Entry
Symbol
purK
Name
5-(carboxyamino)imidazole ribonucleotide synthase [EC:
6.3.4.18 ]
Pathway
map01110 Biosynthesis of secondary metabolites
Module
M00048 De novo purine biosynthesis, PRPP + glutamine => IMP
Reaction
R07404 5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming)
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
K01589 purK; 5-(carboxyamino)imidazole ribonucleotide synthase
Enzymes [BR:ko01000 ]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.4 Other carbon-nitrogen ligases
6.3.4.18 5-(carboxyamino)imidazole ribonucleotide synthase
K01589 purK; 5-(carboxyamino)imidazole ribonucleotide synthase
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Genes
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Taxonomy UniProt
Reference
Authors
Firestine SM, Misialek S, Toffaletti DL, Klem TJ, Perfect JR, Davisson VJ
Title
Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis.
Journal
Reference
Authors
Thoden JB, Kappock TJ, Stubbe J, Holden HM
Title
Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily.
Journal
Sequence
Reference
Authors
Mueller EJ, Meyer E, Rudolph J, Davisson VJ, Stubbe J
Title
N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli.
Journal
Sequence
Reference
Authors
Meyer E, Leonard NJ, Bhat B, Stubbe J, Smith JM
Title
Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway.
Journal
Sequence