KEGG ORTHOLOGY: K01825

ORTHOLOGY: K01825

Entry

K01825 KO

Name

fadB

Definition

3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]

Pathway

ko00071	Fatty acid metabolism
ko00280	Valine, leucine and isoleucine degradation
ko00281	Geraniol degradation
ko00310	Lysine degradation
ko00380	Tryptophan metabolism
ko00410	beta-Alanine metabolism
ko00640	Propanoate metabolism
ko00650	Butanoate metabolism
ko00720	Carbon fixation pathways in prokaryotes
ko00903	Limonene and pinene degradation
ko00930	Caprolactam degradation
ko01040	Biosynthesis of unsaturated fatty acids

Module

M00032	Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00087	beta-Oxidation
M00374	Dicarboxylate-hydroxybutyrate cycle
M00375	Hydroxypropionate-hydroxybutylate cycle

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Carbohydrate metabolism
   00640 Propanoate metabolism
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
   00650 Butanoate metabolism
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
  Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
  Lipid metabolism
   00071 Fatty acid metabolism
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
   01040 Biosynthesis of unsaturated fatty acids
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
  Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
   00310 Lysine degradation
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
   00380 Tryptophan metabolism
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
  Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
  Metabolism of terpenoids and polyketides
   00903 Limonene and pinene degradation
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
   00281 Geraniol degradation
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
  Xenobiotics biodegradation and metabolism
   00930 Caprolactam degradation
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
KEGG pathway modules [BR:ko00002]
Pathway module
  Energy metabolism
   Carbon fixation
    M00375  Hydroxypropionate-hydroxybutylate cycle
     K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
    M00374  Dicarboxylate-hydroxybutyrate cycle
     K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
  Carbohydrate and lipid metabolism
   Fatty acid metabolism
    M00087  beta-Oxidation
     K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
  Nucleotide and amino acid metabolism
   Lysine metabolism
    M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
     K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35  3-hydroxyacyl-CoA dehydrogenase
     K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.17  enoyl-CoA hydratase
     K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
5. Isomerases
  5.1  Racemases and epimerases
   5.1.2  Acting on hydroxy acids and derivatives
    5.1.2.3  3-hydroxybutyryl-CoA epimerase
     K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.8  dodecenoyl-CoA isomerase
     K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase

Other DBs

RN:

R01975 R03026 R03045 R03276 R04137 R04170 R04203 R04204 R04224 R04737 R04738 R04739 R04740 R04741 R04744 R04745 R04746 R04748 R04749 R04756 R05066 R06411 R06412 R06941 R06942 R07935 R07951 R08093 R08094

COG:

COG1250 COG1024

GO:

