KEGG   ORTHOLOGY: K01837Help
Entry
K01837                      KO                                     

Name
BPGM
Definition
bisphosphoglycerate/phosphoglycerate mutase [EC:5.4.2.4 5.4.2.11]
Pathway
Glycolysis / Gluconeogenesis
Glycine, serine and threonine metabolism
Disease
H00664  
Anemia due to disorders of glycolytic enzymes
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K01837  BPGM; bisphosphoglycerate/phosphoglycerate mutase
  Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    K01837  BPGM; bisphosphoglycerate/phosphoglycerate mutase
Enzymes [BR:ko01000]
 5. Isomerases
  5.4  Intramolecular transferases
   5.4.2  Phosphotransferases (phosphomutases)
    5.4.2.4  bisphosphoglycerate mutase
     K01837  BPGM; bisphosphoglycerate/phosphoglycerate mutase
    5.4.2.11  phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)
     K01837  BPGM; bisphosphoglycerate/phosphoglycerate mutase
BRITE hierarchy
Other DBs
Genes
HSA: 
669(BPGM)
PTR: 
463746(BPGM)
PPS: 
100967755(BPGM)
GGO: 
101148078(BPGM)
PON: 
100445966(BPGM)
NLE: 
100586238(BPGM)
MCC: 
706741(BPGM)
MCF: 
101925598(BPGM)
CSAB: 
103226934(BPGM)
RRO: 
CJC: 
100386672(BPGM)
SBQ: 
101031409(BPGM)
MMU: 
12183(Bpgm)
RNO: 
296973(Bpgm)
CGE: 
100757548(Bpgm)
NGI: 
103726061(Bpgm)
HGL: 
101706859(Bpgm)
CCAN: 
109688796
OCU: 
100009096(BPGM)
TUP: 
102496494(BPGM)
CFA: 
482704(BPGM)
AML: 
100479620(BPGM)
UMR: 
103678255(BPGM)
FCA: 
101095644(BPGM)
PTG: 
102952979(BPGM)
AJU: 
106975708(BPGM)
BTA: 
533785(BPGM)
BOM: 
102270409 102275256 102275503 102285424
BIU: 
109557654(BPGM)
PHD: 
102332772(BPGM)
CHX: 
102187916(BPGM)
OAS: 
101121089(BPGM)
SSC: 
106506774(BPGM)
CFR: 
102514048(BPGM)
BACU: 
103009787(BPGM) 103015640
LVE: 
103089210(BPGM)
ECB: 
100065115(BPGM)
MYB: 
102254057(BPGM)
MYD: 
102772643(BPGM)
HAI: 
109389371(BPGM)
RSS: 
109457774(BPGM)
PALE: 
102886645(BPGM)
LAV: 
100673907(BPGM)
MDO: 
100021814(BPGM)
SHR: 
100920227(BPGM)
OAA: 
100075920(BPGM)
GGA: 
418172(BPGM)
MGP: 
100546129(BPGM)
CJO: 
107314945(BPGM)
APLA: 
101803151(BPGM)
ACYG: 
106030917(BPGM)
TGU: 
100224087
GFR: 
102033451(BPGM)
FAB: 
101817641(BPGM)
PHI: 
102108959(BPGM)
CCW: 
104692259(BPGM)
FPG: 
101915204(BPGM)
FCH: 
102046661(BPGM)
CLV: 
102089457(BPGM)
AAM: 
106488955(BPGM)
ASN: 
102373803(BPGM)
AMJ: 
102568684(BPGM)
PSS: 
102447629(BPGM)
CMY: 
102946921(BPGM)
CPIC: 
101941911(BPGM)
ACS: 
100564984(bpgm)
PBI: 
103062795(BPGM)
GJA: 
107125358(BPGM)
XLA: 
444102(bpgm.L) 444279(bpgm.S)
XTR: 
549353(bpgm)
NPR: 
108792024(BPGM)
DRE: 
436903(bpgm)
SRX: 
107716700 107753699
SANH: 
107661509
SGH: 
107576414 107590805
IPU: 
108269072(bpgm)
TRU: 
101074347(bpgm)
TNG: 
GSTEN00029715G001
LCO: 
104940663(bpgm)
NCC: 
104946798(bpgm)
MZE: 
101473870(bpgm)
OLA: 
101172407(bpgm)
XMA: 
102233730(bpgm)
CSEM: 
103380563(bpgm)
LCF: 
108888560(bpgm)
SASA: 
100196266(pmge) 106561646
ELS: 
105021856(bpgm)
SFM: 
108920769 108931367
LCM: 
102350982(BPGM)
CMK: 
103185559(bpgm)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wang Y, Wei Z, Bian Q, Cheng Z, Wan M, Liu L, Gong W
  Title
Crystal structure of human bisphosphoglycerate mutase.
