KEGG   ORTHOLOGY: K01860Help
Entry
K01860                      KO                                     

Name
E5.5.1.7
Definition
chloromuconate cycloisomerase [EC:5.5.1.7]
Pathway
Chlorocyclohexane and chlorobenzene degradation
Fluorobenzoate degradation
Toluene degradation
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Xenobiotics biodegradation and metabolism
   00364 Fluorobenzoate degradation
    K01860  E5.5.1.7; chloromuconate cycloisomerase
   00361 Chlorocyclohexane and chlorobenzene degradation
    K01860  E5.5.1.7; chloromuconate cycloisomerase
   00623 Toluene degradation
    K01860  E5.5.1.7; chloromuconate cycloisomerase
Enzymes [BR:ko01000]
 5. Isomerases
  5.5  Intramolecular lyases
   5.5.1  Intramolecular lyases (only sub-subclass identified to date)
    5.5.1.7  chloromuconate cycloisomerase
     K01860  E5.5.1.7; chloromuconate cycloisomerase
BRITE hierarchy
Other DBs
Genes
PKC: 
PKB_3274(clcb1) PKB_3623(clcb3)
REU: 
BXE: 
Bxe_A1129(clcB)
BXB: 
DR64_3289(tcbD)
BPT: 
Bpet1535(catB2) Bpet3749(catB5)
AXY: 
SJP: 
AG: 
AAD13626(tcbD)
TaxonomyKoalaUniProt
Reference
  Authors
Kajander T, Lehtio L, Schlomann M, Goldman A
  Title
The structure of Pseudomonas P51 Cl-muconate lactonizing enzyme: co-evolution of  structure and dynamics with the dehalogenation function.
  Journal
Protein Sci 12:1855-64 (2003)
DOI:10.1110/ps.0388503
  Sequence

KEGG   ENZYME: 5.5.1.7Help
Entry
EC 5.5.1.7                  Enzyme                                 

Name
chloromuconate cycloisomerase;
muconate cycloisomerase II;
2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing);
2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (ring-opening)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (ring-opening)
Reaction(IUBMB)
(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate [RN:R04259]
Reaction(KEGG)
Substrate
(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate [CPD:C04522]
Product
3-chloro-cis,cis-muconate [CPD:C03585]
Comment
Requires Mn2+. The product of cycloisomerization of 3-chloro-cis,cis-muconate spontaneously eliminates chloride to produce cis-4-carboxymethylenebut-2-en-4-olide. Also acts on 2-chloro-cis,cis-muconate. Not identical with EC 5.5.1.1 (muconate cycloisomerase) or EC 5.5.1.11 (dichloromuconate cycloisomerase).
History
EC 5.5.1.7 created 1983
Pathway
Chlorocyclohexane and chlorobenzene degradation
Fluorobenzoate degradation
Toluene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K01860  
chloromuconate cycloisomerase
Genes
PKC: 
PKB_3274(clcb1) PKB_3623(clcb3)
REU: 
BXE: 
Bxe_A1129(clcB)
BXB: 
DR64_3289(tcbD)
BPT: 
Bpet1535(catB2) Bpet3749(catB5)
AXY: 
SJP: 
Taxonomy
Reference
1  [PMID:7305906]
  Authors
Schmidt E, Knackmuss HJ.
  Title
Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid.
  Journal
Biochem. J. 192 (1980) 339-47.
Reference
2  [PMID:11443090]
  Authors
Kaulmann U, Kaschabek SR, Schlomann M
  Title
Mechanism of chloride elimination from 3-chloro- and 2,4-dichloro-cis,cis-muconate: new insight obtained from analysis of muconate cycloisomerase variant CatB-K169A.
  Journal
J. Bacteriol. 183 (2001) 4551-61.
Reference
3  [PMID:12930985]
  Authors
Kajander T, Lehtio L, Schlomann M, Goldman A
  Title
The structure of Pseudomonas P51 Cl-muconate lactonizing enzyme: co-evolution of  structure and dynamics with the dehalogenation function.
  Journal
Protein. Sci. 12 (2003) 1855-64.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
95990-33-3
KEGG   REACTION: R08119Help
Entry
R08119                      Reaction                               

Name
5-fluoromuconolactone lyase (decyclizing)
Definition
2-Fluoro-cis,cis-muconate <=> 5-Fluoromuconolactone
Equation
Reaction class
C16475_C16477
Enzyme
Pathway
Fluorobenzoate degradation
Microbial metabolism in diverse environments
Orthology
K01860  
chloromuconate cycloisomerase [EC:5.5.1.7]
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