KEGG ORTHOLOGY: K01697

ORTHOLOGY: K01697

Entry

K01697 KO

Name

E4.2.1.22, CBS

Definition

cystathionine beta-synthase [EC:4.2.1.22]

Pathway

ko00260	Glycine, serine and threonine metabolism
ko00270	Cysteine and methionine metabolism

Module

M00035	Methionine degradation
M00338	Cysteine biosynthesis, homocysteine + serine => cysteine

Disease

H00183

Homocystinuria

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    K01697  E4.2.1.22, CBS; cystathionine beta-synthase
   00270 Cysteine and methionine metabolism
    K01697  E4.2.1.22, CBS; cystathionine beta-synthase
KEGG pathway modules [BR:ko00002]
Pathway module
  Nucleotide and amino acid metabolism
   Cysteine and methionine metabolism
    M00338  Cysteine biosynthesis, homocysteine + serine => cysteine
     K01697  E4.2.1.22, CBS; cystathionine beta-synthase
    M00035  Methionine degradation
     K01697  E4.2.1.22, CBS; cystathionine beta-synthase
Enzymes [BR:ko01000]
4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.22  cystathionine beta-synthase
     K01697  E4.2.1.22, CBS; cystathionine beta-synthase

Other DBs

RN:

R00891 R01290 R04942

COG:

COG0031 COG0517

GO:

