other DBs

RN:

GO:

Genes

HSA:	5336(PLCG2)
PTR:	454268(PLCG2)
PPS:	100984694(PLCG2)
GGO:	101133643(PLCG2)
PON:	100457650(PLCG2)
NLE:	100604145(PLCG2)
MCC:	714173(PLCG2)
MCF:	102117471(PLCG2)
CSAB:	103233371(PLCG2)
RRO:	104671624(PLCG2)
CJC:	100390347(PLCG2)
SBQ:	101030999(PLCG2)
MMU:	234779(Plcg2)
RNO:	29337(Plcg2)
CGE:	100752475(Plcg2)
NGI:	103725694 103748739
HGL:	101714597 101715321(Plcg2)
CCAN:	109696649(Plcg2)
OCU:	100340139(PLCG2)
TUP:	102483786(PLCG2)
CFA:	489692(PLCG2)
AML:	100481994(PLCG2)
UMR:	103662093(PLCG2)
FCA:	101080675(PLCG2)
PTG:	102963653(PLCG2)
AJU:	106984018(PLCG2)
BTA:	100337091(PLCG2)
BOM:	102285300(PLCG2)
BIU:	109572707(PLCG2)
PHD:	102318880(PLCG2)
CHX:	102180337(PLCG2)
OAS:	101122126(PLCG2)
SSC:	100518663(PLCG2)
CFR:	102514470(PLCG2)
BACU:	103014764(PLCG2)
LVE:	103070997(PLCG2)
ECB:	100055670(PLCG2)
MYB:	102261553(PLCG2)
MYD:	102773476(PLCG2)
HAI:	109378365(PLCG2)
RSS:	109453719(PLCG2)
PALE:	102883128(PLCG2)
LAV:	100658990(PLCG2)
MDO:	100027579(PLCG2)
SHR:	100919206(PLCG2)
OAA:	100076776(PLCG2)
GGA:	415805(PLCG2)
MGP:	100549684(PLCG2)
CJO:	107319403(PLCG2)
APLA:	101799246(PLCG2)
ACYG:	106044837
TGU:	100219388(PLCG2)
GFR:	102039725(PLCG2)
FAB:	101811465(PLCG2)
PHI:	102103443(PLCG2)
CCW:	104691823(PLCG2)
FPG:	101914329(PLCG2)
FCH:	102058636(PLCG2)
CLV:	102095823(PLCG2)
AAM:	106483269(PLCG2) 106489897
ASN:	102378303(PLCG2)
AMJ:	106736910(PLCG2)
PSS:	102454220(PLCG2)
CMY:	102930635(PLCG2)
CPIC:	101932685(PLCG2)
ACS:	100566814(plcg2)
PBI:	103052396(PLCG2)
GJA:	107105783(PLCG2)
XLA:	108714087(plcg2.L)
XTR:	100496686(plcg2)
NPR:	108786572(PLCG2)
DRE:	561747(plcg2)
SRX:	107722471 107738392
SANH:	107656933 107666218 107666222(plcg2) 107684680
SGH:	107559804(plcg2) 107587040 107587041
IPU:	108264222(plcg2)
TRU:	101072923(plcg2)
TNG:	GSTEN00016798G001
LCO:	104932460(plcg2)
NCC:	104955634 104957481
MZE:	101479429(plcg2)
OLA:	101157053(plcg2)
XMA:	102220131(plcg2)
CSEM:	103379748(plcg2)
LCF:	108902239(plcg2)
SASA:	106573684(plcg2)
ELS:	105018577(plcg2)
SFM:	108926548 108926652(plcg2)
LCM:	102358132(PLCG2) 102358647
CMK:	103175953(plcg2)
API:	100161327
TET:	TTHERM_00317320

Reference

PMID:2849563

Authors

Ohta S, Matsui A, Nazawa Y, Kagawa Y

Title

Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes.

Journal

FEBS Lett 242:31-5 (1988)
DOI:10.1016/0014-5793(88)80979-7

Sequence

[hsa:5336]

Reference

PMID:23555801

Authors

Bernal-Quiros M, Wu YY, Alarcon-Riquelme ME, Castillejo-Lopez C

Title

BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling.

Journal

PLoS One 8:e59842 (2013)
DOI:10.1371/journal.pone.0059842

Sequence

[hsa:5336]

All links

Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (65)   
   KEGG PATHWAY (64)   
   KEGG MODULE (1)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (2)   
Gene (297)   
   KEGG GENES (104)   
   KEGG MGENES (141)   
   RefGene (40)   
   EGENES (9)   
   OC (3)   
Protein sequence (27)   
   UniProt (24)   
   SWISS-PROT (3)   
Literature (2)   
   PubMed (2)   
All databases (403)   

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ORTHOLOGY: K05860

Entry

K05860 KO

Name

PLCE

Definition

phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]

Pathway

ko00562	Inositol phosphate metabolism
ko04014	Ras signaling pathway
ko04015	Rap1 signaling pathway
ko04020	Calcium signaling pathway
ko04024	cAMP signaling pathway
ko04070	Phosphatidylinositol signaling system
ko04919	Thyroid hormone signaling pathway
ko04933	AGE-RAGE signaling pathway in diabetic complications
ko05205	Proteoglycans in cancer

Module

M00130

Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4

Disease

H01657

Nephrotic syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
   04015 Rap1 signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
   04020 Calcium signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
   04070 Phosphatidylinositol signaling system
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
   04024 cAMP signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
Organismal Systems
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
KEGG modules [BR:ko00002]
Pathway module
  Carbohydrate and lipid metabolism
   Lipid metabolism
    M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
     K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
Membrane trafficking [BR:ko04131]
Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
Endocytosis
  Macropinocytosis
   Phospholipase C
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon

Other DBs

RN:

GO:

Genes

HSA:	51196(PLCE1)
PTR:	450620(PLCE1)
PPS:	100992707(PLCE1)
GGO:	101125007(PLCE1)
PON:	100444145(PLCE1)
NLE:	100599747(PLCE1)
MCC:	701758(PLCE1)
MCF:	102142941(PLCE1)
CSAB:	103216291(PLCE1)
RRO:	104666130(PLCE1)
CJC:	100385383(PLCE1) 103796762
SBQ:	101043700(PLCE1)
MMU:	74055(Plce1)
RNO:	114633(Plce1)
CGE:	100754217(Plce1)
NGI:	103750131(Plce1)
HGL:	101706315(Plce1)
CCAN:	109681766(Plce1)
OCU:	100344504(PLCE1)
TUP:	102499439(PLCE1)
CFA:	486808(PLCE1)
AML:	100479318(PLCE1)
UMR:	103667971(PLCE1)
FCA:	101088695(PLCE1)
PTG:	102949488(PLCE1)
AJU:	106965849(PLCE1)
BTA:	519037(PLCE1)
BOM:	102268410(PLCE1)
BIU:	109553155(PLCE1)
PHD:	102328398(PLCE1)
CHX:	102178972(PLCE1)
OAS:	101105703(PLCE1)
SSC:	100157745(PLCE1)
CFR:	102519191(PLCE1)
BACU:	103016185(PLCE1)
LVE:	103080930(PLCE1)
ECB:	100061676(PLCE1)
MYB:	102241624(PLCE1)
MYD:	102754476(PLCE1)
HAI:	109380957 109380958
RSS:	109451494(PLCE1)
PALE:	102898319(PLCE1) 107196691
LAV:	100677444(PLCE1)
MDO:	100023487(PLCE1)
SHR:	100917022(PLCE1)
GGA:	425224(PLCE1)
MGP:	100540174(PLCE1)
CJO:	107316035(PLCE1)
APLA:	101794187(PLCE1)
ACYG:	106042534(PLCE1)
TGU:	100222852(PLCE1)
GFR:	102031533(PLCE1)
FAB:	101810240(PLCE1)
PHI:	102113055(PLCE1)
CCW:	104696321(PLCE1)
FPG:	101913673(PLCE1)
FCH:	102055055(PLCE1)
CLV:	102086659(PLCE1)
AAM:	106494113 106494114(PLCE1)
ASN:	102373514(PLCE1)
AMJ:	102565045(PLCE1)
PSS:	102447740 102463271(PLCE1)
CMY:	102943550(PLCE1)
CPIC:	101944378(PLCE1)
ACS:	100552081(plce1)
PBI:	103066924(PLCE1)
GJA:	107106488(PLCE1)
XLA:	108696196 108697196
XTR:	100495530(plce1)
NPR:	108792005(PLCE1)
DRE:	568288(plce1)
SRX:	107708880 107743958
SANH:	107653923 107664595(plce1)
SGH:	107557325 107598645 107598646 107598647
IPU:	108273837(plce1)
TRU:	101065955(plce1)
TNG:	GSTEN00011175G001 GSTEN00035002G001
LCO:	104932513(plce1)
NCC:	104963128(plce1)
MZE:	101480055(plce1)
OLA:	101164102(plce1)
XMA:	102228460(plce1)
CSEM:	103381430(plce1)
LCF:	108898737(plce1)
SASA:	106577205 106578971 106589374(plce1) 106608514
ELS:	105021417 105025138(plce1)
SFM:	108939627(plce1)
LCM:	102345110(PLCE1)
CMK:	103180693(plce1)
BFO:	BRAFLDRAFT_93082
SPU:	592193
SKO:	102809018
AGA:	AgaP_AGAP002529
AAG:	AaeL_AAEL008246
CQU:	CpipJ_CPIJ018676
AME:	408804(Fucta)
BIM:	100744997
BTER:	100649725
SOC:	105194827
AEC:	105151783
ACEP:	105627765
PBAR:	105425147
HST:	105182316
CFO:	105253013
LHU:	105673877
NVI:	100116596
TCA:	661312
DPA:	109536544 109542350
NVL:	108556911
BMOR:	101735646
PXY:	105385356 105386068 105390130 105397251
API:	100168206
DNX:	107169403
DPX:	DAPPUDRAFT_119242 DAPPUDRAFT_67122
ISC:	IscW_ISCW009315
TUT:	107360575
CEL:	CELE_F31B12.1(plc-1)
CBR:	CBG17587(Cbr-plc-1)
BMY:	Bm1_40160
LOA:	LOAG_01625
TSP:	Tsp_05005
LGI:	LOTGIDRAFT_114718
CRG:	105331084
OBI:	106874430

Reference

PMID:18593525

Authors

Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH

Title

Multiple roles of phosphoinositide-specific phospholipase C isozymes.