  Journal
J Biol Chem 279:39132-8 (2004)
DOI:10.1074/jbc.M405982200
  Sequence
[hsa:669]
KEGG   ENZYME: 5.4.2.4Help
Entry
EC 5.4.2.4                  Enzyme                                 

Name
bisphosphoglycerate mutase;
diphosphoglycerate mutase;
glycerate phosphomutase;
bisphosphoglycerate synthase;
bisphosphoglyceromutase;
biphosphoglycerate synthase;
diphosphoglyceric mutase;
2,3-diphosphoglycerate mutase;
phosphoglyceromutase;
2,3-diphosphoglycerate synthase;
DPGM;
2,3-bisphosphoglycerate mutase;
BPGM;
diphosphoglyceromutase;
2,3-diphosphoglyceromutase
Class
Isomerases;
Intramolecular transferases;
Phosphotransferases (phosphomutases)
BRITE hierarchy
Sysname
3-phospho-D-glycerate 1,2-phosphomutase
Reaction(IUBMB)
3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate [RN:R01662]
Reaction(KEGG)
Substrate
3-phospho-D-glyceroyl phosphate [CPD:C00236]
Product
2,3-bisphospho-D-glycerate [CPD:C01159]
Comment
In the direction shown, this enzyme is phosphorylated by 3-phosphoglyceroyl phosphate, to give phosphoenzyme and 3-phosphoglycerate. The latter is rephosphorylated by the enzyme to yield 2,3-bisphosphoglycerate, but this reaction is slowed by dissociation of 3-phosphoglycerate from the enzyme, which is therefore more active in the presence of added 3-phosphoglycerate. This enzyme also catalyses, slowly, the reaction of EC 5.4.2.11 [phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)] and EC 5.4.2.12 [phosphoglycerate mutase (2,3-diphosphoglycerate-independent)].
History
EC 5.4.2.4 created 1961 as EC 2.7.5.4, transferred 1984 to EC 5.4.2.4
Pathway
Glycolysis / Gluconeogenesis
Metabolic pathways
Orthology
K01837  
bisphosphoglycerate/phosphoglycerate mutase
Genes
HSA: 
669(BPGM)
PTR: 
463746(BPGM)
PPS: 
100967755(BPGM)
GGO: 
101148078(BPGM)
PON: 
100445966(BPGM)
NLE: 
100586238(BPGM)
MCC: 
706741(BPGM)
MCF: 
101925598(BPGM)
CSAB: 
103226934(BPGM)
RRO: 
CJC: 
100386672(BPGM)
SBQ: 
101031409(BPGM)
MMU: 
12183(Bpgm)
RNO: 
296973(Bpgm)
CGE: 
100757548(Bpgm)
NGI: 
103726061(Bpgm)
HGL: 
101706859(Bpgm)
CCAN: 
109688796
OCU: 
100009096(BPGM)
TUP: 
102496494(BPGM)
CFA: 
482704(BPGM)
AML: 
100479620(BPGM)
UMR: 
103678255(BPGM)
FCA: 
101095644(BPGM)
PTG: 
102952979(BPGM)
AJU: 
106975708(BPGM)
BTA: 
533785(BPGM)
BOM: 
102270409 102275256 102275503 102285424
BIU: 
109557654(BPGM)
PHD: 
102332772(BPGM)
CHX: 
102187916(BPGM)
OAS: 
101121089(BPGM)