0004122

Genes

HSA:	875(CBS)
PTR:	736626(CBS)
PPS:	100974696(CBS)
GGO:	101149756(CBS)
PON:	100459501(CBS)
MMU:	12411(Cbs)
RNO:	24250(Cbs)
CFA:	611071(CBS)
AML:	100471372
FCA:	101093038(CBS)
BTA:	514525(CBS)
ECB:	100057612
MDO:	100024374(CBS)
SHR:	100919929(CBS)
OAA:	100080879(CBS)
GGA:	418544 418545(CBS)
MGP:	100550886 100551038(CBS)
TGU:	100222166(CBS) 100225076
ACS:	100566358(cbs) 100566739
XLA:	380308(cbs-a) 446655(cbs-b)
XTR:	493533(cbs)
DRE:	266987(cbsb) 550524(cbsa)
TRU:	101076573
OLA:	101158999
BFO:	BRAFLDRAFT_117945
CIN:	100180445
SPU:	591266
DME:	Dmel_CG1753(Cbs)
DPO:	Dpse_GA14544
DAN:	Dana_GF21711
DER:	Dere_GG19705
DPE:	Dper_GL16398
DSE:	Dsec_GM23059
DSI:	Dsim_GD17507
DWI:	Dwil_GK25034
DYA:	Dyak_GE17904
DGR:	Dgri_GH22312
DMO:	Dmoj_GI22982
DVI:	Dvir_GJ24676
AGA:	AgaP_AGAP000162
AAG:	AaeL_AAEL008467 AaeL_AAEL008468
CQU:	CpipJ_CPIJ012752 CpipJ_CPIJ012753
AME:	551341(Cbs)
NVI:	100115316(NV17942)
TCA:	656954
API:	100166111
PHU:	Phum_PHUM459670
ISC:	IscW_ISCW013852
CEL:	CELE_F54A3.4(cbs-2) CELE_ZC373.1(cbs-1)
CBR:	CBG01937
BMY:	Bm1_32965
TSP:	Tsp_00354
SMM:	Smp_125070.1 Smp_125070.2
NVE:	NEMVE_v1g204029
HMG:	100209141(cbs)
TAD:	TRIADDRAFT_30632
AQU:	100635325(Cbs)
CME:	CMS037C
SCE:	YGR155W(CYS4)
AGO:	AGOS_AGR012C
ERC:	Ecym_7341
KLA:	KLLA0F09317g
LTH:	KLTH0D04092g
PPA:	PAS_chr2-2_0137
VPO:	Kpol_1026p13
ZRO:	ZYRO0G07128g
CGR:	CAGL0E03157g
NCS:	NCAS_0C05620(NCAS0C05620)
NDI:	NDAI_0H00500(NDAI0H00500)
TPF:	TPHA_0K01840(TPHA0K01840)
TBL:	TBLA_0E01580(TBLA0E01580)
TDL:	TDEL_0F02810(TDEL0F02810)
KAF:	KAFR_0I01230(KAFR0I01230)
DHA:	DEHA2C14586g
PIC:	PICST_77227(CYS4)
PGU:	PGUG_01035
LEL:	LELG_01590
CAL:	CaO19.12011 CaO19.4536(CYS4)
CTP:	CTRG_04593
CDU:	CD36_01710
COT:	CORT_0B07990
YLI:	YALI0E09108g
CLU:	CLUG_00057
NCR:	NCU08216
SMP:	SMAC_09602
PAN:	PODANSg4727
TTT:	THITE_2119065
MTM:	MYCTH_2080506
MGR:	MGG_07384
FGR:	FG06544.1
NHE:	NECHADRAFT_68815
SSL:	SS1G_08916
BFU:	BC1G_10936
ANI:	AN5820.2
NFI:	NFIA_083350
AFM:	AFUA_2G07620
AOR:	AOR_1_1574054(AO090011000931)
ANG:	ANI_1_354044(An05g00160)
AFV:	AFLA_047240
ACT:	ACLA_079620
PCS:	Pc13g05320
CIM:	CIMG_00957 CIMG_05649
CPW:	CPC735_053910 CPC735_067650
PBL:	PAAG_08986
URE:	UREG_00902
ABE:	ARB_07681
TVE:	TRV_01035
AJE:	HCAG_07434
PNO:	SNOG_12735
PTE:	PTT_02279
ZTR:	MYCGRDRAFT_104476
TML:	GSTUM_00006909001
