KEGG ORTHOLOGY: K01852

ORTHOLOGY: K01852

Entry

K01852                      KO

Symbol

LSS, ERG7

Name

lanosterol synthase [EC:5.4.99.7]

Pathway

map00100

Steroid biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00101

Cholesterol biosynthesis, FPP => cholesterol

M00102

Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol

Reaction

R03199

(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)

Disease

H00786

Hypotrichosis

H01202

Cataract

H02303

Alopecia-mental retardation syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K01852  LSS, ERG7; lanosterol synthase
Enzymes [BR:ko01000]
5. Isomerases
  5.4  Intramolecular transferases
   5.4.99  Transferring other groups
    5.4.99.7  lanosterol synthase
     K01852  LSS, ERG7; lanosterol synthase

Other DBs

COG:

COG1657

GO:

0000250

Genes

HSA:

4047(LSS)

PTR:	474058(LSS)

PPS:	100974593(LSS)

GGO:	101124004(LSS)

PON:	100432375(LSS)

NLE:	100592843(LSS)

HMH:	116481734(LSS)

MCC:	709227(LSS)

MCF:	102137329(LSS)

MTHB:

126950599

MNI:	105472480(LSS)

CSAB:

103220328(LSS)

CATY:

105575561(LSS)

PANU:

101006026(LSS)

TGE:	112620282(LSS)

MLEU:

105551552(LSS)

RRO:	104667600(LSS)

RBB:

108512153

TFN:	117095879(LSS)

PTEH:

111527943(LSS)

CANG:

105520449(LSS)

CJC:	100409467(LSS)

SBQ:	101032145(LSS)

CIMI:

108311181(LSS)

CSYR:

103257838(LSS)

MMUR:

105879670(LSS)

LCAT:

123630831(LSS)

PCOQ:

105817078(LSS)

OGA:	100948133(LSS)

MMU:	16987(Lss)

MCAL:

110302909(Lss)

MPAH:

110326638(Lss)

RNO:	81681(Lss)

MCOC:

116075533(Lss)

ANU:	117724386(Lss)

MUN:	110546351(Lss)

CGE:	100753498(Lss)

MAUA:

101839557(Lss)

PROB:

127224127(Lss)

PLEU:

114696515(Lss)

MORG:

121435496(Lss)

MFOT:

126501852

AAMP:

119822439(Lss)

NGI:	103739961(Lss)

HGL:	101713900(Lss)

CPOC:

100728014(Lss)

CCAN:

109695890(Lss)

DORD:

105998238(Lss)

DSP:	122121146(Lss)

PLOP:

125351376(Lss)

NCAR:

124992709

MMMA:

107136179(Lss)

OCU:

100359315

OPI:	101531461(LSS)

TUP:	102473663(LSS)

GVR:	103594728(LSS)

CFA:	491611(LSS)

CLUD:

112669241(LSS)

VVP:	112909549(LSS)

VLG:	121479453(LSS)

NPO:	129502133(LSS)

AML:	100482594(LSS)

UMR:	103680679(LSS)

UAH:	113258959(LSS)

UAR:	123779130(LSS)

ELK:

111155646

LLV:

125093088

MPUF:

101694228(LSS)

MNP:	132012493(LSS)

MLK:	131825492(LSS)

NVS:	122908217(LSS)

ORO:	101375055(LSS)

EJU:	114201843(LSS)

ZCA:	113917146(LSS)

MLX:	118026933(LSS)

NSU:	110571098(LSS)

LWW:	102747017(LSS)

FCA:	101080651(LSS)

PYU:	121035833(LSS)

PCOO:

112849346(LSS)

PBG:	122491068(LSS)

PVIV:

125159084(LSS)

LRUF:

124526737

PTG:	102962591(LSS)

PPAD:

109258102(LSS)

PUC:

125920645

AJU:

106987528

HHV:	120223916(LSS)

BTA:	615906(LSS)

BOM:	102277039(LSS)

BIU:	109561307(LSS)

BBUB:

102395472(LSS)

BBIS:

104984908(LSS)

CHX:	102175810(LSS)

OAS:	101106995(LSS)

BTAX:

128049621(LSS)

ODA:	120881088(LSS)

CCAD:

122445445(LSS)

MBEZ:

129548803(LSS)

SSC:	100625138(LSS)

CFR:	102516637(LSS)

CBAI:

105077990(LSS)

CDK:	105090588(LSS)

VPC:	102528619(LSS)

BACU:

103005228(LSS)

BMUS:

118894320(LSS)

LVE:	103077252(LSS)

OOR:	101289294(LSS)

