KEGG ORTHOLOGY: K02257

ORTHOLOGY: K02257

Entry

K02257 KO

Name

COX10

Definition

protoheme IX farnesyltransferase [EC:2.5.1.-]

Pathway

ko00190	Oxidative phosphorylation
ko00860	Porphyrin and chlorophyll metabolism

Module

M00154

Cytochrome c oxidase

Disease

H01354	Leigh syndrome
H01368	Cytochrome c oxidase (COX) deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Energy metabolism
   00190 Oxidative phosphorylation
    K02257  COX10; protoheme IX farnesyltransferase
  Metabolism of cofactors and vitamins
   00860 Porphyrin and chlorophyll metabolism
    K02257  COX10; protoheme IX farnesyltransferase
KEGG modules [BR:ko00002]
Structural complex
  Energy metabolism
   ATP synthesis
    M00154  Cytochrome c oxidase
     K02257  COX10; protoheme IX farnesyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.-
     K02257  COX10; protoheme IX farnesyltransferase
Prenyltransferases [BR:ko01006]
Compound prenylation
  Protoheme farnesyltransferase
   K02257  COX10; protoheme IX farnesyltransferase
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Mitochondrial respiratory chain complex assembly factors
   Complex-IV assembly factors
    K02257  COX10; protoheme IX farnesyltransferase

Other DBs

RN:

R07411

COG:

COG0109

GO:

0008495

Genes

HSA:	1352(COX10)
PTR:	465445(COX10)
PPS:	100980340 100987588
GGO:	101150438
PON:	100174049(COX10)
NLE:	100586480(COX10)
MCC:	718301(COX10)
MCF:	102132338
CSAB:	103242416(COX10)
RRO:	104667954
CJC:	100414136(COX10)
SBQ:	101040253
MMU:	70383(Cox10)
RNO:	691853(Cox10)
CGE:	100764018(Cox10)
NGI:	103752045
HGL:	101726271
CCAN:	109684973
OCU:	100356833
TUP:	102486064
CFA:	489515(COX10)
AML:	100472806(COX10)
UMR:	103660515
FCA:	101091737
PTG:	102968248
AJU:	106983011
BTA:	511440(COX10)
BOM:	102286422
BIU:	109574079
PHD:	102326620
CHX:	102176914
OAS:	101105425
SSC:	100521863(COX10)
CFR:	102512561
BACU:	103013334
LVE:	103072056
ECB:	100073118(COX10)
MYB:	102261324
MYD:	102768527
HAI:	109382206
RSS:	109435005
PALE:	102889718
LAV:	100671416
MDO:	100021387
SHR:	100930365
OAA:	100078034
GGA:	417329(COX10)
MGP:	100547436
CJO:	107322098
APLA:	101790381 101793788
ACYG:	106046704
TGU:	100229692
GFR:	102043819
FAB:	101817753
PHI:	102101672
CCW:	104695659
FPG:	101920943
FCH:	102050069
CLV:	102094955
AAM:	106499378
ASN:	102373916 102382988
AMJ:	102572017(COX10)
PSS:	102449584
CMY:	102932338
CPIC:	101943495
ACS:	100555255
PBI:	103051861
GJA:	107115269
XLA:	108702849(cox10.S) 779326(cox10.L)
XTR:	100145039(cox10)
NPR:	108784750
DRE:	553384(cox10)
SRX:	107753249
SANH:	107692457 107704238
SGH:	107561837 107597828
IPU:	108274223
TRU:	101068124
TNG:	GSTEN00026996G001
LCO:	104934339
NCC:	104945052
MZE:	101472949
OLA:	101161443
XMA:	102216551 102224721
CSEM:	103381808
LCF:	108876571
SASA:	106589628
ELS:	105021168
SFM:	108930288
LCM:	102360192
CMK:	103175416
BFO:	BRAFLDRAFT_117595
CIN:	100180555
SPU:	580927
SKO:	100370708
DME:	Dmel_CG5037
DPO:	Dpse_GA18613
DAN:	Dana_GF15766
DER:	Dere_GG10107
DPE:	Dper_GL19148
DSI:	Dsimw501_GD23677(Dsim_GD23677)
DWI:	Dwil_GK23501
DYA:	Dyak_GE18922
DGR:	Dgri_GH13369
DMO:	Dmoj_GI18678
DVI:	Dvir_GJ17536
MDE:	101895325
AGA:	AgaP_AGAP008884
AAG:	AaeL_AAEL001479
CQU:	CpipJ_CPIJ009365
AME:	409103(Cox10)
BIM:	100739999
BTER:	100649295
SOC:	105204723
AEC:	105154371
ACEP:	105622980
PBAR:	105426560
HST:	105183063
CFO:	105250136
LHU:	105679268
NVI:	100123510
TCA:	107398701
DPA:	109536270
NVL:	108557372
BMOR:	101742139
API:	100168441(Cox10) 100570971
DNX:	107162962
PHU:	Phum_PHUM175020
DPX:	DAPPUDRAFT_57149
ISC:	IscW_ISCW008907
TUT:	107372283
CEL:	CELE_Y46G5A.2(cox-10)
CBR:	CBG07915
NAI:	NECAME_14391
BMY:	Bm1_37295
LOA:	LOAG_07170
HRO:	HELRODRAFT_85716 HELRODRAFT_85763
LGI:	LOTGIDRAFT_64495
CRG:	105325585
OBI:	106868845
SMM:	Smp_057930
OVI:	T265_10288
NVE:	NEMVE_v1g238754
HMG:	100208691
TAD:	TRIADDRAFT_34046
AQU:	105312889
ATH:	AT2G44520(COX10)
ALY:	ARALYDRAFT_483579
CRB:	CARUB_v10025048mg
EUS:	EUTSA_v10001456mg
BRP:	103866143 103866807
BNA:	106392567 106429304 106437122
THJ:	104802511 104817164
CIT:	102621507
CIC:	CICLE_v10020370mg
TCC:	18602834
GRA:	105800340
GHI:	107890593 107935205
EGR:	104414374
GMX:	100806314
PVU:	PHAVU_007G006700g
VRA:	106769666
VAR:	108326394
CCAJ:	109815145
MTR:	MTR_1g116110
CAM:	101511427
ADU:	107467715
AIP:	107618144
LJA:	Lj5g3v2291460.1(Lj5g3v2291460.1) Lj5g3v2292490.1(Lj5g3v2292490.1)
LANG:	109336703
FVE:	101302413
PPER:	18791999
PMUM:	103319063
MDM:	103402518 103402560 103411040 103426263 103431812 103441929
PXB:	103938874 103946305
ZJU:	107419449
CSV:	101222607
CMO:	103483413
RCU:	8264747
JCU:	105631042
POP:	POPTR_0002s22440g(POPTRDRAFT_755787)
VVI:	100261621
SLY:	101251220
SPEN:	107008238
SOT:	102605323
INI:	109182181
SIND:	105167176
BVG:	104907416
NNU:	104606446
OSA:	4323939(B1129H01.4)
DOSA:	Os01t0527700-01(Os01g0527700)
OBR:	102721402
BDI:	100843969
ATS:	F775_12941 F775_21558 F775_29177
ZMA:	100193223 100274057
SITA:	101778955
PDA:	103703554
EGU:	105043841
MUS:	103971737
ATR:	18430872
SMO:	SELMODRAFT_76844 SELMODRAFT_83494
PPP:	PHYPADRAFT_44233
CRE:	CHLREDRAFT_123320(COX10)
VCN:	VOLCADRAFT_79954
OLU:	OSTLU_87130
OTA:	Ot04g05160
BPG:	Bathy08g04550
MIS:	MICPUN_68841
MPP:	MICPUCDRAFT_34718
CSL:	COCSUDRAFT_52878