0003857 0004300 0008692 0004165

Genes

ECO:	b3846(fadB)
ECJ:	Y75_p3334(fadB)
ECD:	ECDH10B_4035(fadB)
EBW:	BWG_3522(fadB)
ECOK:	ECMDS42_3284(fadB)
ECE:	Z5367(fadB)
ECS:	ECs4774(fadB)
ECF:	ECH74115_5285(fadB)
ETW:	ECSP_4899(fadB)
ELX:	CDCO157_4512(fadB)
EOJ:	ECO26_4741(fadB)
EOI:	ECO111_4672(fadB)
EOH:	ECO103_4319(fadB)
ECG:	E2348C_4158(fadB)
EOK:	G2583_4644(fadB)
ELR:	ECO55CA74_22265(fadB)
ECC:	c4793(fadB)
ECP:	ECP_4059(fadB)
ECI:	UTI89_C4431(fadB)
ECV:	APECO1_2611(fadB)
ECX:	EcHS_A4069(fadB)
ECW:	EcE24377A_4365(fadB)
ECM:	EcSMS35_4227(fadB)
ECY:	ECSE_4132(fadB)
ECR:	ECIAI1_4039(fadB)
ECQ:	ECED1_4548(fadB)
ECK:	EC55989_4321(fadB)
ECT:	ECIAI39_3149(fadB)
EOC:	CE10_4505(fadB)
EUM:	ECUMN_4370(fadB)
ECZ:	ECS88_4294(fadB)
ELO:	EC042_4224(fadB)
ELN:	NRG857_19200(fadB)
ELH:	ETEC_4121
ESE:	ECSF_3703
ESO:	O3O_00700(fadB)
ESM:	O3M_24555(fadB)
ESL:	O3K_24635(fadB)
ECL:	EcolC_4164(fadB)
EBR:	ECB_03737(fadB)
EBD:	ECBD_4179(fadB)
EKO:	EKO11_4513
EKF:	KO11_04240(fadB)
EAB:	ECABU_c43480(fadB)
EDH:	EcDH1_4135
EDJ:	ECDH1ME8569_3723(fadB)
EIH:	ECOK1_4315(fadB)
ENA:	ECNA114_4155(fadB)
ELU:	UM146_19485(fadB)
EUN:	UMNK88_4674(fadB)
ELW:	ECW_m4146(fadB)
ELL:	WFL_20230(fadB)
ELC:	i14_4387(fadB)
ELD:	i02_4387(fadB)
ELP:	P12B_c3968(fadB)
EBL:	ECD_03737(fadB)
EBE:	B21_03686(fadB)
ELF:	LF82_0614(fadB)
ECOA:	APECO78_23050(fadB)
EFE:	EFER_3635(fadB)
EBT:	EBL_c37460(fadB)
STY:	STY3577(fadB)
STT:	t3315(fadB)
SEX:	STBHUCCB_35030
STM:	STM3983(fadB)
SEO:	STM14_4789(fadB)
SEV:	STMMW_39531
SEY:	SL1344_3936(fadB)
SEM:	STMDT12_C41330(fadB)
SEJ:	STMUK_3967(fadB)
SEB:	STM474_4161(fadB)
SEF:	UMN798_4321(fadB)
SETU:	STU288_20080(fadB)
SPT:	SPA3823(fadB)
SEK:	SSPA3560(fadB)
SPQ:	SPAB_04939(fadB)
SEI:	SPC_4090(fadB)
SEC:	SC3880(fadB)
SEH:	SeHA_C4309(fadB)
SHB:	SU5_091
SEE:	SNSL254_A4262(fadB)
SEW:	SeSA_A4190(fadB)
SEA:	SeAg_B4213(fadB)
SED:	SeD_A4369(fadB)
SEG:	SG3469(fadB)
SEL:	SPUL_3449(fadB)
SET:	SEN3777(fadB)
SENJ:	CFSAN001992_13770(fadB)
SES:	SARI_03676(fadB)
SBG:	SBG_3514(fadB)
YPE:	YPO3766(fadB)
YPK:	y0464(fadB)
YPA:	YPA_3436(fadB)
YPN:	YPN_0198(fadB)
YPM:	YP_3282(fadB)
YPP:	YPDSF_3386(fadB)
YPG:	YpAngola_A1912(fadB)
YPZ:	YPZ3_3324(fadB)
YPT:	A1122_07015(fadB)
YPD:	YPD4_3315(fadB)
YPX:	YPD8_3316(fadB)
YPH:	YPC_0474(fadB)
YPS:	YPTB0267(fadB)
YPI:	YpsIP31758_0283(fadB)
YPY:	YPK_3933(fadB)
YPB:	YPTS_0283(fadB)
YEN:	YE0268(fadB)
YEP:	YE105_C0269
YEY:	Y11_34751
SFL:	SF3922(fadB)
SFX:	S3830(fadB)
SFV:	SFV_3654(fadB)
SFE:	SFxv_4275(fadB)
SSN:	SSON_4019(fadB)
SSJ:	SSON53_23090(fadB)
SBC:	SbBS512_E4316(fadB)
SDY:	SDY_3899(fadB)
ECA:	ECA0208(fadB)
PCT:	PC1_4044
PCC:	PCC21_001940