Journal

BMB Rep 41:415-34 (2008)

All links

Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (21)   
   KEGG PATHWAY (20)   
   KEGG MODULE (1)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (2)   
Gene (490)   
   KEGG GENES (145)   
   KEGG MGENES (276)   
   RefGene (58)   
   EGENES (7)   
   OC (4)   
Protein sequence (30)   
   UniProt (26)   
   SWISS-PROT (4)   
Literature (1)   
   PubMed (1)   
All databases (554)   

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ORTHOLOGY: K05861

Entry

K05861 KO

Name

PLCZ

Definition

phosphatidylinositol phospholipase C, zeta [EC:3.1.4.11]

Pathway

ko00562	Inositol phosphate metabolism
ko04020	Calcium signaling pathway
ko04070	Phosphatidylinositol signaling system
ko04114	Oocyte meiosis
ko04919	Thyroid hormone signaling pathway

Module

M00130

Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
Environmental Information Processing
  Signal transduction
   04020 Calcium signaling pathway
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
   04070 Phosphatidylinositol signaling system
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
Cellular Processes
  Cell growth and death
   04114 Oocyte meiosis
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
Organismal Systems
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
KEGG modules [BR:ko00002]
Pathway module
  Carbohydrate and lipid metabolism
   Lipid metabolism
    M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
     K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
Membrane trafficking [BR:ko04131]
Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta

Other DBs

RN:

GO:

Genes

HSA:	89869(PLCZ1)
PTR:	743002(PLCZ1)
PPS:	100988020(PLCZ1)
GGO:	101151875(PLCZ1)
PON:	100442086(PLCZ1)
NLE:	100580724(PLCZ1)
MCC:	703293(PLCZ1)
MCF:	102122753(PLCZ1)
CSAB:	103218714(PLCZ1)
RRO:	104655304(PLCZ1)
CJC:	100406733(PLCZ1)
SBQ:	101050254(PLCZ1)
MMU:	114875(Plcz1)
RNO:	497197(Plcz1)
CGE:	100754031(Plcz1)
NGI:	103733964(Plcz1)
HGL:	101709944(Plcz1)
CCAN:	109701042(Plcz1)
OCU:	100359131(PLCZ1)
TUP:	102481589(PLCZ1)
CFA:	486657(PLCZ1)
AML:	100471118(PLCZ1)
UMR:	103677800(PLCZ1)
FCA:	101085554(PLCZ1)
PTG:	102968210(PLCZ1)
AJU:	106977172(PLCZ1)
BTA:	497026(PLCZ1)
BOM:	102274303(PLCZ1)
BIU:	109558802(PLCZ1)
PHD:	102326634(PLCZ1)
CHX:	102170761(PLCZ1)
OAS:	101122850(PLCZ1)
SSC:	397632(PLCZ1)
CFR:	102506863(PLCZ1)
BACU:	102999522(PLCZ1)
LVE:	103075635(PLCZ1)
ECB:	100067798(PLCZ1)
MYB:	102261189(PLCZ1)
MYD:	102752787(PLCZ1)
HAI:	109371226(PLCZ1)
RSS:	109436211 109454242(PLCZ1)
PALE:	102887168(PLCZ1)
LAV:	100663854(PLCZ1)
MDO:	100012056(PLCZ1)
GGA:	418182(PLCZ1)
MGP:	100549451
CJO:	107316456(PLCZ1)
APLA:	101801909(PLCZ1)
ACYG:	106030891(PLCZ1)
TGU:	100229724(PLCZ1)
GFR:	102035295(PLCZ1)
FAB:	101810163(PLCZ1)
PHI:	102108407(PLCZ1)
CCW:	104692298(PLCZ1)
FPG:	101924543(PLCZ1)
FCH:	102059240(PLCZ1)
CLV:	102083512(PLCZ1)
AAM:	106488477(PLCZ1)
ASN:	102382411(PLCZ1)
AMJ:	102576997(PLCZ1)
PSS:	102463553(PLCZ1)
CMY:	102941985(PLCZ1)
CPIC:	101931350(PLCZ1)
ACS:	100555994 100558870
PBI:	103061230 103064700
GJA:	107109019(PLCZ1) 107121264
NPR:	108791809(PLCZ1)
TNG:	GSTEN00029777G001
NCC:	104942417
OLA:	101167285
CMK:	103185584(plcz1)

Reference

PMID:18593525

Authors

Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH

Title

Multiple roles of phosphoinositide-specific phospholipase C isozymes.

Journal

BMB Rep 41:415-34 (2008)

All links

Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (13)   
   KEGG PATHWAY (12)   
   KEGG MODULE (1)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (2)   
Gene (93)   
   KEGG GENES (75)   
   KEGG MGENES (9)   
   RefGene (4)   
   EGENES (4)   
   OC (1)   
Protein sequence (23)   
   UniProt (16)   
   SWISS-PROT (7)   
Literature (1)   
   PubMed (1)   
All databases (141)   

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ORTHOLOGY: K19006

Entry

K19006 KO

Name

PLCH

Definition

phosphatidylinositol phospholipase C, eta [EC:3.1.4.11]

Pathway

ko00562

Inositol phosphate metabolism

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K19006  PLCH; phosphatidylinositol phospholipase C, eta
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K19006  PLCH; phosphatidylinositol phospholipase C, eta
Membrane trafficking [BR:ko04131]
Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K19006  PLCH; phosphatidylinositol phospholipase C, eta
Endocytosis
  Macropinocytosis
   Phospholipase C
    K19006  PLCH; phosphatidylinositol phospholipase C, eta

Other DBs

RN:

GO:

004435

Genes

HSA:	23007(PLCH1) 9651(PLCH2)
PTR:	107974505(PLCH2) 460795(PLCH1) 469461
PPS:	100983463(PLCH2) 100983913(PLCH1)
GGO:	101131911(PLCH1) 101132332(PLCH2)
PON:	100439054(PLCH2) 100459118(PLCH1)
NLE:	100589782(PLCH1) 100597962(PLCH2)
MCC:	694686(PLCH2) 707243(PLCH1)
MCF:	102116711(PLCH1) 102139698(PLCH2)
CSAB:	103225758(PLCH2) 103241439(PLCH1)
RRO:	104653565 104672374 104676457(PLCH1)
CJC:	100386721(PLCH1) 100396419(PLCH2)
SBQ:	101039016(PLCH2) 101044356(PLCH1)
MMU:	269437(Plch1) 269615(Plch2)
RNO:	310463(Plch1) 313756(Plch2)
CGE:	100760460(Plch1) 100769053(Plch2)
NGI:	103740083(Plch1) 103749775(Plch2)
HGL:	101717211(Plch1) 101725366(Plch2)
CCAN:	109679335(Plch1) 109681137 109691444(Plch2)
OCU:	100358542(PLCH1)
TUP:	102485536(PLCH2) 102496252(PLCH1)
CFA:	100684810(PLCH1) 489613(PLCH2)
AML:	100468521(PLCH1) 100476835(PLCH2)
UMR:	103677618(PLCH1) 103678452(PLCH2)
FCA:	101087261(PLCH1) 101089122(PLCH2)
PTG:	102950867(PLCH2) 102955133(PLCH1)
AJU:	106974864(PLCH1) 106984646(PLCH2)
BTA:	513565(PLCH1) 514590(PLCH2)
BOM:	102269456(PLCH1) 102284004(PLCH2)
BIU:	109559080(PLCH1) 109570532(PLCH2)
PHD:	102325766(PLCH1) 102339754(PLCH2)
CHX:	102185202(PLCH2) 108633199(PLCH1)
OAS:	101112368(PLCH1) 101121029(PLCH2)
SSC:	100623940(PLCH2) 100627163(PLCH1)
CFR:	102510365 102512388(PLCH1) 106729436 106730088
BACU:	103001427(PLCH2) 103007983(PLCH1)
LVE:	103073865(PLCH1) 103081277(PLCH2)
ECB:	100049953(PLCH1)
MYB:	102259618(PLCH1) 102262915(PLCH2)
MYD:	102761516(PLCH1) 102775374(PLCH2)
HAI:	109373690(PLCH1) 109391210(PLCH2)
RSS:	109434825(PLCH2) 109447552(PLCH1)
PALE:	102892579(PLCH1) 102892882(PLCH2)
LAV:	100669123(PLCH1) 100675385(PLCH2)
MDO:	100019654(PLCH1) 100027830(PLCH2)
SHR:	100920031(PLCH1) 100933045(PLCH2)
OAA:	100075209(PLCH1)
GGA:	425030(PLCH1) 428180(PLCH2)
MGP:	100538446(PLCH2) 100547179(PLCH1)
CJO:	107318430(PLCH1) 107323431(PLCH2)
APLA:	101800151(PLCH2) 101805220(PLCH1)
ACYG:	106043516(PLCH1) 106044650(PLCH2)
TGU:	100219860(PLCH1) 100228326(PLCH2)
GFR:	102033764(PLCH1) 102037795(PLCH2)
FAB:	101806694(PLCH1) 101817560(PLCH2)
PHI:	102107488(PLCH1) 102114503(PLCH2)
CCW:	104688086(PLCH1) 104693388(PLCH2)
FPG:	101913233(PLCH1) 101920366(PLCH2)
FCH:	102048885(PLCH2) 102049933(PLCH1)
CLV:	102088630(PLCH1) 102098625(PLCH2)
AAM:	106485763(PLCH2) 106497161(PLCH1)
ASN:	102370362(PLCH2) 102386888(PLCH1)
AMJ:	102562350(PLCH2) 102566726(PLCH1)
PSS:	102452900(PLCH2) 102463994(PLCH1)
CMY:	102935782 102942071(PLCH1)
CPIC:	101931114(PLCH2) 101933764(PLCH1)
ACS:	100551923(plch1) 100552819(plch2)
PBI:	103058371(PLCH2) 103064271(PLCH1)
GJA:	107110189(PLCH2) 107122262 107122439(PLCH1)
XLA:	108696538 108697630 108717044 108718120
XTR:	100487353(plch2) 100497252(plch1)
NPR:	108787455(PLCH1) 108794139(PLCH2)
DRE:	100334231(plch2a) 566479(plch1)
SRX:	107710777 107711761 107727881 107741376 107748081 107748961 107749450
SANH:	107671075 107685664 107685665 107687112 107691057 107691356 107697633 107697637
SGH:	107557155 107564964 107566580 107569148 107577563 107595766 107597244 107602463
IPU:	108264778(plch1) 108265040(plch2)
TRU:	101061761 101071670(plch1) 101076439 105419327 105419682
TNG:	GSTEN00005287G001 GSTEN00005403G001 GSTEN00005404G001 GSTEN00027540G001
LCO:	104930967 104931767(plch2) 104933846(plch1)
NCC:	104947924 104951541 104958024 104960732 104960736
MZE:	101464574(plch2) 101474427(plch1) 101475135 106676986
OLA:	101156884 101164891(plch2) 101170362(plch1)
XMA:	102219169 102224567 102225168
CSEM:	103378373 103384884(plch2) 103385692
LCF:	108899127 108899780 108900503(plch2)
SASA:	106567456(plch2) 106572832 106581453 106581476 106582806 106613257 106613270
ELS:	105023783(plch2) 105028724(plch1) 105028828
SFM:	108924653 108924654 108924918(plch2)
LCM:	102353757(PLCH1) 102365142(PLCH2)
CMK:	103175732(plch1) 103184263(plch2)
BFO:	BRAFLDRAFT_231373 BRAFLDRAFT_231438
CIN:	100182882
SKO:	100374538
NVE:	NEMVE_v1g161360
ADF:	107327580 107330270
AQU:	100640663
PPP:	PHYPADRAFT_216835(PLC1)
VCN:	VOLCADRAFT_86296
SRE:	PTSG_01932 PTSG_12022
TET:	TTHERM_00486470
EHX:	EMIHUDRAFT_209393
GTT:	GUITHDRAFT_102497