SSC: 
106506774(BPGM)
CFR: 
102514048(BPGM)
BACU: 
103009787(BPGM) 103015640
LVE: 
103089210(BPGM)
ECB: 
100065115(BPGM)
MYB: 
102254057(BPGM)
MYD: 
102772643(BPGM)
HAI: 
109389371(BPGM)
RSS: 
109457774(BPGM)
PALE: 
102886645(BPGM)
LAV: 
100673907(BPGM)
MDO: 
100021814(BPGM)
SHR: 
100920227(BPGM)
OAA: 
100075920(BPGM)
GGA: 
418172(BPGM)
MGP: 
100546129(BPGM)
CJO: 
107314945(BPGM)
APLA: 
101803151(BPGM)
ACYG: 
106030917(BPGM)
TGU: 
100224087
GFR: 
102033451(BPGM)
FAB: 
101817641(BPGM)
PHI: 
102108959(BPGM)
CCW: 
104692259(BPGM)
FPG: 
101915204(BPGM)
FCH: 
102046661(BPGM)
CLV: 
102089457(BPGM)
AAM: 
106488955(BPGM)
ASN: 
102373803(BPGM)
AMJ: 
102568684(BPGM)
PSS: 
102447629(BPGM)
CMY: 
102946921(BPGM)
CPIC: 
101941911(BPGM)
ACS: 
100564984(bpgm)
PBI: 
103062795(BPGM)
GJA: 
107125358(BPGM)
XLA: 
444102(bpgm.L) 444279(bpgm.S)
XTR: 
549353(bpgm)
NPR: 
108792024(BPGM)
DRE: 
436903(bpgm)
SRX: 
107716700 107753699
SANH: 
107661509
SGH: 
107576414 107590805
IPU: 
108269072(bpgm)
TRU: 
101074347(bpgm)
TNG: 
GSTEN00029715G001
LCO: 
104940663(bpgm)
NCC: 
104946798(bpgm)
MZE: 
101473870(bpgm)
OLA: 
101172407(bpgm)
XMA: 
102233730(bpgm)
CSEM: 
103380563(bpgm)
LCF: 
108888560(bpgm)
SASA: 
100196266(pmge) 106561646
ELS: 
105021856(bpgm)
SFM: 
108920769 108931367
LCM: 
102350982(BPGM)
CMK: 
103185559(bpgm)
 » show all
Taxonomy
Reference
1
  Authors
Ray, W.J., Jr. and Peck, E.J., Jr.
  Title
Phosphomutases.
  Journal
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 6, 1972, p. 407-477.
Reference
2  [PMID:5687724]
  Authors
Rose ZB.
  Title
The purification and properties of diphosphoglycerate mutase from human erythrocytes.
  Journal
J. Biol. Chem. 243 (1968) 4810-20.
Reference
3  [PMID:6255773]
  Authors
Rose ZB.
  Title
The enzymology of 2,3-bisphosphoglycerate.
  Journal
Adv. Enzymol. Relat. Areas. Mol. Biol. 51 (1980) 211-53.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37211-69-1
KEGG   REACTION: R01662Help
Entry
R01662                      Reaction                               

Name
3-phospho-D-glycerate 1,2-phosphomutase
Definition
3-Phospho-D-glyceroyl phosphate <=> 2,3-Bisphospho-D-glycerate
Equation
Reaction class
C00236_C01159
Enzyme
Pathway
Glycolysis / Gluconeogenesis
Metabolic pathways
Orthology
K01837  
bisphosphoglycerate/phosphoglycerate mutase [EC:5.4.2.4 5.4.2.11]
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