CNE:	CNA06170
CNB:	CNBA5980
CGI:	CGB_A6640W
LBC:	LACBIDRAFT_171213
MPR:	MPER_00663 MPER_15900
CCI:	CC1G_00837
SCM:	SCHCODRAFT_53905
UMA:	UM02792.1
PGR:	PGTG_00600
MBR:	MONBRDRAFT_14886
NGR:	NAEGRDRAFT_36304
DDI:	DDB_G0267386(cysB)
DPP:	DICPUDRAFT_49929
TGO:	TGME49_059180
TET:	TTHERM_00558300
PTM:	GSPATT00012786001 GSPATT00013222001 GSPATT00016616001
TBR:	Tb11.02.5400
TCR:	506905.50 508175.360 508177.110 508177.120 508241.140 509149.9 510381.10 511691.10 511691.20
LMA:	LMJF_17_0250(CYSB)
LIF:	LINJ_17_0300(CYSB)
LDO:	LDBPK_170300
LMI:	LMXM_17_0250
LBZ:	LBRM_17_0230(CYSB)
PTI:	PHATRDRAFT_42003(Cbs)
PIF:	PITG_13262 PITG_14697
YEN:	YE1470(uptG)
YEP:	YE105_C2644
YEY:	Y11_03511
ECA:	ECA4113
PCT:	PC1_3903
PCC:	PCC21_038950
PLU:	plu0524
PAY:	PAU_00518(mtcB)
ENT:	Ent638_1770
ENC:	ECL_02360
ENO:	ECENHK_09440
ECLO:	ENC_13590
ESC:	Entcl_0642
EEC:	EcWSU1_01870(cbs)
ENL:	A3UG_09450
EAS:	Entas_1789
EAE:	EAE_18845
EAR:	ST548_p6944
ESA:	ESA_02767
CSK:	ES15_2857
CSZ:	CSSP291_13155
CTU:	CTU_11050
KPN:	KPN_03409
KPU:	KP1_4684
KPM:	KPHS_45360
KPP:	A79E_0713
KPE:	KPK_0709
KPO:	KPN2242_20135
KVA:	Kvar_0682
KOX:	KOX_02795
CKO:	CKO_01706
SPE:	Spro_1627
SRR:	SerAS9_1600
SRS:	SerAS12_1600
SRA:	SerAS13_1601
SMAF:	D781_1541
SMW:	SMWW4_v1c16120
PMR:	PMI0235
ETR:	ETAE_1928(uptG)
ETD:	ETAF_1740(uptG)
ETC:	ETAC_08810
HDE:	HDEF_1873(cysK)
DDC:	Dd586_1871
XBO:	XBJ1_3501
PSI:	S70_10355
ROR:	RORB6_22305
XFA:	XF0603
XFT:	PD1548(cysM)
XFM:	Xfasm12_1704
XFN:	XfasM23_1633
XFF:	XFLM_01955
XCC:	XCC0597(cysB)
XCB:	XC_3636
XCA:	xccb100_3753
XCV:	XCV3726
XCP:	XCR_0750
XAC:	XAC3603(cysB)
XAX:	XACM_3503
XAO:	XAC29_18345
XOO:	XOO0777(cysB)
XOM:	XOO_0707
XOP:	PXO_03155(cysB)
XOR:	XOC_3871(cysB)
XAL:	XALc_2713
XCI:	XCAW_04305(cysK)
SML:	Smlt0616(cbsB)
SMT:	Smal_0488
BUJ:	BurJV3_0508
SMZ:	SMD_0527(cbsB)
PSU:	Psesu_2463
PSD:	DSC_02405
FAU:	Fraau_2990
RHD:	R2APBS1_0565
PAE:	PA0399
PAU:	PA14_05220
PAP:	PSPA7_0499
PAG:	PLES_03971
PAF:	PAM18_0399
PNC:	NCGM2_5799
PDK:	PADK2_02010
PSG:	G655_02035
PPUU:	PputUW4_03161
PFO:	Pfl01_3248
PFS:	PFLU3406
PFC:	PflA506_2874
PPZ:	H045_09415
PDR:	H681_01815
ILO:	IL0218(cysM)
CBS:	COXBURSA331_A0059
CBD:	CBUD_2125
CBG:	CbuG_2033
CBC:	CbuK_2075
LLO:	LLO_0076(cysK)
FTU:	FTT_1287(cbs)
FTF:	FTF1287(cbs)
FTR:	NE061598_07430
FTT:	FTV_1230(cbs)
FTG:	FTU_1314(cbs)
FTL:	FTL_1174