Reference

PMID:15702972

Authors

Hwang JI, Oh YS, Shin KJ, Kim H, Ryu SH, Suh PG

Title

Molecular cloning and characterization of a novel phospholipase C, PLC-eta.

Journal

Biochem J 389:181-6 (2005)
DOI:10.1042/BJ20041677

Sequence

[hsa:23007]

Reference

PMID:16107206

Authors

Zhou Y, Wing MR, Sondek J, Harden TK

Title

Molecular cloning and characterization of PLC-eta2.

Journal

Biochem J 391:667-76 (2005)
DOI:10.1042/BJ20050839

Sequence

[hsa:9651]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (2)   
Gene (664)   
   KEGG GENES (239)   
   KEGG MGENES (328)   
   RefGene (89)   
   OC (8)   
Protein sequence (25)   
   UniProt (21)   
   SWISS-PROT (4)   
Literature (2)   
   PubMed (2)   
All databases (705)   

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ENZYME: 3.1.4.11

Entry

EC 3.1.4.11 Enzyme

Name

phosphoinositide phospholipase C;
triphosphoinositide phosphodiesterase;
phosphoinositidase C;
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase;
monophosphatidylinositol phosphodiesterase;
phosphatidylinositol phospholipase C;
PI-PLC;
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase

Class

Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases

Sysname

1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase

Reaction(IUBMB)

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol [RN:R03435]

Reaction(KEGG)

R03435;
(other) R03332 R10952

Substrate

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637];
H2O [CPD:C00001]

Product

1D-myo-inositol 1,4,5-trisphosphate [CPD:C01245];
diacylglycerol [CPD:C00641]

Comment

These enzymes form some of the cyclic phosphate Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four beta-isoforms regulated by G-proteins, two gamma-forms regulated by tyrosine kinases, four delta-forms regulated at least in part by calcium and an epsilon-form, probably regulated by the oncogene ras, have been found.

History

EC 3.1.4.11 created 1972, modified 2002

Pathway

ec00562	Inositol phosphate metabolism
ec01100	Metabolic pathways

Orthology

K01116	phosphatidylinositol phospholipase C, gamma-1
K05857	phosphatidylinositol phospholipase C, delta
K05858	phosphatidylinositol phospholipase C, beta
K05859	phosphatidylinositol phospholipase C, gamma-2
K05860	phosphatidylinositol phospholipase C, epsilon
K05861	phosphatidylinositol phospholipase C, zeta
K19006	phosphatidylinositol phospholipase C, eta