PWA:	Pecwa_4234(fadB)
PEC:	W5S_4403
ETA:	ETA_02460(fadB)
EPY:	EpC_02330(fadB)
EPR:	EPYR_00243(fadB)
EAM:	EAMY_0223(fadB)
EAY:	EAM_0213(fadB)
EBI:	EbC_02440(fadB)
ERJ:	EJP617_14310(fadB)
PLU:	plu4402(fadB)
PAY:	PAU_03873(fadB)
ENT:	Ent638_3949(fadB)
ENC:	ECL_04951
ENO:	ECENHK_21130(fadB)
ECLO:	ENC_47270
ESC:	Entcl_4192
EEC:	EcWSU1_04336(fadB)
ENL:	A3UG_21950(fadB)
EAS:	Entas_4232
EAE:	EAE_08050(fadB)
EAR:	ST548_p4668
ESA:	ESA_03714(fadB)
CSK:	ES15_3645(fadB)
CSZ:	CSSP291_17190(fadB)
CTU:	CTU_02770(fadB)
KPN:	KPN_04340(fadB)
KPU:	KP1_0203(fadB)
KPM:	KPHS_01860
KPP:	A79E_4847
KPE:	KPK_5333(fadB)
KPO:	KPN2242_24700(fadB)
KVA:	Kvar_4892
KOX:	KOX_07835(fadB)
CKO:	CKO_00188(fadB)
CRO:	ROD_39091(fadB)
SPE:	Spro_0261(fadB)
SRR:	SerAS9_0217
SRS:	SerAS12_0217
SRA:	SerAS13_0216
SMAF:	D781_0228
SMW:	SMWW4_v1c02630(fadB)
PMR:	PMI3550(fadB)
DDA:	Dd703_3747(fadB)
DDC:	Dd586_0200
DDD:	Dda3937_02077(fadB)
DZE:	Dd1591_3901(fadB)
XBO:	XBJ1_0517(fadB)
XNE:	XNC1_3875(fadB)
PAM:	PANA_0201(fadB)
PLF:	PANA5342_4226(fadB)
PAJ:	PAJ_3361(fadB)
PAQ:	PAGR_g4077
PVA:	Pvag_3442(fadB)
PAO:	Pat9b_0194
RAH:	Rahaq_4149
RAQ:	Rahaq2_4267
RAA:	Q7S_21080(fadB)
PSI:	S70_07695(fadB)
MMK:	MU9_771
ROR:	RORB6_17680(fadB)
EBF:	D782_4309
VCH:	VC2758(fadB)
VCE:	Vch1786_I2427(fadB)
VCJ:	VCD_001454(fadB)
VCO:	VC0395_A2534(fadB)
VCR:	VC395_0197(fadB)
VCM:	VCM66_2678(fadB)
VCI:	O3Y_13185(fadB)
VCL:	VCLMA_A2448
VVU:	VV1_0981(fadB)
VVY:	VV0029(fadB)
VVM:	VVMO6_02953
VPA:	VP0030(fadB)
VPB:	VPBB_0029
VHA:	VIBHAR_00460(fadB)
VSP:	VS_0041(fadB)
VEX:	VEA_001988
VEJ:	VEJY3_00140(fadB)
VFU:	vfu_A00358
VFI:	VF_0025(fadB)
VFM:	VFMJ11_0024(fadB)
VSA:	VSAL_I2974(fadB)
PPR:	PBPRA0064(fadB)
VAN:	VAA_00818
PAE:	PA3014(faoA)
PAU:	PA14_25080(fadB)
PAP:	PSPA7_2145(fadB)
PAG:	PLES_20481(fadB)
PAF:	PAM18_1946(fadB)
PNC:	NCGM2_4129(fadB)
PDK:	PADK2_09275(fadB)
PSG:	G655_09715(fadB)
PPU:	PP_2136(fadB)
PPF:	Pput_3606(fadB)
PPG:	PputGB1_1676(fadB)
PPW:	PputW619_1652(fadB)
PPT:	PPS_1699
PPB:	PPUBIRD1_3518(fadB_3)
PPI:	YSA_01503
PPX:	T1E_0604(fadB)
PPUH:	B479_08300(fadB)
PPUU:	PputUW4_03523(fadB)
PST:	PSPTO_3517(fadB)
PSB:	Psyr_3290(fadB)
PSP:	PSPPH_3210(fadB)
PFL:	PFL_1940(fadB)
PFO:	Pfl01_3879(fadB)
PFS:	PFLU1553(fadB)
PFE:	PSF113_3988(faoA)
PFC:	PflA506_1567(fadB)
PPZ:	H045_04280(fadB)
PEN:	PSEEN3728(fadB)
PMY:	Pmen_1580(fadB)
PMK:	MDS_1633
PSA:	PST_1726(fadB)
PSZ:	PSTAB_1620(faoA)
PSR:	PSTAA_1740(fadB)
PSC:	A458_12155(fadB)
PSJ:	PSJM300_06755(fadB)
PSH:	Psest_2654
PBA:	PSEBR_a1747
PFV:	Psefu_2918
PDR:	H681_16260(fadB)
AVN:	Avin_14440(fadB)
AVL:	AvCA_14440(fadB)
AVD:	AvCA6_14440(fadB)
PAR:	Psyc_1934(fadB)