FTH:	FTH_1148(cysK)
FTA:	FTA_1238
FTS:	F92_06485
FTI:	FTS_1148(cysK)
FTM:	FTM_1079(cysK)
FTN:	FTN_1302(cysK)
FCF:	FNFX1_1345
FCN:	FN3523_0707 FN3523_1371
FPH:	Fphi_1379
FRT:	F7308_1019
FNA:	OOM_0454
HCH:	HCH_03693
KKO:	Kkor_1767
CVI:	CV_3395(cysB2)
PSE:	NH8B_0056
BMA:	BMA1621
BMV:	BMASAVP1_A2123
BML:	BMA10229_A3191
BMN:	BMA10247_1397
BPS:	BPSL2215
BPM:	BURPS1710b_2647
BPL:	BURPS1106A_2561
BPD:	BURPS668_2508
BPR:	GBP346_A2630
BPZ:	BP1026B_I1175
BTE:	BTH_I1970 BTH_II1370
BGL:	bglu_1g23070
POL:	Bpro_2830
CFU:	CFU_1537(cysM)
RGE:	RGE_20080(cbs)
DSU:	Dsui_2043
BBA:	Bd3796
BBAT:	Bdt_3675
BEX:	A11Q_2499
BMX:	BMS_3011
ADE:	Adeh_3300 Adeh_3706
ACP:	A2cp1_3442 A2cp1_3846
AFW:	Anae109_3846
ANK:	AnaeK_3378 AnaeK_3763
MXA:	MXAN_2041
MFU:	LILAB_17965
MSD:	MYSTI_02338
CCX:	COCOR_06049(cbs1)
SUR:	STAUR_6221
SCL:	sce0438 sce8782(cysB)
HOH:	Hoch_5286
MLO:	mll4505
MCI:	Mesci_0841
MOP:	Mesop_0888
MAM:	Mesau_00765
SMK:	Sinme_6864
RHI:	NGR_a00730 NGR_b03540
SFH:	SFHH103_04319
SFD:	USDA257_c24040 USDA257_p02710
RTR:	RTCIAT899_PC01145
BBT:	BBta_0633
RPA:	RPA2356
RPT:	Rpal_2600
RVA:	Rvan_1851
CAK:	Caul_4907
PZU:	PHZ_c0071
BSB:	Bresu_1606
RRU:	Rru_A0787
RRF:	F11_04035
RCE:	RC1_1987(cbs)
RPM:	RSPPHO_02829
MAG:	amb1847
TMO:	TMO_c0648(cysB)
SAY:	TPY_1780
SAP:	Sulac_1981
MTU:	Rv1077(cbs)
MTV:	RVBD_1077
MTC:	MT1108
MRA:	MRA_1087(cbs)
MTF:	TBFG_11095
MTB:	TBMG_02910
MTK:	TBSG_02926
MTZ:	TBXG_002890
MTG:	MRGA327_06725
MTI:	MRGA423_06730
MTE:	CCDC5079_0995
MTL:	CCDC5180_0987
MTO:	MTCTRI2_1105(cbs)
MTD:	UDA_1077(cbs)
MTN:	ERDMAN_1202(cbs)
MTJ:	J112_05815
MTUB:	MT7199_1102
MBO:	Mb1106(cbs)
MBB:	BCG_1135(cbs)
MBT:	JTY_1108(cbs)
MBM:	BCGMEX_1107(cbs)
MBK:	K60_011570
MAF:	MAF_10900(cbs)
MCE:	MCAN_10831(cbs)
MCQ:	BN44_11193(cbs)
MCV:	BN43_30130(cbs)
MCX:	BN42_20925(cbs)
MCZ:	BN45_30118(cbs)
MLE:	ML2396(cysM2)
MLB:	MLBr_02396(cysM2)
MPA:	MAP1024(cysM2)
MAV:	MAV_1201
MIT:	OCO_11060
MIR:	OCQ_11090
MIA:	OCU_11050
MID:	MIP_01784
MSM:	MSMEG_5270
MSG:	MSMEI_5131(cbs)
MSA:	Mycsm_05087
MUL:	MUL_0203(cbs)
MVA:	Mvan_4674
MGI:	Mflv_2043
MSP:	Mspyr1_14670
MAB:	MAB_1195
MMV:	MYCMA_0636(cbs)
MMC:	Mmcs_4149
MKM:	Mkms_4224
MJL:	Mjls_4380
MJD:	JDM601_1023(cbs)
MMI:	MMAR_4390(cbs)
MRH:	MycrhN_3513
MMM:	W7S_05415
MCB:	Mycch_4087
MLI:	MULP_04605(cbs)
ASD:	AS9A_3444
CJK:	jk1981(cysY)
CKP:	ckrop_0828
CPU:	cpfrc_00621(tsb)