CVR:	CHLNCDRAFT_23545
APRO:	F751_5808
CME:	CYME_CMT232C
GSL:	Gasu_53250
CCP:	CHC_T00005639001
SCE:	YPL172C(COX10)
AGO:	AGOS_AAL115W
ERC:	Ecym_2363
KLA:	KLLA0C09548g
LTH:	KLTH0D12034g
VPO:	Kpol_1064p24
ZRO:	ZYRO0F11990g
CGR:	CAGL0F03685g
NCS:	NCAS_0C01130(NCAS0C01130)
NDI:	NDAI_0K01130(NDAI0K01130)
TPF:	TPHA_0D01490(TPHA0D01490)
TBL:	TBLA_0D01220(TBLA0D01220)
TDL:	TDEL_0A06550(TDEL0A06550)
KAF:	KAFR_0B03150(KAFR0B03150)
PPA:	PAS_chr1-3_0194
DHA:	DEHA2F18634g
PIC:	PICST_47531(COX10)
PGU:	PGUG_02600
SPAA:	SPAPADRAFT_55660
LEL:	LELG_03973
CAL:	CAALFM_C502040WA(CaO19.3167)
CTP:	CTRG_05324
COT:	CORT_0F01740
CDU:	CD36_51890
CTEN:	CANTEDRAFT_104692
YLI:	YALI0F23727g
CLU:	CLUG_02873
CAUR:	QG37_03744
NCR:	NCU06141
NTE:	NEUTE1DRAFT147903(NEUTE1DRAFT_147903)
SMP:	SMAC_06375
PAN:	PODANSg2746
TTT:	THITE_2117623
MTM:	MYCTH_2308352
CTHR:	CTHT_0018240
MGR:	MGG_05944
TMN:	UCRPA7_2146 UCRPA7_3498
FGR:	FGSG_07547
FPU:	FPSE_10588
FVR:	FVEG_12748
FOX:	FOXG_15419
NHE:	NECHADRAFT_71542
TRE:	TRIREDRAFT_28159
MAW:	MAC_02354
MAJ:	MAA_06878
CMT:	CCM_08191
VAL:	VDBG_07103
VDA:	VDAG_06746
CFJ:	CFIO01_09415
ELA:	UCREL1_7081
PFY:	PFICI_15066
SSL:	SS1G_04105
BFU:	BC1G_00294
MBE:	MBM_09156
PSCO:	LY89DRAFT_710964
GLZ:	GLAREA_10988
ANI:	AN1722.2
AFM:	AFUA_4G08340
AOR:	AOR_1_1250144(AO090023000725)
ANG:	ANI_1_604184(An04g03120)
AFV:	AFLA_111320
ACT:	ACLA_047710
NFI:	NFIA_107820
PCS:	Pc13g08110
PDP:	PDIP_88210
CIM:	CIMG_08854
CPW:	CPC735_063690
PBL:	PAAG_03203
PBN:	PADG_03086
URE:	UREG_02775
ABE:	ARB_05941
TVE:	TRV_04257
PNO:	SNOG_00816
PTE:	PTT_18889
BZE:	COCCADRAFT_9581
BSC:	COCSADRAFT_35762
BOR:	COCMIDRAFT_93641
ZTR:	MYCGRDRAFT_65527
PFJ:	MYCFIDRAFT_98134
BCOM:	BAUCODRAFT_25549
NPA:	UCRNP2_627
TML:	GSTUM_00001943001
SPO:	SPBC365.02c(cox10)
CNE:	CNL04740
CNB:	CNBI2110
CGI:	CGB_D2320C
TMS:	TREMEDRAFT_56616
PPL:	POSPLDRAFT_88872
TVS:	TRAVEDRAFT_29755
DSQ:	DICSQDRAFT_72742
PCO:	PHACADRAFT_251838
SHS:	STEHIDRAFT_90729
HIR:	HETIRDRAFT_315597
PSQ:	PUNSTDRAFT_47218
ADL:	AURDEDRAFT_112738
FME:	FOMMEDRAFT_151758
GTR:	GLOTRDRAFT_111615
LBC:	LACBIDRAFT_144184
MPR:	MPER_08169
MRR:	Moror_22
CCI:	CC1G_12378
SCM:	SCHCODRAFT_230554
ABP:	AGABI1DRAFT86328(AGABI1DRAFT_86328)
ABV:	AGABI2DRAFT134667(AGABI2DRAFT_134667)
CPUT:	CONPUDRAFT_99972
SLA:	SERLADRAFT_361588
WSE:	WALSEDRAFT_60542
WIC:	J056_003754
MGL:	MGL_2373
PGR:	PGTG_18956 PGTG_20114 PGTG_22769
MLR:	MELLADRAFT_26282 MELLADRAFT_87388
MBR:	MONBRDRAFT_16299
SRE:	PTSG_12134
DDI:	DDB_G0288169(cox10)
DPP:	DICPUDRAFT_81366
DFA:	DFA_10887(cox10)
ACAN:	ACA1_267150
PFA:	PFE0970w
PFD:	PFDG_02623
PFH:	PFHG_04756
PYO:	PY06214
PCB:	PCHAS_123470(PC000677.04.0)
PBE:	PB000510.03.0
PKN:	PKH_101310
PVX:	PVX_080280
PCY:	PCYB_102250
TAN:	TA07535
TPV:	TP04_0267
TOT:	TOT_040000633
BEQ:	BEWA_005320
BBO:	BBOV_II003260(18.m06274)
TET:	TTHERM_000370809
SMIN:	v1.2.007856.t1(symbB.v1.2.007856.t1)
FCY:	FRACYDRAFT_271325
TPS:	THAPSDRAFT_15142
AAF:	AURANDRAFT_3278
PIF:	PITG_12264
PSOJ:	PHYSODRAFT_540850
SPAR:	SPRG_05289
EHX:	EMIHUDRAFT_466261
GTT:	GUITHDRAFT_73866
TBR:	Tb927.5.1310(Tb05.30H13.320)
TCR:	509601.59 509767.59
LMA:	LMJF_23_1520
LIF:	LINJ_23_1920
LDO:	LDBPK_231920
LMI:	LMXM_23_1520
LBZ:	LBRM_23_1760
NGR:	NAEGRDRAFT_63810

» show all

Reference

PMID:8078902

Authors

Glerum DM, Tzagoloff A

Title

Isolation of a human cDNA for heme A:farnesyltransferase by functional complementation of a yeast cox10 mutant.

Journal

Proc Natl Acad Sci U S A 91:8452-6 (1994)
DOI:10.1073/pnas.91.18.8452

All links

Ontology (7)   
   KEGG BRITE (5)   
   GO (1)   
   COG (1)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Disease (2)   
   KEGG DISEASE (2)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (921)   
   KEGG GENES (393)   
   KEGG MGENES (311)   
   RefGene (75)   
   EGENES (129)   
   OC (13)   
Protein sequence (252)   
   UniProt (235)   
   SWISS-PROT (17)   
Literature (1)   
   PubMed (1)   
All databases (1194)   

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