Genes

HSA:	113026(PLCD3) 23007(PLCH1) 23236(PLCB1) 51196(PLCE1) 5330(PLCB2) 5331(PLCB3) 5332(PLCB4) 5333(PLCD1) 5335(PLCG1) 5336(PLCG2) 84812(PLCD4) 89869(PLCZ1) 9651(PLCH2)
PTR:	107974505(PLCH2) 450620(PLCE1) 451290(PLCB3) 453330(PLCB2) 454268(PLCG2) 458093(PLCB4) 458253(PLCG1) 460267(PLCD1) 460795(PLCH1) 468279(PLCD3) 469461 469875(PLCB1) 470647(PLCD4) 743002(PLCZ1)
PPS:	100969236(PLCD1) 100969344(PLCB2) 100969660(PLCB1) 100978643(PLCB4) 100980795(PLCD3) 100983463(PLCH2) 100983913(PLCH1) 100984694(PLCG2) 100987524(PLCB3) 100988020(PLCZ1) 100988032(PLCD4) 100992707(PLCE1) 100995010(PLCG1)
GGO:	101125007(PLCE1) 101129357(PLCB3) 101131911(PLCH1) 101132332(PLCH2) 101133643(PLCG2) 101135199(PLCG1) 101136081(PLCD4) 101139984(PLCD1) 101140350(PLCB2) 101142984(PLCD3) 101151875(PLCZ1) 101153613(PLCB1) 101154323(PLCB4) 109024863 109025954
PON:	100171640(PLCD4) 100434502(PLCB1) 100439054(PLCH2) 100442086(PLCZ1) 100443819(PLCD3) 100444145(PLCE1) 100450941(PLCG1) 100457650(PLCG2) 100458716(PLCB2) 100459118(PLCH1) 100460060(PLCB3) 100461961(PLCB4) 100462440(PLCD1)
NLE:	100580724(PLCZ1) 100589782(PLCH1) 100591458(PLCG1) 100596702(PLCD1) 100597115(PLCB1) 100597962(PLCH2) 100598366(PLCD4) 100599747(PLCE1) 100600507(PLCB4) 100600865(PLCB3) 100604145(PLCG2) 100604799(PLCD3) 100606558(PLCB2)
MCC:	694686(PLCH2) 696860(PLCD1) 697069(PLCG1) 699569(PLCD4) 701758(PLCE1) 701951(PLCB2) 703293(PLCZ1) 707243(PLCH1) 714173(PLCG2) 715924(PLCD3) 717764(PLCB3) 718387(PLCB1) 718418(PLCB4)
MCF:	101866682(PLCD1) 101925220(PLCB4) 102116711(PLCH1) 102117471(PLCG2) 102122144(PLCD4) 102122753(PLCZ1) 102123165(PLCB3) 102136896(PLCB2) 102138566(PLCD3) 102138726(PLCG1) 102139698(PLCH2) 102140615(PLCB1) 102142941(PLCE1)
CSAB:	103216291(PLCE1) 103217873(PLCD4) 103218714(PLCZ1) 103221069(PLCD1) 103225758(PLCH2) 103233299(PLCB3) 103233371(PLCG2) 103241439(PLCH1) 103243297(PLCD3) 103245842(PLCB2) 103245987(PLCG1) 103246591(PLCB4) 103246657(PLCB1)
RRO:	104653565 104654736(PLCD3) 104655304(PLCZ1) 104655777(PLCB4) 104657452(PLCD1) 104659669(PLCB2) 104660025(PLCD4) 104666130(PLCE1) 104668296(PLCB1) 104671624(PLCG2) 104672220(PLCG1) 104672374 104673127(PLCB3) 104676457(PLCH1)
CJC:	100385383(PLCE1) 100386721(PLCH1) 100386921(PLCB2) 100390347(PLCG2) 100395085(PLCD3) 100396419(PLCH2) 100397497(PLCG1) 100400803(PLCB3) 100406733(PLCZ1) 100408539(PLCD4) 100408597(PLCD1) 100409716(PLCB1) 100410075(PLCB4) 103796762
SBQ:	101029401(PLCB3) 101030401(PLCD4) 101030999(PLCG2) 101039016(PLCH2) 101043700(PLCE1) 101044356(PLCH1) 101045153(PLCD3) 101046851(PLCB4) 101046976(PLCG1) 101047168(PLCB1) 101050254(PLCZ1) 101052271(PLCB2) 101053112(PLCD1)
MMU:	114875(Plcz1) 18795(Plcb1) 18796(Plcb2) 18797(Plcb3) 18798(Plcb4) 18799(Plcd1) 18802(Plcd4) 18803(Plcg1) 234779(Plcg2) 269437(Plch1) 269615(Plch2) 72469(Plcd3) 74055(Plce1)
RNO:	114633(Plce1) 140693(Plcd4) 24654(Plcb1) 24655(Plcd1) 25031(Plcb4) 25738(Plcg1) 287745(Plcd3) 29322(Plcb3) 29337(Plcg2) 310463(Plch1) 313756(Plch2) 497197(Plcz1) 85240(Plcb2)
CGE:	100751509(Plcd1) 100751872(Plcd4) 100751979(Plcb1) 100752475(Plcg2) 100754031(Plcz1) 100754217(Plce1) 100759620(Plcd3) 100760134(Plcb3) 100760460(Plch1) 100760731(Plcb2) 100769053(Plch2) 100769697(Plcg1) 100770957(Plcb4)
NGI:	103725694 103727720(Plcd4) 103728414 103733964(Plcz1) 103735195(Plcb1) 103738313(Plcd3) 103738797(Plcb3) 103740083(Plch1) 103741502(Plcb2) 103747244(Plcg1) 103748739 103749775(Plch2) 103750131(Plce1) 103751602(Plcd1)
HGL:	101696454(Plcb4) 101697744(Plcb3) 101704621(Plcd3) 101704999(Plcd4) 101705192(Plcg1) 101706315(Plce1) 101708380(Plcb2) 101709944(Plcz1) 101714597 101715010(Plcd1) 101715321(Plcg2) 101717211(Plch1) 101725366(Plch2) 101725860(Plcb1)
CCAN:	109678350(Plcd4) 109679335(Plch1) 109681137 109681766(Plce1) 109683253 109683285(Plcb3) 109683399(Plcg1) 109684223(Plcb1) 109688859 109688860 109688861 109688862 109691444(Plch2) 109691551(Plcd3) 109696649(Plcg2) 109698346(Plcd1) 109701042(Plcz1) 109701244(Plcb2)
OCU:	100340139(PLCG2) 100341512(PLCB1) 100344504(PLCE1) 100347485(PLCD4) 100348672(PLCB2) 100349958(PLCG1) 100350395(PLCB4) 100352032(PLCD3) 100358542(PLCH1) 100359131(PLCZ1) 103347252(PLCD1)
TUP:	102468499(PLCD3) 102469651(PLCG1) 102472532(PLCB3) 102475249(PLCD4) 102476196(PLCB4) 102477438(PLCB1) 102481589(PLCZ1) 102483786(PLCG2) 102485536(PLCH2) 102492903(PLCB2) 102496252(PLCH1) 102499439(PLCE1) 102500184(PLCD1)
CFA:	100684810(PLCH1) 100856190(PLCB2) 476034(PLCB3) 477160(PLCB4) 478910(PLCD4) 485586(PLCD1) 485773(PLCB1) 485874(PLCG1) 486657(PLCZ1) 486808(PLCE1) 489613(PLCH2) 489692(PLCG2) 490929(PLCD3)
AML:	100465232(PLCB3) 100468521(PLCH1) 100469148(PLCD4) 100471021(PLCD3) 100471118(PLCZ1) 100474779(PLCB2) 100476035(PLCD1) 100476835(PLCH2) 100479318(PLCE1) 100480586(PLCG1) 100480603(PLCB4) 100481755(PLCB1) 100481994(PLCG2)
UMR:	103662093(PLCG2) 103662760(PLCD4) 103665878(PLCD3) 103667971(PLCE1) 103669754(PLCG1) 103673552(PLCB2) 103674425(PLCB1) 103674426(PLCB4) 103677618(PLCH1) 103677800(PLCZ1) 103678452(PLCH2) 103679549(PLCB3) 103682206(PLCD1)
FCA:	101080675(PLCG2) 101085554(PLCZ1) 101086518(PLCD3) 101087261(PLCH1) 101087777(PLCD1) 101088695(PLCE1) 101089122(PLCH2) 101090005(PLCB4) 101090455(PLCD4) 101090942 101092262(PLCB1) 101092925(PLCG1) 101092961(PLCB3) 102899339(PLCB2)
PTG:	102949488(PLCE1) 102950867(PLCH2) 102952137(PLCG1) 102952633(PLCD1) 102955133(PLCH1) 102956201(PLCD4) 102959485(PLCB2) 102960646(PLCB4) 102961121(PLCB1) 102961437(PLCB3) 102963235(PLCD3) 102963653(PLCG2) 102968210(PLCZ1)
AJU:	106965849(PLCE1) 106966690(PLCD1) 106968579(PLCB2) 106970106(PLCD4) 106974495(PLCG1) 106974864(PLCH1) 106976431(PLCB4) 106976432(PLCB1) 106977172(PLCZ1) 106981698(PLCB3) 106984018(PLCG2) 106984646(PLCH2) 106988142(PLCD3)
BTA:	100337091(PLCG2) 281985(PLCB4) 281986(PLCD1) 281987(PLCG1) 287026(PLCB1) 497026(PLCZ1) 508888(PLCB2) 513057(PLCD3) 513565(PLCH1) 514590(PLCH2) 515669(PLCB3) 519037(PLCE1) 540771(PLCD4)
BOM:	102264989(PLCB4) 102265099(PLCG1) 102268410(PLCE1) 102269456(PLCH1) 102269641(PLCD3) 102270277 102273347(PLCB1) 102273490(PLCD4) 102274303(PLCZ1) 102276260(PLCB3) 102278948(PLCB2) 102284004(PLCH2) 102285300(PLCG2) 106701107(PLCD1)
BIU:	109553155(PLCE1) 109554384(PLCB3) 109558802(PLCZ1) 109559080(PLCH1) 109564927(PLCB2) 109567698(PLCG1) 109567852(PLCB1) 109567854(PLCB4) 109570532(PLCH2) 109570636(PLCD4) 109572707(PLCG2) 109573523(PLCD3) 109576386 109576389
PHD:	102318466(PLCB4) 102318880(PLCG2) 102321405(PLCD1) 102324368(PLCG1) 102324981(PLCD3) 102325766(PLCH1) 102326634(PLCZ1) 102328353(PLCD4) 102328398(PLCE1) 102333745(PLCB2) 102337250(PLCB3) 102339754(PLCH2) 102342417(PLCB1)
CHX:	102169343(PLCD4) 102169966(PLCB2) 102170761(PLCZ1) 102178972(PLCE1) 102180337(PLCG2) 102180505(PLCB4) 102181878(PLCG1) 102184479(PLCD1) 102185202(PLCH2) 102188148(PLCB1) 102189653(PLCB3) 102190639(PLCD3) 108633199(PLCH1)
OAS:	101103341(PLCG1) 101103585(PLCB1) 101105703(PLCE1) 101106864(PLCB4) 101110367(PLCD1) 101111344(PLCD4) 101112368(PLCH1) 101113074(PLCB2) 101116105(PLCB3) 101118035(PLCD3) 101121029(PLCH2) 101122126(PLCG2) 101122850(PLCZ1)
SSC:	100152497(PLCG1) 100152679(PLCB1) 100157641(PLCB2) 100157745(PLCE1) 100516581(PLCB4) 100518663(PLCG2) 100521111(PLCD3) 100525148(PLCB3) 100623940(PLCH2) 100627099(PLCD1) 100627163(PLCH1) 397119(PLCD4) 397632(PLCZ1)
CFR:	102505338(PLCB3) 102506571(PLCD3) 102506863(PLCZ1) 102507363(PLCD1) 102509058(PLCB2) 102510365 102512388(PLCH1) 102513431(PLCB4) 102513996(PLCB1) 102514470(PLCG2) 102515536(PLCD4) 102519191(PLCE1) 102524452(PLCG1) 106729436 106730088
BACU:	102997432(PLCB4) 102999522(PLCZ1) 103001427(PLCH2) 103006361(PLCB3) 103007077(PLCB2) 103007983(PLCH1) 103014054(PLCD1) 103014562(PLCD3) 103014764(PLCG2) 103016185(PLCE1) 103016663(PLCG1) 103019165(PLCD4) 103020805(PLCB1)
LVE:	103068930(PLCG1) 103070997(PLCG2) 103073047(PLCD1) 103073865(PLCH1) 103075635(PLCZ1) 103078639(PLCB4) 103079287(PLCB1) 103080679(PLCD3) 103080930(PLCE1) 103081277(PLCH2) 103081712(PLCD4) 103083884(PLCB3) 103086280(PLCB2)
ECB:	100049953(PLCH1) 100051485(PLCB4) 100051558(PLCB1) 100054233(PLCD1) 100055407(PLCB3) 100055670(PLCG2) 100057315(PLCB2) 100058665(PLCD4) 100061676(PLCE1) 100064142(PLCD3) 100067798(PLCZ1) 100070545(PLCG1)
MYB:	102238655(PLCB3) 102240650(PLCB1) 102241255(PLCB4) 102241313(PLCD3) 102241624(PLCE1) 102248243(PLCG1) 102252971(PLCD4) 102254054(PLCB2) 102259618(PLCH1) 102261189(PLCZ1) 102261553(PLCG2) 102262661(PLCD1) 102262915(PLCH2)
MYD:	102751685(PLCB1) 102751959(PLCB4) 102752787(PLCZ1) 102754476(PLCE1) 102755123(PLCB3) 102756475(PLCG1) 102758829(PLCD4) 102760213(PLCD3) 102760355(PLCD1) 102760520(PLCB2) 102761516(PLCH1) 102773476(PLCG2) 102775374(PLCH2)
HAI:	109371226(PLCZ1) 109373690(PLCH1) 109378365(PLCG2) 109378976(PLCB4) 109378977(PLCB1) 109379925(PLCG1) 109380562(PLCD4) 109380957 109380958 109383976(PLCB2) 109384329(PLCB3) 109385184(PLCD1) 109391210(PLCH2) 109394976(PLCD3)