DLE:	111186240(LSS)

PSIU:

116753012(LSS)

NASI:

112408627(LSS)

ECB:	100055292(LSS)

EPZ:	103558417(LSS)

EAI:	106842988(LSS)

MYB:	102244769(LSS)

MYD:	102755441(LSS)

MMYO:

118676077(LSS)

MLF:	102417671(LSS)

PKL:	118724659(LSS)

EFUS:

103289763(LSS)

MNA:	107536230(LSS)

DRO:	112306546(LSS)

SHON:

119000237(LSS)

AJM:	119058762(LSS)

PDIC:

114490463(LSS)

PHAS:

123828012(LSS)

MMF:	118617180(LSS)

PPAM:

129075266(LSS)

RFQ:

117035290

PALE:

102897618(LSS)

PGIG:

120616399(LSS)

PVP:	105308829(LSS)

RAY:	107510225(LSS)

MJV:	108409563(LSS)

TOD:	119257142(LSS)

SARA:

101536901(LSS)

LAV:	100662429(LSS)

TMU:

101341011

ETF:	101660403(LSS)

DNM:	101414303(LSS)

GAS:	123247639(LSS)

SHR:	100933933(LSS)

AFZ:

127562541

PCW:	110198829(LSS)

OAA:	100083602(LSS)

GGA:	424037(LSS)

PCOC:

116236010(LSS)

MGP:	100544500(LSS)

CJO:	107316378(LSS)

TPAI:

128076635(LSS)

LMUT:

125696614(LSS)

NMEL:

110399885(LSS)

APLA:

101801199(LSS)

ACYG:

106030113(LSS)

CATA:

118260445(LSS)

AFUL:

116490643(LSS)

TGU:	100223318(LSS)

LSR:	110471683(LSS)

SCAN:

103814750(LSS)

PMOA:

120511549(LSS)

OTC:	121332050(LSS)

PRUF:

121364442(LSS)

GFR:	102037340(LSS)

FAB:	101809334(LSS)

OMA:	130255434(LSS)

PHI:	102113695(LSS)

CCAE:

111931893(LSS)

CCW:	104698254(LSS)

CBRC:

103621389(LSS)

ETL:	114070053(LSS)

ZAB:	102064988(LSS)

ACHL:

103803671(LSS)

SVG:	106862602(LSS)

MMEA:

130588869(LSS)

HRT:	120755422(LSS)

FPG:	101912237(LSS)

FCH:	102059359(LSS)

CLV:	102092351(LSS)

EGZ:	104133503(LSS)

NNI:	104013643(LSS)

PCRI:

104032745(LSS)

PLET:

104622881(LSS)

EHS:	104515075(LSS)

PCAO:

104043881(LSS)

ACUN:

113482095(LSS)

TALA:

104368071(LSS)

PADL:

103922915(LSS)

AFOR:

103902144(LSS)

ACHC:

115342554(LSS)

HALD:

104315455(LSS)

HLE:	104831410(LSS)

AGEN:

126043019

GCL:

127018416

CCRI:

104165960(LSS)

CSTI:

104553151(LSS)

CMAC:

104481172(LSS)

MUI:	104546177(LSS)

BREG:

104638911(LSS)

FGA:	104077424(LSS)

GSTE:

104258188(LSS)

LDI:	104351049(LSS)

MNB:	103777685(LSS)

OHA:	104338891(LSS)

NNT:	104409407(LSS)

SHAB:

115609105(LSS)

DPUB:

104296669(LSS)

PGUU:

104464273(LSS)

ACAR:

104525530(LSS)

CPEA:

104392152(LSS)

AVIT:

104280786(LSS)

CVF:	104292074(LSS)

RTD:	128913050(LSS)

CUCA:

104064562(LSS)

TEO:	104372184(LSS)

BRHI:

104491306(LSS)

AAM:	106492318(LSS)

AROW:

112975121(LSS)

NPD:	112955597(LSS)

TGT:	104575220(LSS)

DNE:	112978872(LSS)

SCAM:

104146172(LSS)

ASN:	102375533(LSS)

AMJ:	102568061(LSS)

CPOO:

109323021(LSS)

GGN:	109301919(LSS)

CMY:	102946034(LSS)

CCAY:

125644881(LSS)

DCC:	119863738(LSS)

CABI:

116829071(LSS)

MRV:	120374232 120374242 120374980

ACS:	100558321(lss)

ASAO:

132770038(LSS)

PVT:

110090934

SUND:

121919889(LSS) 121928990

PMUR:

107294412 107296168(LSS)

CTIG:

120297402 120300363(LSS)

PGUT:

117659519 117664346 117671165(LSS)

APRI:

131199205(LSS)

PTEX:

113440660 113440982(LSS)

NSS:	113410919 113419569(LSS)

VKO:	123024380(LSS)

PMUA:

114582271(LSS) 114598445 114598953

PRAF:

128400306(LSS) 128415723 128415724

ZVI:	118079446 118097047(LSS)

HCG:	128339346(LSS)

GJA:	107122323(LSS)

STOW:

125434939(LSS)

EMC:	129329110(LSS)

XLA:	108703025(lss.S)

XTR:	733925(lss)

NPR:	108793617(LSS)

RTEM:

120943921(LSS)

BBUF:

121008548 121008549

BGAR:

122944874 122945066

MUO:	115475079(LSS)

GSH:	117361610(LSS)

DRE:	795400(lss)

SRX:	107714200 107741934

SANH:

107660663 107673746

SGH:	107555930(lss)

CCAR:

109088812(lss)

CAUA:

113108388(lss)

CGIB:

127964807

PTET:

122351234(lss)

LROH:

127171349(lss)

OMC:	131547123(lss)

PPRM:

120461497(lss)

RKG:	130096623(lss) 130096625

MAMB:

125270564(lss)

CIDE:

127518423

MASI:

127448494

TROS:

130555680(lss)

TDW:	130427446(lss)

MANU:

129452200(lss)

IPU:

108266196

IFU:	128609021(lss)

PHYP:

113526032(lss)

SMEO:

124383367(lss)

TFD:	113654128(lss)

TVC:	132850334(lss)

AMEX:

103022113(lss)

CMAO:

118807202(lss)

EEE:	113567698(lss)

CHAR:

122132216(lss)

TRU:	101062227(lss)

TFS:	130531768(lss)

TNG:	GSTEN00029216G001

LCO:	104920782(lss)

TBEN:

117485814(lss)

CGOB:

115026579(lss)

PGEO:

117466554 117466555

GACU:

117549462(lss)

EMAC:

134866806(lss)

ELY:	117249962(lss)

EFO:	125900133(lss)

PLEP:

121949264(lss)

SLUC:

116053545

ECRA:

117952976(lss)

ESP:	116698456(lss)

PFLV:

114564414(lss)

GAT:	120834092(lss)

PPUG:

119229081(lss)

AFB:	129104578(lss)

CLUM:

117750212(lss)

PSWI:

130204218(lss)

MSAM:

119903407(lss) 119903566

SCHU:

122885012(lss)

CUD:	121522678(lss)

ALAT:

119026489(lss)

MZE:	101485469(lss)

ONL:

100690152

OAU:	116309479(lss)

OLA:	101157258 101157497(lss)

OML:	112155265(lss)

CSAI:

133446492(lss)

XMA:	102229476(lss)

XCO:	114148334(lss)

XHE:	116723508(lss)

PRET:

103461854(lss)

PFOR:

103138128(lss)

PLAI:

106939999(lss)

PMEI:

106916303(lss)

GAF:	122840377(lss)

PPRL:

129355998

CVG:	107086194(lss)

CTUL:

119774029(lss)

GMU:	124870941(lss)

NFU:	107373714(lss)

KMR:	108247360 108247361 108247362

ALIM:

106529310(lss) 106529311

NWH:	119418993 119418994 119419509 119419797

AOCE:

111582860(lss)

MCEP:

125017960 125017961

CSEM:

103392388(lss)

POV:	109644787(lss)

SSEN:

122759031(lss)

HHIP:

117755142(lss)

HSP:	118119648(lss)

SMAU:

118282754(lss)

LCF:

108897198

SDU:	111218455(lss)

SLAL:

111667391(lss)

XGL:	120801101(lss)

HCQ:	109517560(lss)

SSCV:

125974142

SBIA:

133512647(lss)

PEE:	133410738(lss)

PTAO:

133486710(lss)

BPEC:

110167885(lss)

MALB:

109972638(lss)

BSPL:

114846833(lss)

SJO:	128368108(lss)

SASA:

106581851(lss)

STRU:

115156153(lss)

OTW:	112225134(lss)

OMY:	110501565(lss)

OGO:	124041837(lss)

ONE:	115137059(lss)

OKI:	109871110(lss)

OKE:	118385938(lss)

SALP:

111959367(lss)

SNH:	120064445(lss)

CCLU:

121551435(lss)

ELS:	105016172(lss)

SFM:	108924262(lss)

PKI:	111845428(lss)

AANG:

118222420(lss)

LOC:	102696203(lss)

PSPA:

121323023(lss)

ARUT:

117400328(lss)