CPL:	Cp3995_0630(cbs)
CPG:	Cp316_0641(cbs)
CPP:	CpP54B96_0630(cbs)
CPK:	Cp1002_0619(cbs)
CPQ:	CpC231_0619(cbs)
CPX:	CpI19_0618(cbs)
CPZ:	CpPAT10_0620(cbs)
COR:	Cp267_0647(cbs)
COP:	Cp31_0626(cbs)
COD:	Cp106_0603(cbs)
COS:	Cp4202_0613(cbs)
COI:	CpCIP5297_0630(cbs)
COE:	Cp258_0625(cbs)
COU:	Cp162_0618(cbs)
CRD:	CRES_0026
CUL:	CULC22_00669(tsb)
CUC:	CULC809_00662
CUE:	CULC0102_0772
NFA:	nfa48320
NCY:	NOCYR_4624(cbs) NOCYR_4658
NBR:	O3I_012920 O3I_036500 O3I_036905
RHA:	RHA1_ro05843
RER:	RER_42660(cbs)
ROP:	ROP_59040(cbs)
REQ:	REQ_12820(cysB)
GBR:	Gbro_1617
GPO:	GPOL_c14990(cysB)
GOR:	KTR9_1593
TPR:	Tpau_3152
SRT:	Srot_0777 Srot_1980
SCO:	SCO3077(SCE25.18c)
SMA:	SAV_3510(cysM1)
SGR:	SGR_4452
SCB:	SCAB_5301 SCAB_54591
SSX:	SACTE_2542
SVL:	Strvi_8487
SCT:	SCAT_2096(CBS)
SCY:	SCATT_20800
SFA:	Sfla_3825
SBH:	SBI_04548
SHY:	SHJG_4550
SHO:	SHJGH_4312
SVE:	SVEN_2831
SDV:	BN159_5202(cbs)
SALB:	XNR_1985
STRP:	F750_2908
KSK:	KSE_47260(cbs)
LXX:	Lxx17700(cysM2)
CMI:	CMM_0872(cysB)
CMS:	CMS_0127
CMC:	CMN_00832(cysB)
MTS:	MTES_2412
ART:	Arth_3062
AAU:	AAur_3038
ACH:	Achl_2762
AAI:	AARI_24020
APN:	Asphe3_28910
ARR:	ARUE_c31870(cbs1) ARUE_c37930(cbs2)
RSA:	RSal33209_0896
KRH:	KRH_16340
MLU:	Mlut_17600
BCV:	Bcav_1054
XCE:	Xcel_2671
IVA:	Isova_2483
CFL:	Cfla_0925
CFI:	Celf_2962
CGA:	Celgi_1363
ICA:	Intca_0941
PAC:	PPA1290 PPA2278
MPH:	MLP_44570(cbs)
NCA:	Noca_0939
KFL:	Kfla_5676
TFU:	Tfu_0438
NDA:	Ndas_0083
NAL:	B005_2873
TCU:	Tcur_1048
SRO:	Sros_3752 Sros_8566
FRA:	Francci3_0375
FRE:	Franean1_6424
FRI:	FraEuI1c_6723
FAL:	FRAAL0784(cysM)
FSY:	FsymDg_0714
NML:	Namu_4422
GOB:	Gobs_4209
BSD:	BLASA_4025(cbs)
MMAR:	MODMU_4605(cbs)
KRA:	Krad_1082
SEN:	SACE_0899(cysM2)
SVI:	Svir_31890
TBI:	Tbis_3118
AMD:	AMED_8107
AMN:	RAM_41650
AMM:	AMES_7985
PDX:	Psed_0938
AMI:	Amir_0700
SESP:	BN6_07740 BN6_39490
STP:	Strop_0912
SAQ:	Sare_0855
MAU:	Micau_0918
MIL:	ML5_1162
VMA:	VAB18032_09295
AMS:	AMIS_7790
ASE:	ACPL_952
CAI:	Caci_0644
SNA:	Snas_0943
BLO:	BL1156(cbsSV)
BLJ:	BLD_0914(cysK)
BLN:	Blon_2004
BLON:	BLIJ_2079
BLF:	BLIF_0472
BLL:	BLJ_0532
BLB:	BBMN68_918(cysK)
BLM:	BLLJ_0455
BLK:	BLNIAS_02110
BLG:	BIL_13890
BAD:	BAD_0490(cbsSV)
BLA:	BLA_1096(cbsSV)
BLC:	Balac_0564
BLT:	Balat_0564
BBB:	BIF_00615
BBC:	BLC1_0538
BNM:	BALAC2494_00563
BLV:	BalV_0541
BLW:	W7Y_0566
BLS:	W91_0587
BNI:	BANAN_02860