RSS:	109434825(PLCH2) 109436211 109440363 109440549 109440574 109441747 109444239(PLCB2) 109445340(PLCD1) 109447552(PLCH1) 109449030(PLCB4) 109449033(PLCB1) 109450510(PLCB3) 109451494(PLCE1) 109452690(PLCD4) 109453719(PLCG2) 109454242(PLCZ1) 109456634(PLCG1) 109458499(PLCD3)
PALE:	102878454(PLCD1) 102879238(PLCB3) 102883128(PLCG2) 102884893(PLCD4) 102885207(PLCB4) 102885781(PLCB1) 102885953(PLCB2) 102887168(PLCZ1) 102892579(PLCH1) 102892882(PLCH2) 102896228(PLCG1) 102896686(PLCD3) 102898319(PLCE1) 107196691
LAV:	100656701(PLCD3) 100658990(PLCG2) 100660015(PLCD1) 100663829(PLCB3) 100663854(PLCZ1) 100668575(PLCB2) 100669123(PLCH1) 100670617(PLCB4) 100672435(PLCB1) 100675385(PLCH2) 100676480(PLCD4) 100677444(PLCE1) 100677739(PLCG1)
MDO:	100011291(PLCD4) 100012056(PLCZ1) 100019654(PLCH1) 100023487(PLCE1) 100024144(PLCD3) 100027579(PLCG2) 100027830(PLCH2) 100031263(PLCB3) 100031660(PLCB1) 100031869(PLCB2) 100032696(PLCG1) 100033281(PLCB4)
SHR:	100916816(PLCD3) 100917022(PLCE1) 100919206(PLCG2) 100919591(PLCD4) 100920031(PLCH1) 100922938(PLCB3) 100923119(PLCG1) 100929015(PLCB2) 100933045(PLCH2) 100933386(PLCD1) 100934049(PLCB4) 100934311(PLCB1)
OAA:	100075209(PLCH1) 100076776(PLCG2) 100078508(PLCB1) 100078757(PLCG1) 100081349 100083809(PLCD1) 100084272(PLCB4)
GGA:	415805(PLCG2) 416730(PLCB4) 418182(PLCZ1) 419175(PLCG1) 420416(PLCD1) 423014(PLCB2) 424214 425030(PLCH1) 425224(PLCE1) 427687(PLCB1) 428180(PLCH2) 428279(PLCD3) 776273
MGP:	100538446(PLCH2) 100540174(PLCE1) 100540750(PLCD4) 100542227(PLCD1) 100542272 100547179(PLCH1) 100547667(PLCB4) 100548128 100548670(PLCG1) 100549451 100549684(PLCG2) 100551436(PLCD3) 664713(PLCB2)
CJO:	107307599 107308792(PLCD1) 107310620 107310934(PLCB4) 107310953(PLCB1) 107314230(PLCB2) 107316035(PLCE1) 107316456(PLCZ1) 107316914(PLCD4) 107318430(PLCH1) 107319403(PLCG2) 107322901(PLCG1) 107323431(PLCH2) 107325007(PLCD3)
APLA:	101790966(PLCB1) 101792010 101794187(PLCE1) 101796325(PLCD1) 101796880(PLCD3) 101798692(PLCG1) 101799246(PLCG2) 101800151(PLCH2) 101801909(PLCZ1) 101804382(PLCD4) 101804447(PLCB2) 101805172(PLCB4) 101805220(PLCH1)
ACYG:	106030891(PLCZ1) 106036606(PLCB4) 106036632(PLCB1) 106036853(PLCD1) 106039320(PLCD4) 106042207 106042534(PLCE1) 106043486(PLCG1) 106043516(PLCH1) 106044650(PLCH2) 106044837 106046916(PLCD3) 106047056(PLCB2)
TGU:	100219122(PLCB1) 100219388(PLCG2) 100219860(PLCH1) 100220070(PLCG1) 100221959(PLCB4) 100222362 100222852(PLCE1) 100224924 100227504(PLCD4) 100228326(PLCH2) 100229323(PLCD1) 100229635(PLCB2) 100229724(PLCZ1)
GFR:	102031336(PLCB4) 102031533(PLCE1) 102032882(PLCG1) 102033764(PLCH1) 102034984(PLCD4) 102035295(PLCZ1) 102037268(PLCB1) 102037795(PLCH2) 102038983 102039725(PLCG2) 102040502(PLCD1) 102041993(PLCD3) 102045029(PLCB2)
FAB:	101806047(PLCB2) 101806517(PLCG1) 101806694(PLCH1) 101809831(PLCD3) 101810163(PLCZ1) 101810240(PLCE1) 101811465(PLCG2) 101812094(PLCB4) 101816161(PLCD1) 101816169(PLCB1) 101817537(PLCD4) 101817560(PLCH2) 101820005
PHI:	102100115(PLCD4) 102100609(PLCB4) 102100695(PLCD3) 102100949 102103443(PLCG2) 102105081(PLCB2) 102107488(PLCH1) 102108407(PLCZ1) 102108822(PLCD1) 102113003(PLCB1) 102113055(PLCE1) 102114427(PLCG1) 102114503(PLCH2) 106629033 106629087
CCW:	104686410(PLCD1) 104687887(PLCG1) 104688086(PLCH1) 104691519(PLCB1) 104691520(PLCB4) 104691823(PLCG2) 104692298(PLCZ1) 104692596 104692980(PLCB2) 104693388(PLCH2) 104693970(PLCD4) 104696321(PLCE1) 104698537(PLCD3)
FPG:	101911097(PLCD3) 101912415(PLCB2) 101912447(PLCG1) 101913233(PLCH1) 101913673(PLCE1) 101914329(PLCG2) 101916711(PLCB4) 101918282 101919734(PLCD1) 101920366(PLCH2) 101920700(PLCD4) 101922366(PLCB1) 101924543(PLCZ1)
FCH:	102046961 102048018(PLCB2) 102048448(PLCB1) 102048885(PLCH2) 102049427(PLCD1) 102049933(PLCH1) 102050720(PLCD3) 102054061(PLCD4) 102054421(PLCB4) 102055055(PLCE1) 102057302(PLCG1) 102058636(PLCG2) 102059240(PLCZ1)
CLV:	102083512(PLCZ1) 102083893(PLCD4) 102086659(PLCE1) 102086985(PLCD1) 102088630(PLCH1) 102095823(PLCG2) 102096635(PLCB2) 102096927(PLCD3) 102097554(PLCB4) 102098150(PLCB1) 102098341(PLCG1) 102098590 102098625(PLCH2)
AAM:	106483269(PLCG2) 106485763(PLCH2) 106486714(PLCB2) 106488145(PLCG1) 106488477(PLCZ1) 106489897 106490470(PLCB4) 106490480(PLCB1) 106494113 106494114(PLCE1) 106494802 106494848(PLCD1) 106495647(PLCD3) 106497161(PLCH1) 106499321
ASN:	102368121(PLCD1) 102368895 102369875(PLCG1) 102370362(PLCH2) 102371353(PLCB3) 102373514(PLCE1) 102378303(PLCG2) 102379390(PLCB4) 102381048(PLCB2) 102381939(PLCB1) 102382411(PLCZ1) 102386888(PLCH1) 102387019(PLCD3)
AMJ:	102560430(PLCB4) 102562350(PLCH2) 102563626(PLCG1) 102565045(PLCE1) 102566726(PLCH1) 102566880(PLCB1) 102572359(PLCB2) 102574067 102575027(PLCD3) 102576343(PLCD1) 102576994(PLCB3) 102576997(PLCZ1) 106736910(PLCG2) 109282420
PSS:	102447740 102449462(PLCB3) 102452900(PLCH2) 102454220(PLCG2) 102455767(PLCB4) 102455868(PLCD1) 102459349(PLCD4) 102459944(PLCG1) 102460883(PLCB1) 102461092(PLCB2) 102461099 102463271(PLCE1) 102463553(PLCZ1) 102463994(PLCH1)
CMY:	102930635(PLCG2) 102931046(PLCB2) 102932254(PLCB3) 102932314(PLCD1) 102935782 102935898(PLCD4) 102941985(PLCZ1) 102942020(PLCB1) 102942071(PLCH1) 102942246(PLCB4) 102943550(PLCE1) 102944142(PLCG1) 102944425(PLCD3) 102946940
CPIC:	101930785(PLCB2) 101930905 101931114(PLCH2) 101931350(PLCZ1) 101931546(PLCB4) 101932685(PLCG2) 101932753(PLCB1) 101933267(PLCD3) 101933764(PLCH1) 101935550(PLCG1) 101940400(PLCB3) 101941573(PLCD1) 101944378(PLCE1) 101944484(PLCD4)
ACS:	100551754(plcb2) 100551923(plch1) 100552081(plce1) 100552636(plcd4) 100552819(plch2) 100555994 100558870 100559347(plcg1) 100559401(plcd3) 100560758(plcb4) 100566814(plcg2) 100566853(plcb1) 100566976 100567266(plcd1) 100567752(plcb3) 103281908 103282571
PBI:	103051665(PLCD4) 103052396(PLCG2) 103053551(PLCD3) 103055449(PLCB2) 103056024(PLCD1) 103057663(PLCB4) 103058371(PLCH2) 103061230 103062216(PLCB1) 103062888 103064271(PLCH1) 103064298 103064700 103064933(PLCG1) 103066383 103066924(PLCE1)
GJA:	107105783(PLCG2) 107106488(PLCE1) 107106753(PLCB1) 107107624 107109019(PLCZ1) 107109685(PLCG1) 107110189(PLCH2) 107115054 107115177(PLCB3) 107116964(PLCD4) 107119642(PLCB2) 107120612(PLCD3) 107121264 107121439 107121463 107122262 107122439(PLCH1) 107123869 107123894(PLCB4)
XLA:	108696196 108696538 108697196 108697630 108699254(plcb2.L) 108700851(plcd3.L) 108702553(plcd3.S) 108702812 108702938(plcd4.S) 108714087(plcg2.L) 108716399(plcb4.L) 108716400 108717044 108718120 108718712(plcd1.L) 108719445 108719811(plcd1.S) 397692(plcb3.L) 398359(plcg1.L) 398360(plcg1.S) 445848(plcb4.S) 733258(plcb1.S) 735225(plcd4.L)
XTR:	100125098(plcb4) 100379715(plcd4) 100487267(plcb3) 100487353(plch2) 100488677(plcd1) 100495530(plce1) 100496658 100496674(plcg1) 100496686(plcg2) 100497252(plch1) 100497993(plcd3) 101734935(plcb2) 780394(plcb1)
NPR:	108784616(PLCD1) 108785980(PLCD3) 108786572(PLCG2) 108786812(PLCG1) 108787455(PLCH1) 108789042 108789286(PLCB2) 108791809(PLCZ1) 108792005(PLCE1) 108793965(PLCB3) 108794139(PLCH2) 108795338(PLCB4) 108795563(PLCB1)
DRE:	100001532(plcb3) 100334231(plch2a) 100537538 337489(plcd1b) 373867(plcg1) 407700(plcb4) 555443(plcd1a) 561747(plcg2) 562569(plcd3b) 565669(plcd4a) 566479(plch1) 568288(plce1) 569040(plcd3a) 569376(plcb2)
SRX:	107707789 107708880 107710777 107711761 107712192 107712202(plcb4) 107713547 107714237 107716052 107718154 107720035(plcd3) 107721661 107722471 107722543 107723006 107726572 107727881 107728313 107728323 107737900 107738025 107738392 107739328 107740752 107741014 107741376 107741909 107743958 107744270 107744333 107747732 107748081 107748961 107749450 107751666 107754248 107754249 107757379
SANH:	107653530 107653923 107654535 107656933 107659797 107659823 107660629 107661090 107661968 107662566 107663134 107663155 107663156 107663201(plcg1) 107664595(plce1) 107666218 107666222(plcg2) 107670428 107671075 107673750 107674588 107678713(plcb2) 107678738 107682610 107683256 107684680 107685664 107685665 107687112 107687884 107688433 107689396 107691057 107691356 107697633 107697637 107701657 107703619
SGH:	107552867 107552868 107552879 107552896 107555902 107557155 107557325 107557477 107557888 107557900 107557901 107559804(plcg2) 107560167(plcb2) 107561636 107562619 107564330 107564333 107564964 107566580 107569148 107569311 107577563 107578054 107579600 107581738 107583283 107584946 107585437 107586990 107587040 107587041 107589883 107591255 107591554 107594127 107594128 107595766 107596071 107597244 107598645 107598646 107598647 107600964 107602463
IPU:	108256573(plcd1) 108258041(PLCB4) 108258091(PLCB1) 108259491 108259894(plcd3) 108264222(plcg2) 108264778(plch1) 108265040(plch2) 108266487(plcd4) 108267602(PLCB3) 108269611(plcb2) 108270307(plcb1) 108270308 108273813 108273837(plce1) 108275796(plcg1) 108280636