PSEX:

120531243(lss)

LCM:	102361349(LSS)

CMK:	103188931(lss)

CPLA:

122551472(lss)

HOC:	132817289(lss)

LERI:

129698860(lss)

PMRN:

116945955(LSS)

LRJ:	133345016(LSS)

BFO:

BBEL:

SPU:

LPIC:

PMEO:

PVUL:

BGT:

GAE:

HRF:	124120694 124141585

HRJ:	124253014 124263131

ATH:	AT3G45130(LAS1)

ALY:

9311782

EUS:	EUTSA_v10001913mg

THJ:

104799632

MNT:	112090552 112095065

PALZ:

118061782

PVIR:

120640014 120645568

SCE:	YHR072W(ERG7)

SEUB:

DI49_2476

SPAO:

SPAR_H01130

AGO:	AGOS_AGR351W

ERC:

Ecym_8182

KLA:	KLLA0_B10175g

KMX:	KLMA_30341(ERG7)

LTH:	KLTH0H14850g

VPO:	Kpol_339p12

ZRO:	ZYRO0D10164g

CGR:	CAGL0J10824g

NCS:	NCAS_0H01640(NCAS0H01640)

NDI:	NDAI_0C01970(NDAI0C01970)

TPF:	TPHA_0E01120(TPHA0E01120)

TBL:	TBLA_0A03120(TBLA0A03120)

TGB:	HG536_0E02890

TDL:	TDEL_0E02760(TDEL0E02760)

KAF:	KAFR_0D04670(KAFR0D04670)

KNG:	KNAG_0B04580(KNAG0B04580)

ZMK:	HG535_0C03300

PPA:	PAS_chr2-1_0391

DHA:	DEHA2C05764g

PIC:	PICST_77382(ERG7)

PGU:	PGUG_05319

SPAA:

SPAPADRAFT_55185

LEL:	PVL30_000557(ERG7)

CAL:	CAALFM_C202460WA(ERG7)

CTP:	CTRG_01395

COT:	CORT_0A05450

CDU:	CD36_17130(ERG7)

CTEN:

CANTEDRAFT_105173

YLI:	YALI0F04378g

CLU:	CLUG_00911

CLUS:

A9F13_10g01925

CAUR:

CJI96_0003797

SLB:	AWJ20_3290(ERG7)

PKZ:	C5L36_0B03220

BNN:	FOA43_004550(ERG7)

BBRX:

BRETT_001869(ERG7)

OPA:	HPODL_03376

SLUD:

SCDLUD_004580

NCR:

NCU01119

NTE:	NEUTE1DRAFT127722(NEUTE1DRAFT_127722)

SMP:	SMAC_03193

PAN:	PODANSg8579

PBEL:

QC761_207490(ERG7)

PPSD:

QC762_207490(ERG7)

PPSP:

QC763_207490(ERG7)

PPSA:

QC764_207490(ERG7)

TTT:	THITE_129749

MTM:	MYCTH_2301508

CTHR:

MGR:

PPEI:

PGRI:

TMN:	UCRPA7_3525

FGR:	FGSG_05950

FPU:	FPSE_03029

FPOA:

FPOAC1_008913

FVN:	FVRRES_09528

FVR:	FVEG_04575

FOX:	FOXG_07651

NHE:	NECHADRAFT_72055

FFC:	NCS54_01171500 NCS54_01418400

FKR:	NCS57_01162100 NCS57_01400300

FMU:	J7337_006616

TRE:	TRIREDRAFT_59846

TRR:	M419DRAFT_136748

MAW:

MAC_04069

MAJ:

MAA_01453

PCHM:

VFPPC_03863 VFPPC_14013

CMT:

CCM_09526

AMUS:

LMH87_002893

PLJ:	VFPFJ_08272

PTKZ:

JDV02_004823

VAL:	VDBG_01893 VDBG_07639

VDA:	VDAG_01664 VDAG_09360

CFJ:	CFIO01_01052

CLUP:

CLUP02_07513

CHIG:

CH63R_03890 CH63R_07103

SAPO:

SAPIO_CDS8304

ELA:	UCREL1_4598

PFY:	PFICI_07703

SSL:	SS1G_01528

BFU:	BCIN_02g00670

MBE:

MBM_02694

PSCO:

LY89DRAFT_584828

GLZ:	GLAREA_06531

ANI:	ANIA_08249 ANIA_11065

AFM:	AFUA_4G12040 AFUA_5G04080

ACT:	ACLA_001090

NFI:	NFIA_038030 NFIA_104210

AOR:	AO090020000194 AO090102000611 AO090166000068

ANG:	An09g01330 An09g06490

AFV:	AFLA_010467 AFLA_011429 AFLA_012044

ALUC:

AKAW2_40649S(ERG7_3)

ACHE:

ACHE_60781A(ERG7)

APUU:

APUU_20800A(ERG7_1) APUU_31278A(ERG7_2) APUU_60585A(ERG7_3)

PCS:	N7525_004959 N7525_010232

PDP:	PDIP_53520

POU:	POX_a00430

TMF:	EYB26_004386

TRG:	TRUGW13939_08302

CIM:	CIMG_02792 CIMG_06646

CPW:	CPC735_031030 CPC735_036410

URE:	UREG_03791

PBL:	PAAG_04196

PBN:	PADG_07451

ABE:

ARB_06777

TVE:

TRV_05691

AJE:	HCAG_00613

BGH:	BDBG_01260

PNO:	SNOG_11162

PTE:

PTT_15458

BZE:	COCCADRAFT_86820

BSC:	COCSADRAFT_197124

BOR:	COCMIDRAFT_8644

AALT:

CC77DRAFT_728315

ARAB:

EKO05_0010152

PFJ:	MYCFIDRAFT_32198

FFU:	CLAFUR5_07287

CBET:

CB0940_09907

NPA:	UCRNP2_3498

TML:	GSTUM_00011699001

SPO:	SPAC13G7.01c(erg7)

SOM:	SOMG_02776(erg7)

CNE:

CND02520

CNG:	CNAG_01129

CDEU:

CNBG_0697

TASA:

A1Q1_07921

CCAC:

CcaHIS019_0100810(ERG7)

TVS:	TRAVEDRAFT_167400

SHS:	STEHIDRAFT_57720

HIR:	HETIRDRAFT_453585

PSQ:	PUNSTDRAFT_106358

ADL:	AURDEDRAFT_115430

FME:	FOMMEDRAFT_100769

GTR:	GLOTRDRAFT_82165

RSX:	RhiXN_05057

LBC:	LACBIDRAFT_185468

CCI:	CC1G_05695

ABP:	AGABI1DRAFT55056(AGABI1DRAFT_55056)

ABV:	AGABI2DRAFT206259(AGABI2DRAFT_206259)

PCUB:

JR316_0008240

MPR:	MPER_02146 MPER_03149

E1B28_003115 E1B28_007407

CPUT:

CONPUDRAFT_127073

SLA:	SERLADRAFT_451021

WSE:	WALSEDRAFT_14803

WIC:	J056_002076

UMA:	UMAG_10079

PFP:	PFL1_02548

SGRA:

MGL:

MRT:

MSYM:

PGR:	PGTG_12360

PTRC:

PtA15_14A170 PtA15_9A541

PSTR:

Pst134EA_009496 Pst134EA_021210

DDI:	DDB_G0269226(cas1)

DPP:	DICPUDRAFT_74059

TBR:	Tb927.7.5230

TBG:	TbgDal_VII6010

TCR:	506825.170 508175.70

LMA:	LMJF_06_0650

LIF:	LINJ_06_0670

LDO:	LDBPK_060670

LPAN:

LPMP_060620

MEIN:

methR_P0930

MFB:	MFUL124B02_14110

» show all

Reference

PMID:6027261

Authors

Dean PD, Ortiz de Montellano PR, Bloch K, Corey EJ

Title

A soluble 2,3-oxidosqualene sterol cyclase.

Journal

J Biol Chem 242:3014-5 (1967)

Reference

PMID:7639730

Authors

Baker CH, Matsuda SP, Liu DR, Corey EJ

Title

Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library.

Journal

Biochem Biophys Res Commun 213:154-60 (1995)
DOI:10.1006/bbrc.1995.2110

Sequence

[hsa:4047]

Reference

PMID:8134375

Authors

Corey EJ, Matsuda SP, Bartel B

Title

Molecular cloning, characterization, and overexpression of ERG7, the Saccharomyces cerevisiae gene encoding lanosterol synthase.

Journal

Proc Natl Acad Sci U S A 91:2211-5 (1994)
DOI:10.1073/pnas.91.6.2211

Sequence

[sce:YHR072W]

Reference

PMID:16531458

Authors

Suzuki M, Xiang T, Ohyama K, Seki H, Saito K, Muranaka T, Hayashi H, Katsube Y, Kushiro T, Shibuya M, Ebizuka Y

Title

Lanosterol synthase in dicotyledonous plants.

Journal

Plant Cell Physiol 47:565-71 (2006)
DOI:10.1093/pcp/pcj031

Sequence

[ath:AT3G45130]

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