BDE:	BDP_0670(cysK)
BBI:	BBIF_1302(cysK)
BBP:	BBPR_1344(cysK)
BBF:	BBB_1324(cysB)
BBV:	HMPREF9228_1358
BBRU:	Bbr_0538(cysK)
BTP:	D805_1238
CWO:	Cwoe_0908
AYM:	YM304_15010
PUV:	PUV_18680(cbs)
WCH:	wcw_1144(cysK)
SRU:	SRU_1123
SRM:	SRM_01301(cysK) SRM_03001(cysB)
CPI:	Cpin_3667
NKO:	Niako_4523
PHE:	Phep_1434
SHG:	Sph21_2928
SCN:	Solca_1154
HHY:	Halhy_1607 Halhy_6320
SGN:	SGRA_2550
CMR:	Cycma_2820
BBD:	Belba_3728
EVI:	Echvi_4660
SLI:	Slin_5829
FLI:	Fleli_2924
FAE:	FAES_3839
MTT:	Ftrac_0803
GFO:	GFO_2397
FJO:	Fjoh_1927
FPS:	FP0871 FP1196
FBR:	FBFL15_1703 FBFL15_2349
FCO:	FCOL_00990 FCOL_10485
FIN:	KQS_10835 KQS_10900
COC:	Coch_1829
CCM:	Ccan_10000
RBI:	RB2501_10222 RB2501_15549
ZPR:	ZPR_1144 ZPR_2343
CAT:	CA2559_00130 CA2559_08106
RAN:	Riean_0472
RAI:	RA0C_0694
RAR:	RIA_1801
RAG:	B739_1544
RAE:	G148_1149
FBC:	FB2170_12721
CAO:	Celal_3438
CLY:	Celly_2204 Celly_2721
WVI:	Weevi_0419 Weevi_1710
KDI:	Krodi_0116 Krodi_2944
LAN:	Lacal_1808 Lacal_2360
ZGA:	zobellia_2590(cysK2) zobellia_4054(cysK1)
MRS:	Murru_3001
ASL:	Aeqsu_1987 Aeqsu_2814
ORH:	Ornrh_2124
PTQ:	P700755_000665 P700755_003414
NDO:	DDD_2061 DDD_3497
POM:	MED152_00895(cysK) MED152_03850(cbs)
FBA:	FIC_00717 FIC_01300
FTE:	Fluta_4004
OHO:	Oweho_0910 Oweho_2012
GAU:	GAU_3907(cbs)
SACI:	Sinac_7195
AVA:	Ava_4156
CSG:	Cylst_0490
CALO:	Cal7507_6039
CTE:	CT1921
CPC:	Cpar_0287
CCH:	Cag_1634
CPB:	Cphamn1_2178
CLI:	Clim_2126
PLT:	Plut_0281
PPH:	Ppha_2553
PAA:	Paes_1945
IAL:	IALB_2142
HAU:	Haur_3718
STI:	Sthe_2024
MPZ:	Marpi_1110
MBN:	Mboo_1990
MPL:	Mpal_1157
HJE:	HacjB3_02915
HXA:	Halxa_2345
PYN:	PNA2_1580
PYA:	PYCH_09090
TBA:	TERMP_01384
APE:	APE_1223.1

» show all

Reference

PMID:12644499 (A.pernix)

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)

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Ontology (7)   
   KEGG BRITE (4)   
   GO (1)   
   COG (2)   
Pathway (493)   
   KEGG PATHWAY (8)   
   KEGG MODULE (485)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (9)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (5)   
Gene (2799)   
   KEGG GENES (636)   
   KEGG DGENES (19)   
   KEGG EGENES (59)   
   KEGG MGENES (2085)   
Protein sequence (550)   
   UniProt (550)   
Literature (1)   
   PubMed (1)   
All databases (3860)   

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