TRU:	101061761 101062624(plcd1) 101065367(plcb1) 101065481 101065955(plce1) 101066005 101069039(plcg1) 101069591 101071670(plch1) 101072923(plcg2) 101073102(plcb3) 101076025(plcb2) 101076189(plcd3) 101076439 101077179(plcd4) 101078575 101078708(plcb4) 105419327 105419682
TNG:	GSTEN00000204G001 GSTEN00002207G001 GSTEN00003549G001 GSTEN00005287G001 GSTEN00005403G001 GSTEN00005404G001 GSTEN00006212G001 GSTEN00011175G001 GSTEN00011828G001 GSTEN00015123G001 GSTEN00016798G001 GSTEN00018741G001 GSTEN00019817G001 GSTEN00020280G001 GSTEN00020281G001 GSTEN00020282G001 GSTEN00020283G001 GSTEN00023915G001 GSTEN00027101G001 GSTEN00027540G001 GSTEN00027858G001 GSTEN00029777G001 GSTEN00032419G001 GSTEN00035002G001
LCO:	104919801(plcb4) 104920858(plcb1) 104924817(plcb2) 104925092(plcg1) 104926417 104927718 104927956 104928901(plcb3) 104930729 104930967 104931767(plch2) 104932460(plcg2) 104932513(plce1) 104933846(plch1) 104935185 104935685 104936009(plcd4) 104937066 109138593 109140342 109140514(plcd1)
NCC:	104942417 104943867 104946378(plcb4) 104946859(plcd3) 104947200(plcb2) 104947924 104948204(plcb3) 104950405 104951541 104951799(plcb1) 104954046 104954784 104955628 104955629 104955634 104956409 104957481 104957849 104958024 104958258 104960732 104960736 104961884 104963128(plce1) 104963179 104963181 104964222 104964925(plcg1)
MZE:	101464574(plch2) 101464832(plcb4) 101465812(plcb1) 101466745(plcd4) 101468079 101469784 101470576(plcg1) 101473405 101473979(plcd1) 101474135(plcb3) 101474427(plch1) 101475135 101475994(plcb2) 101477371 101478971 101479429(plcg2) 101480055(plce1) 106674672 106676986
OLA:	100049465(plcb2) 100049529 100049535(plcb4) 101156540(plcd4) 101156884 101157053(plcg2) 101163005(plcg1) 101163204 101164102(plce1) 101164891(plch2) 101166030 101166226(plcd3) 101167285 101167907 101167946 101170362(plch1) 101172698(plcb1) 101172720 101172964 101173208 101175056 101175365 105357398
XMA:	102216385 102217197 102217766(plcg1) 102217878 102219169 102219479 102220131(plcg2) 102223820(plcb4) 102224078(plcb1) 102224567 102225168 102228460(plce1) 102228874(plcd1) 102229810 102229997(plcd4) 102230660(plcb2) 102233270 102236784
CSEM:	103377214(plcd1) 103378373 103379748(plcg2) 103381058(plcb1) 103381059(plcb4) 103381430(plce1) 103382183 103384259 103384884(plch2) 103385127(plcb3) 103385539(plcg1) 103385692 103387749 103389737 103389807(plcb2) 103392383(plcd4) 103392750 103396221 103399084 103399890
LCF:	108872744 108872939 108876760 108877896(plcg1) 108879537 108881708(plcd1) 108883910 108892548(plcb2) 108893282 108896906(plcb4) 108896922(plcb1) 108897205(plcd4) 108898737(plce1) 108899127 108899780 108900503(plch2) 108902239(plcg2) 108902591
SASA:	100380422(plcd4) 106560399 106566556(plcg1) 106567456(plch2) 106569808 106571556 106571557(plcb4) 106571738 106572832 106573684(plcg2) 106574281 106575211 106577205 106578106 106578971 106579107 106579767 106581453 106581476 106582806 106586132 106589374(plce1) 106590697(plcd1) 106591031 106592034 106592886 106593689 106594992 106595124 106599624 106600791 106607244 106608040 106608052 106608062 106608063 106608066 106608514 106610872(plcb2) 106610916 106613257 106613270
ELS:	105007096(plcb3) 105007252 105010329(plcd1) 105011953 105013964(plcg1) 105015712(plcb2) 105016179(plcd4) 105017520(plcb1) 105017521(plcb4) 105018577(plcg2) 105021417 105022523 105022998 105023783(plch2) 105025138(plce1) 105028724(plch1) 105028828 105028902 105030417 105031658
SFM:	108919358(plcb2) 108919945(plcd3) 108922946 108924218(plcd4) 108924653 108924654 108924918(plch2) 108925497(plcb3) 108926447 108926548 108926652(plcg2) 108928009 108929291 108929356(plcb4) 108932641 108932661 108934038(plcd1) 108936962(plcg1) 108939627(plce1) 108941601
LCM:	102345110(PLCE1) 102345855(PLCB1) 102346126 102347797(PLCD1) 102348275(PLCB4) 102348562(PLCD3) 102349822 102352804 102353757(PLCH1) 102354402(PLCD4) 102358132(PLCG2) 102358647 102362364(PLCB2) 102362442(PLCG1) 102363030 102365142(PLCH2) 102365542(PLCB3)
CMK:	103171709 103172407 103172669 103173793 103173857 103175732(plch1) 103175953(plcg2) 103180693(plce1) 103184263(plch2) 103185584(plcz1) 103186275(plcg1) 103186433(plcb4) 103187499(plcb2) 103187635(plcb1) 103189707 103189708 103189804(plcd4) 103191092 103191121 103191382
BFO:	BRAFLDRAFT_115415 BRAFLDRAFT_170074 BRAFLDRAFT_202613 BRAFLDRAFT_202677 BRAFLDRAFT_205043 BRAFLDRAFT_223817 BRAFLDRAFT_231373 BRAFLDRAFT_231438 BRAFLDRAFT_241494 BRAFLDRAFT_281182 BRAFLDRAFT_285727 BRAFLDRAFT_93082
CIN:	100178711 100182086 100182882 100185660 100186259(plcb4)
SPU:	100888919 100891267(PLCdsu) 494023(plcd) 579102 587412(plcb4) 592193
SKO:	100374538 100376870 100377106 100377901 102802106 102804539 102809018
DME:	Dmel_CG3620(norpA) Dmel_CG4200(sl) Dmel_CG4574(Plc21C)
DPO:	Dpse_GA17564 Dpse_GA18024(Dpse_small-wing) Dpse_GA18269
DAN:	Dana_GF19146 Dana_GF19456 Dana_GF20639
DER:	Dere_GG17956 Dere_GG18703 Dere_GG24713
DPE:	Dper_GL14297 Dper_GL15831 Dper_GL18869
DSE:	Dsec_GM12340 Dsec_GM13428 Dsec_GM16735
DSI:	Dsimw501_GD16687(Dsim_GD16687) Dsimw501_GD17281(Dsim_GD17281) Dsimw501_GD23017(Dsim_GD23017)
DWI:	Dwil_GK15712 Dwil_GK23786 Dwil_GK25059
DYA:	Dyak_GE16341 Dyak_GE16747(Dyak_Plc21C) Dyak_GE17264
DGR:	Dgri_GH10584 Dgri_GH12692 Dgri_GH24286
DMO:	Dmoj_GI14457 Dmoj_GI16411 Dmoj_GI23110
DVI:	Dvir_GJ17032 Dvir_GJ18791(Dvir_small-wing) Dvir_GJ23620
MDE:	101890926 101896046 101900328
AGA:	AgaP_AGAP001936 AgaP_AGAP002529 AgaP_AGAP009115 AgaP_AGAP011152
AAG:	AaeL_AAEL004431 AaeL_AAEL008246 AaeL_AAEL009380 AaeL_AAEL010124 AaeL_AAEL017393
CQU:	CpipJ_CPIJ000778 CpipJ_CPIJ008193 CpipJ_CPIJ008403 CpipJ_CPIJ018676
AME:	408791(Plc) 408804(Fucta) 408996(norpA2) 551709(sl)
BIM:	100740167 100741416 100744997 100745742 100748682
BTER:	100642628 100644023 100647687 100649725 100649981
SOC:	105193187 105194827 105194901 105196430 105200207 105206257
AEC:	105143133 105144421 105151783 105153332 105153367
ACEP:	105617321 105620891 105621470 105624086 105627765
PBAR:	105423419 105425147 105431231 105433233 105434284
HST:	105182316 105182692 105184531 105188458 105189361
CFO:	105249554 105250162 105253013 105254466 105255784 105257806
LHU:	105670772 105671798 105673001 105673877 105674793
NVI:	100115054 100116596 100120894 100122708 100123217
TCA:	659062 660210 661312 662602
DPA:	109533383 109534788 109536412 109536544 109537047 109539915 109539926 109541674 109542350
NVL:	108556911 108558941 108561344 108562170
BMOR:	100329153(PLCb1) 100329154(PLCb4) 100329155(PLCg) 101735646
PXY:	105381166 105384635 105385356 105386068 105388539 105389487 105390130 105394759 105396020 105397251
API:	100161327 100162131 100166756 100166969 100168206
DNX:	107162504 107163546 107163682 107169403
PHU:	Phum_PHUM019460 Phum_PHUM231170 Phum_PHUM447590 Phum_PHUM602870
DPX:	DAPPUDRAFT_100827 DAPPUDRAFT_119242 DAPPUDRAFT_204745 DAPPUDRAFT_206341(Plcb2) DAPPUDRAFT_226357(Plcb1) DAPPUDRAFT_236642 DAPPUDRAFT_237502 DAPPUDRAFT_253811 DAPPUDRAFT_313504 DAPPUDRAFT_317364 DAPPUDRAFT_54889 DAPPUDRAFT_61075 DAPPUDRAFT_67122
ISC:	IscW_ISCW001177 IscW_ISCW001178 IscW_ISCW009315 IscW_ISCW014053 IscW_ISCW015942 IscW_ISCW020642
TUT:	107359684 107360466 107360575 107362492 107366993
CEL:	CELE_B0348.4(egl-8) CELE_F31B12.1(plc-1) CELE_R05G6.8(plc-4) CELE_T01E8.3(plc-3)
CBR:	CBG05896(Cbr-plc-4) CBG06373(Cbr-egl-8) CBG17587(Cbr-plc-1) CBG18715(Cbr-plc-3)
NAI:	NECAME_11673 NECAME_13344 NECAME_13574
BMY:	Bm1_31705 Bm1_40160 Bm1_42205 Bm1_51505
LOA:	LOAG_00547 LOAG_01625 LOAG_02789 LOAG_16338 LOAG_16339
TSP:	Tsp_02482 Tsp_02544 Tsp_05005 Tsp_07594 Tsp_10563 Tsp_13132
HRO:	HELRODRAFT_109918 HELRODRAFT_189171 HELRODRAFT_62499 HELRODRAFT_88112 HELRODRAFT_92027 HELRODRAFT_94839
LGI:	LOTGIDRAFT_107866 LOTGIDRAFT_114718 LOTGIDRAFT_123959 LOTGIDRAFT_142432 LOTGIDRAFT_234838
CRG:	105318640 105331084 105335651 105340725 105342681 105343409
OBI:	106870488 106874041 106874430 106880478 106884061
SMM:	Smp_146330
OVI:	T265_05106
NVE:	NEMVE_v1g101739 NEMVE_v1g114299 NEMVE_v1g124290 NEMVE_v1g136833 NEMVE_v1g161360 NEMVE_v1g174
ADF:	107327580 107328601 107330270 107333500 107341838 107341839 107346860 107357605
HMG:	100189549(plcbh1) 100198602 100200484 100212273
TAD:	TRIADDRAFT_29799 TRIADDRAFT_61893 TRIADDRAFT_61894
AQU:	100633163 100640663 100641378 109583910
ATH:	AT2G40116 AT3G08510(PLC2) AT3G55940 AT4G38530(PLC1) AT5G58670(PLC1) AT5G58690(PLC5) AT5G58700(PLC4)
ALY:	ARALYDRAFT_486035 ARALYDRAFT_490617 ARALYDRAFT_495989 ARALYDRAFT_495993 ARALYDRAFT_671640 ARALYDRAFT_685532 ARALYDRAFT_903282
CRB:	CARUB_v10007023mg CARUB_v10013310mg CARUB_v10016918mg CARUB_v10018550mg CARUB_v10024587mg CARUB_v10026125mg CARUB_v10026144mg CARUB_v10026170mg
EUS:	EUTSA_v10010330mg EUTSA_v10013042mg EUTSA_v10013061mg EUTSA_v10013134mg EUTSA_v10016400mg EUTSA_v10020359mg EUTSA_v10024782mg