PCR:	Pcryo_2227(fadB)
PRW:	PsycPRwf_2100(fadB)
ACI:	ACIAD0335(fadB)
ACD:	AOLE_17905(fadB)
ABM:	ABSDF3220(fadB)
ABY:	ABAYE3470(fadB)
ABC:	ACICU_00322(fadB)
ABN:	AB57_0387(fadB)
ABB:	ABBFA_003230(fadB)
ABX:	ABK1_0349
ABZ:	ABZJ_00349
ABR:	ABTJ_03469
ABD:	ABTW07_0352
ABH:	M3Q_566
ABAD:	ABD1_02830(fadB)
ACC:	BDGL_003212(fadB)
MCT:	MCR_0091(fadB)
SON:	SO_0021(fadB)
SDN:	Sden_0015(fadB)
SFR:	Sfri_0013(fadB)
SAZ:	Sama_0032(fadB)
SBL:	Sbal_0021(fadB)
SBM:	Shew185_0016(fadB)
SBN:	Sbal195_0020(fadB)
SBP:	Sbal223_0020(fadB)
SBT:	Sbal678_0020
SBS:	Sbal117_0021
SBB:	Sbal175_0020
SLO:	Shew_0019(fadB)
SPC:	Sputcn32_0013(fadB)
SHP:	Sput200_0013
SSE:	Ssed_0023(fadB)
SPL:	Spea_0018(fadB)
SHE:	Shewmr4_0018(fadB)
SHM:	Shewmr7_0016(fadB)
SHN:	Shewana3_0024(fadB)
SHW:	Sputw3181_0013(fadB)
SHL:	Shal_0016(fadB)
SWD:	Swoo_0021(fadB)
SWP:	swp_0035(fadB)
SVO:	SVI_0052(fadB-1)
ILO:	IL0011(fadB)
CPS:	CPS_0393(fadB)
PHA:	PSHAa0011(fadB)
PAT:	Patl_0201(fadB)
PSM:	PSM_A0012(fadB)
SDE:	Sde_1605(fadB)
MAQ:	Maqu_1144(fadB)
MHC:	MARHY2136(fadB)
MAD:	HP15_1512
MBS:	MRBBS_1699(fadB)
AMC:	MADE_1003310(fadB) MADE_1018740(fadB)
AMAC:	MASE_02315(fadB)
AMB:	AMBAS45_02605(fadB)
AMG:	AMEC673_02395(fadB)
AMK:	AMBLS11_02585(fadB)
AMAA:	amad1_02940(fadB)
ALT:	ambt_15565(fadB)
GAG:	Glaag_4107
GNI:	GNIT_2932(fadB)
GPS:	C427_5358(fadB)
TTU:	TERTU_1620(fadB)
FBL:	Fbal_0012
HCH:	HCH_04756(fadB)
CSA:	Csal_2393(fadB)
HEL:	HELO_1758(fadB)
ABO:	ABO_1652(fadB)
ADI:	B5T_01517(fadB)
KKO:	Kkor_0013(fadB)
MMW:	Mmwyl1_1578(fadB)
MME:	Marme_2899
MPC:	Mar181_2192
TOL:	TOL_1157
AHA:	AHA_0139(fadB)
ASA:	ASA_4250(fadB)
AVR:	B565_3934
OCE:	GU3_01845(fadB)
SAGA:	M5M_01685(fadB) M5M_18535(fadB)
GPB:	HDN1F_10070(fadB)
BCT:	GEM_4690
DAR:	Daro_2350(fadB)
HOH:	Hoch_1660
MSL:	Msil_1395(fadB)
AZL:	AZL_a11100(fadB)
RBA:	RB1092(faoA)
SACI:	Sinac_3405

» show all

Reference

PMID:17298899

Authors

Sato S, Nomura CT, Abe H, Doi Y, Tsuge T

Title

Poly[(R)-3-hydroxybutyrate] formation in Escherichia coli from glucose through an enoyl-CoA hydratase-mediated pathway.

Journal

J Biosci Bioeng 103:38-44 (2007)

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Ontology (9)   
   KEGG BRITE (3)   
   GO (4)   
   COG (2)   
Pathway (626)   
   KEGG PATHWAY (30)   
   KEGG MODULE (596)   
Chemical reaction (48)   
   KEGG ENZYME (4)   
   KEGG REACTION (29)   
   KEGG RCLASS (15)   
Gene (424)   
   KEGG GENES (335)   
   KEGG EGENES (2)   
   KEGG MGENES (87)   
Protein sequence (292)   
   UniProt (292)   
Literature (1)   
   PubMed (1)   
All databases (1400)   

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