BRP:	103828094 103841495 103845299 103845301 103845302 103848861 103851627 103856668 103857907 103863617 103866016 103866980 103870613
BNA:	106349466 106359635 106364955 106383590 106387397 106387427 106388063 106388090 106388407 106395165 106400157 106401032 106401409 106411102 106420251 106420273 106420503 106420706 106427003 106427964(PLC) 106430919 106430929 106440574 106440577 106441571 106443579 106450263 106452856 106454594
THJ:	104799392 104810099 104810100 104810710 104810768 104814915
CIT:	102623592 102623883 102624539 102629782 102630072
CIC:	CICLE_v10028054mg CICLE_v10028080mg CICLE_v10028087mg CICLE_v10031019mg CICLE_v10031029mg
TCC:	18585851 18585852 18590488 18590489 18590491
GRA:	105768302 105770227 105770228 105771549 105773437 105777827 105780353 105799161
GHI:	107889062 107891618 107900444 107900445 107906622 107906624 107906625 107931804 107959192 107959193 107959194 107959195 107960006
EGR:	104421075 104421076 104421083 104422365 104422367 104422368 104432644 104454389
GMX:	100037460 100776483 100777010 100784534 100786997 100788788 100799027 100803394 100817915 100820253 547863 547864 547865
PVU:	PHAVU_001G243100g PHAVU_001G243200g PHAVU_001G243300g PHAVU_008G224000g PHAVU_008G224100g PHAVU_008G224200g PHAVU_008G261100g
VRA:	106757766 106757865(PLC1) 106764143 106764604(PLC2) 106764606 106764607
VAR:	108326859 108327843 108329771 108337111 108337350 108337572 108338381
CCAJ:	109790806 109790807 109791083 109797332 109803749 109807238 109811219
MTR:	MTR_3g069280 MTR_3g070560 MTR_3g070710 MTR_3g070720 MTR_5g071010 MTR_5g071040 MTR_5g082580 MTR_5g082590 MTR_5g082620
CAM:	101499071 101499385 101502612 101502929 101503581 101504327 101504660
ADU:	107457672 107457704 107457717 107458352 107458360 107469474 107469481 107469492
AIP:	107606651 107608057 107609151 107609560 107609693 107622996 107623420 107624328
LJA:	Lj0g3v0130579.1(Lj0g3v0130579.1) Lj0g3v0130589.1(Lj0g3v0130589.1) Lj0g3v0148389.1(Lj0g3v0148389.1) Lj0g3v0189439.1(Lj0g3v0189439.1) Lj0g3v0189439.2(Lj0g3v0189439.2) Lj2g3v2256390.1(Lj2g3v2256390.1) Lj2g3v2256400.1(Lj2g3v2256400.1) Lj2g3v2747660.1(Lj2g3v2747660.1) Lj2g3v2747660.2(Lj2g3v2747660.2) Lj2g3v2748690.1(Lj2g3v2748690.1) Lj6g3v0521600.1(Lj6g3v0521600.1) Lj6g3v0521600.2(Lj6g3v0521600.2) Lj6g3v0521600.3(Lj6g3v0521600.3) Lj6g3v0521670.1(Lj6g3v0521670.1)
LANG:	109326813 109328447 109328448 109340327 109340384 109356693 109356694 109356756 109357350 109360697
FVE:	101302205 101302496 101303890 101304756 101311837
PPER:	18772015 18773491 18774669 18785127 18785526
PMUM:	103320887 103320896 103320905 103332782 103332783
MDM:	103406415 103418706 103432827 103432829 103437320 103438122 103447387
PXB:	103936781 103936790 103938929 103938930 103958605 103958607
ZJU:	107410786 107410802 107413847 107413865
CSV:	101203631 101204232 101209542 101212421
CMO:	103485573 103497077 103497078 103501442
RCU:	8277605 8277606 8285994 8286460 8286461 8286462
JCU:	105628146 105630259 105630267 105630282 105630315 105630322 105646265 105646272
POP:	POPTR_0001s25910g(POPTRDRAFT_815304) POPTR_0001s25930g(POPTRDRAFT_752026) POPTR_0008s06830g(POPTRDRAFT_803315) POPTR_0008s06840g(POPTRDRAFT_564023) POPTR_0009s05130g(POPTRDRAFT_875869) POPTR_0010s19610g(POPTRDRAFT_567270) POPTR_0010s19620g(POPTRDRAFT_805439)
VVI:	100241574 100243703 100246006 100248420 100255373 100267383 100853282
SLY:	100301919(PLC5) 100301920 100301921 100301922 100301923 100301941 101261499(PLC7)
SPEN:	107002343 107012970 107020453 107021827 107022350 107023791
SOT:	102583742(PLC1) 102588383(plc3) 102590316 102596402 102602093(plc2) 102603424
INI:	109173625 109173626 109181610 109182836 109186825
SIND:	105160885 105160886 105161539 105167050
BVG:	104891635 104899948 104899949 104899950 104899951 104903334 104903337
NNU:	104594891 104595046 104602598
OSA:	4332497 4337686 4344391(P0627E10.3) 4352524
DOSA:	Os03t0289300-00(Os03g0289300) Os05t0127200-01(Os05g0127200) Os07t0694000-01(Os07g0694000) Os12t0562400-00(Os12g0562400)
OBR:	102702115 102703305 102706922 102707180
BDI:	100831986 100835224 100839274 100840369
ATS:	F775_10271 F775_14422 F775_32754
SBI:	8084994
ZMA:	100136827 100191466 100191939 103626494 542162(PLC)
SITA:	101756981 101770957 101774810 101782785
PDA:	103706677 103706679 103709636 103718431 103718441 103718899
EGU:	105044613 105044614 105045827 105045828 105057087(PIPLC) 105057088
MUS:	103969012 103969014 103972891 103974417 103984258 103986180
ATR:	18433394 18433395
SMO:	SELMODRAFT_109775 SELMODRAFT_158000 SELMODRAFT_180165 SELMODRAFT_75628
PPP:	PHYPADRAFT_110278(PLC2) PHYPADRAFT_133245(PLC3) PHYPADRAFT_154928(PLC7) PHYPADRAFT_202996(PLC4) PHYPADRAFT_216835(PLC1) PHYPADRAFT_221032(PLC5) PHYPADRAFT_228841(PLC6)
CRE:	CHLREDRAFT_142126
VCN:	VOLCADRAFT_86296
OLU:	OSTLU_50249
OTA:	Ot08g01240
BPG:	Bathy04g01280
MIS:	MICPUN_51586
MPP:	MICPUCDRAFT_55672
CCP:	CHC_T00005154001
SCE:	YPL268W(PLC1)
AGO:	AGOS_ACR024W
ERC:	Ecym_3005
KLA:	KLLA0D00638g
LTH:	KLTH0C11660g
VPO:	Kpol_449p13
ZRO:	ZYRO0F00352g
CGR:	CAGL0A01177g
NCS:	NCAS_0D02230(NCAS0D02230)
NDI:	NDAI_0I02690(NDAI0I02690)
TPF:	TPHA_0J00210(TPHA0J00210)
TBL:	TBLA_0A07020(TBLA0A07020)
TDL:	TDEL_0G04680(TDEL0G04680)
KAF:	KAFR_0B06460(KAFR0B06460)
PPA:	PAS_chr4_0700
DHA:	DEHA2A04510g
PIC:	PICST_42966(PLC1)
PGU:	PGUG_00206
SPAA:	SPAPADRAFT_73417
LEL:	LELG_05130
CAL:	CAALFM_C703710CA(PLC1)
CTP:	CTRG_05145
COT:	CORT_0G03510
CDU:	CD36_73380(PLC1)
CTEN:	CANTEDRAFT_105288
YLI:	YALI0C04180g
CLU:	CLUG_03263
NCR:	NCU01266
NTE:	NEUTE1DRAFT127609(NEUTE1DRAFT_127609)
SMP:	SMAC_03962
PAN:	PODANSg8027
TTT:	THITE_2106937
MTM:	MYCTH_2300779
CTHR:	CTHT_0066170
MGR:	MGG_02444
TMN:	UCRPA7_5786
FGR:	FGSG_02980 FGSG_05898
FPU:	FPSE_02260 FPSE_12239
FVR:	FVEG_04539 FVEG_16850
FOX:	FOXG_06598 FOXG_06661 FOXG_07102 FOXG_07227 FOXG_07611 FOXG_12081 FOXG_14448 FOXG_15032
NHE:	NECHADRAFT_75847 NECHADRAFT_85080
TRE:	TRIREDRAFT_60194
MAW:	MAC_06035
MAJ:	MAA_06168
CMT:	CCM_07897
VAL:	VDBG_03354
VDA:	VDAG_09958
CFJ:	CFIO01_12970
ELA:	UCREL1_8660
PFY:	PFICI_11085
SSL:	SS1G_05754
BFU:	BC1G_01559
MBE:	MBM_09817
PSCO:	LY89DRAFT_698179
GLZ:	GLAREA_07735
ANI:	AN0664.2
AFM:	AFUA_1G13250
AOR:	AOR_1_976194(AO090012000557)
ANG:	ANI_1_884074(An08g06320)
AFV:	AFLA_018170
ACT:	ACLA_022180
NFI:	NFIA_012260
PCS:	Pc13g12130
PDP:	PDIP_26340
CIM:	CIMG_06831
CPW:	CPC735_032410
PBL:	PAAG_07722
PBN:	PADG_02814
URE:	UREG_03646
ABE:	ARB_06692
TVE:	TRV_04036
AJE:	HCAG_00760 HCAG_00761
PNO:	SNOG_10714
PTE:	PTT_08861
BZE:	COCCADRAFT_5314
BSC:	COCSADRAFT_262210
BOR:	COCMIDRAFT_21499
ZTR:	MYCGRDRAFT_66273
PFJ:	MYCFIDRAFT_148132(PLC)
BCOM:	BAUCODRAFT_120631
NPA:	UCRNP2_6478
TML:	GSTUM_00002161001
SPO:	SPAC22F8.11(plc1)
CNE:	CNC04820
CNB:	CNBC2360
CGI:	CGB_C7130W
TMS:	TREMEDRAFT_38681
TVS:	TRAVEDRAFT_136210
DSQ:	DICSQDRAFT_64218
PCO:	PHACADRAFT_254611
SHS:	STEHIDRAFT_146709 STEHIDRAFT_99869
HIR:	HETIRDRAFT_174607 HETIRDRAFT_235382
PSQ:	PUNSTDRAFT_81102
ADL:	AURDEDRAFT_169456
FME:	FOMMEDRAFT_124022
GTR:	GLOTRDRAFT_140049 GLOTRDRAFT_50083
LBC:	LACBIDRAFT_233152 LACBIDRAFT_315547 LACBIDRAFT_329174
MPR:	MPER_02532 MPER_08907
MRR:	Moror_139 Moror_17332
CCI:	CC1G_07213 CC1G_07975 CC1G_09463
SCM:	SCHCODRAFT_109536 SCHCODRAFT_79892 SCHCODRAFT_82573
ABP:	AGABI1DRAFT129320(AGABI1DRAFT_129320) AGABI1DRAFT72480(AGABI1DRAFT_72480)
ABV:	AGABI2DRAFT120986(AGABI2DRAFT_120986) AGABI2DRAFT212030(AGABI2DRAFT_212030)
CPUT:	CONPUDRAFT_131189
SLA:	SERLADRAFT_471357 SERLADRAFT_480572
WSE:	WALSEDRAFT_11682 WALSEDRAFT_69643
WIC:	J056_000494
UMA:	UMAG_02982
PFP:	PFL1_05016
MGL:	MGL_2569
PGR:	PGTG_13407
MLR:	MELLADRAFT_112249
MBR:	MONBRDRAFT_21166 MONBRDRAFT_34469
SRE:	PTSG_01932 PTSG_02362 PTSG_03830 PTSG_09606 PTSG_12022
DDI:	DDB_G0292736(plc)
DPP:	DICPUDRAFT_96532
DFA:	DFA_07345 DFA_07346(plc)
ACAN:	ACA1_368260
TAN:	TA06965
TPV:	TP01_0775
TOT:	TOT_010000726
BEQ:	BEWA_038560
BBO:	BBOV_IV011070(23.m06338)
CPV:	cgd4_2560
CHO:	Chro.40288
TET:	TTHERM_00238850 TTHERM_00317320 TTHERM_00486470
PTM:	GSPATT00008002001 GSPATT00029973001 GSPATT00030070001 GSPATT00031253001 GSPATT00031342001 GSPATT00034681001
SMIN:	v1.2.010004.t1(symbB.v1.2.010004.t1) v1.2.033641.t1(symbB.v1.2.033641.t1)
PTI:	PHATRDRAFT_42683(PLC-delta) PHATRDRAFT_bd1000 PHATRDRAFT_bd1611
FCY:	FRACYDRAFT_186252 FRACYDRAFT_193320 FRACYDRAFT_203452
TPS:	THAPS_263246
AAF:	AURANDRAFT_18506(PLC1) AURANDRAFT_21478 AURANDRAFT_54465
SPAR:	SPRG_04373
EHX:	EMIHUDRAFT_100814 EMIHUDRAFT_107969 EMIHUDRAFT_113919 EMIHUDRAFT_116213 EMIHUDRAFT_121888 EMIHUDRAFT_209393 EMIHUDRAFT_219576 EMIHUDRAFT_467823 EMIHUDRAFT_99535
GTT:	GUITHDRAFT_102497
TBR:	Tb11.02.3780
TCR:	504149.160
LMA:	LMJF_22_1680 LMJF_30_2950
LIF:	LINJ_22_1530 LINJ_30_2970
LDO:	LDBPK_221530 LDBPK_302970
LMI:	LMXM_29_2950
LBZ:	LBRM_22_1590
NGR:	NAEGRDRAFT_1225 NAEGRDRAFT_59073 NAEGRDRAFT_80564

Reference

1 [PMID:6275838]

Authors

Downes CP, Michell RH.

Title

The polyphosphoinositide phosphodiesterase of erythrocyte membranes.

Journal

Biochem. J. 198 (1981) 133-40.

Reference

Authors

Thompson, W. and Dawson, R.M.C.

Title

The triphosphoinositide phosphodiesterase of brain tissue.

Journal

Biochem. J. 91 (1964) 237-243.

Reference

3 [PMID:9182519]

Authors

Rhee SG, Bae YS.

Title

Regulation of phosphoinositide-specific phospholipase C isozymes.

Journal

J. Biol. Chem. 272 (1997) 15045-8.

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

BRENDA, the Enzyme Database:

CAS:

63551-76-8

All links

Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (5)   
   KEGG REACTION (3)   
   KEGG RCLASS (2)   
Gene (6018)   
   KEGG ORTHOLOGY (7)   
   KEGG GENES (2303)   
   KEGG MGENES (2513)   
   RefGene (597)   
   EGENES (598)   
Protein sequence (7688)   
   UniProt (7280)   
   SWISS-PROT (67)   
   RefSeq(pep) (215)   
   PDBSTR (102)   
   PMD (24)   
DNA sequence (487)   
   RefSeq(nuc) (295)   
   GenBank (131)   
   EMBL (61)   
3D Structure (45)   
   PDB (45)   
Protein domain (20)   
   InterPro (18)   
   Pfam (1)   
   PROSITE(DOC) (1)   
All databases (14278)   

Download RDF

REACTION: R03435

Entry

R03435 Reaction

Name

1-Phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase

Definition

1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate + H2O <=> D-myo-Inositol 1,4,5-trisphosphate + 1,2-Diacyl-sn-glycerol

Equation

C04637 + C00001 <=> C01245 + C00641

Reaction class

RC00017	C00641_C04637
RC00425	C01245_C04637

Enzyme